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Lending late neurons a helping hand

University of Geneva researchers found that delayed neuronal migration in the fetus causes behavior disorders comparable to autism. They also discovered that correcting late neuron activity can restore interneuronal connections and prevent behavioral problems.

SourceUniversité de Genève·JournalNature Communications·DateNov 7, 2017

People with tic disorders at increased suicide risk

A new study in Biological Psychiatry found that people with Tourette's disorder and chronic tic disorder are over four times more likely to die by suicide than the general population. Persistent tics into adulthood were a strong predictor of suicide risk, with patients nearly four times more likely to attempt suicide.

SourceElsevier·JournalBiological Psychiatry·DateJul 5, 2017

Identified brain circuitry bridges neural and behavioral roles in PTSD

A comprehensive review of rapidly changing data identified four neural-behavioral models associated with PTSD, pinpointing specific circuits in the brain that mediate between chemical changes and behavioral expressions. The study provides detailed tables to help healthcare providers recognize signs and symptoms of PTSD for diagnosis.

SourceNYU Langone Health / NYU Grossman School of Medicine·JournalNew England Journal of Medicine·DateJun 21, 2017

Treating autism by targeting the gut

Researchers found that restoring a healthy balance in gut bacteria can treat Autism Spectrum Disorder (ASD) symptoms. The review highlights several studies showing positive impacts of probiotics, prebiotics, diet changes and faecal matter transplants on ASD symptoms.

SourceFrontiers·JournalFrontiers in Cellular Neuroscience·DateJun 19, 2017

Cause of obsessive-compulsive disorder discovered

The absence of protein SPRED2 alone can trigger excessive grooming behavior in mouse models. The study identifies the Ras/ERK-MAP kinase cascade as a key signaling pathway involved in obsessive-compulsive disorder (OCD). Administering an inhibitor to this pathway improves OCD symptoms, suggesting new potential treatments.

SourceUniversity of Würzburg·JournalMolecular Psychiatry·DateMar 16, 2017

OCD-like behavior linked to genetic mutation

A Northwestern University study found that eliminating certain receptor genes in mice leads to obsessive-compulsive disorder (OCD)-like behaviors, such as excessive grooming. The research provides strong evidence for the biological basis of OCD and may lead to new treatments for the disorder.

SourceNorthwestern University·JournalCell Reports·DateFeb 22, 2017

Traffic light in the brain

A team of researchers has identified five subareas in the prefrontal cortex that play key roles in decision-making processes related to movement. By deactivating specific brain regions using optogenetics, the study found that inhibition and excitation areas work together to regulate movement. These findings have implications for unders...

SourceUniversity of Freiburg·JournalCurrent Biology·DateFeb 10, 2017

Personality traits linked to differences in brain structure

Researchers analyzed a large dataset of brain images from over 500 individuals to identify correlations between brain cortical anatomy and the Big Five personality traits. High levels of neuroticism were associated with increased thickness in certain regions, while openness was linked to reduced thickness and increased area and folding.

SourceUniversity of Cambridge·JournalSocial Cognitive and Affective Neuroscience·DateJan 24, 2017

Prenatal infection may alter brain development via epigenetic changes

A new study published in Biological Psychiatry found that prenatal infection can cause long-term alterations in the programming of the offspring's genome through epigenetic modifications, leading to behavioral abnormalities. The findings suggest that earlier infection may lead to more serious effects on neurodevelopment.

SourceElsevier·JournalBiological Psychiatry·DateJan 24, 2017

Switching off the brain

A new optogenetic tool has been developed to inhibit neural activity in the Drosophila model, allowing researchers to study the relationship between neural circuits and behavior. This breakthrough could accelerate the development of therapies for neurological and psychiatric disorders.

SourceDuke-NUS Medical School·JournalNature Methods·DateJan 23, 2017