Antibiotics
Articles tagged with Antibiotics
A precision nanoparticle strategy to combat multidrug-resistant pneumonia
Researchers develop hemoglobin-based nanoparticles to deliver tigecycline directly to Klebsiella pneumoniae infection sites, improving survival rates and reducing bacterial burden. The novel strategy overcomes dose-limiting toxicity and enhances pharmacokinetics of the antibiotic.
Tiny bacterial “nanoweapons” offer new hope against drug-resistant infections
Researchers engineer bacterial vesicles into multifunctional tools that can kill pathogens, boost vaccines, and deliver targeted therapies. Engineered BEVs address key limitations of existing therapies, including improving vaccine responses and antibiotic delivery.
Singapore researchers advance phage therapy in fight against antimicrobial resistance
Researchers identified how Mycobacterium abscessus evades treatment and proposed a strategy to overcome resistance, offering a pathway towards more effective treatments. A combination therapy targeting both smooth and rough variants proved more effective than single-phage treatment.
Researchers identify natural compound that disarms drug-resistant bacteria
A naturally occurring fatty acid called geranylgeranoic acid (GGA) has been discovered to disrupt the ability of MRSA bacteria to stick to human molecules and detect their environment, making it harder for them to cause disease. Researchers tested GGA in mice and found it prevented skin lesions and reduced infection severity.
Comparing veterinary antimicrobial stewardship: Why Brazil needs stronger monitoring systems
The study reveals critical gaps in Brazil's veterinary antimicrobial stewardship, compared to the UK and Netherlands' comprehensive monitoring systems. Brazil's fragmented approach makes it difficult to detect trends and respond to emerging resistance threats.
Risk of celiac disease is not a reason to avoid antibiotics
A nationwide Swedish study of 27,789 individuals with confirmed celiac disease found no link between antibiotic use and increased risk of developing the autoimmune disorder. The study also revealed a higher proportion of prior antibiotics used among those with normal mucosa, suggesting other factors may contribute to its development.
New study finds high rates of outpatient antibiotic exposure in children with medical complexity
A new study found that children with three or more complex chronic conditions had the highest annual prescription rates and frequent use of broad-spectrum antibiotics. This highlights the need for targeted antibiotic stewardship efforts in this vulnerable population.
IBS treatment response predicted by gut microbiome in new study
Researchers found distinct gut microbiome characteristics that predicted treatment response to the low FODMAP diet and rifaximin. Patients who responded to these treatments had different microbial signatures, with increases in diversity for those on the low FODMAP diet and resilience against antibiotics for those on rifaximin.
Foxes and birds could be ‘early warning system’ to survey spread of antibiotic resistance into ecosystems
Researchers discovered highly antibiotic-resistant bacteria in wildlife samples, including foxes and birds, indicating potential early warning system for AMR spread. The study highlights the need for environmental interventions to prevent resistance from reaching clinical settings.
Shorter antibiotic courses show similar outcomes to longer use for some pneumonia patients
For eligible patients with community-acquired pneumonia, shorter treatment durations may be as safe and effective as traditional longer regimens. The study found no meaningful differences in mortality, readmissions, or C. difficile infections among patients who received three to four days of antibiotics.
Researchers find a new "molecular handle" to build complex medicines
A team of chemists has found a simple way to attach the highly sought-after dichloromethyl group onto complex compounds using proline. This method enables the precise assembly of molecules with unparalleled purity and selectivity, simplifying the synthesis of complex drug compounds.
Influence of antibiotic use on mental health during pregnancy
A study published in BMC Public Health found an association between antibiotic use and maternal mental health during pregnancy. Researchers analyzed data from over 94,000 pregnant women and discovered a stepwise pattern of psychological distress linked to increasing antibiotic exposure. The findings suggest that avoiding unnecessary an...
New biochar-based technology boosts antibiotic removal from water using low-energy ultrasound
Researchers developed a novel composite material that combines biochar, carbon nanotubes, and iron carbide, significantly accelerating the breakdown of antibiotics in water. The system achieved up to 15 times higher removal rates compared to conventional materials, while requiring substantially less energy.
Neanderthals may have used birch tar for wound care
A new study suggests that Neanderthals used birch tar not only as an adhesive but also to treat wounds, showing effective antimicrobial properties against S. aureus bacteria. The research findings are relevant in light of the global rise in bacterial resistance to antibiotics.
New test dissolves threat of fake drugs
Researchers have developed a low-cost fake drug detector that uses an infrared sensor to track pill dissolution rates. The device can identify legitimate medications from counterfeit ones with high accuracy, making it a valuable tool in the fight against global health threats.
Inappropriate antibiotic use for COVID-19 is linked to resistance
Using azithromycin within one day triggers antibiotic resistance in the respiratory tract, according to a study published in Nature Microbiology. The researchers followed hospitalized COVID-19 patients and found that azithromycin changed the mix of microbes in the upper airway, leading to persistent changes for more than a week.
Antibiotics can affect the gut microbiome for several years
A new study found that antibiotics can alter the gut microbiome for up to four to eight years after treatment, with certain types of antibiotics having a stronger impact. The study analyzed data from 14,979 adults and found links between antibiotic use and changes in gut microbiome composition, including diversity of bacterial species.
Antibiotic resistance can vary depending on where the bacteria live
Research shows that bacteria harbor resistance genes may respond differently to antibiotics under non-standard conditions. This affects treatment efficacy and contributes to understanding antimicrobial resistance development and spread. Understanding these variations is crucial to combat global public health threats.
Multi-scale plant defense strategies against antibiotic stress revealed
Researchers have discovered plant defense strategies against antibiotic stress, including chloroplast-centered adaptation and microbiome coordination. Plants accumulate antibiotics in roots, activate detoxification enzymes, and restructure endophytic bacterial communities to counter stress. These findings suggest plants as bioremediati...
Ultrasound-activated ‘nanoagents’ kill superbugs hiding in biofilms
Researchers design nanoagents to carry antibiotics deep into bacterial infections, releasing them upon gentle ultrasound activation. This approach reduces antibiotic resistance and improves treatment of biofilm-related infections.
Fe₃O₄@mPEG-Ag nanoparticles: a new frontier in combating antibiotic resistance
Researchers introduce Fe₃O₄@mPEG-Ag nanoparticles as a non-antibiotic strategy to combat drug-resistant bacteria. The novel nanomaterial demonstrates strong antibacterial activity against clinically relevant multidrug-resistant strains.
Digital clinical decision support algorithm substantially reduced antibiotic prescribing without compromising clinical recovery, according to non-randomized controlled trial in 32 Rwandan health centers
A digital clinical decision support algorithm substantially reduced antibiotic prescribing in pediatric outpatient care in Rwanda, according to a non-randomized controlled trial. The study found no compromise in clinical recovery, suggesting the algorithm's effectiveness in guiding appropriate treatment.
Emerging class of antibiotics to tackle global tuberculosis crisis
A team of scientists at the University of Sydney has discovered how three naturally occurring antibiotic compounds disrupt the ClpC1–ClpP1P2 complex, a vital protein degradation machine in Mycobacterium tuberculosis. This finding uncovers surprising complexity and provides valuable insight into designing more effective anti-TB treatments.
Study reveals how antibiotic structure controls removal from water using biochar
A new study reveals that biochar's ability to remove antibiotics from water depends on their molecular structure. The research found that subtle structural differences among tetracycline antibiotics influence their adsorption onto rice straw biochar, with some antibiotics binding more quickly than others.
Novel vaccine protects against C. diff disease and recurrence
A novel vaccination approach cleared harmful gut bacterium Clostridioides difficile (C. diff) in an animal model of infection. The experimental vaccine protected against illness, death, tissue damage and infection recurrence through mucosal immunization.
Bacteria frozen in ancient underground ice cave found to be resistant against 10 modern antibiotics
Researchers discovered a 5,000-year-old bacterial strain in an underground ice cave that shows resistance to multiple modern antibiotics. The Psychrobacter SC65A.3 strain has over 100 resistance-related genes and can inhibit the growth of several major antibiotic-resistant superbugs.
Shorter treatment regimens are safe options for preventing active tuberculosis
A one- and three-month antibiotic treatment regimens both had few adverse reactions and high rates of completion in preventing active tuberculosis, says a new study published in PLOS Medicine. The regimens were deemed successful and neither proved superior to the other.
Technology transfer for Corallopyronin A successfully completed with Phyton Biotech
Phyton Biotech has successfully transferred the manufacturing process for Corallopyronin A (CorA), a novel anti-infective agent with potent activity against filarial infections and bacterial infections. The technology transfer marks an important milestone in the Company's specialty GMP fermentation capabilities.
Risk factors for the development of food allergy in infants and children
A meta-analysis of childhood food allergy risk factors reveals a combination of major and minor factors, including genetics and antibiotic exposure. The study provides insights into the complex interplay of these factors in the development of food allergies in infants and children.
New guide aims to tame the chaos of UTI care
The Ann Arbor Guide provides two algorithms for triaging adults with suspected UTIs, one for non-pregnant women and the other for men. It also emphasizes the importance of accurate testing and treatment to prevent overuse of antibiotics and antibiotic resistance.
Antibiotic therapy for uncomplicated acute appendicitis
Researchers support using antibiotics for uncomplicated acute appendicitis due to low recurrence rates at 10-year follow-up. The treatment option is recommended for adult patients, reducing the need for future surgery.
Why don’t antibiotic-making bacteria self-destruct?
Researchers discovered that Paenibacillus produces lariocidin, a powerful antibiotic, but the bacteria avoid its effects due to an enzyme called lrcE. This enzyme modifies lariocidin, preventing it from binding to the bacterial ribosomal RNA and protecting the producer.
A protein found in the GI tract can neutralize many bacteria
Researchers discovered that protein intelectin-2 has broad-spectrum antimicrobial activity against bacteria in the GI tract. It strengthens the mucus barrier and can directly neutralize or restrain bacteria, making it a potential therapeutic agent.
Traditional herb offers new hope for antibiotic-free pig farming
The study highlights the multifunctional natural substitute for antibiotics in swine production, demonstrating broad antimicrobial, antioxidant, anti-inflammatory, and immune-regulating effects. Dietary supplementation improves intestinal barrier integrity, increases growth metrics, and reduces fecal E. coli.
New test shows which antibiotics actually work
Researchers developed a new method to measure how effectively antibiotics kill bacteria, crucial for treating complex infections. The 'antimicrobial single-cell testing' method predicts treatment success by observing individual bacteria under different conditions.
Microbes that break down antibiotics help protect ecosystems under drug pollution
Certain microbes can act as community protectors by breaking down antibiotics and stabilizing entire microbial ecosystems. Antibiotic degraders create safer microenvironments, allowing sensitive microbes to survive.
New clinical standards strengthen antimicrobial stewardship in tuberculosis care
The new clinical standards for antimicrobial stewardship in tuberculosis care aim to integrate TB into existing AMS frameworks, strengthening surveillance and resistance monitoring. The standards prioritize effectiveness, safety, and resistance prevention, promoting structured expert consultation services and targeted testing.
4 million for study with personalized phage therapy
The study will select the exact phage that is appropriate for each patient's bacteria, and aims to reduce antibiotic use and healthcare costs. Bacteriophages have been shown to be effective against resistant bacteria causing urinary tract infections.
The antibiotic delafloxacin emerges as a potential therapeutic alternative against Legionella
A study published in the International Journal of Infectious Diseases found that delafloxacin inhibits Legionella replication more effectively than levofloxacin. The antibiotic demonstrates promising intracellular activity, which could support further clinical investigation as a potential treatment for Legionnaires' disease.
Tropical disease oroya fever: Elucidation of disease mechanism opens possibility for novel therapy
A team of researchers has identified two proteins critical to the destruction of red blood cells by the Oroya fever pathogen. This discovery paves the way for a potential novel therapy against this deadly neglected tropical disease.
Comeback of the biphenomycins
Researchers at HIPS have fully elucidated the biosynthetic pathway of biphenomycins, a potent antibiotic family against Gram-positive pathogens. They can now produce sufficient quantities and create new variants with improved pharmaceutical properties to combat drug-resistant S. aureus infections.
The Lancet: New single dose oral treatment for gonorrhoea effectively combats drug-resistant infections, trial finds
A new single-dose oral medication called zoliflodacin shows promise as a treatment for antibiotic-resistant gonorrhoea, with over 90% of infections cured at genital sites. The medication is well-tolerated and has the potential to improve global efforts to control drug-resistant gonorrhea infections.
Seaweed based carbon catalyst offers metal free solution for removing antibiotics from water
A new seaweed-based carbon catalyst has been developed that can rapidly break down antibiotic norfloxacin in water without using toxic metals or sulfur chemicals. The catalyst, made from kappa carrageenan and doped with nitrogen and sulfur, shows high specific surface area and degrades antibiotics through non-radical pathways.
In pneumonia’s tug-of-war, lung microbiome could tip the balance
A study found that lung microbiomes play a significant role in pneumonia, with patients having oral-like pneumotypes more likely to recover. The researchers identified four distinct microbial patterns, or 'pneumotypes,' associated with different types of pneumonia.
Tuberculosis: Scientists develop novel drug candidate for combating resistant pathogens
Researchers at Martin Luther University Halle-Wittenberg have developed a promising new substance that inhibits the ability of tuberculosis bacteria to produce energy and causes them to die. The compound, PRP020, targets the pathogen's ATP synthase but attacks a different site than existing drugs like bedaquiline.
Plant phenolic acids supercharge old antibiotics against multidrug resistant E. coli
Researchers found that plant phenolic acids can dramatically boost the activity of existing antibiotics against multidrug resistant E. coli, reducing the chance of new resistance emerging. The compounds also make it easier for antibiotics to enter and stay inside bacterial cells.
Antibiotics could trigger immune response through gut microbiome metabolites
Researchers discovered that antibiotics can induce the production of pro-inflammatory compounds in the gut microbiome, which stimulates the immune system and induces antimicrobial peptides. This finding could lead to new therapeutic properties for these compounds in restructing the gut microbiome.
Parkinson's drug as basis for new anti-infectives
Researchers at HIPS and Helmholtz Centre for Infection Research discovered that tolcapone interacts with LecA protein, a key component of Pseudomonas aeruginosa. The study identified several derivatives that inhibit LecA significantly more strongly than tolcapone.
Nasal microbiome: Resource scarcity as opportunity
A study reveals that competition for biotin, a vital vitamin, drives interactions between harmful Staphylococcus aureus and harmless commensal bacteria. This resource scarcity could lead to new strategies for fighting multi-resistant germs.
New study reveals how a common antibiotic disrupts nitrogen cycling and boosts greenhouse gas emissions in estuaries
A new study identifies how sulfamethoxazole, a common antibiotic, affects denitrification in estuarine sediments. The results show that the antibiotic disrupts the balance of nitrogen cycling processes, leading to increased nitrous oxide emissions and greenhouse gas warming.
New nanogel technology destroys drug-resistant bacteria in hours
A novel nanogel technology has been developed to kill drug-resistant bacteria, including Pseudomonas aeruginosa and Escherichia coli, with high selectivity and efficiency. The technology uses a heteromultivalent nanogel that binds to specific proteins on the bacterial surface, disrupting the membrane and leading to rapid bacterial death.
A promising avenue for improving antibiotic efficacy
Researchers at Institut Pasteur found that aminoglycosides use sugar transporters to enter bacteria, increasing their effectiveness and potentially reducing the need for high doses. By doubling the number of transporters, they improved antibiotics' penetration rate and efficacy in even the most resistant E. coli strains.
Everyday levels of antibiotics in the environment may accelerate the global spread of resistance, new study finds
A new study shows that even small amounts of antibiotics in the environment can significantly accelerate the spread of antibiotic resistance genes among bacteria. The research found that low concentrations of antibiotics can stabilize existing resistance and promote the development of new resistance traits.
Repurposed antibiotic shows promise against Central Nervous System Tuberculosis in NUS Medicine study
Researchers have demonstrated that doxycycline can improve survival rates and neurological outcomes in children with Central Nervous System Tuberculosis. The study found that treating CNS-TB laboratory models with doxycycline alongside standard TB drugs suppressed inflammation, preserved brain tissue, and improved vascular integrity.
Evolving antibiotic resistance under pressure
Researchers used an experimental evolution approach to map genetic mutations in A. baumannii treated with tigecycline and colistin, confirming and extending existing knowledge on major mechanisms of resistance. The study's findings aim to develop genomics-based predictions of drug resistance and susceptibility.
Antibiotics linked to lower risk of complications after obstetric tear
A clinical trial found that antibiotics within 24 hours of an obstetric tear can significantly reduce the risk of clinically relevant wound complications. The treatment group experienced fewer complications and reported better wellbeing compared to the placebo group. This finding supports the use of prophylactic antibiotics in routine ...
Home treatment with IV antibiotics could relieve NHS pressure
A University of East Anglia study found that treating patients at home with IV antibiotics can save the NHS over £3,500 per patient and potentially free-up vital hospital beds. The treatment involves having antibiotics prepared at home and continuously delivered into the bloodstream by an elastomeric pump.
New antibiotic for drug-resistant bacteria found hiding in plain sight
Researchers have discovered a promising new antibiotic, pre-methylenomycin C lactone, which is over 100 times more active than the current antibiotic methylenomycin A. This finding provides hope in the fight against antimicrobial resistance (AMR), which affects millions of people worldwide.
Could slime mold microbes be a source of potent antimicrobials?
Researchers optimized lab culture conditions to boost levels of low-abundance chlorinated compounds in slime mold cells, identifying CDF-2 and CDF-3 as potent antibiotics against Gram-positive bacteria. The compounds' similar molecular structure suggests a critical role in protecting against harmful bacteria.