A recent study found that breast cancer recurrence remains low even after ten years when patients receive tailored radiotherapy. The research involved 848 patients who underwent chemotherapy and surgery, and showed that radiotherapy can be reduced or eliminated in low-risk patients, leading to a significant decrease in side effects.
A new study shows that polyurethane-coated breast implants are associated with lower rates of capsular contracture and the need for corrective surgery after radiotherapy. Women who received these implants had a significantly lower risk of developing scarring and needing further surgery compared to those who received standard implants.
A new clinical trial will investigate whether adding the oral medication vorasidenib to standard chemotherapy improves progression-free survival for people with newly-diagnosed, grade 3 IDH-mutant astrocytoma. The study aims to recruit 400 individuals with this type of brain cancer and evaluate the safety and side-effect profile of the...
The NRG-LU005 trial found that immunotherapy atezolizumab did not improve survival for patients with limited-stage small cell lung cancer when added to chemoradiation. Twice-daily radiation therapy, however, was associated with improved survival in this population.
The Alliance for Clinical Trials in Oncology is spotlighting new trials for colorectal cancer in March, focusing on early detection methods and treatments for treatment delays and loss of appetite. The trials aim to improve patient outcomes, with several enrolling patients with newly diagnosed colon or rectal cancer.
A new UCLA study suggests that adding hormone therapy to post-operative radiotherapy may provide little survival benefit for most men with prostate cancer, especially those with low PSA levels. However, men with higher PSA levels before radiation may see modest improvements in survival and metastasis-free survival.
Researchers found that radiation-resistant cancer cells are vulnerable to NK cell-mediated killing due to increased expression of specific cellular membrane proteins, creating an 'evolutionary double-bind'. The combination of radiation therapy and NK cell-based immunotherapy was more effective in suppressing both sensitive and resistan...
A study by St. Jude Children's Research Hospital found that radiation therapy contributes to hearing loss in children treated for brain tumors, leading to greater cognitive decline. Children with severe hearing loss experienced a more significant decline in cognitive measures compared to those without.
A Phase 3 trial found stereotactic radiation targeting individual tumors improved symptom burden, cognitive outcomes, and daily function compared to whole brain radiation. Patients managed with stereotactic radiation also displayed better performance status and could remain more independent with everyday activities.
Research at University of Seville and CABIMER reveals circadian protein Cryptochrome1 regulates DNA repair in response to time of day. Effective radiotherapy timing found to improve sensitivity of breast and prostate cancers, but not lung or glioma cancers.
A new study published in Redox Biology found that an experimental neuroprotective drug called P7C3-A20 can prevent the negative side effects of whole brain radiotherapy, including memory problems and depression. The drug was shown to reduce oxidative stress and protect nerve cells in mice with WBRT-induced brain damage.
A novel technical approach employs high-energy electrons to directly irradiate a flowing molten salt target containing natural uranium, generating 99Mo primarily through the photofission reaction of 238U. This method mitigates nuclear proliferation risks and offers substantial advantages in terms of material security.
A meta-analysis of individual patients with oligometastatic prostate cancer shows that metastasis-directed radiation therapy (MDT) significantly improves patient outcomes, including delayed disease progression and better quality of life. The study included 574 men and found a median of 7.6 months before disease progression in the MDT a...
A novel radiation therapy QA method has been developed by combining Monte Carlo simulation with deep learning to generate patient-specific dose verification. This integrated technology accelerates quality assurance and paves the way for efficient online adaptive radiation therapy.
A new Phase II trial will examine whether giving chemotherapy or chemotherapy combined with immunotherapy before surgery can improve survival compared to surgery alone. The trial aims to identify a treatment that will help patients live longer without the cancer returning.
A machine learning model has identified the most important drivers of cancer survival in nearly all countries, highlighting factors such as national wealth, access to radiotherapy and universal health coverage. The model provides data-driven roadmaps for policymakers to prioritize resources and close survival gaps.
A new clinical trial, RECIPROCAL, seeks to optimize targeted radiation therapy for men with advanced prostate cancer by adjusting treatment based on individual PSA levels. The trial aims to minimize side effects while preserving survival benefits.
Proton therapy has been shown to provide a significant survival benefit for patients with head and neck cancers. In another study, researchers have identified a promising target for treating pancreatic cancer by inhibiting the mitochondrial enzyme GFER. Additionally, diagnostic breast MRI may be unnecessary for some patients with early...
Researchers found that patients with low physical activity levels are at higher risk of developing lymphedema. The study used a lymph scanner to measure tissue water and identified limits for what is considered lymphedema. Regular physical activity may help reduce the risk of lymphedema after head and neck cancer treatment.
Researchers at UT Health Sciences Center have developed an AI-enhanced platform called ENRICH, which leverages advanced analytics with community-based human support to reduce treatment interruptions and improve cancer outcomes. The program identifies patients at highest risk for interruption and deploys targeted support resources.
Researchers at the University of Plymouth investigate why drugs used to treat other tumours are ineffective against NF2-related schwannoma and meningioma tumours. They explore repurposing clinically tested cancer drugs to target MDR mechanisms, which may lead to effective therapies for patients with these tumours.
A Phase III trial has demonstrated the survival benefit of proton therapy compared to traditional radiation therapy for oropharyngeal cancer patients, with improved overall survival at five years. Proton therapy also resulted in reduced toxicities and feeding tube dependence, highlighting its potential as a standard treatment option.
A study published in JAMA Oncology found that shorter courses of androgen deprivation therapy can effectively control prostate cancer without increasing risks. The ideal duration of ADT depends on cancer risk, allowing for more personalized treatment plans.
Craniopharyngiomas are managed effectively with stereotactic radiosurgery (SRS), which provides high-dose radiation to tumors while minimizing risks to surrounding tissues. Studies have shown comparable control rates to conventional radiotherapy, but SRS is associated with lower incidence of hypothalamic obesity and long-term sequelae.
Recent advances in multimodal imaging, including MRI, diffusion imaging, perfusion imaging, MRS, and PET/CT, have improved early detection and differential diagnosis of radiation-induced brain injury (RIBI). Emerging therapeutic strategies target underlying pathological mechanisms, such as neuroinflammation, oxidative stress, and vascu...
The American Society for Radiation Oncology (ASTRO) has published its first clinical guideline on radiation therapy for gastric cancer. The guidelines provide evidence-based recommendations for the role of radiation therapy in multidisciplinary care, including patient selection, integration with systemic therapy and treatment delivery.
A national quality improvement program led by the American College of Surgeons found that providing structured support to cancer patients can reduce missed radiation appointments by up to 40%. The study, involving over 90,000 cancer patients, identified transportation barriers and illness as top reasons for missed appointments.
Experts warn that new drugs for advanced breast cancer are unaffordable and may lead to unequal treatment access worldwide. The consensus panel recommended prioritizing most effective treatments and using next-generation sequencing for personalized medicine.
A new study found that patients with early-stage breast cancer who underwent a mastectomy and anti-cancer drugs had similar 10-year survival rates whether or not they received chest wall radiotherapy. The research team concludes that radiotherapy may no longer be necessary for these patients, reducing treatment burden and potential sid...
The American Society for Radiation Oncology (ASTRO) has announced three winning research proposals for the 2025 ASTRO-AstraZeneca Small Cell Lung Cancer Therapy Challenge. The selected projects aim to improve therapies and outcomes for patients with limited-stage SCLC through immunotherapy and radiation techniques.
The DEFEND study aims to assess whether virtual exercise sessions can be successfully delivered to patients with cancer receiving chemotherapy. Researchers will evaluate the impact on physical function, fatigue, and disability.
Art forms like novels, poems, music, film, and paintings often depict radiation therapy as having both lifesaving and life-threatening potential. Researchers explored how radiation therapy is represented in various art genres to understand its impact on patients.
Researchers create novel antibody-based treatment that combines diagnostic and therapeutic capabilities to target LRRC15-expressing tumors, slowing growth and extending survival. The approach shows promise in preclinical models by priming tumors for immune response and boosting immunotherapy's effectiveness.
Research found that inflammatory markers are linked to different aspects of cancer-related fatigue, with some effects persisting after treatment. The study suggests targeting inflammation for developing treatments to alleviate this debilitating symptom.
A study found that stereotactic body radiotherapy (SBRT) after prostate surgery is safe and effective in preventing cancer recurrence, with low side effects and manageable treatment. The results suggest SBRT may be a faster and simpler option for men at risk of recurrent prostate cancer.
A diet rich in cysteine has been shown to activate immune cells that help regenerate intestinal tissue, potentially offering a new way to heal tissue damage from radiation or chemotherapy treatment. The researchers found that cysteine initiates a chain of events leading to the activation of CD8 T cells, which produce cytokines like IL-...
Researchers identified specific ways to address religion and spirituality during radiation therapy, highlighting their importance in patient coping mechanisms. The study found that nearly all patients considered spiritual history questions helpful, especially those related to coping with stress.
A new clinical trial report finds that stereotactic radiation therapy offers long-term survival outcomes comparable to surgery for patients with small, early-stage non-small cell lung cancer. The study included a larger patient population than previously published randomized studies and followed these patients for much longer.
A large phase III trial found that stereotactic body radiation therapy (SBRT) preserves quality of life, with fewer declines in bowel and urinary functioning. However, SBRT does not outperform standard radiation therapy for disease-free survival, with higher rates of biochemical failure and rising PSA after treatment.
A phase III trial finds that intensity-modulated radiation therapy (IMRT) and proton beam therapy resulted in similar quality-of-life outcomes and low rates of side effects for people with locally advanced oropharyngeal cancer. Excellent tumor control and fewer long-term side effects were seen with both treatments.
A phase III trial comparing proton and photon radiation therapy for breast cancer found that patients report equally strong health-related quality of life with either treatment. Patients treated with protons were more likely to say they would recommend or choose it again, but overall patient-reported outcomes were similar.
A phase III trial suggests that post-operative radiation therapy can reduce cancer recurrence in patients with high-risk disease. Patients who received radiation experienced significantly fewer pelvic recurrences and improved locoregional recurrence-free survival compared to those who did not receive radiation.
A retrospective study found that radiation therapy controlled ventricular tachycardia with fewer complications than standard catheter ablation. Radiation therapy was similarly effective in controlling arrhythmia and showed lower serious side effects, especially in the early time window.
Dr. Amar Kishan has been recognized for his groundbreaking research on radiation treatments for genitourinary system cancers. He is the recipient of the 2025 Steven A. Leibel Memorial Award, presented by ASTRO and ABR Foundation.
A new randomized study validates a predictive gene expression test that identifies patients with recurrent prostate cancer who will benefit from adding hormone therapy to radiation. The test, PAM50, groups tumors into molecular subtypes and predicts treatment outcomes.
A new PSMA-targeting radioligand therapy added to stereotactic body radiotherapy (SBRT) more than doubled progression-free survival in men with recurrent prostate cancer, delaying the start of hormone therapy by up to 24 months. The study found minimal side effects and identified biological markers that may predict treatment benefits.
A new clinical trial found that adding a PSMA-targeting agent to stereotactic radiation therapy doubled progression-free survival in patients with limited metastatic prostate cancer. The study also showed that the treatment delayed hormone therapy by 24 months and improved local control.
A new clinical trial found that patients with mild-to-moderate knee osteoarthritis reported significant reductions in pain and improved physical function after receiving low-dose radiation therapy. The study showed a 70% response rate in the high-dose group, compared to 42% in the placebo group.
Researchers from UCLA presented findings on targeted radioactive therapy, new SBRT approaches and advances in MRI- and 5DCT-guided imaging. The LUNAR clinical trial looked at adding a targeted therapy before ablative radiotherapy for men with recurrent prostate cancer.
Researchers developed a genomic model to tailor radiation doses to individual patients with HPV-positive throat cancer. The study found that higher scores on the Genomic Adjusted Radiation Dose (GARD) model were associated with improved survival outcomes, even when patients received the same radiation dose.
Researchers found that SBRT and surgery had similar 10-year outcomes for patients with early-stage non-small cell lung cancer, with radiation offering quality-of-life benefits. The study also showed a higher acute complication rate caused by surgery.
The American Society for Radiation Oncology, American Society of Clinical Oncology, and Society of Surgical Oncology jointly published a guideline outlining when post-mastectomy radiation therapy (PMRT) is appropriate based on new evidence. PMRT reduces cancer recurrence risk in patients with node-positive disease or high-risk features.
Researchers have developed a new technique to measure boron in individual cancer cells, enabling the study of how drugs interact with tumour cells. This breakthrough could lead to more effective treatments for head and neck cancers.
Researchers at MD Anderson have made significant advancements in treating kidney cancer, including the use of metastasis-directed targeted radiation therapy to delay systemic treatments. Additionally, preliminary data from an ELI-002 vaccine trial showed promise in delaying relapse of KRAS-mutated pancreatic and colorectal cancers.
Researchers developed CerviPro, a multimodal deep learning model that accurately identifies high-risk patients with locally advanced disease. The model achieved superior predictive performance compared to conventional methods and provided critical prognostic insights.
A Mayo Clinic study shows that a shorter, less intense course of radiation and chemotherapy after minimally invasive surgery significantly reduces treatment-related side effects while maintaining high cure rates. The findings apply to intermediate-risk patients, with slightly better disease control in high-risk patients.
Researchers at the University of Navarra have developed FLIP-HEDOS, a model that simulates how much radiation blood absorbs during cancer treatment. The study highlights the importance of protecting blood from radiation, which can impair immune function and lead to hematologic toxicity.
Researchers successfully treat mouse tumor with radioactive carbon ion beam, achieving complete control without major neurological side effects. The BARB project advances image-guided particle therapy using exotic beams, showing feasibility and effectiveness.
The Huntsman Cancer Institute is launching new clinical trials to explore how theranostics can help more patients. Theranostics combines diagnostics and therapeutics to deliver targeted radiation directly to cancer cells, offering a powerful approach to finding and treating cancer.
The researchers developed a novel approach to virtual contrast enhancement in MRI imaging, using pixelwise gradient methods with Generative Adversarial Networks. The model excelled in capturing intricate details and textures, outperforming its predecessor in texture representation.