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Moffitt researchers identify key factors impacting adaptive therapy

Researchers at H. Lee Moffitt Cancer Center & Research Institute have identified key factors impacting the effectiveness of adaptive therapy in cancer treatment. The study found that spatial organization and competition between drug-resistant cells play a crucial role in determining the success of adaptive therapy.

SourceH. Lee Moffitt Cancer Center & Research Institute·JournalCommunications Medicine·TypeComputational simulation/modeling·DateMay 9, 2022

Nonlethal parasites reduce how much their wild hosts eat, leading to ecosystem effects

A study led by Washington University in St. Louis found that nonlethal parasitic infections reduce herbivory rates and trigger trophic cascades impacting plant communities. The research used a mathematical model and global meta-analysis to highlight the ecological consequences of common parasitic infections in wild animals.

SourceWashington University in St. Louis·JournalProceedings of the National Academy of Sciences·TypeComputational simulation/modeling·DateMay 9, 2022

Development of an ensemble model to anticipate short-term COVID-19 hospital demand

Researchers developed an ensemble model combining multiple individual predictive models to anticipate COVID-19 hospital demand, achieving a significant reduction in prediction error. The study's findings show that incorporating early predictors such as epidemiological data and mobility data leads to better forecasts.

SourceInstitut Pasteur·JournalProceedings of the National Academy of Sciences·TypeData/statistical analysis·DateMay 9, 2022

New modelling shows that ‘shielding’ strategies instead of lockdowns would have led to tens of thousands more deaths

A new study published in PLOS Global Public Health found that shielding vulnerable populations while allowing the virus to spread through the rest of the population would have failed. The research reveals that even with perfect shielding, healthcare capacity would have been overwhelmed, and tens of thousands more deaths would have occu...

SourceUniversity of Bath·JournalPLOS Global Public Health·TypeComputational simulation/modeling·DateApr 26, 2022

Learning chemical networks give life a chiral twist

A mathematical model reveals that spontaneous symmetry breaking in chemical reactions leads to homochirality, optimizing energy harvesting from the environment. This phenomenon could explain how life developed on primordial Earth and has implications for the synthesis of chiral drug molecules.

SourceInstitute for Basic Science·JournalNature Communications·TypeComputational simulation/modeling·DateApr 26, 2022

Rational neural network advances machine-human discovery

A novel 'rational' neural network reveals underlying mathematical equations through Green's functions, enabling humans to understand machine-generated findings. This breakthrough in partial differential equation learning holds promise for advancing scientific exploration of weather systems, climate change, and more.

SourceCornell University·JournalScientific Reports·DateApr 5, 2022

Social media data could help predict the next COVID surge

Researchers have developed a new forecasting approach using machine learning and anonymized datasets from Facebook that significantly outperforms conventional models for projecting COVID trends at the county level. The model captures shifting trends in numbers reflecting lockdowns, waning immunity, or masking policies.

SourceUniversity of Colorado at Boulder·JournalInternational Journal of Data Science and Analytics·TypeData/statistical analysis·DateMar 21, 2022

Data science to help find the most appropriate rehabilitation methods for osteoarthritis patients

A study using data science and mathematical models identifies the most suitable rehabilitation method for each patient with osteoarthritis. The research aims to provide personalized treatment recommendations for healthcare professionals, ultimately leading to more effective care for patients.

SourceUniversity of Jyväskylä - Jyväskylän yliopisto·JournalAnnals of Medicine·TypeRandomized controlled/clinical trial·DateMar 17, 2022

CityU research estimates vaccine donation from high to low- and middle-income countries will help end COVID-19 pandemic

A team led by City University of Hong Kong researcher Dr Zhang Qingpeng found that donating 46% to 80% of COVID-19 vaccines to low- and middle-income countries can significantly reduce infection rates and mortality. The study suggests prioritizing vaccines for countries with high incidence, prevalence, and mortality rates.

SourceCity University of Hong Kong·JournalNature Human Behaviour·TypeData/statistical analysis·DateMar 1, 2022

Illinois team significantly improves BioCro software for growing virtual crops

Researchers from the University of Illinois have revamped the popular crop growth simulation software BioCro, allowing modelers to use the technology more easily. The updated version includes faster and more accurate algorithms, enabling researchers to try new simulations more easily and link to other models.

SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·Journalin silico Plants·TypeComputational simulation/modeling·DateFeb 28, 2022

Researchers from the GIST use artificial intelligence to identify potential unsafe locations in cities

GIST researchers propose a new strategy for crime prevention using artificial intelligence, trained on a large-scale dataset of deviant incident reports and corresponding images. The model, called DevianceNet, can accurately classify and detect deviant places, making it a useful tool in urban safety development.

SourceGIST (Gwangju Institute of Science and Technology)·TypeComputational simulation/modeling·DateFeb 23, 2022

NIST researchers link cutting-edge gravity research to safer operation of construction cranes

Researchers from NIST have developed a mathematical model that predicts the strength and timing of changes in velocity required for crane operators to apply when transporting heavy loads. This equation can be applied to various situations, including moving a load with initial rest and large distances.

SourceNational Institute of Standards and Technology (NIST)·JournalAmerican Journal of Physics·TypeComputational simulation/modeling·DateFeb 18, 2022

Scientists discover how our circadian rhythm can be both strong and flexible

Researchers found that the master clock and slave clock operate via distinct molecular mechanisms, allowing for robustness and flexibility in regulating bodily rhythms. The master clock's ability to adapt to environmental changes enables quick adjustment to new time zones after international flights.

SourceInstitute for Basic Science·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateFeb 17, 2022

Too soon to lift mask mandates for most elementary schools in U.S., study finds

A Harvard T.H. Chan School of Public Health study suggests that US elementary schools should only remove masks when local COVID-19 case rates are below a certain threshold to avoid increased transmission. The study provides a framework for school decision-makers to estimate the level of mitigation needed to meet their goals.

SourceHarvard T.H. Chan School of Public Health·JournalJAMA Network Open·TypeComputational simulation/modeling·DateFeb 15, 2022

Withdrawal of rivers and lakes is faster near cities

A study published in AGU Advances found that water depletion from rivers and lakes accelerates near urban centers due to factors like increased evaporation and groundwater exploitation. Researchers analyzed satellite imagery of the US from 1984 to 2018 and developed a model predicting surface water loss proximity to cities.

SourceUniversità di Bologna·JournalAGU Advances·DateFeb 10, 2022

Why do locusts form destructive swarms?

Researchers at Tel Aviv University found that a specific type of bacteria, Weissella, becomes dominant in the gut microbiomes of locusts when they form swarms. This change may provide the bacteria with an evolutionary advantage, allowing them to spread and infect more locusts.

SourceTel-Aviv University·JournalEnvironmental Microbiology·DateFeb 9, 2022

Study predicts that routine immunisation with the first typhoid conjugate vaccine (TCV) could avert 46-74% of typhoid fever cases

A mathematical modeling study predicts that routine immunization with TCV could avert 46-74% of all typhoid fever cases in 73 countries. Vaccination is also expected to reduce the relative prevalence of antimicrobial-resistant typhoid by 16%, preventing millions of cases and deaths.

SourceCenter for Disease Dynamics, Economics & Policy·JournalThe Lancet Infectious Diseases·TypeComputational simulation/modeling·DateFeb 3, 2022

The price is right: Pusan National University scientists develop new model to determine pricing of vulnerable exchange options

Researchers at Pusan National University have developed a new model using 'double Mellin transforms' and the 'method of dimension reduction' to accurately price vulnerable exchange options. The model provides an effective and accurate mathematical solution, enabling quick deployment without long calculations.

SourcePusan National University·JournalThe North American Journal of Economics and Finance·TypeComputational simulation/modeling·DateFeb 1, 2022

The power of chaos: a robust and low-cost cryptosystem for the post-quantum era

A team of researchers from Ritsumeikan University developed an unprecedented stream cipher using chaos theory to create highly secure cryptographic systems. The new system is resistant to statistical attacks and eavesdropping, even against quantum computers, making it a promising solution for post-quantum era cryptosystems.

SourceRitsumeikan University·JournalIEEE Transactions on Circuits and Systems·TypeComputational simulation/modeling·DateFeb 1, 2022

A mathematical secret of lizard camouflage

A multidisciplinary team at UNIGE has developed a simple mathematical equation to explain the complex distribution of scales in ocellated lizards. This discovery contributes to a better understanding of skin color pattern evolution and provides an optimal pattern for animal survival.

SourceUniversité de Genève·JournalPhysical Review Letters·TypeNews article·DateJan 27, 2022

Schools and the pandemic: Simulation model allows for safe operation

Researchers developed a school simulation model that shows how the virus spreads in different settings and calculates the effectiveness of measures against its spread. The model reveals that elementary and lower secondary schools can keep reproduction rates below 1 with classroom ventilation, wearing masks, and class size reduction.

SourceComplexity Science Hub·JournalNature Communications·TypeComputational simulation/modeling·DateJan 27, 2022

Mathematical model may help improve treatments and clinical trials of patients with COVID-19 and other illnesses

A mathematical model developed by researchers at Massachusetts General Hospital has identified biological markers that can predict treatment responses in COVID-19 patients. The model reveals differences in patient characteristics and response to therapy, enabling clinicians to provide optimal care for diverse patients.

SourceMassachusetts General Hospital·JournalEBioMedicine·TypeComputational simulation/modeling·DateJan 14, 2022

Equivariant representations for molecular Hamiltonians and N-center atomic-scale properties

Researchers develop a symmetrized N-center representation that provides a natural, fully equivariant framework for learning properties associated with multiple atoms. The approach gives excellent accuracy for predicting atomic properties despite using only linear or kernel regression.

SourceNational Centre of Competence in Research (NCCR) MARVEL·JournalChemical Physics·TypeComputational simulation/modeling·DateJan 10, 2022

Possible chemical leftovers from early Earth sit near the core

New research suggests that ultra-low velocity zones in the deep mantle may be regions made of different rocks than the rest of the mantle, with compositions potentially linked to the early Earth. The study's findings imply the presence of layered structures within these zones, shedding light on their origin and evolution.

SourceUniversity of Utah·JournalNature Geoscience·TypeComputational simulation/modeling·DateDec 30, 2021

Cough or fever first? Study analyzes order of COVID-19 symptoms

A new study published in PLOS Computational Biology found that the order of COVID-19 symptoms varies depending on the SARS-CoV-2 variant. In the USA, cough was most likely to be the first symptom, while fever and diarrhea were more common third symptoms.

SourcePLOS·JournalPLOS Computational Biology·TypeComputational simulation/modeling·DateDec 16, 2021