Radiation Therapy
Articles tagged with Radiation Therapy
ERASur colorectal cancer trial reaches one-third patient accrual milestone
The ERASur clinical trial is investigating whether total ablative therapy can improve overall survival in patients with newly diagnosed, limited metastatic colorectal cancer. The study has reached one-third patient accrual milestone, signaling strong momentum.
Trial now enrolling seeks to answer key question: Does adding chemotherapy to hormone therapy improve survival for metastatic prostate cancer?
The ASPIRE trial aims to enroll 1,200 participants with advanced prostate cancer and assess the impact of chemotherapy on overall survival and disease progression. Genetic profiling is included to identify patients who benefit most from intensified treatment.
Age, sex, and cancer type influence risk of subsequent cancers among survivors
A study published in PLOS Medicine found that age at initial diagnosis, sex, and type of first cancer significantly affect the risk of developing a subsequent primary cancer. Older age and male sex were associated with a higher risk, while survivors of lung, bladder, and skin melanoma were also at increased risk.
New scoring tool shows radiation can reprogram pancreatic tumor environment
A new composite scoring system, HOST-Factor, quantifies the functional state of the tumor microenvironment in pancreatic cancer. The study demonstrates the effectiveness of pulsed low-dose-rate chemoradiation in shifting the tumor microenvironment from a tumor-promoting to a tumor-restricting state.
Alliance for Clinical Trials in Oncology supports April Head and Neck Awareness Month
The Alliance for Clinical Trials in Oncology has several active trials specifically designed to help people with head and neck cancers. Trials include testing high-dose prophylactic gabapentin to prevent opioid use during treatment, as well as immunotherapy with nivolumab and cabozantinib for mucosal melanoma and nasopharyngeal carcino...
Alliance study shows new promise against locally advanced lung cancer
A study by the Alliance Foundation Trials shows that combining immunotherapy and chemotherapy before surgery can help more patients with locally advanced non-small cell lung cancer undergo complete cancer resection, improving their long-term health. The treatment also led to high rates of lymph node clearance and successful surgical re...
New study pinpoints barriers to timely head and neck cancer treatment in rural areas
A new study led by Dartmouth Cancer Center identifies key barriers to timely head and neck cancer treatment in rural areas, including transportation and caregiver challenges. The research highlights the importance of dedicated staff, strong community ties, and peer support in navigating the complexity of cancer care.
Rare scalp reaction identified in lung cancer patient receiving amivantamab after radiotherapy
A rare scalp reaction resembling erosive pustular dermatosis was identified in a lung cancer patient treated with amivantamab following cranial radiotherapy. The reaction appeared to be related to impaired wound healing due to dual inhibition of EGFR and MET signaling pathways.
AACR: UT MD Anderson shares latest breakthroughs in cancer research
Researchers from UT MD Anderson Cancer Center present studies on single-cell technologies, integrative computational approaches, and experimental therapeutics, highlighting innovations in mRNA vaccines and spatial multi-omics techniques. The studies aim to improve immunotherapy responses and detect treatment-resistant glioma cells.
UT MD Anderson shares latest research breakthroughs
Researchers at UT MD Anderson have made significant advancements in cancer care, including a blood-based biomarker for cancer risk in people with Lynch Syndrome and a new target to sensitize pancreatic tumors to immunotherapy. The studies also identified a strategy to overcome radiation therapy resistance in lung cancer.
Study identifies strategy to overcome radiation therapy resistance in lung cancer
Researchers at the University of Texas M.D. Anderson Cancer Center have identified a way lung cancer cells evade radiation therapy and developed a strategy to overcome this challenge using a DHODH inhibitor. The study found that inhibiting DHODH with leflunomide can help overcome radiation resistance by promoting ferroptosis, allowing ...
Are we seeing changes in the rates of secondary blood-related cancers that develop due to chemotherapy or radiation?
A study from Japan has revealed a gradual increase in tAML rates, especially after breast cancer treatment. The study analyzed data from the Osaka Cancer Registry and found that the annual incidence of tAML increased from 0.13 to 0.36 per 100,000 population between 1990 and 2020.
Radiation therapy improves outcomes for 'supermassive’ bile duct tumors
Researchers at UT MD Anderson found that high-dose radiation delivery significantly improves patient outcomes, with a median survival of 28.7 months compared to 11.9 months for chemotherapy alone.
First-in-class radio-theranostic utilizes novel antibody developed at UT MD Anderson
Researchers developed a novel antibody that targets the 4lg isoform of B7-H3, overexpressed in many cancer types. The antibody, BetaBart, has potential use as a radio-theranostic treatment that brings targeted radiation to tumor cells.
Tumor DNA circulating in patients’ blood after pre-surgery treatments predicts whether breast cancer will return
A study found that tumor DNA in patients' blood can predict whether breast cancer will return, especially after neoadjuvant treatment. Patients with detectable DNA at the end of treatment were 3.5 times more likely to relapse during follow-up.
Radiotherapy rather than surgery may help reduce risk of lymphoedema in patients with breast cancer: results from pilot study
A pilot study found that axillary radiotherapy may be as effective as surgery in killing cancer cells while reducing the risk of painful swelling. The trial compared radiotherapy to axillary lymph node dissection and found similar cancer outcomes, but lower rates of lymphoedema after radiotherapy.
Breast cancer recurrence remains low, even after ten years, with radiotherapy tailored to patient’s individual risk
A recent study found that breast cancer recurrence remains low even after ten years when patients receive tailored radiotherapy. The research involved 848 patients who underwent chemotherapy and surgery, and showed that radiotherapy can be reduced or eliminated in low-risk patients, leading to a significant decrease in side effects.
Breast reconstruction using polyurethane-coated implants reduces scarring and the need for further surgery
A new study shows that polyurethane-coated breast implants are associated with lower rates of capsular contracture and the need for corrective surgery after radiotherapy. Women who received these implants had a significantly lower risk of developing scarring and needing further surgery compared to those who received standard implants.
New alliance clinical trial aims to improve outcomes in brain tumors
A new clinical trial will investigate whether adding the oral medication vorasidenib to standard chemotherapy improves progression-free survival for people with newly-diagnosed, grade 3 IDH-mutant astrocytoma. The study aims to recruit 400 individuals with this type of brain cancer and evaluate the safety and side-effect profile of the...
NRG Oncology/Alliance trial finds immunotherapy did not improve survival when added to chemoradiotherapy for small cell lung cancer
The NRG-LU005 trial found that immunotherapy atezolizumab did not improve survival for patients with limited-stage small cell lung cancer when added to chemoradiation. Twice-daily radiation therapy, however, was associated with improved survival in this population.
Alliance for Clinical Trials in Oncology highlights new and open colorectal cancer trials in March
The Alliance for Clinical Trials in Oncology is spotlighting new trials for colorectal cancer in March, focusing on early detection methods and treatments for treatment delays and loss of appetite. The trials aim to improve patient outcomes, with several enrolling patients with newly diagnosed colon or rectal cancer.
Hormone therapy may not benefit most men receiving radiotherapy after prostate surgery, UCLA study finds
A new UCLA study suggests that adding hormone therapy to post-operative radiotherapy may provide little survival benefit for most men with prostate cancer, especially those with low PSA levels. However, men with higher PSA levels before radiation may see modest improvements in survival and metastasis-free survival.
Scientists report landmark “evolutionary double-bind” strategy to overcome treatment resistance in prostate cancer
Researchers found that radiation-resistant cancer cells are vulnerable to NK cell-mediated killing due to increased expression of specific cellular membrane proteins, creating an 'evolutionary double-bind'. The combination of radiation therapy and NK cell-based immunotherapy was more effective in suppressing both sensitive and resistan...
Hearing loss contributes to cognitive decline after childhood cancer treatment
A study by St. Jude Children's Research Hospital found that radiation therapy contributes to hearing loss in children treated for brain tumors, leading to greater cognitive decline. Children with severe hearing loss experienced a more significant decline in cognitive measures compared to those without.
Targeted radiation therapy improves quality of life outcomes for patients with multiple brain metastases
A Phase 3 trial found stereotactic radiation targeting individual tumors improved symptom burden, cognitive outcomes, and daily function compared to whole brain radiation. Patients managed with stereotactic radiation also displayed better performance status and could remain more independent with everyday activities.
Radiotherapy is more effective when administered at the right time of day
Research at University of Seville and CABIMER reveals circadian protein Cryptochrome1 regulates DNA repair in response to time of day. Effective radiotherapy timing found to improve sensitivity of breast and prostate cancers, but not lung or glioma cancers.
New study shows how to protect the brain to prevent depression and cognitive impairment caused by whole brain radiotherapy
A new study published in Redox Biology found that an experimental neuroprotective drug called P7C3-A20 can prevent the negative side effects of whole brain radiotherapy, including memory problems and depression. The drug was shown to reduce oxidative stress and protect nerve cells in mice with WBRT-induced brain damage.
Production of 99Mo via photofission reaction in natural-uranium-bearing molten salt targets
A novel technical approach employs high-energy electrons to directly irradiate a flowing molten salt target containing natural uranium, generating 99Mo primarily through the photofission reaction of 238U. This method mitigates nuclear proliferation risks and offers substantial advantages in terms of material security.
Study shows strong evidence for effectiveness of metastasis-directed radiation therapy in prostate cancer
A meta-analysis of individual patients with oligometastatic prostate cancer shows that metastasis-directed radiation therapy (MDT) significantly improves patient outcomes, including delayed disease progression and better quality of life. The study included 574 men and found a median of 7.6 months before disease progression in the MDT a...
Novel radiation therapy QA method: Monte Carlo simulation meets deep learning for fast, accurate epid transmission dose generation
A novel radiation therapy QA method has been developed by combining Monte Carlo simulation with deep learning to generate patient-specific dose verification. This integrated technology accelerates quality assurance and paves the way for efficient online adaptive radiation therapy.
Clinical trial seeks improved survival for head and neck cancer patients
A new Phase II trial will examine whether giving chemotherapy or chemotherapy combined with immunotherapy before surgery can improve survival compared to surgery alone. The trial aims to identify a treatment that will help patients live longer without the cancer returning.
AI model identifies how every country can improve its cancer outcomes
A machine learning model has identified the most important drivers of cancer survival in nearly all countries, highlighting factors such as national wealth, access to radiotherapy and universal health coverage. The model provides data-driven roadmaps for policymakers to prioritize resources and close survival gaps.
New prostate cancer trial seeks to reduce toxicity without sacrificing efficacy
A new clinical trial, RECIPROCAL, seeks to optimize targeted radiation therapy for men with advanced prostate cancer by adjusting treatment based on individual PSA levels. The trial aims to minimize side effects while preserving survival benefits.
MD Anderson shares latest research breakthroughs
Proton therapy has been shown to provide a significant survival benefit for patients with head and neck cancers. In another study, researchers have identified a promising target for treating pancreatic cancer by inhibiting the mitochondrial enzyme GFER. Additionally, diagnostic breast MRI may be unnecessary for some patients with early...
How to reduce the risk of lymphedema
Researchers found that patients with low physical activity levels are at higher risk of developing lymphedema. The study used a lymph scanner to measure tissue water and identified limits for what is considered lymphedema. Regular physical activity may help reduce the risk of lymphedema after head and neck cancer treatment.
UT Health Sciences researchers demonstrate breakthroughs in cancer treatment quality through AI-enhanced data analytics
Researchers at UT Health Sciences Center have developed an AI-enhanced platform called ENRICH, which leverages advanced analytics with community-based human support to reduce treatment interruptions and improve cancer outcomes. The program identifies patients at highest risk for interruption and deploys targeted support resources.
Study explores why some drug therapies are ineffective for brain tumor patients
Researchers at the University of Plymouth investigate why drugs used to treat other tumours are ineffective against NF2-related schwannoma and meningioma tumours. They explore repurposing clinically tested cancer drugs to target MDR mechanisms, which may lead to effective therapies for patients with these tumours.
Proton therapy shows survival benefit in Phase III trial for patients with head and neck cancers
A Phase III trial has demonstrated the survival benefit of proton therapy compared to traditional radiation therapy for oropharyngeal cancer patients, with improved overall survival at five years. Proton therapy also resulted in reduced toxicities and feeding tube dependence, highlighting its potential as a standard treatment option.
Study suggests many men may not need long-term hormone therapy for prostate cancer
A study published in JAMA Oncology found that shorter courses of androgen deprivation therapy can effectively control prostate cancer without increasing risks. The ideal duration of ADT depends on cancer risk, allowing for more personalized treatment plans.
Stereotactic radiosurgery for craniopharyngioma management
Craniopharyngiomas are managed effectively with stereotactic radiosurgery (SRS), which provides high-dose radiation to tumors while minimizing risks to surrounding tissues. Studies have shown comparable control rates to conventional radiotherapy, but SRS is associated with lower incidence of hypothalamic obesity and long-term sequelae.
State-of-the-art multimodal imaging and therapeutic strategies in radiation-induced brain injury
Recent advances in multimodal imaging, including MRI, diffusion imaging, perfusion imaging, MRS, and PET/CT, have improved early detection and differential diagnosis of radiation-induced brain injury (RIBI). Emerging therapeutic strategies target underlying pathological mechanisms, such as neuroinflammation, oxidative stress, and vascu...
ASTRO publishes first clinical guideline on radiation therapy for gastric cancer
The American Society for Radiation Oncology (ASTRO) has published its first clinical guideline on radiation therapy for gastric cancer. The guidelines provide evidence-based recommendations for the role of radiation therapy in multidisciplinary care, including patient selection, integration with systemic therapy and treatment delivery.
Cancer quality improvement program cuts missed radiation appointments by 40%
A national quality improvement program led by the American College of Surgeons found that providing structured support to cancer patients can reduce missed radiation appointments by up to 40%. The study, involving over 90,000 cancer patients, identified transportation barriers and illness as top reasons for missed appointments.
Policymakers around the world face difficult choices on funding new drugs for advanced breast cancer
Experts warn that new drugs for advanced breast cancer are unaffordable and may lead to unequal treatment access worldwide. The consensus panel recommended prioritizing most effective treatments and using next-generation sequencing for personalized medicine.
Radiotherapy after mastectomy can be avoided, study finds
A new study found that patients with early-stage breast cancer who underwent a mastectomy and anti-cancer drugs had similar 10-year survival rates whether or not they received chest wall radiotherapy. The research team concludes that radiotherapy may no longer be necessary for these patients, reducing treatment burden and potential sid...
Winners of the ASTRO-AstraZeneca small cell lung cancer therapy challenge announced
The American Society for Radiation Oncology (ASTRO) has announced three winning research proposals for the 2025 ASTRO-AstraZeneca Small Cell Lung Cancer Therapy Challenge. The selected projects aim to improve therapies and outcomes for patients with limited-stage SCLC through immunotherapy and radiation techniques.
New Alliance clinical trial studies impact of exercise on cancer patients
The DEFEND study aims to assess whether virtual exercise sessions can be successfully delivered to patients with cancer receiving chemotherapy. Researchers will evaluate the impact on physical function, fatigue, and disability.
How is radiation therapy portrayed in art?
Art forms like novels, poems, music, film, and paintings often depict radiation therapy as having both lifesaving and life-threatening potential. Researchers explored how radiation therapy is represented in various art genres to understand its impact on patients.
Scientists create radiotheranostic approach designed to combat aggressive cancers
Researchers create novel antibody-based treatment that combines diagnostic and therapeutic capabilities to target LRRC15-expressing tumors, slowing growth and extending survival. The approach shows promise in preclinical models by priming tumors for immune response and boosting immunotherapy's effectiveness.
Could reducing inflammation help combat fatigue in people with early-stage breast cancer?
Research found that inflammatory markers are linked to different aspects of cancer-related fatigue, with some effects persisting after treatment. The study suggests targeting inflammation for developing treatments to alleviate this debilitating symptom.
Short-course radiation therapy after prostate surgery helps keep cancer from returning
A study found that stereotactic body radiotherapy (SBRT) after prostate surgery is safe and effective in preventing cancer recurrence, with low side effects and manageable treatment. The results suggest SBRT may be a faster and simpler option for men at risk of recurrent prostate cancer.
MIT study suggests a cysteine-rich diet may promote regeneration of the intestinal lining
A diet rich in cysteine has been shown to activate immune cells that help regenerate intestinal tissue, potentially offering a new way to heal tissue damage from radiation or chemotherapy treatment. The researchers found that cysteine initiates a chain of events leading to the activation of CD8 T cells, which produce cytokines like IL-...
Study explores use of religion and spirituality to help patients cope with stress of radiation therapy for gynecologic cancers
Researchers identified specific ways to address religion and spirituality during radiation therapy, highlighting their importance in patient coping mechanisms. The study found that nearly all patients considered spiritual history questions helpful, especially those related to coping with stress.
First randomized study comparing proton and photon radiation therapy for breast cancer finds both preserve quality of life
A phase III trial comparing proton and photon radiation therapy for breast cancer found that patients report equally strong health-related quality of life with either treatment. Patients treated with protons were more likely to say they would recommend or choose it again, but overall patient-reported outcomes were similar.
Radiation therapy after surgery safely reduces pelvic relapse risk from locally advanced, muscle-invasive bladder cancer
A phase III trial suggests that post-operative radiation therapy can reduce cancer recurrence in patients with high-risk disease. Patients who received radiation experienced significantly fewer pelvic recurrences and improved locoregional recurrence-free survival compared to those who did not receive radiation.
Radiation therapy shows promise for patients with severe heart rhythm disorder
A retrospective study found that radiation therapy controlled ventricular tachycardia with fewer complications than standard catheter ablation. Radiation therapy was similarly effective in controlling arrhythmia and showed lower serious side effects, especially in the early time window.
Dr. Amar Kishan honored with Steven A. Leibel Memorial Award
Dr. Amar Kishan has been recognized for his groundbreaking research on radiation treatments for genitourinary system cancers. He is the recipient of the 2025 Steven A. Leibel Memorial Award, presented by ASTRO and ABR Foundation.
Ten-year clinical trial report finds radiation comparable to surgery for early-stage non-small cell lung cancer
A new clinical trial report finds that stereotactic radiation therapy offers long-term survival outcomes comparable to surgery for patients with small, early-stage non-small cell lung cancer. The study included a larger patient population than previously published randomized studies and followed these patients for much longer.
Shorter radiation improves patient experience but not disease control for intermediate-risk prostate cancer
A large phase III trial found that stereotactic body radiation therapy (SBRT) preserves quality of life, with fewer declines in bowel and urinary functioning. However, SBRT does not outperform standard radiation therapy for disease-free survival, with higher rates of biochemical failure and rising PSA after treatment.