Articles tagged with Gene Products
A research team discovered that a protein complex consisting of SMG1, SMG8, and SMG9 ensures the efficient execution of nonsense-mediated mRNA decay (NMD). The study found that this complex is essential for maintaining the stability of NMD under various conditions.
A new study reveals that selfish chromosomes exploit the Overdrive gene to destroy rival sperm, boosting their chances of passing into the next generation. The gene acts as a quality control checkpoint during sperm development, normally eliminating abnormal sperm cells, but selfish chromosomes hijack the system to kill competitors.
Scientists discovered a protective variant of the HAQ-STING gene that prevents COPA Syndrome. This finding opens the door to a new gene therapy for the condition, which currently has no cure.
Researchers at UNC-Chapel Hill have found that tardigrades can increase DNA repair genes' production in response to radiation, making them more resilient to damage. This discovery could lead to new ideas on protecting other animals and microorganisms from damaging radiation.
The LY6 gene family has been found to be overexpressed in uterine corpus endometrial carcinoma (UCEC), leading to poor patient survival. Several LY6 genes have been identified as potential tumor-associated antigens and biomarkers for UCEC detection and prognosis.
Researchers found that severe herpesvirus infections can strongly activate host cellular immunity, leading to a therapeutic effect on refractory adult T-cell leukemia/lymphoma. This activation may play an important role in the survival of patients with this intractable disease.
Researchers from North Carolina State University have developed a new method for identifying genes relevant to the aging process in the C. elegans roundworm model. By exposing thousands of worms to random genetic mutations, they can pinpoint which genes are associated with protein aggregation and reduced lifespan.
A new study has discovered that rare pieces of genetic code can serve as another layer of control in the genome, essential for fertility and evolutionary innovation. Researchers found that certain tissues are more tolerant of diverse codons, particularly the testes, which may play a critical role in fertility.
A research team from the Max Planck Institute for Terrestrial Microbiology has identified 1,000 biosynthetic gene clusters, over half of which are previously unknown. These natural products have been found to be eukaryotic proteasome inhibitors that suppress the immune system of insects, as well as other virulence factors.
Researchers will use transcriptomics and chemogenetics to identify molecular targets for pain management. The project aims to advance knowledge on pain mechanisms and develop novel therapeutic strategies.
The study found that all 86 tridomain homologues of NDP-heptose synthetases are conserved in Actinobacteria, with three types of gene clusters encoding different natural products. The kinase domains of four selected proteins were found to be dysfunctional.
Researchers discover that gastrin-releasing peptide (GRP) is widely conserved among vertebrates, but the NMB/bombesin system has diversified in some lineages. GRP has evolved independently from a single ancestral homologue and plays a role in regulating energy intake and expenditure in both amphibians and mammals.
Researchers have developed a way to control multiple genes in yeast cells, paving the way for more sustainable production of bio-based products. The study demonstrates the use of dCas12a to regulate gene expression in Saccharomyces cerevisiae, unlocking its potential for producing pharmaceuticals, fuels, and food additives.
Researchers developed a genetic editing toolkit for Culex mosquitoes, which transmit devastating diseases like West Nile virus and avian malaria. The new CRISPR tools aim to create gene drives that can disable pathogen transmission in the targeted mosquito population.
Scientists have developed a new framework for describing gene content and order across Brassica species, which will aid in evolution studies. This framework enables the acceleration of beneficial gene exchange between species, ultimately leading to more climate-resilient crops.
UC Riverside researchers identified a gene, RCB, that enables plants to sense heat and respond accordingly. This discovery is crucial in developing heat-tolerant crops to address the impact of global warming on crop yields by one-third by 2050.
Researchers discovered a large class of mammalian genes are not completely shared across spermatids, leading to uneven allele distribution and potential mechanisms for sperm-level natural selection. Single-cell RNA sequencing revealed 'genoinformative markers' that can act as selfish genetic elements.
The Integrator protein complex plays a crucial role in regulating gene expression by terminating non-productive transcription. This mechanism ensures the production of wasteful transcripts is limited while maintaining thousands of transcription start sites for potential functional genes.
The NIH Platform Vector Gene Therapy (PaVe-GT) project uses AAV9 as a platform vector to develop gene therapy products for four rare diseases. The project aims to improve the delivery of therapeutic genes into target cells, paving the way for access to gene therapy for patients with difficult-to-treat conditions.
Researchers at LMU find that H. pylori's genetic diversity enables it to exploit different cellular niches in the stomach lining, contributing to chronic infections and cancer risk.
A global group of scientists proposes splitting the existing genus Lactobacillus into two genera, with 25 new genera having distinct names. This change aims to improve scientific accuracy and reflect closely related bacterial genes.
A new Northwestern University study reveals that the percentage of African ancestry influences gene production, affecting disease risk and medication response. The research highlights the importance of considering individual ancestry in precision medicine and drug discovery for diverse populations.
Researchers found a technical bias in RNA-seq data, leading to false results and misinterpretation of biological functions. The study highlights the importance of proper statistical handling to filter out false calls and preserve genuine findings.
A recent study by researchers at the University of Kansas has identified a crucial gene in chlamydia that allows it to acquire new DNA from its host. The discovery highlights the importance of understanding this process, which is essential for developing targeted therapeutics against the disease.
Researchers developed a computational algorithm to identify biologically active small molecules encoded in human microbiome-derived sequencing data. They uncovered novel TII-PKS BGCs with antimicrobial activity against neighboring microbes, as well as anti-cancer effects, in samples from diverse countries.
Researchers at Karolinska Institutet have uncovered a chromosome-wide mechanism that maintains balance in sex chromosomes' gene expression. The study found that genes on the X chromosome produce waves of gene products at a faster tempo, driven by special DNA elements called enhancers.
The Crispr method enables researchers to monitor proteins' function live under natural conditions, eliminating the need for overproduction. This facilitates analysis of genes and gene products, allowing for more accurate results.
Researchers at the University of Illinois have discovered a new biochemical trick used by microbes to produce an antimicrobial compound effective against malaria. The discovery reveals a completely unknown production pathway, which may lead to the development of more efficient and cost-effective methods for producing similar compounds.
Researchers developed a new gene activation method that targets previously difficult-to-activate genes in bacteria, including those involved in infections and industrial applications. This technique has the potential to revolutionize the production of useful products with high efficiency and cost-effectiveness.
Researchers at the University of Illinois have discovered a novel biosynthetic pathway in bacteria that can produce therapeutic compounds. The pathway, found in Pseudomonas syringae, combines elements of both ribosome-based and enzyme-mediated synthesis, allowing for efficient production of natural products.
A multi-institution research team, led by Worcester Polytechnic Institute's Eric Young, is developing a biosecurity tool to identify genetically engineered organisms in the environment. The tool uses unique DNA signatures to distinguish between engineered and naturally occurring microorganisms.
Researchers at Cornell University have identified a new stealthy, jumping gene called mcr-9, which resists the world's last-resort antibiotic colistin, threatening global health. The discovery enables early detection and isolation of resistant bacteria in hospitals and food products.
Researchers have developed a high-throughput method to produce and screen engineered antimicrobial lanthipeptides, which could lead to the creation of new antibiotics. The method involves synthesizing DNA strands coding for different ring combinations and screening them for antimicrobial potential using micro-alginate beads.
Scientists at the University of Illinois have developed a technique to activate large silent gene clusters in Streptomyces bacteria, yielding new natural products and potential anti-microbial drugs. By using transcription factor decoys, researchers successfully expressed genes that had previously remained dormant.
A recent study by Medical University of Vienna professor Leopold Eckhart reveals the key molecular and evolutionary origins of mammalian adaptations in skin proteins. The research found that fully aquatic mammals require only one set of epidermal keratins, suggesting a unique evolutionary path.
Researchers at Tokyo Medical and Dental University developed a method to increase lentiviral particle production, enabling safe and efficient gene introduction into cells. The discovery utilizes the SPSB1 protein to activate transcription factors, leading to up to 12-fold boosted virus production.
Scientists have identified a crucial gene controlling stem juiciness in sorghum, which could enhance drought tolerance but also increase disease susceptibility. The discovery has significant implications for breeding and improving crop yields.
Researchers have identified an unusual biosynthetic pathway in bacteria that can produce a key feature of a phosphonate compound, which has antifungal properties. By deciphering this process, scientists aim to accelerate the search for new natural products with potential pharmaceutical and industrial applications.
Scientists have developed a new method to rank the risk of resistance genes in bacteria, allowing for better prediction of antibiotic evolution and development. By analyzing 200 genes, researchers identified key factors influencing gene transfer and integration into new hosts.
The protein 'smallish' plays a crucial role in regulating cell polarity, essential for shape generation and coordinated cell changes. Researchers found that smallish helps control the correct shape of cells, even when knocked out, due to stored proteins in egg cells.
Researchers discovered that humans lost a gene linked to a toxic sugar in red meat, protecting us from some diseases but increasing health risks. The study also found that certain fish have the gene, making caviar high in the sugar, while birds and reptiles do not.
The new software, called Scallop, can reconstruct complete RNA transcripts from fragments of RNA sequences with improved accuracy. This advancement will help scientists better understand the regulation of gene expression.
A new study sheds light on the molecular mechanism that shapes behavior in fruit flies, revealing a causal link between epigenetics and genetics. Researchers found that epigenetic marks interact with genes to regulate differences in feeding behaviors.
Scientists developed ELM-seq technique to scan DNA sequences and find optimal 'control dials' that regulate gene activity. The study revealed importance of RNA message's first letter and three-dimensional structure in determining gene transcription and translation.
The first commercial CRISPR product is expected to debut in 2020: a waxy corn used for paper glue and food thickeners. Researchers can use CRISPR to identify genes in crops that may be good candidates for editing, potentially leading to improved cotton quality, non-browning mushrooms, drought-resistant corn, and grocery store tomatoes.
Researchers use CRISPR-Cas9 gene-editing technology to activate silent genes in Streptomyces bacteria, revealing potential new compounds with distinct structures that could lead to novel classes of drugs. The study aims to combat antibiotic resistance and cancer by identifying new chemical scaffolds.
Researchers have identified approximately 30 terpene synthase genes that contribute to diverse flavors in cannabis. These genes play a role in producing natural products like limonene, myrcene, and pinene, which are responsible for the plant's characteristic aromas.
A team of scientists discovered a comprehensive set of suppressive mutations in yeast cells, which could help explain how some people remain healthy despite carrying catastrophic mutations. The findings provide new insights into the complex relationship between genetic suppression and disease-causing mutations.
Research suggests that extra-coding RNAs play a critical role in regulating DNA methylation patterns in the adult brain, particularly in memory formation. By interacting with DNA methyltransferase enzymes, ecRNAs control the addition or removal of methyl groups at precise spots on chromosomal DNA.
A new study suggests that neurons often co-express functionally distinct alternative products from the same gene, facilitating acquisition of complex shapes and functions. Co-expression of alternative variants is essential for proper development of axons and dendrites in mice.
A study in yeast reveals that nutrients can affect gene expression, suggesting a complex interplay between metabolism and genetics. The findings have implications for understanding how cells respond to certain drugs and may explain why some individuals fail to respond to treatment.
Researchers at Princeton University discovered the mode of action of antibiotic tropodithietic acid (TDA), revealing its ability to kill cancer cells. TDA's unique mechanism involves disrupting cell membrane function, rendering it a potential anticancer agent.
Researchers report a new way to identify and discover new natural molecules that could fight human diseases, including leukemia. By analyzing genome data from bacteria, they identified a new compound called tambromycin with anti-leukemia properties.
Scientists discover that Xist RNA is insufficient to silence one of the two X chromosomes in every female cell, suggesting a complex interplay between molecules. This finding could lead to new ways to fight X-linked diseases in females, including those linked to autism, hemophilia, and muscular dystrophy.
VIB and UGent scientists developed a new method to predict plant size by analyzing RNA molecules. This approach allows breeders to select disease-resistant plants earlier and accelerate breeding programs. The study's findings have the potential to improve agricultural productivity and address global food security challenges.
A Pitt researcher used gene regulatory networks to uncover the origins of a recently evolved structure in male fruit flies, finding that it was created by reusing existing networks during development. This discovery sheds light on how complex animal forms arose and challenges the idea that new structures must be encoded by new genes.
Researchers at the John Innes Centre found that Euglena gracilis has over 32,000 active protein-encoding genes, significantly more than humans. The single cell algae can produce various natural compounds, including vitamins, essential amino acids, and a sugar polymer with anti-HIV effects.
Scientists at Helmholtz Munich discovered a novel lncRNA called PARTICLE that regulates cells' response to ionizing radiation by limiting DNA methylation. This finding contradicts the established LNT model and raises questions about the risk of low-dose radiation exposure.
Researchers at Max Planck Institute show that supplying D-lactate or glycolate, two products of the gene DJ-1, can restore mitochondrial activity and prevent neuron degeneration in Parkinson's disease. These substances may also have a general role in protecting cells from decline.
Case Western Reserve researchers discovered thousands of novel long non-coding RNA transcripts that can direct protein synthesis in cells. This breakthrough challenges conventional wisdom on lncRNA's role and holds promise for treating cancer and genetic disorders.