Articles tagged with Human Microbiota
A phase I trial found that combining fecal transplants with immunotherapy is safe and shows promise in improving clinical responses in 65% of patients. The study used healthy donor microbiome to enhance immune system attack on cancer, offering a new paradigm shift in melanoma treatment.
The study found that the presence of microbiota increases tacrolimus levels in the blood, reducing the risk of rejection but also increasing side effects. Clinical tests revealed two specific types of bacteria associated with reduced tacrolimus dosages, and a link between Anaerostipes bacteria and diabetes prevention.
The study mapped out metabolite by-products of bacteria processing amino acids linked to cardiovascular disease, comparing patient data to assess disease risk. Researchers developed a method for assessing absolute metabolite levels in the bloodstream, allowing identification of cutoff values for low versus high risk.
Researchers at Rutgers University found that vaginal seeding restored beneficial bacteria to the skin surface and stools of C-section babies, similar to those born vaginally. The study suggests that this technique may help prevent metabolic and immune-related diseases in C-section babies.
Researchers tracked the evolution of Staphylococcus aureus in patients with eczema, discovering rapid mutations in a gene that enables the bacteria to grow faster on the skin. These findings could lead to targeted treatments by targeting variants of S. aureus associated with eczema symptoms.
Researchers discovered multiple virus types persisting within organs such as kidneys and brain, challenging our understanding of the human microbiome. The findings suggest viruses may contribute to chronic diseases like cancer or autoimmune disorders, while also playing a role in immune system regulation.
Researchers at the Forsyth Institute have discovered a molecule naturally produced by the human host that targets and inhibits Fusobacteria, an opportunistic oral pathogen linked to colorectal cancer. The findings suggest a chemically modified version of this molecule could be used as a potential therapeutic to prevent colorectal cance...
A recent study published in Frontiers found that maternal vaginal microbiome composition does not significantly influence the development of infants' stool microbiome during the first weeks and months of life. Instead, exposure to breast milk and environmental factors are believed to play a more significant role.
Fruit fly gut remodels itself to accommodate beneficial microbiome species, maintaining long-term stability of the gut environment. The research team identified physical conditions and substances that facilitate colonization by desirable species.
Researchers at Indiana University School of Medicine discovered that bacteria causing vaginal infections can also be present in men and transmitted through heterosexual sex. The study found that only men who reported having vaginal sex carried the bacteria, with detectable presence for at least two months after intercourse.
A study by researchers at TUM found that gut bacteria play a crucial role in liver regeneration. The microbiome produces short-chain fatty acids, which are essential for liver cell growth and division. In mice treated with antibiotics, liver regeneration was delayed or not possible, but a
A team of leading experts in reproductive biology, microbiome science, and immunology found that the concept of a foetal microbiome is inaccurate. The detection of microbiomes in foetal tissues was attributed to contamination during vaginal delivery, clinical procedures, or laboratory analysis.
An international study led by the University of Trento revealed that social interactions play a key role in shaping the composition of our microbiomes. The researchers found that adults acquire microbes through close contact with family members, partners, and friends, while infants acquire them later on at birth.
Researchers developed a machine learning model that uses microbiome data from wastewater to estimate the number of individuals represented in a sample. The method was trained on over 1,100 people's samples and can be used to link wastewater properties to individual-level data.
Researchers at Baylor College of Medicine and Rice University developed a new contamination detection tool called Squeegee to establish reproducibility in microbiome identification. The tool uses computer analysis to detect 'breadcrumbs' of contaminants, improving the accuracy of metagenomic sequencing analysis in low biomass studies.
Researchers at Harvard University developed a Human Vagina Chip to study the effects of microbiome on vaginal health. The chip replicated the human vaginal tissue microenvironment, including its microbiome, and showed that certain strains of bacteria can help maintain an acidic environment and reduce inflammation.
A Rutgers study found that COVID-19 patients, especially those treated with antibiotics, experience significant disruptions in their gut microbiome balance. This imbalance may lead to the development of targeted probiotic supplements to improve treatment outcomes.
A live biotherapeutic product made from three Lactobacillus species has been shown to reduce lung damage in neonatal mice with chronic lung disease. The study found that the product can ameliorate redox imbalance and damages caused by experimental microbial dysbiosis, using a humanized mouse model of lung microbiome transplant.
Researchers from Rutgers Cancer Institute have identified specific microorganisms associated with inflammation and poor survival in pancreatic tumors. These microbial signatures can be used as new targets for earlier diagnosis or treatment of the fourth leading cause of cancer death.
Tagbo Niepa's research aims to capture and store a person's healthy gut microbiome, then restore balance when ill. The technology has the potential to revolutionize illness treatment, especially for diseases like C. diff infection.
Using biofertilizer on 80% of their planted area, Brazilian soybean growers enjoy environmental and economic benefits by employing the microbiome instead of chemical fertilizers. The use of biofertilizer saves farmers huge amounts of money, with costs significantly lower than chemical fertilizer.
Researchers found that bodies with lower BMI had decreased bacterial diversity, while those with higher BMI maintained constant diversity. The study suggests intrinsic factors like disease and medication load may impact microbial life in the surrounding soil.
Researchers are exploring ways to target and manipulate the human microbiome, with potential applications in treating diseases such as depression, obesity, and retinal disorders. The conference will feature presentations on innovative strategies and recent findings in modulating microbiota and microbial components.
Biomedical engineers at Duke University found that high levels of horizontal gene transfer help keep microbiomes stable and efficient, allowing for the creation of bespoke systems for environmental cleanup and biofuel production. The study suggests a dynamic division of labor among microorganisms enables robustness and flexibility.
Researchers discovered a significant difference in saliva bacteria between college students who reported recent suicidal thoughts and those without. Students with recent suicidal ideation had higher levels of bacteria associated with inflammatory health conditions and lower levels of Alloprevotella rava, which promotes brain health.
Researchers led by Osaka University found that Fusobacterium nucleatum produces polyamines through metabolic cross-feeding, creating favorable conditions for periodontal pathogens to grow and spread. This integration of a metabolic network within the oral microbiome may promote the development of periodontitis.
Researchers found that non-nutritive sweeteners can change the composition and function of gut microbes in humans, leading to altered glucose tolerance. The study suggests a personalized effect on glycemic responses due to individual variations in microbiome composition.
The article discusses new guidelines for big data research, including the potential for group harm. It also explores biobank research from an African American community's perspective and the implementation of electronic consent procedures during the COVID-19 pandemic.
Researchers discovered cancer cells produce a unique collagen that alters the tumor microbiome and promotes cancer progression. Loss of this collagen reduces cancer cell proliferation and boosts anti-tumor immune response, offering a potential therapeutic strategy.
The 9th World Congress on Targeting Microbiota will discuss recent advances in microbiome research, including the potential of naked mole rat's gut microbiome to extend human lifespan. The congress also explores gene editing and microbiome therapy for depression and cancer immunotherapy.
Gut bacteria produce inositol lipids, vital for cellular processes in humans, and these substances impact the symbiosis between bacteria and their hosts. The discovery sheds light on how gut bacteria thrive in their human hosts.
Researchers have developed a new mass spectrometry-based method to study the functionality of microbiota, enabling a broader understanding of gut microbiota dynamics. The new method produces reliable results without fluctuation and is freely accessible for the research community.
The 13th Annual Meeting on Skin Challenges 2022 will discuss recent advances in skin ageing, focusing on extracellular vesicles and their therapeutic potential. Experts will also share findings on the skin microbiome and its role in age-related diseases.
Researchers explore the emergence of antibiotic resistance genes in bioaerosols, including sources and detection strategies. The study highlights the need for monitoring and understanding the relationship between human, animal, and environmental microbiomes to counter the spread of AR.
A study found that indoor pollutants and human activities impact home biology and chemistry. Researchers detected diverse molecules from skin care products, food, and feces in a test home, with human-derived metabolites dominating the microbiome.
Researchers have found a negative correlation between Helicobacter pylori infection and inflammatory bowel disease (IBD) prevalence, suggesting the bacterium may protect against IBD. This is supported by studies showing improved gut microbiota diversity and increased abundance of beneficial bacteria in H. pylori-infected individuals.
A recent study found that certain bacteria species in the gut are associated with a higher risk of colorectal cancer in younger populations. The research suggests that dietary patterns high in processed meats, low-calorie drinks, and liquor may contribute to this increased risk.
Researchers developed a machine learning model to predict NAFLD development based on gut microbiome data, showing 90% of subjects who developed the disease had subtle differences in their samples. The model combines easily measurable information from blood and microbiome data with high accuracy.
Research reveals antibiotics can knock out essential gut bacteria, leading to reduced motivation and endurance in athletes. The study found that high-performance mice were more affected by antibiotic treatment, highlighting the microbiome's impact on exercise behaviors.
A recent study published in eLife found that wildlife living in urban environments have picked up some gut bugs from humans, leading to a 'humanization' of their microbiota. The researchers analyzed gut microbiomes in distantly related vertebrates from urban and rural areas and discovered significant differences between the two.
A recent study found that even tiny marine invertebrates have distinct and diverse microbial communities, called microbiomes. These findings challenge the assumption that closely related animals share similar microbiomes.
A new study by the University of Exeter found that antibiotic-resistant plasmid molecules can spread quickly through bacterial communities, making them more resistant to antibiotics. This raises concerns about the potential for antimicrobial resistance to spread in environmental settings and impact human health.
The Mount Sinai Microbiome Lab will use advanced methods to study the microbiome's role in autoimmune diseases such as rheumatoid arthritis and systemic lupus. The lab aims to identify microbial features that can help find more precise matches between diseases and treatments.
A study published in Med found that the human microbiome's variation explains different patient responses to statins. The researchers discovered a Bacteroides enriched microbiome with lower diversity was associated with stronger LDL-lowering effects but greater disruption of blood glucose levels.
Researchers found that elevated plasma levels of proline and a diet rich in this amino acid are associated with severe depression. The study also discovered a link between microbiota alterations and proline metabolism impacting depressive mood.
A new study suggests that supplementing a diet with Ascidiacea, also known as sea squirts, reverses some main signs of aging in animal models. The researchers found that plasmalogens, vital to body processes, decrease with age and contribute to neurodegenerative diseases like Alzheimer's and Parkinson's.
Researchers observed that bacteria change their swimming behavior to avoid getting stuck in confined spaces. In open areas, bacteria meander without discernible pattern, but upon entry into tight spaces, they straighten their paths to escape, suggesting physical features like walls and corners serve as crucial cues.
Research reveals that an imbalance in gut microbiota, known as dysbiosis, may contribute to the development and progression of Parkinson's disease. Studies found a direct correlation between gut dysbiosis and Parkinson's, with certain bacteria contributing to protein aggregation and neuronal damage.
The 9th World Congress on Targeting Microbiota 2022 will focus on recent advances in the microbiota field and therapeutic strategies. Key findings include research on probiotic strains, natural mineral waters, and extracellular vesicles.
A new technique called Operational Genomic Units (OGU) allows for improved resolution and simplicity in analyzing microbiome samples. By using individual genomes as basic units, researchers can pinpoint biologically relevant characteristics such as age and sex with greater accuracy.
The Logan Science Journalism Program has selected 12 accomplished science and health journalists to participate in its 35th annual fellowship program. The fellows will spend 10 days learning contemporary research techniques at the Marine Biological Laboratory, Woods Hole.
Researchers have engineered probiotic bacteria to produce the dopamine precursor L-DOPA, a potential treatment for Parkinson's disease. The new approach eliminates side effects and reduces treatment complications, offering a promising alternative to existing treatments.
Researchers found that changes in viral communities may enable persistent HPV infection and progression to cancer, associated with bacterial composition and inflammation. Low Lactobacillus abundance and bacteriophage presence were also linked to increased risk.
A study published in Cell Host & Microbe found that individuals with more Caudovirales in their gut microbiota performed better at executive processes and verbal memory, while those with higher levels of Microviridae deteriorated in brain's executive abilities. Dairy products may be a possible means of acquiring Caudovirales.
Researchers analyzed the gut microbiome of 1,241 middle-aged individuals and found that about half of the bacterial species were modified by drug treatment, while 75% of disturbances occurred in early stages of overweight and type 2 diabetes. The study suggests that an imbalanced gut microbiome may play a role in heart disease development
A recent study found that a subset of immune cells within the alveolar bone marrow were activated by the presence of commensal oral microbes, leading to increased osteoclast-mediated bone resorption and bone loss. Reducing the burden of commensal microbes through oral antiseptic rinses can help protect against alveolar bone loss.
A new study found that almost half of all publicly available human microbiome samples come from the US, despite it representing only 4.3% of global population. This raises concerns about the applicability of future microbiome-based medical treatments to countries with limited resources.
Researchers at TUM discover that intestinal bacteria interact with Paneth cells in the gut mucus layer, leading to chronic inflammation. This finding may lead to new treatments for IBD.
A new study in mice suggests that an unhealthy vaginal microbiome in pregnant mothers can increase pup deaths and alter development in surviving babies. A healthier diet rich in fiber-containing fruits and vegetables may counteract these effects, particularly in vulnerable populations.
The Microbiome and Metagenomics Center at UC San Diego will analyze stool samples from 10,000 All of Us Research Program participants to develop algorithms predicting individual responses to food. This will enable personalized nutrition recommendations based on an individual's genetics, gut microbes, and lifestyle factors.