A recent study by UT Southwestern researchers reveals that the NAD+ molecule plays a crucial role in controlling genes essential for fat cell differentiation and cancer growth. The findings suggest that compartmentalized synthesis of NAD+ integrates cellular information to control gene expression, maintaining metabolic health.
A Norwegian University of Science and Technology study found that individuals with coronary heart disease who are physically active live longer, regardless of their weight. The study revealed that even slight physical activity is better than none at all, but sustained high-intensity exercise is crucial for reaping benefits.
Weichselbaum, Professor and Chairman of Radiation and Cellular Oncology at the University of Chicago, has made significant contributions to understanding oligometastasis. His work on curing tumors through surgery or radiation therapy has been supported by several studies demonstrating successful treatments.
Researchers discovered Pluto's dunes on the boundary of a major mountain range, likely formed by methane ice grain sublimation and transported by moderate winds. The unique features suggest recent formation within the last 500,000 years.
The 5G-Crosshaul consortium developed a transport network that integrates backhaul and fronthaul, enabling flexible and software-defined reconfiguration of networking elements. This configuration allows for high-capacity transmission and low-latency switching.
Researchers have developed a new route to molecular modelling using photonic quantum technologies, which could lead to more efficient pharmaceutical developments. The method simulates the motion of atoms within molecules at the quantum level, allowing for a frame-by-frame reconstruction of atomic motions to create a virtual movie.
Researchers calculate fundamental property of protons and neutrons with unprecedented 1 percent precision, matching long-standing experimental results. The new calculation provides a critical benchmark for applying lattice QCD to nuclear physics problems, which could aid in dark matter searches and answer outstanding questions about th...
A new mouse study suggests that the widely used antimicrobial ingredient triclosan may have adverse effects on colonic inflammation and colon cancer. Researchers found that triclosan altered gut microbiota, increased inflammation, and spurred disease development in mice.
The Southeast Center for Mathematics and Biology aims to connect mathematical theory with biological data, educating a new generation of scientists at the math-biology interface. The center will train graduate students and post-doctoral fellows in interdisciplinary research.
A novel gene encoding the enzyme thebaine synthase has been isolated from the opium poppy, enabling the commercial production of non-plant based biosynthetic manufacturing systems for active opioid agents and intermediates. This breakthrough opens the door to creating new opioid molecules with reduced addictiveness.
A new study found that men with higher levels of testosterone and dehydroepiandrosterone (DHEA) had weaker religious ties. The research analyzed data from over 1000 men and suggests that physiological factors, such as hormones, may play a role in shaping religiosity later in life.
New social psychology studies predict the likelihood of believing conspiracy theories, finding that people with high confidence in their politics understanding are more likely to endorse conspiracies. Researchers suggest that challenging one's assumptions and seeking credible perspectives can lead to more informed opinions.
A randomized, controlled trial found that 77% of patients who received remote phone or video counseling sessions underwent genetic testing, compared to just six percent in the usual care group. The study also highlights the importance of addressing disparities in genetic testing and knowledge among community practice patients.
Researchers found that Galectin-1 can lower blood pressure by reducing activity of L-type calcium channels in arteries. This discovery offers a novel approach to treating hypertension, potentially with minimal side effects.
A systematic review of 4,600 clinical trials found that nearly any type of exercise can improve cognitive performance, particularly mental processing speed. Consistent exercise over a longer period may be needed for improved cognition in older adults.
Researchers found that triclosan causes colon inflammation and worsens colon cancer in mice, raising concerns about its safety for human consumption. The study suggests that individuals with inflammatory bowel disease or colon cancer may be more vulnerable to the chemical's adverse effects.
Seoul National University researchers create a skin-like electronic system that wirelessly activates soft robots through a simple lamination process. The e-skin pair features wireless inter-skin communication and can perform four-state control signals over distances of more than 5 meters.
Researchers developed a portable eye function test to diagnose schizophrenia faster and more accurately. The study found that the device detected reduced electrical activity in the retina of participants with schizophrenia.
Researchers manipulate neurons in the amygdala to eliminate natural craving for sweet taste, while still recognizing flavors. The findings suggest a promising area of focus for treating eating disorders by isolating emotional reactions from flavor identification.
A free tax preparation program in pediatric clinics helped over 753 clients receive $1.6 million in federal tax returns, with a significant improvement in tax filings and client knowledge about the EITC. The program also reduced financial stress for low-income families and maximized their tax refunds.
Researchers from University of South Florida have identified oleic and linoleic acids in ancient pottery from Sicily, dating back to the Early Bronze Age. The discovery confirms olive oil existed in Italy hundreds of years earlier than previously recorded.
A longitudinal study by the University of Sussex found that new mothers' voices temporarily drop after childbirth, becoming lower-pitched and more monotonous. The researchers analyzed women's voices over a 10-year period and found that this 'vocal masculinising' is not caused by aging.
Researchers have discovered a way to harness bismuth's unique property, called catalytic plasticity, to convert carbon dioxide into liquid fuels and industrial chemicals. This approach could potentially provide sustainable routes to making fuels and reduce greenhouse gas emissions.
Researchers at UT Southwestern found that mice with increased autophagy levels live longer, healthier lives, with a 10% extension in lifespan. The study also shows protection against age-related cancers and diseases.
Researchers found stroke patients took longer to fall asleep, had poorer sleep efficiency, and were more prone to errors during the day. The study suggests sleep problems in stroke patients are due to psychological strain, pain, and reduced physical activity, highlighting the importance of good sleep for recovery.
A new Spinosaurus fossil from Africa is reported to be the smallest known individual of this giant, sail-backed theropod. The tiny claw phalanx found in Cretaceous-aged sandstones retains the same locomotor adaptations as larger adults.
A new study surveyed 330 UK micro-business owners, finding that internalised motivation (fair fiscal system) and extrinsic motivation (severe penalties) predict self-reported tax compliance. Internalised motivation but not extrinsic motivation predicts tax compliance when considered together.
A new study published in Biological Psychiatry provides updated estimates of the lifetime and 12-month prevalence of eating disorders in the US. The study found that 0.80% of US adults will be affected by anorexia nervosa, 0.28% by bulimia nervosa, and 0.85% by binge eating disorder in their lifetime.
A new geological study provides evidence supporting a coastal theory of early settlement in the Americas. The research suggests that part of a coastal migration route became accessible to humans 17,000 years ago, coinciding with the receding of ancient glaciers.
Research found that oil and gas wastewater used as a dust suppressant on unpaved roads contains harmful pollutants, including salt, radioactivity, and toxic metals. These substances can be detrimental to human health and aquatic life, potentially contaminating nearby bodies of water.
New research reveals that global warming hits poorest regions hardest, with temperate nations like the UK being less affected than tropical countries such as the Democratic Republic of Congo. The study found that as average temperatures rise to 1.5°C or 2°C, wealthy areas will experience fewer climate changes compared to poor nations.
Women with insufficient vitamin D levels before pregnancy were more likely to experience miscarriage compared to those with sufficient levels. Vitamin D was found to play a protective role in maintaining pregnancy.
A recent study published in Acta Paediatrica reveals that Greenlandic children are growing taller than ever before, with average heights now comparable to those of Danish children. This shift is attributed to a combination of genetic factors and improved maternal health, particularly among mothers who are obese.
A novel data-driven approach called PanDrugs prioritizes cancer treatments based on patient genetic alterations. The method integrates pathway context and collective gene impact to provide therapeutic options for patients with limited druggable genes.
Ludwig scientist Ralph Weichselbaum receives the David A. Karnofsky Memorial Award and Lecture for his discoveries in basic mechanisms of signal transduction and gene expression following radiation exposure. Jedd Wolchok, another Ludwig researcher, is named a 2018 ASCO Fellow for his work on harnessing the immune system to treat cancer.
Researchers developed a computer model that forecasts tumour changes, allowing for early disease course prediction and personalized treatment. The study reveals driver mutations can accelerate tumour growth by up to 30%.
Researchers from the Genomics Institute of the Novartis Research Foundation developed a fully automated screening system that solves the slow and low-throughput problem of high-throughput screening in flow cytometry. The system achieves a throughput of 50,000 wells per day, enabling robust phenotypic drug discovery.
The Citizen-Enabled Aerosol Measurements for Satellites project deploys 250 air samplers across Colorado and the Northwest, collecting precise measurements of air quality. The study aims to improve satellite-derived pollution estimates and better understand where air pollution is dirtiest.
Wild Barbary macaques that have more social partners tend to form larger huddles at night, allowing them to conserve energy and reduce environmental stress. This social thermoregulation behavior is linked to higher fitness levels, as it enables monkeys to better cope with adverse weather conditions.
Researchers at MIT's CSAIL have developed a system called VirtualHome that can simulate detailed household tasks and train artificial agents to execute them. The system uses natural language descriptions of activities, such as making coffee or setting the table, to instruct robots on how to complete tasks.
A recent study by Aarhus University found a fivefold risk of nasal cancer following styrene exposure. The researchers also discovered that styrene doubles the risk of acute myeloid leukemia in workers exposed to high levels of styrene. These findings, combined with animal evidence and epidemiological studies, led WHO to classify styren...
A nearly complete skeleton of a new extinct pheasant species from China preserves the oldest evidence of modified vocalization sounds. The fossil features an extremely long and coiled trachea, similar to those found in birds with louder, lower-frequency songs.
A 2013 CLL patient achieved complete remission with a single CAR T cell infusion, sparking insights into the human genome and immune response that may enhance response rates. The successful treatment was linked to the specific location of the CAR gene within the patient's T cell DNA.
The study, led by Dr Christian Brand, finds that both lifestyle change and zero-emission technologies are needed to meet Scotland's 80% carbon reduction target by 2050. Lifestyle changes such as walking, cycling, and using clean public transport can show quicker results than gradual transitions to electric vehicles.
Ibrutinib, a drug approved for lymphoma and leukemia, shows potential in treating glioblastoma by slowing tumor growth and extending survival rates. Combining ibrutinib with radiation therapy overcomes resistance and extends lifespan more effectively than either treatment alone.
A new study analyzing data from Danish women found that taking antidepressants did not change significantly before or after an abortion, and actually decreased over time. The research supports recent reports concluding that abortion does not cause depression, anxiety, or PTSD.
A new online tool, EcoCast, provides fishermen with computer-generated maps to target productive fishing spots while avoiding protected species. By predicting where different marine species are likely to be found under various ocean conditions, EcoCast aims to improve the economic and environmental sustainability of fisheries.
The survey aims to discover the extent to which child abuse leads to mental health problems and psychopathic personality traits. Researchers hope to find ways to prevent future perpetration of violence and reduce levels of abuse.
Colorectal cancer screening may need to be started earlier than previously recommended, with a new study suggesting starting at age 45. Researchers estimate that cutting mortality from colorectal cancer could save up to 70% of lives if everyone followed the revised guidelines.
A new study from the University of Eastern Finland finds that sensory-based food education increases children's willingness to choose vegetables, berries and fruit. The method Sapere uses a child-centered approach to promote healthy dietary habits in early childhood education.
Weizmann Institute of Science researchers found a natural defense mechanism that prompts the body to alleviate intestinal inflammation. Boosting signals in certain cells, such as those making up the inner lining of the gut, may help treat inflammatory bowel diseases and potentially even colon cancer.
A new computer model developed by Dr. Jane Lixin Dai and Prof. Enrico Ramirez-Ruiz enables the categorization of variations in observations of Tidal Disruption Events, allowing for a better understanding of black hole properties and the study of rare celestial events.
Research finds that lone water molecules in oil solvents directly control supramolecular processes. The tiny water concentration affects molecular aggregates and reversible bonds, leading to unexpected outcomes in previous experiments.
The Gutenberg Research College awarded four new fellows and recognized Adela Yarbro Collins and John J. Collins with a 2018 Gutenberg Research Award worth EUR 10,000. The GRC supports top-level researchers through funding that enables them to promote science and the arts.
Researchers deciphered seismometer readings from a 2017 Montecito landslide to determine the disaster's scale and location. The findings suggest that seismometers can be used to provide an early warning of incoming debris flows, potentially saving lives.
The NCI-MATCH trial has released findings from three treatment arms, offering hope for targeted therapies in patients with specific gene abnormalities. The trial's results could aid in identifying effective treatments for various cancers, paving the way for future research.
Researchers have developed a method to simulate molecular motion using a photonic chip, allowing for the creation of virtual movies of molecular dynamics. This technology has the potential to improve the accuracy of molecular models and aid in the development of new pharmaceuticals.
Researchers at Osaka University identified a cellular network involving Th17 cells and stromal cells that secretes inflammatory cytokines to initiate and maintain rheumatoid arthritis. By targeting this network, a novel immunotherapeutic approach has been proposed to reduce chronic joint inflammation.
The University of Cincinnati will examine the effectiveness of combining tissue plasminogen activator (tPA) with either argatroban or eptifibatide in treating acute ischemic stroke patients. The five-year NIH grant will enroll 1,200 patients across the US and assess outcomes at 90 days post-stroke.
A new study found that contaminated black plastic is entering consumer products due to inefficient recycling practices, posing a risk to human health. The researchers also discovered potential harm to marine environments through the spread of microplastics.