A genetic variation in TMEM106B has been identified as a potential risk factor for chronic traumatic encephalopathy (CTE) disease severity and pathology. The study found that this variation may predict increased CTE pathology and brain inflammation, and is associated with a higher risk of developing dementia.
Researchers at Lobachevsky University have synthesized a high-purity sample of barium hypomanganate chloride and characterized its crystal structure and chemical environment. The study has stabilized the degree of manganese oxidation and measured its isobaric heat capacity, revealing anomalous behavior below 15K.
A study of male and female mice found that chronic short sleep and chronic fragmentation of sleep accelerate Alzheimer's disease-related tau pathology. Healthy sleep habits during adolescence and early adulthood may help prevent progression of neurodegenerative diseases.
A new pathology test using AI can accurately predict clinically significant prostate cancer disease progression following surgery, helping guide treatment decisions. The Precise MD post-op test reclassified 58% of intermediate risk patients as low risk and 42% as high risk for significant disease progression.
Yongxin Zhao, assistant professor at Carnegie Mellon University, has received a National Institutes of Health (NIH) Director's New Innovator Award. He will use the grant to develop transformative nanoscale imaging techniques for analyzing complex diseases.
MIT researchers have developed a plug-and-play technology that automates chemical synthesis, allowing chemists to focus on analytical and creative aspects of their research. The system can optimize reactions in a single day, cutting weeks or months of optimization time.
Mitochondria use one-way doors called mitochondrial calcium uniporter channel complexes (MCUCs) to control access, but the exit door proteins are abundant only in areas far from the entrances. This separation allows mitochondria to operate at maximum efficiency even when stressed.
Researchers have discovered that neurons themselves trigger the immune system response in Rasmussen's encephalitis, leading to synaptic damage. By blocking this signalling pathway, they may be able to develop new treatments for the disease.
A study published in PLOS ONE found that the jaw joint bone structure of carnivorans is more closely related to their body size than their diet. Researchers used 3D printing and CT scans to analyze the mandibular condyle, a key joint in the jaw, and discovered no significant correlation between diet and jaw joint strength or complexity.
Drs. Jonathan Rothberg, Roger Klein and Kevin Halling are being recognized for their groundbreaking work and longstanding commitment to advancing patient care and the field of molecular diagnostics. Drs. Rothberg is receiving AMP's highest honor for his pioneering work in genomics and inventions like massively parallel DNA sequencing.
The Association for Molecular Pathology recommends a minimum of 34 critical genes for high-throughput pan-myeloid sequencing tests to standardize clinical practice and improve patient care. The report provides evidence-based guidelines for the management of chronic myeloid neoplasms, including diagnostic and prognostic information.
Researchers have developed a new method for making valuable compounds by combining enzymatic and photocatalysts. The study, published in Nature, found that this combination can create important active pharmaceutical intermediates for producing pharmaceutical drugs.
The study reveals how a fusion protein found in cancer cells enhances target gene expression by converting microsatellite repeats into active enhancers. Blocking this process prevents tumor growth.
Researchers at Berkeley Lab have discovered a method to make the linkages between COFs much more sturdy, giving them new characteristics and expanding their applications. The technique targets weak links and forms resilient bonds that hold up in harsh chemical environments.
A Massachusetts General Hospital research team has developed a system that incorporates neuroinflammation into their 'Alzheimer's in a dish' model, fully replicating the disease's pathology. The system includes neural cell death and glial cells that provide immune functions.
A new study finds contact sports associated with an increased risk of Lewy Body Disease (LBD), which can cause Parkinson's disease and dementia. LBD was linked to problems with movement, cognition, depression, sleep, and visual hallucinations, independent of CTE pathology.
Researchers at the University of Pittsburgh developed a new approach to model complex chemical reactions, enabling better understanding of fundamental reactions and their impact on chemical engineering. PhD student Yasemin Basdogan created an artistic depiction of the research for the journal cover.
Research suggests that low-dose aspirin regimens could decrease amyloid plaque pathology in mice by stimulating lysosomes. Activating cellular waste removal mechanisms is a promising strategy for slowing disease progression.
A new microscope system can image living tissue in real time and molecular detail, allowing for the study of concurrent processes within cells and tissue. This technology has the potential to track tumor progression and improve cancer diagnosis.
Researchers have developed a rhesus macaque model to study Zika brain pathology, revealing similar brain lesions as in human infants with congenital Zika syndrome. The findings suggest that therapies can be tested using fewer animals, providing hope for the development of new treatments.
Professor Lee recognized for his work on metabolic engineering to develop sustainable chemical materials, with notable research in drug-drug and food interactions using AI and novel enzymes. He is the second Asian recipient of the prestigious award, honoring Professor Peter V. Danckwerts.
The study found that on-site pathology testing reduced the need for medical evacuations by up to 35%, resulting in estimated total cost savings of $21.75 million per year. This technology enabled early diagnosis, treatment, and evacuation for critically ill patients in remote communities.
A recent study published in the Journal of Consulting and Clinical Psychology found that patients' self-reports of personality disorder traits are more accurate than previously believed. The research suggests that clinicians' diagnoses may be less reliable than thought, and that using similar evaluation tools can bridge the gap between...
Researchers at Temple University Health System have discovered a way to reverse memory deficits and tau pathology in mice with dementia. By administering a drug that blocks leukotriene formation, they were able to improve spatial learning and working memory in treated animals.
Researchers at North Carolina State University have created ChemMaps, a webserver that allows users to interactively navigate the chemical space of over 8,000 drugs and 47,000 environmental compounds in 3D. The platform features two main maps: DrugMap and EnvMap, which include approved drugs and environmental chemicals, respectively.
A team of scientists has created a map of the molecular network in the aging brain, revealing two new Alzheimer's disease target genes that can be deleted or modified to treat the disease. The study provides a unique resource linking molecular changes in nearly 500 older brains to cognition and brain pathology.
Researchers have discovered that soil microbes use chemical signals to defend against each other and devastating crop diseases. The study found that certain bacteria can induce fungi to produce protective compounds, while the fungus's own defense mechanisms are triggered by the bacterial invasion.
Researchers have developed a computer program that can comprehensively determine differences in individuals' blood types with over 99% accuracy. This breakthrough has the potential to prevent serious complications and fatalities from blood transfusion reactions.
A collaborative study led by the University of Miami Miller School of Medicine found that a monoclonal antibody cocktail therapy was effective in clearing the virus from pregnant women's blood but failed to prevent fetal transmission and treat infected fetuses. Researchers are now working on engineering antibodies to target the fetus.
A new study implicates a role for light-induced electrical activity in controlling chemical codes in the brain, potentially leading to chemical imbalances underlying mental illness. The researchers found that manipulating brain electrical activity prevented neurotransmitter switching associated with anxious and depressed behavior.
A team of researchers at LSTM has developed a new approach to treating snakebite using antivenom produced from a different species than the one that caused the bite. The study, published in Communications Biology, shows that this approach can be effective in neutralizing certain pathologies caused by venomous snakes.
Janardan K. Reddy, a world-renowned pathologist, has been awarded the ASIP Gold-Headed Cane Award for his significant research contributions to liver biology, particularly peroxisomes and carcinogenesis. He is also recognized for his exceptional teaching and mentoring skills.
Dr. Charles N. Serhan received the ASIP 2018 Rous-Whipple Award for his work on molecular and cellular basis of inflammation and its resolution, recognizing his discovery of endogenous anti-inflammatory mediators that activate anti-microbial defense mechanisms.
Researchers bridge the gap between organic and theoretical chemistry by proving the validity of 'curly arrows' in depicting chemical reactions. The study provides a new method to model electronic structure during chemical reactions, connecting traditional depictions with state-of-the-art quantum chemical calculations.
A new approach to analyzing prostate gland tissue uses cellular metabolites to differentiate between aggressive and less aggressive tumors. The study found that metabolite levels can predict tumor grade, stage, and recurrence risk, helping guide treatment strategy.
Researchers found that beta-amyloid triggers calcineurin, leading to loss of dendritic spines and synapses in Alzheimer's disease. Rescuing synapses with extra Pin1 or FK506, an FDA-approved drug for transplant rejection, may slow disease progression.
A new study by Boston Medical Center found chemical peels to be a relatively safe treatment option for people with darker skin. The research revealed that less than four percent of participants experienced unwanted side effects.
A University of Melbourne study reveals that one in four Americans report chemical sensitivity, with nearly half experiencing severe health problems. The research found a significant increase in diagnosed cases of Multiple Chemical Sensitivities, affecting an estimated 55 million adults.
A study published in Biological Psychiatry reveals distinct molecular changes in gene expression between men and women with major depressive disorder, suggesting different pathology and treatment needs.
The Association for Molecular Pathology (AMP) has published consensus-based recommendations for clinical CYP2C19 genotyping allele selection. The guidelines aim to standardize testing across laboratories and improve concordance, enabling better patient care.
Researchers found four cases of amyloid beta pathology in brain blood vessels after childhood neurosurgery, sparking concerns over potential transmission of protein pathology. The study's findings were supported by a review of medical literature and suggest that neurosurgical instruments may be responsible.
Using a super resolution microscopic technique, researchers have developed a method to follow chemical reactions in very small volumes, including inside living cells and individual organelles. This breakthrough enables the study of the chemistry of life with unprecedented precision.
A study by Tokyo Medical and Dental University found that protein YAP rescued SCA1 pathology when expressed during development, but not as an adult. The researchers also discovered a link between YAP and the transcriptional co-activator RORα, which plays a crucial role in cerebellum development.
A panel of experts has issued new guidelines for molecular diagnostic testing and treatment decisions in lung cancer. The updates reflect recent advancements and decades of work to identify the genetic underpinnings of lung cancer, helping oncologists match patients with effective therapies.
A Boston University study identified evidence of early Chronic Traumatic Encephalopathy (CTE) brain pathology after head impact, even in the absence of signs of concussion. The researchers found that head impact caused persistent changes in brain electrical functions and damaged blood vessels, leading to CTE.
Dr. Jeffrey Actor has been awarded $1.7 million to investigate a novel recombinant lactoferrin for use as a preclinical research tool to alter granuloma pathology in tuberculosis. This could limit development of lung disease and slow transmission of organisms between individuals.
Researchers at the University of Texas at Austin have created a first-of-its-kind chemical oscillator using DNA molecules, enabling precise molecular control and complex behaviors. The discovery opens doors to creating molecular machines that can perform sophisticated tasks such as communication and signal processing.
Researchers used digital pathology slide images to train computer algorithms that could detect the spread of breast cancer to lymph nodes with high accuracy. The study found that AI algorithms outperformed human pathologists in detecting cancer spread, suggesting potential improvements in diagnosis and treatment outcomes.
Researchers have developed an AI application that can detect lymph node metastases in breast cancer patients with high accuracy, similar to human pathologists. This breakthrough could improve the efficiency of surgical pathology work and provide better prognostication.
A new PET tracer has been developed to effectively gauge the effectiveness of promising Alzheimer's treatments in mouse models. The tracer binds to BACE1, a key enzyme involved in amyloid-β development, and accurately measures its effects on brain metabolism, neuroinflammation, and amyloid-β pathology.
The Universal Genomics Instructor Handbook and Toolkit provides a comprehensive 'how-to' guide for implementing genomics education in various medical specialties. The toolkit contains four exercises and resources for clinicians to gain introductory training in genomic medicine.
A new microscope technology using ultraviolet light enables fast and accurate imaging of fresh tissue samples, revolutionizing pathology and medical research. This approach eliminates the need for time-consuming slide preparation and preserving tissue, making it an essential tool for improving patient care and research nationwide.
The partnership aims to apply advanced chemical engineering research to industrial-scale chemical manufacturing, reducing waste generation, utility, and energy costs. The University of Pittsburgh's Chemical and Petroleum Engineering Department is developing new educational programs and internships to prepare students for the industry.
Researchers from QUT, KIT, and Ghent University create a light-switchable chemical reaction system to revolutionize chip printing. The system uses visible light to reversibly switch certain chemical processes, potentially making it cheaper, simpler and safer.
Optic nerve hypoplasia is a leading cause of childhood blindness in developed nations, and researchers have discovered the biological mechanism behind it. The condition affects brain growth during development, particularly with the CASK gene, which helps provide architectural support for neuronal communication.
The Association for Molecular Pathology publishes consensus recommendations for validating next-generation sequencing bioinformatics pipelines. The guidelines emphasize the critical role of trained molecular laboratory professionals and provide practical advice for laboratories.
A comprehensive study of heart-spleen and heart-kidney networks reveals the interconnectedness of organ damage after a heart attack. Researchers found histological and cellular changes in the spleen and kidney, as well as bimodal inflammatory responses and irreversible dysregulation in the cardiosplenic and cardiorenal networks.
Using ALMA's unparalleled sensitivity and resolution, the team identified eight massive dusty clouds along the center of the galaxy, each with a unique chemical signature. The clouds are thought to be aggregates of dense, warm cocoons around young stars, driving complex chemical reactions and molecule formation.
Researchers found a connection between abnormal glucose breakdown in the brain and the severity of Alzheimer's symptoms, with lower glycolysis rates and higher brain glucose levels correlated to more severe pathology. The study suggests that targeting glycolysis defects could lead to new treatments for Alzheimer's disease.
A collaborative study has found that a combination of three monoclonal antibodies prevents Zika virus infection in primates. The treatment completely blocked the virus from taking hold in the animals, indicating a promising intervention to protect uninfected pregnant women and their fetuses.