Articles tagged with Hepatocytes
Researchers have created a stem cell-based model of the human liver, allowing for the study of how Ebola virus infects liver cells. The infected cultures showed that viral infection directly disrupts liver function, while immune cells can transfer the virus to other cells.
Researchers at UVA have discovered the mechanism behind gene regulation during organ development, shedding light on how genetic material interacts with transcription factors to create different cell types. The study's findings could offer insights into the initiation of certain cancers and inspire new therapeutic development.
A new study identifies PDIA3 as a molecule targeted by the immune system in response to stress, contributing to liver damage in type 2 diabetes and obesity. Elevated levels of antibodies for PDIA3 have been found in people with these conditions, but improving diet and weight can reverse this liver condition.
A groundbreaking study by Hebrew University researchers has discovered the most primitive blueprint for embryo cell creation. The team identified 14,000 sites in the DNA that control the development of all embryonic organs.
Researchers from Tianjin Medical University General Hospital review sarcopenic obesity's impact on liver disease, including nonalcoholic fatty liver disease and cirrhosis. The study aims to clarify the pathogenesis of sarcopenic obesity and identify potential therapeutic avenues.
Researchers discuss Hepatitis D's life cycle and interactions with its host, exploring strategies for further research to combat this overlooked virus. HDV coinfects people with hepatitis B, rapidly progressing to liver cirrhosis and cancer if left untreated, with a review published in the Chinese Medical Journal.
A study found that a methionine-deficient diet alters gene expression and DNA methylation in liver cells, increasing the risk of non-alcoholic fatty liver disease. A methionine-supplemented diet had the opposite effect, reducing the risk of liver damage.
A study by Brazilian scientists reveals that autophagy can modulate the accumulation of mutant mitochondrial DNA in cells during aging. The researchers found that mice with liver-specific atg7 knockout showed reduced buildup of mutant DNA, suggesting a potential therapeutic target for diseases associated with mitochondrial DNA mutations.
A new review highlights the risks of fatty liver disease caused by metabolic dysfunction, characterized by fat accumulation in liver cells and oxidative stress. The progression of the disease can lead to inflammation, fibrosis, and cirrhosis with a high risk of hepatocellular carcinoma.
Researchers determined the 3D structure of NTCP, a protein crucial for liver function and HBV/HDV infection. The study reveals two essential conformations: one 'open' pore for bile salt binding and a 'closed' conformation preventing virus recognition.
The study identifies two subpopulations of liver ILC1s, Ly49E+ and Ly49E-, with distinct origins and functions. The Ly49E+ subset is produced by embryonic hematopoietic precursors and exhibits stronger cytotoxicity, while the Ly49E- subset has stronger immune memory potential.
Researchers discover that type 1 TPCs encode SV channels in plant vacuoles, while type 2 TPCs likely encode distinct ion channels. This study provides functional and evolutionary insights into the TPC family in plants, shedding light on their role in plant growth and defence mechanisms.
Researchers have found a way to partially reset liver cells to more youthful states, allowing them to heal damaged tissue at a faster rate than previously observed. The use of reprogramming molecules improves cell growth and leads to better liver tissue regeneration in mice.
Researchers discovered a key protein, c-Maf, required for naive endothelial cells to mature into liver sinusoidal blood vessels. Induced liver sinusoidal endothelial cells (iLSECs) support hepatocytes, promoting healthy function.
Researchers found that one viral protein suppresses infection with hepatitis E. However, experimental studies in mice revealed a different pattern, suggesting the two viruses affect each other in complex ways. Further analysis of liver cells is needed to shed light on the underlying causes of co-infection.
Researchers at Osaka City University found that globin family members can suppress liver inflammation and fibrosis in mice. The proteins' antioxidant capacity was greater than glutathione and vitamin C, suggesting a potential therapy for liver fibrosis.
Scientists have discovered the signature of genes expressed by hematopoietic stem cells that can produce healthy blood cells after being transplanted. This finding could enable scientists to expand these cells outside the body or convert other types of stem cells into functional blood cells.
Researchers have clarified the mechanism behind activating genes in drosophila fly sex cells, which may hold clues to understanding diseases. The study's findings suggest that DNA packaging plays a crucial role in regulating gene expression, with abnormal packaging potentially leading to misregulation and disease.
Researchers have identified a molecular mechanism underlying liver cirrhosis, a deadly disease poorly understood. The discovery, made using genetically modified mice, reveals that the lack of MCRS1 protein leads to bile acid accumulation and fibrosis, opening new avenues for treatment.
Researchers have identified a novel estrogen compound that provides benefits similar to hormone replacement therapy but without the risk factors associated with it. The compound has been shown to reduce excess lipid deposition in the liver and prevent the progression of fibrosis, which can lead to liver failure and metabolic problems.
Researchers identified five genes mutated in people with liver disease, affecting insulin sensitivity and fat metabolism. These mutations reduce the liver's ability to respond to dietary sugars and fats.
Researchers from Sanford Burnham Prebys have discovered a new source of stem cells that could help treat people living with Alagille syndrome. These 'outside the box' liver stem cells may offer hope for those with the rare genetic disorder, which causes severe liver damage and death.
Researchers at Skoltech have discovered structures called apical bulkheads in liver cells that are responsible for the narrow shape of bile canaliculi. The discovery reveals a key role for the Rab35 protein in regulating hepatocyte lumina formation and suggests potential avenues for medical applications in fatty liver disease and fibrosis
Non-alcoholic fatty liver disease affects 25% of the global population, leading to inflammation and fibrosis. Researchers discovered that hepatocyte reprogramming is controlled by molecular switches, resulting in dysfunction.
Researchers at University of California San Diego have found that immunotoxins targeting mesothelin can prevent liver cells from producing collagen, a precursor to fibrosis and cirrhosis. In mouse models, these antibodies killed 60-100% of human mesothelin-producing cells, reducing collagen deposition.
Scientists have discovered a new mechanism by which the liver adapts to injury by decreasing bile synthesis and shunting it to the bloodstream. This adaptation may explain why some patients with liver injury develop symptoms later than others, and could lead to new treatments for these patients.
Researchers found that high serum levels of human IL-11 in mice with paracetamol toxicity led to liver cell death. However, blocking IL-11 signalling protected against liver damage and promoted survival. The study suggests a restorative effect when using anti-IL11 therapy.
A study by MUSC researchers found that the transcription factor GATA6 plays a crucial role in liver cell development, allowing cells to differentiate into liver cells rather than other types. This finding could provide insight into how inherited liver diseases occur in children.
Researchers developed a novel gene therapy approach that utilizes acetaminophen to correct disease-causing mutations and make liver cells immune to its toxic effects. This allows treated cells to multiply and reduces the need for liver transplants in treating genetic disorders.
Researchers developed Seq-Scope technology to visualize all gene expression from a tissue sample, offering ultra-high-resolution imaging. The method, using high-throughput sequencing and barcode-based spatial coordinates, enables diagnosis of diseases at the microscopic scale.
A new study found that blocking ABCB10 protein in liver cells protects against insulin resistance and fatty liver disease. Increased bilirubin content inside mitochondria driven by ABCB10 activity contributes to fatty liver disease. The findings could inspire the development of therapies targeting ABCB10 or mitochondrial bilirubin.
A team of scientists at Cincinnati Children's Hospital Medical Center has discovered a promising new approach to preventing obesity-driven liver damage. By controlling a subgroup of immune system cells that trigger non-alcoholic fatty liver disease (NAFLD), researchers have identified a potential treatment target.
Researchers from Utrecht University publish a consensus on what constitutes an organoid, highlighting the importance of using primary cells for personalized therapies. The new system categorizes organoids into three types based on defining characteristics, providing clarity for future research and clinical applications.
Researchers have made new discoveries about fetal liver cells that could help make liver cell transplants more effective. Fetal liver cells can multiply and maintain function for long periods when used in transplants, but adult liver cells do not share this ability.
Researchers developed a chimeric mouse model that accurately reproduces human non-alcoholic fatty liver disease (NAFLD) by combining both human and murine cells. The study reveals striking differences in liver cell behavior, metabolism, and gene expression, providing new insights into the disease's mechanisms.
Researchers have found a way to make cell cultures respond more closely to normal cells, allowing drugs to be screened for toxicity earlier in the research timeline. By changing two components of the media used to culture the cells, they can make liver cancer cells behave more like normal liver cells.
A new technique developed by HUG-CELL reconstructs livers in the laboratory using extracellular matrix and human cells. The method, which can be used to produce other organs as well, shows promise for increasing organ supply and reducing rejection risks for transplant patients.
A team of scientists at the University of Pennsylvania School of Medicine has identified nine potential COVID-19 treatments, including three FDA-approved drugs. The study found that these drugs, such as cyclosporine, work by inhibiting the replication of the virus in respiratory cells and suppressing inflammation.
A study published in Science found that adult liver contains hematopoietic progenitors that can differentiate into tissue-resident lymphocytes. These findings reveal a local pathway for the development of innate lymphoid cells, providing insights into the liver's unique immune features.
Researchers at the University of Wisconsin-Madison have developed a new technique to target and destroy disease-causing proteins, which could lead to new drug treatments. By utilizing the cell's own recycling machinery, they aim to restore a healthy balance in cells.
Researchers at University of Tsukuba have developed a novel technique for transplanting HSCs into mouse embryos without destroying the host hematopoietic system. This breakthrough enables the study of fetal hematopoiesis and paves the way for future humanization using human HSCs.
A subset of liver cells takes on a greater workload to maintain metabolic function during regeneration, while others multiply in a coordinated manner. The liver's ability to regenerate and maintain its metabolic activity is crucial for the body's overall health.
Researchers from UT Southwestern Medical Center identified the cells responsible for liver tissue maintenance and regeneration, specifically those in zone 2. These cells can evade death, regenerate hepatocytes, and sustain liver function after damage.
Cytoglobin has been identified as a key player in delaying liver fibrosis progression in mice. The enhancement of CYGB on hepatic stellate cells or intravenous injection of recombinant CYGB suppresses liver damage and cirrhosis. This discovery holds promise for developing new anti-fibrotic therapy for human chronic liver diseases.
Researchers found that non-metastatic cells can spread to distant organs through a new mechanism involving the fibrotic niche induced by malignant cells. This discovery suggests targeting the fibrotic niche as a promising strategy to control solid tumor progression.
Researchers developed a stem cell-based cell culture model for nonalcoholic fatty liver disease (NAFLD), revealing key findings on gene expression, lipid droplet morphology, and metabolic networks. The model also showed promising results with AdipoRon, a synthetic analogue that positively influences hepatocyte metabolism.
Researchers at Osaka University discovered that liver cancer cells induce autophagy in nearby stromal cells, leading to the secretion of GDF15, which enhances tumor growth. High levels of GDF15 are associated with a poorer prognosis in HCC patients.
Researchers discovered that MpSYP12B redirects the secretory pathway to form the liverwort oil body, providing strong empirical support for the organelle paralogy hypothesis. The oil body accumulates compounds with bioactivities, including antibacterial and anticancer properties.
Researchers found that a protein called Cx43 allows stress signals from one liver cell to spread to neighboring cells, causing dysfunction. Mice with deleted Cx43 were protected from insulin resistance, glucose intolerance, and non-alcoholic fatty liver disease.
Researchers found that inducing liver regeneration with thyroid hormone boosted CRISPR/Cas9-mediated gene correction, achieving 10.8% and 3.5% efficiency rates in neonatal and adult mice respectively. This discovery could lead to more efficient gene therapy for human diseases.
Researchers have discovered that malaria parasites secrete the protein EXP2 to create pores in host cell membranes, facilitating entry. Blocking or decreasing liver infection can prevent malaria. The findings open a new pathway for prophylactic interventions and may lead to the development of treatments.
Acute liver failure is a rapidly progressing disease with an 80% mortality rate. Researchers identified three new subsets of liver cells that contribute to the condition's development, as well as signals from the gut microbiome. Selectively blocking these signals and depleting the microbiome led to marked improvement in liver function ...
Scientists have developed a new method to study glycans and their interactions with proteins, expanding our understanding of liver disease and the immune system. Galectin-3, a glycan-binding protein, was found to interact with hundreds of receptors in live liver stellate cells and immune cells.
Researchers at Scripps Research Institute have discovered that hepatocytes, the primary cell type in the liver, actively defend against certain viruses by absorbing and silencing them. This finding opens up new avenues for developing treatments for viral illnesses, including COVID-19.
A research team has identified p16 high cells detectable in all organs, enriched with age, that fail to proliferate and exhibit heterogeneous senescence-associated phenotypes. Eliminating these cells improved nonalcoholic steatohepatitis-related conditions.
Scientists discover that stressed liver cells quickly become senescent after hemorrhagic shock, a condition that accounts for 30-40% of trauma-related deaths. This rapid transition to senescence may help prevent organ failure, but drugs targeting senescent cells can be lethal in the context of injury.
Researchers at Gruthan Bioscience aim to develop a new class of cholesterol-lowering drugs for patients with familial hypercholesterolemia, a rare form of high cholesterol. The startup plans to use its novel cell platform to identify and test promising compounds.
Researchers found that inhibition of the MAGL enzyme impairs liver regeneration, while targeting lipid metabolism may have opposite effects on fibrosis and regeneration. The study suggests a complex relationship between MAGL and liver function.
Researchers at the University of Pittsburgh School of Medicine have discovered that pigs can grow a new liver in their lymph nodes, which could potentially treat various liver diseases. The study found that large animals with damaged livers can regenerate hepatocytes, forming an ectopic liver that takes over liver functions.
A research group at Linköping University has developed a dynamic bioink that allows cells to survive and thrive during 3D printing. The bioink's properties can be modified as required, enabling the creation of tissue-mimicking materials with tailored functionalities.