Articles tagged with Telomerase
A research team has found that vital RNA needed to maintain telomeres in roundworms exists inside another gene's intron. This discovery suggests a common strategy for anti-aging therapies and regenerative medicine in humans, and could support species survival.
Researchers at Boston Children's Hospital have developed a new approach to lengthening telomeres using synthetic RNA. The technique, known as eTERC, has been shown to increase telomere length in human stem cells and leave normal cell mechanisms intact. Additionally, polygenic scores have been developed to estimate the combined effect o...
Researchers found that telomerase inactivation in immune cells or connective tissue cells slows tumor growth, but creates conditions for aggressiveness. In contrast, endothelial cell preservation suppresses metastasis.
A systematic review of 24 studies suggests resveratrol can enhance the quantity and quality of egg cells, called oocytes. The compound may also treat infertility related to endometriosis and obesity.
Researchers discovered TERT gene activation as a key factor in determining the clinical course of pulmonary carcinoid tumours, with aggressive growth linked to telomerase activation. The study aims to improve treatment planning and targeted therapeutic strategies for cancer types.
Researchers found that inhibiting telomerase, an enzyme related to cell growth and division, can suppress abnormal vascular growth in the retina. This discovery provides a potential alternative treatment option for wet AMD, which is currently treated with anti-VEGF injections.
Researchers at MD Anderson Cancer Center have identified a small molecule compound that restores physiological levels of telomerase reverse transcriptase (TERT), reducing cellular senescence and tissue inflammation. TERT restoration also spurred new neuron formation with improved memory and enhanced neuromuscular function.
A new study reveals that different chromosomes have separate end-specific telomere-length distributions, challenging the scientific consensus. Researchers found that most telomeres were either the shortest or longest across all individuals, suggesting that specific chromosome ends may be the first to trigger stem-cell failure.
Scientists have discovered two new end-replication problems in DNA replication, affecting both the leading and lagging strands. This revelation changes our understanding of telomere biology and may hold clinical implications for individuals with telomere disorders, such as Coats plus syndrome.
Researchers discovered that ATR kinase inhibits telomerase, preventing it from adding excessive telomeres to damaged DNA. This finding has implications for optimizing CRISPR techniques and studying cancer.
Researchers found GV1001 decreases BACE and Aβ1-42 levels, reducing neurodegeneration and senescence in 3xTg-AD mice. It also increases survival, telomere length, and telomerase activity, contributing to improved lifespan.
Imetelstat, a telomerase inhibitor, successfully treated anaemia in MDS patients for up to one year, reducing the need for red blood cell transfusions. The drug offers a novel mechanism of action for patients with lower-risk MDS who do not respond to standard treatment.
Researchers found a link between short telomeres in ATII cells and lung fibrosis in post-COVID-19 patients. The study revealed loss of ATII cellularity and shorter telomeres concomitant with increased fibrotic lung parenchyma remodeling.
Researchers have studied targeting telomeres as a potential therapeutic strategy for non-small cell lung cancer. Telomere dysfunction and telomerase deficiency slowed tumor progression, increasing vulnerability to DNA damage and immune system response.
Researchers at the University of Pittsburgh School of Medicine have discovered a genetic link between melanoma tumors and telomere maintenance, which could lead to new treatments for the disease. The study found that mutations in the TPP1 gene stimulate telomerase activity, promoting long telomeres that enable cancer cells to divide in...
Researchers have discovered a new pathway for producing telomerase RNA from protein-coding messenger RNA, offering potential innovations in mRNA vaccines and understanding of telomere biology. This finding has implications for reversing cellular aging and extending human lifespan.
Researchers discovered a telomere transfer reaction between immune cells that extends their lifespan and confers long-term protection. This 'anti-ageing' mechanism has potential clinical applications for diseases like cancer and dementia, and may enable people to live healthier and longer.
A recent study published in Cancer Research identified a unique vulnerability in certain high-risk cancers that can be exploited for targeted therapy. Researchers found that cancer cells with alternative lengthening of telomeres (ALT) have a common weakness, leading to resistance to DNA-damaging agents and chemotherapy.
Scientists from A*STAR and NUS Cancer Science Institute identified a key cancer progression mechanism that could lead to more effective treatments. The discovery involves reactivating the hTERT gene, which is responsible for prolonging telomeres in cancer cells.
Researchers have discovered that human urine-derived stem cells have the ability to regenerate tissue and become various cell types, making them a promising source for stem cell therapy. The study also highlights the importance of telomerase activity in maintaining regenerative potential.
Researchers have identified a new potential treatment for neuroblastoma by targeting the ALT mechanism, which is responsible for chemotherapy resistance. The study found that activating ATM kinase at telomeres promotes chemotherapy resistance in ALT neuroblastoma and suggests a cancer-specific approach to treating this disease.
Scientists at Washington State University identified a DNA region known as VNTR2-1 that drives telomerase gene activity, which helps prevent aging in certain cells. The study suggests that this 'junk DNA' sequence contributes to genetic diversity of aging and cancer development.
The study investigates the role of cell cycle progression on analyzing telomerase activity in cancer cells based on an AIEgen-based fluorescence detecting system. The results show that cancer cells exhibit increased fluorescence intensity during different stages of the cell cycle, while normal cells do not.
Researchers have found that telomere shortening protects against cancer in humans. The study used CRISPR gene-editing technology to analyze mutant cells with long telomeres and found that they were at greater risk of developing breast, colorectal, melanoma, and thyroid cancers.
Researchers from Kazan Federal University and Moscow State University studied the Est3 subunit of telomerase, revealing its importance for stabilizing the whole protein complex. The study used NMR spectrometry to understand the spatial structure and interactions of Est3 molecules.
Researchers successfully tagged telomerase with fluorescent molecules, revealing its two-step binding mode to chromosomes. The study also shows how telomerase mutation promotes tumorigenesis, offering a new target for therapeutic strategies.
A team of researchers at Michigan State University has developed a new method using optical tweezers to observe telomerase activity in unprecedented precision. This breakthrough aims to help find more effective and safe cancer treatments by targeting the telomerase enzyme.
Researchers at Northwestern University have developed a promising molecular tool that targets and inhibits telomerase, an enzyme that enables cancer cells to live forever. The small molecule, called NU-1, irreversibly binds to telomerase, shutting down its activity and sensitizing cells to chemotherapies.
Researchers from Arizona State University uncover the structure and function of plant telomerase RNA, a 'missing link' between ciliates and humans. This discovery may hold promise for extending human lifespan and improving health in elderly individuals by understanding the regulation of telomerase enzyme.
Researchers have identified a new way to target the third most common oncogene, TERT. The study reveals that TERT messenger RNA is held up in the nucleus, and keeping it trapped could be an effective strategy for treating cancer. This discovery offers a promising new approach in the fight against TERT over-activation.
Researchers discovered that telomerase, which promotes unlimited cell division in cancer cells, also prevents tumors and slows a key stage in normal cell death. In healthy adult cells, telomerase activates just before cell death, buffering cells from aging stresses and reducing DNA damage.
Researchers found a way to reduce telomerase activity in cancer cells by using specific oligonucleotides, which may lead to new antitumor drugs. The study showed that the combination of oligonucleotides reduced telomerase activity by 10 times within 24 hours.
A recent study published by the European Society of Cardiology found that endurance training but not resistance training slows or reverses cellular aging. Telomerase activity and telomere length increased in volunteers who underwent endurance and high-intensity training, suggesting a potential mechanism for healthy aging.
Researchers at CNIO develop gene therapy with telomerase, proving effective in mice against diseases caused by excessive telomere shortening. The study finds that the gene therapy does not increase the risk of developing cancer, even in a cancer-prone setting.
Researchers have gained a deeper understanding of telomerase, an enzyme that maintains DNA in telomeres. Telomerase is active in cancer cells, enabling them to grow and spread. The study provides clues about how to target the enzyme's activity to develop new drugs.
Scientists have discovered two antioxidant enzymes that work together to prevent telomeric DNA oxidation, leading to telomere shortening and eventual cell death. Disrupting these enzymes in cancer cells has shown promising results in preventing the enzyme telomerase from extending telomeres.
Researchers found targeting telomerase and inhibiting mitochondrial function synergistically killed NRAS-mutant melanoma cells, inducing extensive cell death and DNA damage. Combination therapy also improved survival in a mouse model.
Researchers at the University of California - Berkeley have discovered the molecular structure of human telomerase, a key enzyme in aging and cancer. The detailed picture reveals possible drug-target sites, allowing for more targeted treatments to be developed.
Stanford researchers discover that telomerase-expressing liver cells can rapidly regenerate the liver during normal turnover or tissue damage. These rare cells are evenly distributed throughout the liver's lobules and play a crucial role in enabling the organ to replace damaged cells, potentially leading to cancer.
Researchers from Moscow State University discovered the structure of a key region of the telomerase enzyme, which plays a crucial role in cellular aging and DNA replication. The study's findings have significant implications for developing potential anticancer drugs and understanding the regulation of telomerase activity.
A study published in Clinical Cancer Research demonstrated the efficacy of targeting aberrantly active telomerase to treat therapy-resistant melanoma. The research found that a modified telomerase substrate impaired telomere dysfunction and induced cell death in melanoma cells, suggesting a potential therapeutic strategy.
Researchers from Arizona State University reveal a hidden secret of the immortality enzyme telomerase, which holds promise for reversing cellular aging and extending human lifespan. Understanding the enzyme's mechanism may lead to effective anti-aging therapeutics.
Researchers created a 3D model of telomerase, an enzyme that lengthens chromosome ends, in baker's yeast. The study provides new insights into how telomerase recruits itself to chromosome tips and sheds light on its role in cancer cell survival.
Researchers at NUS Cancer Science Institute discovered a molecular pathway in which TIP60 inhibits cancer cell growth by targeting telomerase. This finding offers a new approach to treating various types of cancer triggered by high telomerase levels.
New research reveals a two-step process for cell immortalization and cancer development, with telomerase playing a complex role. Telomerase levels are insufficient to lengthen all telomeres, leading to genomic instability and tumor formation.
In vivo reprogramming induces signs of telomere rejuvenation, reversing aging's hallmark: short telomeres. The process involves telomerase activation and elongation, similar to early stages of tumor development.
Cancer cells counteract telomere breakdown by building them up with the enzyme telomerase. A new study using CRISPR gene editing technology reveals telomerase's mechanism, allowing scientists to identify potential targets for anti-cancer drugs.
Researchers have identified the precise point of origin for TERRA RNAs, which protect telomeres and maintain chromosomal stability. The discovery sheds light on the importance of TERRA in cell viability and telomere preservation.
Researchers identified a new gene, NAF1, associated with pulmonary fibrosis-emphysema in people with abnormally short telomeres. The mutation affects telomerase RNA stability, leading to decreased telomerase levels and increased risk of lung disease.
Researchers found that treating patients with a male hormone increased telomere length and improved hemoglobin mass. The study suggests a possible approach to combat diseases caused by telomerase deficiency.
Researchers at CNIO have developed a new method to create mice with hyper-long telomeres using epigenetic changes, avoiding genetic manipulation. This technique results in fewer signs of molecular aging and a lower incidence of cancer in the mice.
Researchers at CNIO have developed a gene therapy to repair telomeres, delaying ageing and potentially treating aplastic anaemia. The treatment uses virus-delivered telomerase enzyme to extend telomeres, increasing blood cell production.
A new study found that Transcendental Meditation and lifestyle changes stimulate genes that produce telomerase, reducing blood pressure and cardiovascular disease. This pilot trial showed both approaches increased telomerase gene expression, with significant reductions in blood pressure after 16 weeks.
Researchers from UCLA and UC Berkeley have produced high-resolution images of the telomerase enzyme, revealing its structural details and interactions. The study sheds light on telomerase's role in aging and cancer, providing potential new strategies for treating disease.
A study reveals the key structure of telomerase, an enzyme that enables cancer cells to proliferate indefinitely. Researchers have discovered how the enzyme carries out its crucial function in protecting chromosome ends.
Scientists at The Wistar Institute have developed a highly specific telomerase inhibitor that targets the enzyme in approximately 90% of cancers. By binding to a specific pocket on the outer surface of telomerase, the inhibitor prevents the enzyme from properly assembling, leading to cell cycle arrest and senescence.
Scientists at Emory University School of Medicine found that alpha lipoic acid can stimulate telomerase, the enzyme that lengthens telomeres, with positive effects in a mouse model of atherosclerosis. The discovery highlights a potential avenue for treating chronic diseases.
A new study found that mutations in the telomerase reverse transcriptase (TERT) gene increase the risk of emphysema in smokers. Female smokers with these mutations may be more susceptible to the disease. The researchers also discovered a link between telomere shortening and other health problems, such as osteoporosis and liver disease.
Researchers at the University of Louisville have identified mutations that destabilize a DNA structure, turning a gene off in over 75% of glioblastomas and melanomas. This discovery provides a new model for understanding cancer-specific activation of telomerase, an enzyme promoting cell division.
Researchers at CNIO have developed a gene therapy that reactivates the telomerase gene only in the heart of adult mice, resulting in increased survival rates and regeneration of cardiomyocytes. This study provides proof-of-concept for treating chronic and acute heart failure and opens new avenues for age-related diseases.