Articles tagged with Antibiotics
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A recent study found that Metagenomic next-generation sequencing (mNGS) can detect pathogens in 86% of cases, outperforming conventional microbiological tests which identified pathogens in only 67% of cases. mNGS guides treatment decisions and improves patient outcomes by detecting rare/atypical pathogens.
A large cohort study found that early antibiotic treatment did not significantly improve outcomes for patients with nonsevere COVID-19. The results argue against routine antibiotic use in this population due to associated risks.
Researchers have discovered that microalgae species can remove antibiotic residues from water, including sulfamethoxazole and trimethoprim. This process also produces biomass with potential commercial value, including biodiesel production.
Research suggests that antibiotics taken during infancy, especially in the first three months, may lead to earlier onset of puberty in girls. The study, which analyzed data on over 322,000 children in South Korea, found a significant association between early antibiotic exposure and increased risk of central precocious puberty.
Researchers have discovered that combining antibiotics with an enzyme called endolysin can protect against infection by resistant bacteria in all bodily organs, including the brain. This breakthrough could lead to a new treatment for meningitis, a life-threatening disease caused by resistant bacteria.
Researchers developed a topical antibiotic gel that cured middle ear infections in chinchillas within 24 hours. The gel, containing negatively charged liposomes, was more effective than previous formulations in delivering antibiotics across infected eardrums.
A global study led by Stockholm Resilience Centre reveals that countries have the power to reduce antibiotic resistance through effective domestic interventions. The study found strong associations between country-level action and changes in antibiotic use and resistance, with a handful of countries leading the way.
Scientists have discovered a novel immune signaling pathway in bacteria that turns viral infection machinery against the virus, potentially informing future biotech tools and phage therapy. This discovery reveals an ancient defense strategy that could help fight superbugs.
Mathematical modeling research from University of Utah Health suggests that treating moderate cases with antibiotics could limit the spread of cholera and reduce the likelihood of antibiotic resistance. In areas where cholera spreads slowly, aggressive antibiotic use may even stop outbreaks entirely.
A new study by Virginia Tech researchers suggests that bacteriophages, or virus-like particles, may increase the sensitivity of gut bacteria to antibiotics. The team created a mouse model that allows them to control phage populations and found evidence that phages can exacerbate antibiotic damage.
Researchers found that antibiotic exposure in the first two years of life was significantly associated with a higher body mass index (BMI) in childhood. The study followed 33,095 vaginally born children in Finland to see if antibiotics before pregnancy, during pregnancy, and after birth were linked to higher BMI at age two and age 12.
Researchers identified piperacillin as an effective treatment for Lyme disease, which causes devastating symptoms in half a million individuals annually. The antibiotic works by targeting the bacteria's unique cell wall synthesis pattern, leading to its death without harming beneficial gut microbes.
The ERA4TB project aims to develop new antibiotics against TB, while TAINT-TB focuses on contrast agents for precise diagnosis. The TCOLF-TC312 project uses humanized mice to study TB and its interactions with the immune system.
Human consumption of antibiotics has increased by 65% since 2000, resulting in estimated 8,500 tonnes reaching river systems globally. Chronic environmental exposure can reduce microbial diversity and increase antibiotic-resistant genes, impacting fish and algae health.
Researchers detected widespread contamination of retail chicken meat in Bangladesh with antibiotic-resistant E. albertii, a lesser-known but deadly pathogen. The study highlights the need for improved hygiene measures and stricter regulations to prevent foodborne infections.
Researchers found that repeated antibiotic use before age 2 is associated with a higher risk for asthma, food allergies, and hay fever later in life. The study suggests that judicious use of antibiotics in children under 2 may impact long-term health outcomes.
Chinese researchers create a fully green technological system for sustainable continuous production of beta-lactam antibiotics, leveraging Zr-MOFs for effective enzyme immobilization. The developed method preserves native enzymatic activity while enhancing operational stability and recyclability.
A landmark study found that over 3 million children worldwide lost their lives in 2022 due to antimicrobial resistance (AMR)-related infections. The study data also revealed a sharp rise in the use of Watch and Reserve antibiotics, posing serious long-term risks.
A new class of antibiotic has been shown to be effective in treating MRSA infections, with a daily dose of epidermicin NI01 demonstrating equal efficacy to the current standard of care. The findings justify further pre-clinical development and could lead to new gel-type therapies for skin infections.
A team of researchers found that a gene regulatory network in gut microbes plays an auxiliary role in bacterial fitness and adaptability. By maintaining basal levels of genetic activity, the network allows bacteria to adapt to their constantly changing environment.
A study analyzing over 3 million bacterial samples found that antibiotic resistance initially rises but stabilizes over time, reaching an equilibrium in most species. The study suggests that continued increase in antibiotic resistance is not inevitable and provides new insights to monitor drug resistance.
A new class of agents has been developed to inhibit hospital germs, particularly targeting the toxin α-hemolysin produced by Staphylococcus aureus. The compound H052 showed high effectiveness in cell culture and animal models, increasing survival rates in infected mice.
Researchers identified a new way to fight infections like Lyme and syphilis by disrupting the bacteria's 'motor', preventing it from spreading through the body. The findings could have wide-ranging impacts on the treatment of infections in the future as concern about antibiotic-resistant strains grows.
Scientists at University of Lausanne classify 35 commonly used drugs in Switzerland based on their ecotoxicity. The classification reveals that painkillers like diclofenac and antibiotics like ciprofloxacin have significant consequences for aquatic biodiversity.
A study reveals that most Acinetobacter baumannii infections in a Malaysian hospital belonged to the Global Clone 2 lineage, which is also dominant worldwide. The majority of bacterial samples were resistant to multiple antibiotics, including carbapenems.
Researchers at University of Illinois Chicago developed a powerful new antibiotic, Lariocidin, which targets ribosomes to prevent bacterial protein production. Its unique structure allows it to evade common bacterial defenses and transporters, making it a promising candidate for treating deadly infections.
Researchers at the University of Pennsylvania School of Engineering and Applied Science have discovered a new class of antibiotics derived from frog secretions, which show promise in targeting harmful bacteria without affecting human cells or beneficial gut bacteria. The synthetic peptides were developed using structure-guided design a...
The COVID-19 pandemic significantly reduced ambulatory antibiotic use in France, with most antibiotics showing a notable decrease. Antibiotic use remained lower than expected levels for at least 12 months following the first lockdown.
Researchers discovered that a drug-resistant type of bacteria has adapted to produce antimicrobial genetic tools, eliminating its cousins and replacing them as the dominant strain. The finding validates a system developed at Pitt and UPMC for detecting infectious disease outbreaks.
The Chinese Medical Association has released updated guidelines for pediatric mycoplasma pneumoniae infection, emphasizing a multi-faceted diagnostic approach and evidence-based treatment strategies. The guidelines highlight the importance of accurate diagnosis and responsible antibiotic use to combat rising resistance.
Researchers found that lower doses (20mg) and higher doses (100mg) of doxycycline were equally effective in treating lymphocytic scarring alopecia, a rare skin condition causing permanent hair loss. The low-dose regimen resulted in fewer side effects and no compromise on efficacy or anti-inflammatory benefit.
A new study using a microfluidic device found that certain infections may not be as resistant to antibiotics as previously thought. The researchers tested three different antibiotic agents against Pseudomonas aeruginosa and found a gradient of antibiotic activity dependent on the flow rate.
A new study suggests that sevelamer, a FDA-approved dialysis drug, can remove off-target antibiotics from the gut in mice. This could potentially prevent antibiotic resistance from emerging and protect current antibiotics from becoming ineffective.
Researchers have developed a new method to deliver antibiotics directly into the bladder tissue, eliminating over 90% of bacteria from the bladder. The nanogel-based drug delivery system shows promise in treating UTIs and could potentially lead to an eventual cure.
A recent study has discovered that microplastics can facilitate the development of antimicrobial resistance in bacteria, even in the absence of antibiotics. The researchers used different types and sizes of plastic to expose E. coli bacteria to various antibiotics and found significant increases in multidrug resistance after exposure.
A pioneering study identified a crucial interaction between Helicobacter pylori and non-H. pylori bacteria in pre-cancerous stage of gastric cancer. Researchers found that bacterial leakage into deeper gastric tissues may represent a previously overlooked factor in cancer progression.
Researchers at UC Irvine have developed a new family of antibiotics that targets two key areas of bacterial cells, offering a potential solution to the growing threat of antibiotic resistance. The new drug candidates may help eliminate the need for continuous redesign of new antibiotics.
Researchers developed novel antibiotic BTZ-043 to target drug-resistant tuberculosis. The study showed that BTZ-043 effectively penetrates TB lesions and accumulates there in high concentrations, making it a promising treatment option for TB patients.
A study found that even with impeccable cleaning, hospital sink drains can host bacterial populations that change over time. Dominant species include Stenotrophomonas and Pseudomonas aeruginosa, known to cause ventilator-associated pneumonia and sepsis.
Researchers have discovered Random Antimicrobial Peptide Mixtures (RPMs) as a promising non-antibiotic antimicrobial agent for cultured meat production. RPMs successfully eliminate bacterial contamination without harming stem cell viability or contributing to antibiotic resistance.
Researchers have identified a protein shuttling mechanism in bacteria that enables them to pump out a wide spectrum of antibiotics. This complex of proteins, known as MacAB-TolC, forms a conduit that drains out not only antibiotics but also virulence factors.
Researchers found that people with diabetes are more likely to develop antibiotic-resistant strains of Staphylococcus aureus, which can spread rapidly and evade treatment. Controlling blood sugar levels through insulin use may be key in preventing antibiotic resistance.
A new study published in the Journal of Crohn's and Colitis reveals that vancomycin may be an effective treatment for people with inflammatory bowel disease (IBD) and autoimmune liver disease. The antibiotic achieved clinical remission in 80% of patients, with significant decreases in inflammatory markers and mucosal healing.
Researchers at Texas A&M University have developed a low-cost technology using curcumin to curb bacterial resistance. The study shows that photodynamic inactivation can trigger deleterious reactions within bacteria, killing them and reducing the number of antibiotic-resistant strains.
Researchers at UCSF have discovered how a unique type of virus called a jumbo phage protects itself inside bacteria. The shield works via a set of secret handshakes that allow only useful proteins to pass through, giving the phage an advantage over regular phages when fighting infections.
Researchers from the University of Basel challenged the idea that persisters are responsible for antibiotic ineffectiveness. They found that nutrient starvation increases Salmonella resilience, making antibiotics less effective. This discovery could lead to more effective therapies against difficult-to-treat infections.
Researchers found a strong association between asthma and repeated antibiotic use in predicting nasal polyp recurrence after endoscopic sinus surgery. The study suggests that patients with severe chronic rhinosinusitis with nasal polyps may benefit from additional treatments like biologics to manage the disease.
Researchers identified a unique genetic signature that can predict bacterial antibiotic resistance. The finding could help develop precision-based treatments and reduce overuse of antibiotics.
Researchers discovered a mechanism involving protein aggregation that allows bacteria to enter a dormant state, making them resistant to antibiotics. The study also found that protein aggregates can promote bacterial survival in stressful environments.
A West Virginia University legal scholar argues that current laws favor biologic drugs with longer exclusivity periods, affecting their pricing. The scholar suggests reducing exclusivity for biologics to bring them in line with small-molecule drugs, which could lower drug costs.
Researchers have discovered a complex mechanism that allows bacteria to build resistance to antibiotics, involving a KorB-KorA regulatory system. This finding offers a fresh insight into long-range gene silencing in bacteria and provides a potential target for novel therapeutics.
A new compound, V-161, has been discovered to effectively inhibit the growth of vancomycin-resistant Enterococci (VRE) by targeting a crucial enzyme. The study reveals that V-161 not only disrupts the enzyme function but also reduces VRE colonization in the mouse small intestine.
New research reveals that certain antibiotics can suppress the evolution of resistance to phages in E. coli bacteria by targeting a subset of LPS mutants. By modulating these mutants, antibiotics like chloramphenicol and gentamicin reduce phage resistance.
Researchers found that short-course antibiotics can be as effective as traditional longer treatments in preventing death and recurrence of pneumonia. This approach offers significant value for healthcare systems by reducing hospital expenditure while maintaining excellent patient outcomes.
A study published in Pediatric Investigation found that microbial cell-free DNA testing predicted infectious organisms consistent with traditional culturing tests in 26.9% of pediatric patients, but its utility was variable due to factors like antibiotic exposure and contamination.
A large UK trial found that adding procalcitonin (PCT) to routine care did not reduce IV antibiotic use in hospitalized children. The study, part of the BATCH trial, enrolled nearly 2,000 children and tested PCT's effectiveness in guiding treatment decisions.
Researchers have discovered a new target for antibiotics, the methylerythritol phosphate pathway, which is essential for bacteria's energy metabolism. By blocking this pathway, bacteria can be killed without affecting human cells.
Researchers analyzed 7,000 S. aureus samples to identify key genetic changes that enable bacterial survival in humans. The study revealed mutations associated with nitrogen metabolism and immune system evasion strategies.
A recent study found a 59% decrease in river antibiotic pollution due to improved manure recycling and reduced direct discharge. However, this reduction came with an unintended consequence: increased antibiotic leaching into groundwater by 15%, mainly from expanded manure use as fertilizer.
Researchers from Tokyo Metropolitan University created nanostructured alumina surfaces with unprecedented antibacterial properties without hindering cell cultures. The technology promises a game-changer in regenerative medicine by enabling antibiotic-free cell culture and reducing the risk of antibiotic-resistant strains.