Articles tagged with Morbidity
A new study finds significant variation in life-threatening maternal complications among Medicaid enrollees, with rates differing by state and race-ethnicity. The five states with the highest rates of severe maternal morbidity included D.C., California, Nevada, New Jersey, and New York.
A phase 2 study found that ANGPTL3 inhibitor therapy reduced triglycerides by up to 70% in patients with severe hypertriglyceridemia who had previously experienced acute pancreatitis. The treatment, evicanumab-dgnb, also showed potential for cardiovascular prevention by reducing apolipoprotein B levels.
A recent study published in the American Journal of Emergency Medicine found that men over 65 are at a higher risk of developing skull fractures due to head trauma from falls. The research compared geriatric males and females, with surprising results indicating males had a significantly increased incidence of skull fracture.
A new study found that stroke patients experience a daily rhythm in cerebral blood flow regulation, with greater regulation during afternoon hours compared to morning and night times. This discovery may improve health outcomes by guiding daily activity and personal care during stroke recovery.
A recent study published in the British Journal of Surgery found that patients undergoing liver surgery fare better in higher-volume hospitals. In-hospital mortality rates were lower in these facilities, with a rate of 2.8%, compared to 3% in lower-volume hospitals.
A new study reveals rural pregnant individuals are less likely to have adequate health insurance before, during, and after pregnancy compared to urban residents. This disparity affects access to quality care and increases the risk of adverse maternal health outcomes.
A new study found that women with pre-pregnancy migraine had greater risks of preterm delivery, gestational hypertension, and preeclampsia. Migraine with aura was associated with a higher risk of preeclampsia than without aura.
A team of researchers from MedUni Vienna has identified the polymeric immunoglobulin receptor (pIgR) as a key player in protecting against alcohol-induced liver damage. The study found that pIgR-mediated secretion of antibodies in the intestines helps to prevent bacterial translocation and inflammation in the liver.
A new study reveals that US pregnancies are shorter than those in England and the Netherlands, with average lengths declining by over half a week between 1990 and 2020. This finding suggests that reducing medical interventions during the birthing process could improve maternity care outcomes in the US.
Researchers developed a blood test using circulating microparticle proteins to predict placenta accreta spectrum (PAS) cases as early as the second trimester. The study found five unique proteins that can distinguish PAS patients from control patients, enabling safe predication before delivery.
A 16-year longitudinal study found associations between DNA methylation-based measures and neuropsychologically-validated cognitive decline in midlife. The results suggest that these measures may serve as biomarkers for a molecular aging mechanism, potentially identifying individuals at risk of cognitive impairment and dementia.
Researchers developed a new epigenetic biomarker, GrimAge version 2, which leverages two DNAm-based estimators of plasma proteins to predict mortality risk. The study found that GrimAge 2 outperforms existing clinical biomarkers in predicting mortality across multiple racial/ethnic groups and associations with age-related conditions.
A study in Serrana, Brazil showed that mass vaccination reduced severe cases and death rates even while gamma and delta variants were circulating. Vaccination coverage reached 80% of the target population.
A study of nearly 4,000 patients found that the longer the time between COVID-19 diagnosis and surgery, the greater the risk of major cardiovascular events during or following surgery. This association could inform discussions on optimal surgical timing and perioperative outcomes for patients with a history of COVID-19 infection.
A national US study found that people with disabilities who misuse opioid drugs are 73% more likely to attempt suicide. The study, which looked at over 38,000 adults, also found that those with disabilities were more likely to have serious thoughts of suicide and make a plan or attempt to take their own life.
Administration of vaccine boosters to nursing home residents significantly reduces SARS-CoV-2 infections and hospitalizations. The study suggests that booster vaccination may play a crucial role in preventing COVID-19-related morbidity and mortality among vulnerable populations.
A new protocol at Cedars-Sinai improves the timeliness of treatment for women with severe pregnancy-related hypertension, reducing maternal stroke risk. Despite racial disparities in hypertension rates, the initiative found no significant delays in treatment based on race or ethnicity.
A Rutgers study found that high rental costs are linked to life-threatening maternal outcomes, with 260 such cases per 10,000 deliveries for those without a high school education. Providing affordable housing could reduce this gap by 20%.
A University of Massachusetts Amherst study found that over 37% of insured Massachusetts residents experienced an insurance transition during the perinatal period. Individuals with Medicaid and Medicaid managed care were more likely to have a transition than those covered by private insurance, suggesting disruptions in continuity of care.
A US study of 166,000 childbirths from 2018-2021 found persistent racial and ethnic disparities in severe maternal morbidity during the COVID-19 pandemic. Policy reforms to address residential segregation and structural racism are warranted to improve maternal health.
A study published in JACC: CardioOncology found that exercise during chemotherapy improves long-term cardiorespiratory fitness and alleviates adverse effects of cancer treatment. After treatment, an exercise program can recover lost function. The optimal timing of exercise intervention is during chemotherapy.
The COVID-19 pandemic led to a significant decline in life expectancy globally, with countries in Eastern Europe and the US suffering worst losses. Vaccination efforts partially mitigated these impacts, particularly for older age groups.
A large randomized clinical trial demonstrated Octagam 10% as an efficacious and well-tolerated treatment option for adult dermatomyositis patients. The study showed improved outcomes in patients with this rare disease, providing a much-needed treatment alternative.
Researchers at the University of Alabama at Birmingham found that noninvasive ventilation in nano-preterm infants did not show an advantage in reducing bronchopulmonary dysplasia or death. In contrast, infants who received invasive respiratory support had lower rates of severe intraventricular hemorrhage and death.
Participation in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) is associated with improved birth outcomes, including lower infant mortality. The review also found that WIC participants are more likely to receive child preventative services, such as vaccines.
The AABB has released clinical practice guidelines for the appropriate use of COVID-19 convalescent plasma, recommending its use for nonhospitalized patients at high risk for disease progression. The guidelines suggest that CCP is most effective when transfused with high neutralizing titers early after symptom onset.
The NIH announced five cash prize winners and four honorable mentions in its Maternal Health Diagnostics Challenge. The winning technologies aim to reduce maternal morbidity and mortality, with a focus on detecting and differentiating common pregnancy-related conditions.
The American College of Physicians (ACP) has issued a position paper on the ethical use of genetic testing and precision medicine in internal medicine. The guidelines address key issues such as incidental findings, education for physicians and patients, and counseling needs. ACP emphasizes the need for ongoing surveillance and anticoag...
A new study published in JAMA Surgery found that surgeons who oversee multiple surgeries simultaneously have a higher risk of complications and death. For surgeries involving one anesthesiologist directing CRNA or resident care, those managing three to four overlapping cases saw complication rates rise by 14%.
A Rutgers study found that women are more likely to die or require repeat surgery five years after abdominal aortic aneurysm repair. The researchers highlighted the need for increased inclusion of women in aortic device creation and trial enrollment, given differences in aortic anatomy between men and women.
Children born to mothers with polycystic ovary syndrome (PCOS) are at a higher risk of developing infections, allergies, and other childhood illnesses by age 13. The study found that children of mothers with PCOS were 32% more likely to be admitted to hospital for various health problems.
Research shows increased risk of severe maternal sickness/complications associated with higher maternal age, levels of obesity, and previous Caesarean section. The study suggests that UK maternity services are adapting to meet the needs of an increasingly complex pregnant population.
A longitudinal cohort study found significant reductions in liver disease and mortality among people with HCV infection who received treatment. The study's findings suggest that continued testing, treatment, and community-based interventions could lead to the elimination of HCV infection within the next decade.
A new study found that the fourth COVID-19 vaccine reduces the risk of death among elderly individuals in long-term care facilities by 72%. The study, which included approximately 40,000 residents, also showed a significant reduction in hospitalizations and infections.
A new study found that road fatalities and injuries kill more young people than communicable and non-communicable diseases or self-harm. The number of deaths attributed to road fatalities for adolescents has increased in some countries, particularly in low and low-middle income countries.
A new study published in iScience found that the co-development of the gut microbiome, immune system, and respiratory system is correlated with a baby's respiratory health. Disruption of any of these systems resulted in greater respiratory morbidity for infants, highlighting the importance of timing in intervening with therapies.
A new modeling study found that reducing excess prevalence of low birthweight, preterm birth, or small-for-gestational-age birth in low- and middle-income countries could lead to substantial long-term human capital gains. The study estimates potential gains of 20.3 million school years and $68.8 billion in lifetime income per birth coh...
Researchers linked dietary cholesterol to exacerbation of viral infections in mice, showing that high levels of cholesterol made mice sicker when infected with influenza. The study found that dietary cholesterol increased the number of cytokine-producing immune cells in the lungs, contributing to excessive inflammation.
A nationwide study analyzing rates of percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI) found a nearly 30% decline following the COVID-19 pandemic. STEMI cases have yet to recover to pre-pandemic levels, suggesting continued hesitation among patients to seek hospital care despite having a heart att...
A new study suggests that tailoring diabetes screening for Black, Hispanic, and Asian Americans based on lower BMI thresholds and younger ages can significantly reduce disparities in diabetes diagnosis rates. This approach may improve health equity by identifying cases earlier and reducing mortality rates associated with diabetes.
A systematic review and meta-analysis of 108 studies found that people with severe mental illness, including schizophrenia, have twice the cardiovascular-related mortality rate as the general population. The association has grown stronger over recent decades, with a possible link to changes in antipsychotic use and smoking prevalence.
A new study published in the Chinese Medical Journal assessed mortality risk in middle-aged and older Chinese individuals with multiple diseases. The study identified four multimorbidity patterns, with cardiometabolic being the most common, and found that individuals with these patterns had a significantly increased mortality risk.
Researchers at Karolinska Institutet studied long-term outcomes of bioprosthetic aortic valves implanted between 2003 and 2018. They found significant differences in performance depending on valve model, with Perimount having the lowest risk of replacement and mortality among patients
CLABSIs contribute significantly to infant morbidity and mortality in the NICU, leading to prolonged hospitalization and increased healthcare costs. The Society for Healthcare Epidemiology of America provides practical guidance on preventing CLABSI through implementation of specific strategies.
A study of vaginal births in New York State hospitals found that labor neuraxial analgesia – having an epidural or combined spinal and epidural – was associated with a decreased risk of severe maternal morbidity. The use of epidural anesthesia was linked to a 14% reduction in the risk of severe maternal morbidity, with racial and ethni...
A new study by Dr. Brian Stansfield and Dr. Jessica Gancar found a clear linear relationship between mortality and red blood cell transfusion volume in newborns on ECMO, with a 14% decrease in survival chances for every transfusion. The study suggests that reducing transfusion volumes may improve outcomes.
Adults with spinal cord injuries have a near-80% increased risk of developing psychological conditions compared to those without the injury. Chronic pain is equally negatively impacting mental health, associated with post-traumatic stress disorder and other mental health conditions in most cases.
A study of 236,000 individuals found patient- and prescription-related factors significantly linked to opioid-related fatal or nonfatal overdose. The research highlights the need for careful prescribing practices and post-discharge follow-up to prevent such overdoses.
A new study found high rates of trauma for mothers and babies from forceps and vacuum deliveries, with over 25% of forceps deliveries resulting in severe perineal tears. Researchers call for a reassessment of the safety of these birthing practices.
A new study by Carnegie Mellon University estimates that current regulatory analyses of air pollution significantly understate mortality costs among racial minorities. The study found that using race- and ethnicity-specific data increases premature mortality estimates related to PM2.5 from pollution exposure, with a $100 billion annual...
A new study reveals that poor women in rural India are more likely to die during childbirth due to lack of access to safe hospital births. The research found that only 26% of women in low-performing states deliver in hospitals, compared to 87% of those exposed to mass media.
Countries without face mask mandates experienced significantly higher COVID-19 deaths per million than those with mandates, according to a new study. Masks provided a supplementary layer of protection that could prevent unnecessary deaths.
Research suggests that severe maternal morbidity rates continue well into the late postpartum period, particularly among Black women, those with anxiety and depression. The study found alarming data showing increasing rates of maternal mortality later in the first year postpartum.
Researchers developed an AI program that accurately identified patients at risk of serious illness due to blood infections, with an accuracy rate of 82%. The technology has the potential to serve as an early warning system for doctors, enabling them to rank patients based on their risk level.
A new study reveals that childhood adversity is a major contributor to early and preventable causes of mortality and long-term physical and mental health issues. Childhood adversity was found to be associated with elevated risk for chronic diseases, including heart disease and cancer.
A new health program aims to improve pregnancy outcomes for Black patients by combining four evidence-based strategies, including racially concordant care providers and coordinated care. The five-year study will enroll 432 women and compare their experiences with usual maternity care versus a new model.
Researchers from UNC School of Medicine, MAHEC, and community partners will address racial disparities in maternal care by improving data accountability and providing community-based doula support. The study aims to decrease pregnancy complications for Black women and improve outcomes in maternal care.
The Patient-Centered Outcomes Research Institute (PCORI) has awarded $254 million to fund 28 new research studies aimed at reducing health disparities in maternal morbidity, preventing youth suicide, and improving behavioral health outcomes. Four studies will assess interventions to improve prenatal care for Black women and their child...
A study published in Obstetrics and Gynecology found that residents in majority-Black neighborhoods experience higher rates of severe pregnancy-related health problems. Neighborhood-level public health interventions may be necessary to lower these rates.
A study analyzing over 73 million hospitalizations found that site of delivery is a key factor contributing to racial disparities in maternal mortality. Black women are more likely to die from severe maternal morbidity at birth or immediately after childbirth compared to White and Hispanic women.