Articles tagged with Human Microbiota
A study of 2,000+ participants found nine specific gut microbe metabolites associated with coronary heart disease risk. The researchers call for further research into these molecules as potential novel treatments.
Recent studies show that T cells support milk production and have lasting effects on maternal health and infant immunity. The review highlights emerging evidence of the crucial role of immune cells in lactation, which can inform strategies to improve maternal and infant health outcomes.
A global team of scientists, led by University of Houston microbiologist Madhan Tirumalai, has identified the critical role of biofilms in human space exploration. Biofilms could influence astronaut health, drug delivery and space agriculture, while also posing risks to astronaut health.
A new study uses metabolic modeling to predict which probiotics will successfully establish themselves in a person's gut and how prebiotics affect short-chain fatty acid production. The findings demonstrate the utility of these models for personalized probiotic and prebiotic interventions.
A global atlas mapping two key gut bacteria has uncovered a treasure trove of bacterial strains adapted to the infant gut, not found in commercial probiotic products. The study reveals region-specific strains that have naturally evolved to thrive in a baby's microbiome, shaped by regional diets and environments.
Researchers identified 11 genetic regions influencing gut bacteria and roles they play, including connections to gluten intolerance, haemorrhoids, and cardiovascular diseases. The study analyzed genetic data from over 28,000 individuals, providing insights into the complex relationship between genes and gut microbiome.
Researchers developed wearable devices that track hydrogen levels in flatus to better understand gut microbial metabolism. The Human Flatus Atlas project aims to establish normal ranges for flatulence production, helping to identify excessive gas complaints and inform dietary interventions.
A new study found that fecal microbiota transplantation can enhance the effectiveness of immunotherapy in patients with advanced metastatic renal cell carcinoma. The research showed improved clinical outcomes, including longer progression-free survival and higher response rates, in patients who received donor-derived fecal microbiota t...
A new scientific review summarizes 12 human clinical trials on the cardiometabolic effects of wild blueberries, finding improvements in blood vessel function and beneficial changes to the gut microbiome. Regular consumption of one cup per day may support overall health benefits.
Researchers have identified a previously unknown mechanism that can reduce the risk of allergies and asthma in children. Certain bifidobacteria produce a substance called 4-hydroxyphenyl lactate (4-OH-PLA), which dampens immune responses to allergens, reducing the production of IgE antibodies.
A new international study found significant changes in gut bacteria at the onset of inflammatory bowel disease (IBD), a condition that affects the digestive system. The study reveals a loss of beneficial anaerobic bacteria and an increase in oxygen-tolerant bacteria, which may trigger inflammation.
Researchers have discovered that certain gut bacteria with similar structures to the protective layer of nerves can misdirect the immune system and cause it to attack its own nervous system. This mechanism accelerates the progression of multiple sclerosis.
Research suggests that owning a family dog during adolescence can boost mental well-being and social support by altering the gut microbiota. The study found that adolescents with dogs had higher mental health scores and lower social problems compared to those without dogs.
A study reveals that competition for biotin, a vital vitamin, drives interactions between harmful Staphylococcus aureus and harmless commensal bacteria. This resource scarcity could lead to new strategies for fighting multi-resistant germs.
Research reveals that medications can reshape the trillions of microbes in the gut by competing for nutrients, leading to predictable changes in the microbiome. The study provides a framework for predicting how a person's microbial community might change with a given drug, potentially helping scientists find ways to prevent side effects.
A comprehensive review synthesizes current insights into the intricate connections between gut microbiota and sleep regulation, highlighting the crucial role of peripheral organs in modulating brain function and behavior. Disruptions in gut microbiota composition are closely linked to sleep disturbances across multiple disorders.
The microbiota is recognized as a dynamic organ producing molecules that regulate gene expression, immunity, and mitochondrial function. Biomarkers of inflammation, metabolism, and aging can be predicted through microbiota signatures, establishing the microbiota as a pillar of predictive medicine.
Researchers found that people with MS have a distinct oral microbiome compared to healthy individuals, characterized by a loss of beneficial bacteria and an increase in disease-causing bacteria. The study suggests that oral microbial and metabolic changes may contribute to inflammation and disease processes in MS.
Scientists found that breathing dusty air from the Salton Sea can alter the lung microbiome and trigger immune responses in mice. The study suggests that chronic exposure to such dust could have significant health effects, including asthma.
Dr. Amin's transformative insights reshape international understanding of depression genetics, identifying novel therapeutic targets and biomarkers for diagnosis and treatment. Her systemic disease model challenges traditional views of depression as a brain disorder.
Researchers from the University of South Australia explore the connection between the gut and brain to decipher their role in mental health and wellbeing. The study found that changes in the gut microbiome can directly affect brain chemistry, suggesting a potential link between gut health and mental illness.
The Gladstone Infectious Disease Institute is broadening its research scope to tackle pressing health challenges beyond viruses. Scientists are discovering new ways to combat antibiotic-resistant bacteria and explore the interconnectedness of viruses and bacteria in causing chronic diseases.
Research links oral bacteria to Parkinson's disease via the gut-brain axis, finding Streptococcus mutans produces metabolite imidazole propionate that contributes to disease progression. Targeting the oral-gut microbiome may offer a new therapeutic approach for Parkinson's treatment.
Researchers identified 27 species of bacteria and fungi that collectively increase the risk of pancreatic cancer by 3.5 times. The study analyzed saliva samples from 122,000 healthy individuals and found that boosting the mouth's microbiome may protect against cancer.
Researchers at DTU have discovered a way to combat antibiotic-resistant bacteria by nourishing special bifidobacteria that is naturally occurring in the gut. Special lactic acids produced by bifidobacteria play a key role in keeping antibiotic-resistant bacteria at bay.
A study published in Cell Host & Microbe found a significant link between the maternal gut microbiome and preterm birth. The researchers identified Clostridium innocuum as a key bacteria species that may contribute to preterm birth by degrading estradiol, a critical hormone during pregnancy.
A new scientific review reveals that stress, hardship, and social challenges reshape a person's gut bacteria and brain performance, making it harder to keep weight off. Social determinants of health play a key role in obesity risk, and addressing these conditions is crucial for long-term solutions.
A UC Berkeley professor and her team have discovered gene clusters in the oral microbiome that produce molecules helping good bacteria stick to teeth, outcompeting acid-producing cavities. The researchers plan to introduce these gene clusters into healthy bacteria to form strong biofilms, reducing cavities.
Researchers have discovered that gut bacteria can recognize diverse chemical signals, including those from nutrients, DNA, and other metabolites. This allows them to detect and respond to nutritional values, suggesting that finding sources of nutrients is a primary function of motility in these bacteria.
Researchers at Kyushu University discovered that combining yogurt intake with hot spring bathing enhances gut microbiota diversity and improves defecation status, suggesting a potential application for preventive medicine. The study found significant improvements in gut health outcomes, particularly among healthy adults.
Researchers found that a compound produced by Lactobacillus bacteria can reverse liver and gut damage caused by aflatoxin exposure. The molecule, 10-hydroxystearic acid, activated PPARα signaling to repair liver tissue and support gut health.
Researchers will explore the intersection of mitochondria and microbiota through extracellular vesicles for diagnostics, targeted drug delivery, and regenerative medicine. The conference aims to accelerate scientific progress by building bridges between disciplines.
Institute for Systems Biology researchers use microbial community-scale metabolic models to simulate C. diff behavior in human gut microbiome samples. They accurately predict colonization states, susceptibility, and response to probiotics, offering a path to prevent C. diff before it starts.
A new study has identified a common bacterial strain that produces signaling proteins influencing hormonal balance and affecting weight, bone density and blood sugar levels. The researchers discovered that RORDEP-producing bacteria can vary greatly between individuals and that people with high levels of these bacteria tend to be leaner.
Researchers have mapped the microbiome of agri-food systems, revealing how diverse and balanced microbes keep our food safe, nutritious, and sustainable. The map highlights areas where targeted interventions such as probiotics and biofertilizers can improve food quality and reduce antibiotic use.
Researchers have mapped microbial networks underpinning healthy food systems, highlighting the need for integrated approaches to address climate crisis, antibiotic overuse and pesticide reliance. This work is driving microbiome-based solutions for animal, human and environmental health.
Researchers at ETH Zurich and Stanford University quantified the number of molecules produced by gut bacteria that reach the human body daily. This knowledge helps understand how the gut microbiome influences health and behavior.
Four leading Japanese corporations in the health and nutrition sectors have joined forces to advance microbiome science. The event aims to explore recent research and development achievements, engage with industry innovators, and promote practical applications of fundamental research.
The 12th World Congress on Targeting Microbiota explores the microbiome's role in diagnostics, therapeutics, and systems biology. Emerging data reveal bidirectional interactions between psychotropic medications and the microbiome, highlighting new approaches to mental health.
A study by University of California, Riverside researchers found that inhaling agricultural dust can alter the gut microbiome and impair intestinal function, leading to increased 'leaky gut' and associated chronic diseases. The study highlights the need for protective measures for agricultural workers.
Japan is set to host a global summit on microbiome medicine and fermentation science, featuring pioneering research and collaboration among industry leaders. The event aims to promote personalized nutrition, microbial diagnostics, and next-generation therapeutics.
Djenet Bousbaine's research explores how the immune system responds to beneficial skin microbes, triggering wound-healing T cells and robust B cell responses. This phenomenon is observed in humans, non-human primates, and found to be evolutionary conserved.
A global effort to preserve healthy microbes is now entering an active growth phase, with a team of scientists laying out an ethical framework to ensure equitable collaboration and depositor sovereignty. The Microbiota Vault Initiative aims to safeguard microbial diversity for future generations.
Deepshika Ramanan, a Salk Assistant Professor, has been recognized as a Rita Allen Foundation Scholar for her innovative research on maternal immunity and lactation. She will receive annual grants of up to $110,000 to conduct groundbreaking work in neuroscience, cancer, immunology, and pain.
A new systematic review reveals a significant connection between the gut microbiome and brain function in bipolar patients, affecting treatment responses. Patients who responded to treatment had distinct gut microbiome profiles similar to healthy individuals.
A study of twins reveals that certain bacteria in the small intestine may trigger MS. Researchers identified two specific bacteria, Lachnoclostridium sp and Eisenbergiella tayi, which are associated with the disease. The findings suggest a new potential therapeutic target for MS treatment.
A new study suggests that certain microbiome compositions in babies born vaginally, specifically with a higher amount of pioneer bacteria B. longum, are less likely to be hospitalised for viral lower respiratory tract infections (vLRTI) in the first two years of life.
Researchers found that obese mice displayed more anxiety-like behaviors and showed different signaling patterns in the hypothalamus, a region involved in regulating metabolism. The study also observed distinct differences in the makeup of gut bacteria in obese mice compared to lean mice.
Researchers identified seven bacteria with a potential barrier effect against vancomycin-resistant enterococci. The addition of the bacterial mixture reduced the proliferation of pathogenic bacteria in mice, suggesting a promising therapeutic approach.
A study published in Cell Metabolism finds that a combination of gut bacteria and acetate reduces obesity in mice. The researchers discovered that the specific combination of Bacteroides species and acetate leads to increased fat burning and reduced sugar storage, resulting in weight loss.
The international conference will focus on translating phage research into clinical reality, exploring key sessions and major speakers. Companies from various sectors are attending the event, highlighting the growing interest in phage therapy.
Researchers discover certain skin bacteria metabolize cis-urocanic acid using enzyme urocanase, fine-tuning immune response to UV radiation. This finding opens the door to microbiome-aware sun protection, where resident microbes are considered in sun protection strategies.
A new study provides a method to estimate sample size required for microbiome studies based on effect sizes and analysis methods. For strong associations, around 500 participants were needed to achieve 80% statistical power, while weaker associations may require thousands of samples.
The 8th World Congress on Targeting Phage Therapy 2025 will bring together global phage community to address clinical, regulatory, and industrial challenges. The event will feature cutting-edge research, real-world clinical insights, and applications of bacteriophage therapy across medicine, oncology, agriculture, and industry.
The summit will highlight the latest research on coronavirus, plant-based protein, and probiotics, with a focus on their applications in clinical practice. Studies have found that COVID-19 affects the gut microbiome in children, while dietary protein like S100B may promote a healthy microbiome.
A study by Flinders University found that certain bacteria in the throat may indicate greater health vulnerability in older adults. The presence of Staphylococcus aureus was linked to higher mortality rates, even after adjusting for other health factors.
The Blavatnik Awards for Young Scientists in the UK recognize promising scientists under 42 for their work on pressing issues. The three winners are tackling infant mortality, green manufacturing, and predicting long-term climate change. Their prize-winning research will receive £100,000 in unrestricted funds.
Researchers developed a synthetic microbiome therapy using limited strains of gut bacteria to effectively protect against C. difficile infections in mice. The treatment was as effective as traditional fecal transplants and had fewer safety concerns, offering a new alternative for treating this notoriously difficult-to-treat infection.
A new study developed a human microbiota modelling system capable of predicting each person's sensitivity to an emulsifier, such as carboxymethylcellulose (CMC), using a simple stool sample. The model identified a specific metagenomic signature of sensitivity to CMC, allowing for the prediction of individual susceptibility.
Researchers at TUM have developed a new therapeutic approach combining dietary therapy with fecal microbiome transfer to sustain inflammation-free states in Crohn's disease patients. The study found that the gut microbiome changes as a result of dietary therapy contribute to treatment success.