Articles tagged with Protein Markers
Researchers at DZNE identified five particularly affected cell types in the motor cortex, which are equally susceptible to ALS and FTD. The study used molecular fingerprinting to analyze human tissue samples and found that excitatory cells are primarily affected by the disease.
Researchers discovered that levetiracetam prevents the production of toxic amyloid-beta 42 peptides and plaques in neurons. Administering the drug to high-risk individuals may slow cognitive decline and prevent Alzheimer's symptoms if started early, possibly up to 20 years before symptoms appear.
Researchers have developed a new class of engineered nanoparticles that can bind to and degrade specific disease-related proteins. This technology has the potential to treat diseases such as dementia and brain cancer by eliminating harmful proteins.
Researchers have discovered that inhibiting the metalloprotease ADAM19 can reduce gut inflammation and cell aging markers across species. The study found that blocking ADAM19 reduced gut damage and inflammation in fruit flies, mice, and human cells, offering a promising path for creating treatments to maintain healthy tissues.
Researchers found that measuring lipoprotein markers in a simple blood test can identify individuals at high risk of cardiovascular disease more effectively. The study analyzed data from over 200,000 people and showed that the total number of 'bad cholesterol' particles is the most important factor to consider when testing for future h...
Researchers discovered temperature influences plant cell fate by regulating epigenetic marks. Low ambient temperatures can rescue developmental defects by compensating for PRC2 loss, highlighting the importance of H3K27me3 in maintaining cellular identity.
The study reveals that CBL-CIPK complex senses specific Ca2+ signals, phosphorylates ZIP12, and initiates its partial degradation to fine-tune the plant's response to Zn deficiency environments. This negative feedback mechanism effectively regulates zinc homeostasis and maintains efficient resource utilization.
Researchers have discovered RNA pseudouridine as a novel diagnostic target for colorectal cancer. The study found correlations between pseudouridine modifications and clinical markers, enabling potential non-invasive diagnosis. The findings provide a molecular framework for RNA epigenetics-based stratification and targeted interventions.
A study has identified an early blood marker for hereditary Alzheimer's disease, beta-synuclein, which can detect neurodegeneration up to 11 years before dementia symptoms. This biomarker could help with early diagnosis and treatment, improving the potential of new medicines for Alzheimer's.
A new study has found that older age is linked to higher levels of three dementia biomarkers in the blood. Researchers also discovered sex differences in biomarker levels, with female participants having higher levels of glial acidic proteins.
A new study by UCL researchers found that people with visual Alzheimer's disease have a unique distribution of proteins and markers in their brain, leading to symptoms such as reading difficulties. In contrast, those with memory-led Alzheimer's disease have different protein patterns, resulting in symptoms like memory loss.
A University of Minnesota Medical School study identified a key heart marker predicting ischemic stroke and dementia, which could lead to improved patient outcomes. The left atrium's ability to stretch was found to be the most accurate predictor.
Researchers developed new AI models, InstaNovo and InstaNovo+, to vastly improve accuracy and discovery in protein science. These models excel in tasks such as de novo peptide sequencing, identifying microorganisms, and discovering novel peptides, with implications for personalized medicine, cancer immunology, and beyond.
Researchers developed a novel blood test that accurately indicates spinal cord injury (SCI) severity and predicts potential recovery. The test identifies multiple biomarkers, including DNA and proteins, to rapidly diagnose SCI and project long-term neurological functional recovery.
Researchers at FAMU-FSU College of Engineering have developed a method for studying protein degradation within immune cells using engineered microparticles. This approach provides real-time insights into immune system function and dysfunction, offering valuable tools for understanding diseases such as cancer, Alzheimer’s disease, and a...
A study using NHANES data found that inflammation, rather than diet and exercise, has the strongest association with telomere shortening. Managing chronic inflammation may be key to preserving telomere length and promoting healthy aging.
A team of scientists has created a new method to selectively modify specific proteins in complex biological environments. They achieved this using aptamers and deoxyoxanosine, allowing precise conjugation of desired sites on target proteins. This breakthrough technology has the potential to revolutionize cancer diagnosis and treatment.
Researchers found that giving plasma, rather than whole blood, improves outcomes in patients with traumatic brain injury (TBI) or shock. Plasma recipients had distinct proteomic profiles associated with later stages of clot formation, neuron survival, and wound repair.
A new study led by University College London researchers found that social disadvantages can accelerate ageing and increase disease risk. People with favourable socioeconomic conditions show fewer signs of biological ageing than peers of the same age.
A USC study found proteins and pathways involved in inflammation are associated with changes in bone mineral density (BMD) over time. The research identified potential biomarkers that could serve as early indicators of a person's risk for bone health issues later in life.
Researchers at MD Anderson have made significant breakthroughs in understanding pancreatic cancer's evolutionary process and developing new treatment strategies. They also discovered that surgical resection can enhance antitumor response in patients receiving immune checkpoint therapy for advanced kidney cancer.
Researchers found that p-tau proteins in blood are elevated in both Alzheimer's and ALS patients, making them less specific for Alzheimer's diagnosis. However, they also show promise as potential biomarkers for early detection of ALS or monitoring disease progression.
Researchers found that high-fat diets caused significant changes in the brains of aged rats, including inflammatory markers and impaired memory functions, even after only three days. The study suggests that aging and diet-related inflammation may be key factors contributing to age-related memory decline.
Researchers at POSTECH developed a super-photostable organic dye, PF555, to track proteins in cells over extended periods. This breakthrough enables observation of endocytosis and protein interactions, revealing EGFR's active navigation in its environment.
A new study published in The Lancet Digital Health found that accelerated ageing in specific organs can predict diseases across the entire body. Organ ageing rates were linked to increased risks of various diseases, including cardiovascular disease, respiratory infections, and dementia.
Scientists at Nagoya University have developed a new mRNA technology that can produce up to 200 times more protein than traditional methods. This breakthrough enables the creation of healthy proteins to treat illnesses or toxic proteins to kill unwanted cells.
A new study identified USP5 as an enzyme crucial for breaking down unneeded or damaged proteins in the heart. Low levels of USP5 lead to protein buildup, triggering dilated cardiomyopathy in animal models. Increasing USP5 levels helps clear protein 'junk', improving heart function and reducing disease progression.
Researchers at UCSF describe how to curb MYC levels by disrupting the protein assembly line controlled by RBM42. Disrupting RBM42 in pancreatic cancer cells stopped them from growing, suggesting drugs could be developed to do the same for other fast-growing cancers.
A University of Oklahoma researcher is exploring alternate strategies for identifying and targeting Alzheimer's and related diseases using a $2.2 million federal grant. The study aims to understand the mechanisms linking aging to cognitive decline, potentially leading to new treatments for dementia.
The foundation has awarded eight recipients of the 2025 Damon Runyon-Rachleff Innovation Award, including five early-career researchers with initial grants of $400,000 over two years. The awardees aim to develop novel cancer therapies using innovative approaches such as engineered skin bacteria and small molecule-boosted drug delivery.
Researchers at University of Birmingham have discovered three new protein biomarkers TFF3, LCN2, and CEACAM5 that show strong predictive potential for colorectal cancer. These biomarkers are linked to cell adhesion and inflammation, processes closely associated with cancer development.
The UK Biobank has launched a groundbreaking study to measure over 5,400 proteins in 600,000 samples, offering unprecedented insights into disease development and progression. This massive dataset will enable researchers to explore how changes in protein levels influence diseases and develop personalized treatments.
Researchers have identified 11 genes affected by PFAS exposure, which could serve as markers to detect neurotoxicity. The study found distinct molecular structures within each type of PFAS drive changes in gene expression, highlighting the need for individual investigation.
Scientists develop novel MST detection method using CrAss-like phages (CLPs) to detect human fecal contamination, showing high efficacy and accuracy. The method uses PCR to detect CLP DNA, offering a cost-effective and selective approach to monitoring water quality.
Researchers have developed a new diagnostic test that uses two markers found in the synovial fluid of patients' joints to differentiate osteoarthritis from inflammatory arthritis. The algorithm, based on the ratio of cartilage oligomeric matrix protein and interleukin-8, has been validated with high accuracy.
A new blood-based biomarker, placental growth factor (PlGF), has been identified as a potential tool for detecting early brain changes associated with cognitive impairment and dementia. Elevated PlGF levels were found to be linked to increased vascular permeability, leading to white matter injury and subsequent cognitive decline.
Researchers developed a new tool called SigRM to analyze single-cell epitranscriptomics data, enabling the study of RNA modifications in individual cells. This can provide valuable insights into gene regulation and its impact on health and disease, particularly in complex conditions like cancer.
A new implantable device, inspired by a tree branch, uses DNA sensors to continuously monitor inflammation biomarkers in the body. The device accurately measures protein biomarkers of inflammation in diabetic rats and has potential applications for managing acute and chronic conditions.
Researchers have developed implantable sensors that track protein levels in real time, enabling continuous monitoring of inflammation at the cellular level. The technology has been successfully tested in diabetic rats, detecting changes in cytokine proteins associated with inflammation.
A new study reveals that glyphosate exposure in mice can cause lasting brain inflammation and accelerate Alzheimer's disease-like pathology, even after a significant pause from exposure. The herbicide's byproducts have been found to accumulate in brain tissue, raising serious concerns about its safety for human populations.
Researchers developed a novel computational pipeline to identify protein biomarkers linked to Alzheimer's risk, offering insights into disease mechanisms and potential therapeutic targets. The pipeline, MR-SPI, can predict 3D structural changes in proteins, providing a deeper understanding of the molecular mechanisms driving disease.
Scientists at Purdue University have identified new molecular markers for neurodegenerative diseases by analyzing protein behavior with age. The study sheds light on how phosphorylation causes protein aggregation, a hallmark of these diseases.
A new study shows that preventing F-actin accumulation in the brains of aging fruit flies can maintain cellular recycling, extend lifespan and improve cognitive function. This discovery may offer a promising direction for developing interventions to promote healthier aging in humans.
Researchers at ETH Zurich have developed a method to study protein interactions using LiP mass spectrometry, identifying thousands of interaction interfaces between proteins. They found that stress situations alter around five dozen protein complexes and their interactions, with a key player being the SAGA complex.
Scientists have developed MINFLUX microscopy to measure distances within biomolecules, down to one nanometer, and with Ångström precision. This allows for the detection of different conformations of individual proteins and the observation of their interactions.
Researchers validate a new blood test platform that can measure multiple biomarkers of Alzheimer's disease, potentially improving early diagnostics and treatment. The platform captures changes in proteins related to neurodegenerative diseases and may help track disease progression over time.
A new non-invasive imaging technique has been shown to accurately detect clear-cell renal cell carcinoma, the most common form of kidney cancer. The technique uses a monoclonal antibody drug that targets the protein CA9, highly expressed in up to 95% of clear cell kidney cancers.
Researchers at Tel Aviv University discovered that aneuploid cells, which have an abnormal number of chromosomes, are more susceptible to certain types of anticancer drugs. The studies found that disrupting the MAPK pathway increases the sensitivity of these cancer cells to chemotherapy.
Researchers at Macquarie University discovered that oral cancer cells use protein interactions to block the immune response, offering new clues for treatment. The study found that a protein called STAT3 and its partner proteins may be involved in pathways that help cancer avoid the immune system.
Recent advancements in high-throughput proteomics have unveiled new insights into protein involvement in various cancers. The review explores four key techniques, including mass spectrometry and next-generation tissue microarrays, highlighting their strengths and limitations for large-scale molecular analyses.
A new study found that 2-bromopalmitate treatment reverses cell senescence in human vascular smooth muscle cells, reducing DNA damage markers and promoting cell proliferation. The research suggests a critical role for protein palmitoylation in regulating the senescent phenotype.
Researchers at Umeå University have identified unique inflammatory protein profiles in the blood of individuals with severe periodontitis, which is associated with lower levels of EGF and OLR-1 proteins. The study provides a promising lead for developing biomarkers and treatments for the disease.
Researchers validate increase of specific t-Cys sites associated with aging in human proteome, suggesting potential role in age-related diseases. The study expands beyond classical proteinopathic paradigms, highlighting trioxidized cysteine as a key molecular mechanism underlying aging.
A recent study published in JAMA Psychiatry found that children with persistently raised inflammation are at a higher risk of experiencing serious mental health disorders, including psychosis and depression, in early adulthood. The research also discovered that those who experienced inflammation at a young age were more likely to devel...
A team led by Emory researchers found strong evidence supporting a new understanding of the mechanism behind Alzheimer's disease. They identified more than 20 proteins that co-accumulate with amyloid beta, suggesting they may play an important role in brain damage rather than the amyloid itself.
A new method for detecting pancreatic cancer has been introduced using glycopeptide probes that selectively detect specific antibodies in blood samples. These probes mimic tumor-associated antigens and show promise for early detection screenings.
ProDOL, a novel microscopy technique, enables precise quantification of labelled proteins in living cells, overcoming existing limitations. The method's accuracy and versatility make it a valuable tool for biomedical research, particularly in understanding cellular signalling processes.
The Rice University lab has developed a new noninvasive technique, called REMIS, that can measure gene expression and gene therapy delivery in specific brain regions using ultrasound. This technology could revolutionize brain-based gene therapy for neurodegenerative diseases.
Researchers discovered elevated levels of neurofilament light chain protein in Parkinson's disease and dementia with Lewy bodies, suggesting potential early detection methods. The study found different protein patterns between the prodromal stage and established diseases.
A new DNA-powered signal amplification technology called ACE significantly enhances the sensitivity of mass cytometry, enabling the detection of multiple proteins in single cells. This breakthrough allows researchers to investigate complex biological processes and study immune cell functions with unprecedented depth.