Articles tagged with Oligomers
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A research team led by Professor Joongoo Lee successfully expanded ribosome range to produce ring-shaped backbones in proteins. This breakthrough could open doors to novel therapeutics and advanced biomaterials.
Researchers at KAIST have identified a key mechanism behind neuroinflammatory responses in Parkinson's disease, which is regulated by an RNA editing enzyme called ADAR1. This discovery suggests that targeting this enzyme could serve as a novel therapeutic strategy for treating the disease.
A new Northwestern University study finds that NU-9 improves neuron health in animal models of Alzheimer's disease by addressing the underlying mechanisms of misfolded proteins. The drug reduces protein buildup and prevents inflammation, showing potential for treating neurodegenerative diseases.
Researchers investigated peptide clumping behavior using molecular dynamics simulations and AI techniques. They discovered that aromatic amino acids enhance aggregation, while hydrophilic ones inhibit it, offering insights into peptide structure and function.
Researchers have developed a nanodrug that targets miR-10b, a small noncoding RNA implicated in cancer cell invasion and proliferation. The study shows that inhibiting miR-10b reduces the stemness of breast cancer cells, supporting dedifferentiation as a potential therapeutic mechanism.
Researchers at Osaka University have created molecular wires with periodic twists that increase electrical conductivity. The discovery could lead to the development of cheaper and biocompatible electronic devices.
The Indian Institute of Science team developed a novel technique to fabricate structurally colored films with a liquid gallium metal and polydimethylsiloxane substrate. These films change color in response to mechanical deformation, showing potential applications in smart bandages, movement sensors, and reflective displays.
Researchers at the University of Virginia Health System discovered that tau proteins damage brain cells by warping their nuclei, altering gene function and increasing tau production. This finding could lead to new treatments for Alzheimer's disease and other tauopathies.
EPFL researchers have created a novel biosensor, ImmunoSEIRA, to detect misfolded protein biomarkers linked to Parkinson's and Alzheimer's diseases. The sensor employs AI-powered neural networks for disease stage quantification and features gold nanorod arrays with antibodies for specific protein detection.
Researchers have discovered that toxic proteins, known as tau oligomers, are transported through synapses and contribute to the decline in brain function. The study found small clumps of tau oligomers inside synapses, which can spread through the brain and lead to neuron death.
Recent development in identification of oligomeric products from lignin depolymerization reveals understanding of formation causes and potential valorization routes. Common targeted products include monomeric phenols, aromatics, and cycloalkanes.
Researchers have developed a method to transform lignin, a biopolymer found in biomass, into chemically recyclable plastics using light. This breakthrough could advance the circular plastic economy by producing next-generation materials with reduced waste.
Developing low-molecule non-fullerene semiconductors, researchers aim to combine the best from both worlds. Oligomer acceptors have been shown to increase performance and ensure a long operating life.
Researchers found that B-type procyanidins induce hormesis in hemodynamic and metabolic responses, with optimal doses triggering improved cognitive functions and stress resistance. The study suggests a link between B-type procyanidin intake and CNS neurotransmitter receptor activation.
Researchers discovered that copper accelerates protein aggregation in Parkinson's disease, forming ring-shaped structures that can be used as therapeutic targets. The study provides new clues to the development of the neurodegenerative disease.
Researchers discovered a soil microbe's enzyme that converts CO2 into carbon compounds 20 times faster than plant enzymes during photosynthesis. The enzyme uses pairs of molecules working in sync like jugglers, with a spot of molecular glue and twisting motion facilitating the reaction.
Researchers at Johns Hopkins Medicine discovered a critical step in the molecular circuitry of immune cells that mobilizes the immune system to fight off foreign invaders. The findings, published in iScience, shed light on subtle genetic variations among human populations that may explain individual responses to infections.
Scientists have successfully stored energy in bean plant roots using conjugated oligomers, creating a new biohybrid system for sustainable energy storage. The research demonstrates that the roots of intact plants can function as networks of conductors, storing up to 100 times more energy than previous experiments.
Scientists have successfully encoded a passage from Jane Austen's Mansfield Park in a series of oligomers, allowing for efficient information storage. The technique uses urethane-like plastics and enables dense data storage without DNA-based approaches.
Tau oligomers form droplets within TIA1 droplets selectively, producing highly lethal effects on neurons. The study provides a tool to screen compounds that can inhibit tau oligomer formation, offering hope for Alzheimer's and frontotemporal dementia treatment.
Researchers demonstrate that basic features of simple polymers and prebiotic environment can give rise to selection processes that reduce disorder. They identify specific base sequences that enable oligomers to fold into particular shapes, leading to the emergence of catalytically active complexes like ribozymes.
A team of researchers from Aarhus University successfully understood why a very extended structure is crucial for an essential protein from the human immune system. The study offers new opportunities to adjust the immune system's activity both up and down, with potential applications in cancer treatment and autoimmune disease therapy.
Scientists have developed novel, non-toxic organic emitters for the near-infrared range, achieving high external quantum efficiencies in OLEDs. The new materials surpass previous reports by demonstrating improved radiative rates and reduced aggregation quenching.
A team of researchers from Ruhr-Universität Bochum and Vrije Universiteit Amsterdam have determined the development stages of Aβ fibrils, which form the basis of Alzheimer's disease plaques. The study provides new insights into the formation of oligomers, potentially harmful structures that contribute to the toxic effect of Aβ.
Researchers at the University of New Mexico have found that combining certain polymers and oligomers with UV light can almost completely kill the coronavirus. This method provides a fast-acting and highly effective coating that reduces virus concentrations by five orders of magnitude.
Scientists have created a new class of paints that can achieve the lustrous metallic look of gold or bronze without using metal flakes. The organic dyes can be dissolved in water and are stable over time, making them suitable for commercial use in ink-jet printers and potentially in electronic systems.
Researchers from ICIQ's Llobet team developed a new oligomeric material as a catalyst for water oxidation, achieving unprecedented current densities. The hybrid material behaves as a rugged and powerful electro-anode, stable at neutral pH and outperforming existing materials.
Scientists at DGIST discovered that specific proteins in nasal discharge can indicate the onset and progression of Alzheimer's disease, providing a novel approach for early detection. The levels of two particular Aβ oligomers were consistently higher in patients with AD, allowing for non-invasive screenings to assess AD progression.
Functional star-shaped polymers exhibit improved thermostability, making them suitable for medical diagnostics and targeted drug delivery. The study establishes a relationship between the synthesis conditions and the structure of the obtained compounds.
Researchers have developed an antibody that can accurately detect and quantify toxic amyloid-beta oligomers, a hallmark of Alzheimer's disease. This discovery could lead to improved diagnostic methods and ultimately help monitor the progression of the disease.
Researchers used high-speed atomic force microscopy to visualize the formation of Sup35NM amyloid fibrils in real time. They discovered that oligomers and fibrils have distinct structural characteristics, challenging previous assumptions about their relationship.
Scientists studied oligomer self-assembly at an oil-water interface to create tunable, monolayer thick surfaces with custom properties. Adjusting ions in the water phase aided in forming well-defined interfaces and modifying surface size and shape.
A team of scientists at Monash University has successfully created dynamic covalent oligomers that mimic the combination of complementary DNA strands. This breakthrough could lead to improved nanostructures for solar capture technology and molecular electronics, as well as enhanced interfaces between prostheses and human tissue.
Researchers found that spherical droplets of chain-like liquid crystal molecules transform into complex shapes upon cooling, exhibiting polydispersity-driven effects. The key to this phenomenon lies in the presence of both long-chain and short-chain rods within the drop.
A study published in Journal of Alzheimer's Disease shows that a small molecule drug inhibits tau self-association and blocks neurotoxic tau oligomers in an animal model. The compound reduces insoluble tau aggregates and decreases misfolded tau accumulation, demonstrating promising results for treating Alzheimer's disease.
The study reveals that the GAS7 protein's BAR domain is essential for phagocytic cup formation, enabling macrophages to efficiently consume debris. The protein's oligomerization and membrane binding are critical for this process.
Researchers at the IPC PAS have discovered how beta-amyloid molecules interact with cell membranes, revealing that small oligomers destroy the membrane and large ones aggregate to form fibrils. Their research may lead to new treatments by modifying amyloid interaction with membranes.
University of Warwick researchers introduce fluorescently labelled Tau oligomers into single brain neurons and observe significant effects on action potential dynamics and synaptic transmission. They find that Tau oligomers interfere with memory storage by mis-localising at synapses.
Researchers from McMaster University mapped a toxic protein linked to Alzheimer's disease, providing new insights into its behavior and interactions with neurons. The findings highlight the importance of understanding the structural features that differentiate toxic and non-toxic forms of amyloid beta.
Researchers developed a new method to assess medicines' actions by matching them to unique protein receptors, potentially speeding up drug development. The method reduces time and labor in finding the right response to drug candidates by several orders of magnitude.
Scientists employed complementary techniques to investigate the reactivity of isoprene at the water interface, finding that oligomers formed exclusively in electrosprays. Computer simulations confirmed these results, highlighting the importance of surface-specific techniques when studying interfacial processes.
Biologist Aleksey Belikov proposes that rapid progression of age-related diseases results from vicious cycles triggered by biochemical reactions. The study highlights the importance of interrupting these cycles in preventing disease progression.
Researchers identified exosomes as the main vehicle for spreading toxic proteins that trigger Alzheimer's Disease. Exosomes carrying oligomer amyloid-beta facilitate brain cell death, and their measurement could serve as a diagnostic tool.
A team of researchers has successfully combined carefully structured light with metal nanostructures to alter the properties of generated light at the nanometer scale. This breakthrough could lead to advancements in photonics, such as frequency conversion of light and optical processing.
The study reveals how toxic oligomers disrupt brain cell membranes, creating defects that lead to neuronal death. Understanding this process offers an opportunity to develop new treatments for Parkinson's Disease.
A phase 1 clinical trial found radavirsen to be safe and well-tolerated in healthy individuals. The study suggests that radavirsen may be effective in treating influenza at a dose of 8mg/kg.
Researchers at Carnegie Mellon University developed an approach to quickly and cheaply remove over 99% of bisphenol A (BPA) from water. The solution involves combining TAML activators with hydrogen peroxide, breaking down harmful chemicals in water.
A new method using a semilocal density functional produces more accurate estimates of excitation energy compared to other commonly used functionals, while requiring less computing power.
Scientists track movement of serotonin transporter proteins in cell membranes using 'single molecule microscopy' method. PIP2 binding is found to mediate stable oligomer formation of the transporter, with implications for psychostimulant effects.
Researchers developed a new imaging technique that allows studying protein misfolding and toxicity in neurodegenerative diseases. The technique enables visualizing changes in protein molecules' surfaces, shedding light on the mechanisms behind these devastating diseases.
Researchers discovered that a simple physical mechanism governs the formation of protein filaments, which are associated with diseases such as Alzheimer's and Type 2 diabetes. Understanding this process could lead to new therapies and materials for nanotechnology.
Rice University scientists use computer simulations to model the energy landscape of amyloid beta protein aggregation, a key step in Alzheimer's disease progression. The research predicts that specific sequences on protein molecules interact to form toxic oligomers.
A new study reveals that altering the amyloid beta protein by changing one amino acid creates an intermediate form with enhanced toxicity. This discovery provides a promising tool for investigating the neurotoxic effects of amyloid beta oligomers and could lead to new targets for drug development efforts.
A new study from UTMB reveals that a single dose of immunotherapy reverses memory problems in an animal model of Alzheimer's disease. The therapy targets toxic tau oligomers, which are also linked to amyloid beta levels.
Researchers at the University of Basel have created a helical molecule with unique properties, where one strand winds around a central axis like a staircase banister. This 'twisted world' enables dynamic changes in chirality, opening up new possibilities for basic research and industrial applications.
Oligomers are identified as the enemy that kills nerve cells and causes symptoms of Parkinson's disease. The study reveals two types of oligomers with different degrees of flexibility, which can link up to inhibit fibril formation.
Researchers have developed a new technology to detect misfolded protein fragments, known as Aβ oligomers, in cerebrospinal fluid that could lead to early diagnosis of Alzheimer's disease. The test showed high sensitivity and specificity, distinguishing between Alzheimer's patients and those with other neurodegenerative disorders.
Researchers have successfully constructed a human Fab library and identified a single-domain antibody that specifically targets amyloid-beta 42 oligomers. This breakthrough discovery offers new hope for treating Alzheimer's disease by reducing amyloid-beta burden and improving memory performance.
Researchers discovered that Alzheimer's drugs designed to target amyloid plaques are ineffective against small Aβ clumps called oligomers. Future studies aim to develop new drugs specifically targeting these oligomers to potentially treat the disease.
Traumatic brain injuries generate toxic tau oligomers that cause nerve cells to clump together and spread to other parts of the brain. These damaging protein assemblages can contribute to memory deficits, seizures, and disruptions in the sleep-wake cycle.