Articles tagged with Inflammatory Bowel Diseases
Researchers have identified HERC4 as a crucial component of the TNF-induced cell death pathway, linking survival and death signalling. The protein's ubiquitination of RIPK1 initiates the formation of Complex II, triggering cell death through apoptosis or necroptosis.
Researchers at Children's Hospital of Philadelphia found that dietary interventions can significantly alter outcomes in Hirschsprung disease, suggesting previously unknown mechanisms to improve care for children. The study discovered that a standard diet can induce microscopic and cellular changes in the colons of animal models, leadin...
Researchers have mapped cellular differences between two similar bowel diseases, identifying hidden immune activity that may explain why one carries a much higher risk of colon cancer. The study found that patients with PSC-associated IBD had a distinct microbiome and higher levels of immune activity even in the absence of inflammation.
A Swedish registry study found that IBD patients with multiple close relatives having colorectal cancer are significantly more likely to develop the disease. The study suggests that future cancer screening guidelines should consider the number of cancer cases in a patient's family.
A preliminary study by Weill Cornell Medicine investigators found that antifungal therapy can reduce IBD symptoms and improve the gut microbiome in patients with Candida overgrowth. The study compared the effects of two weeks of treatment with nystatin or fluconazole in 53 patients with mild-to-moderate Crohn's disease or ulcerative co...
Researchers have created a detailed map of childhood Crohn's disease before and after treatment, identifying specific cell signatures that predict disease severity and treatment outcomes. The study suggests that anti-TNF therapy may push the pediatric cell ecosystem towards more resistant disease.
Researchers have identified a hidden defect in the gut that can damage intestinal cells, even in patients with well-controlled disease. The study found that this defect can be present in patients with clinically mild disease and can lead to future flares.
A large population-based study found that emergency diagnoses are common across multiple conditions, including Parkinson’s disease and coronary heart disease, and are consistently associated with worse outcomes. The study suggests that emergency diagnosis is a common phenomenon across diverse diseases and is linked to higher mortality ...
Researchers combined AI, genetics, and gut microbiome analysis to shed light on intestinal fibrosis in Crohn's disease. They identified a shared set of 43 key genes linked to disease progression and found that bowel fibrosis is driven by ongoing immune activation, damage to the intestinal lining, and changes in gut bacteria.
A new review article discusses how artificial intelligence can predict disease trajectories and enable precision medicine strategies for inflammatory bowel disease. AI-based systems can standardize interpretation of endoscopic images, detect mucosal healing, and support recognition of dysplasia in patients with long-standing colitis.
Researchers found that patients with inflammatory bowel disease (IBD) are at a significantly higher risk of developing psychiatric disorders, particularly depression and anxiety. The study highlights the importance of early screening and integration of psychological care into routine IBD management to improve quality of life.
Researchers identified unique antibody signatures against viruses and bacteria in nearly 2,000 blood samples collected over a decade, showing immune system changes years before diagnosis. The study supports the theory of molecular mimicry and provides an important framework for understanding IBD's earliest stages.
Researchers have discovered a hidden network of specialized mesenchymal support cells in the intestine that work together to maintain its inner lining. The study found four distinct populations of cells with unique genetic programs, each occupying specific locations and influencing stem cell activity and immune responses.
Researchers found that prenatal and early-life exposure to PFAS is associated with increased intestinal inflammation in childhood, as measured by elevated fecal calprotectin levels. This study suggests that environmental exposures during critical stages of development may influence long-term intestinal health and future inflammatory bo...
Researchers at Olivia Newton-John Cancer Research Institute discovered that reduced BECLIN1 levels weaken the gut's protective barrier, leading to increased susceptibility to inflammation and disease. This finding may help explain why some people are more susceptible to gut inflammation and associated diseases.
A genetic study has identified a link between irritable bowel syndrome and lipid metabolism, specifically triglyceride regulation. The research found that variations in the GCKR gene play a key role in this connection, highlighting a new approach to treating IBS
Researchers have found that oyster meat extract can effectively reduce TNF-α-induced intestinal inflammation by interrupting NF-kB signalling pathways and decreasing COX-2 enzyme expression. This natural supplement has potential as a sustainable solution for managing chronic inflammatory diseases.
Scientists discovered a natural microbial compound that protects the gut and supports future treatments for inflammatory bowel disease. UroA activates a protective pathway in intestinal epithelial cells, triggering the release of molecules associated with maintaining normal intestinal function and repairing the gut lining.
A new study found that beef protein worsens gut inflammation in mice with IBD, while pea protein shows protective effects. The research suggests that dietary protein source plays a key role in shaping gut health.
Researchers have identified a previously unknown genetic cause of Crohn’s disease and uncovered its link to inflammation through the RIPK1 pathway. This discovery may guide more precise treatments and improve patient matching based on unique biology.
Scientists discovered a direct link between estrogen and gut inflammation in Crohn's disease. The study used zebrafish models to show that estrogen signalling plays a crucial role in maintaining normal gut health. This finding could lead to more personalized approaches to treatment, especially for females affected by the disease.
A team of researchers has identified a distinct blood protein pattern that can accurately diagnose pediatric inflammatory bowel disease and differentiate between its two main forms. The discovery, using proteomics technology, showed high accuracy in identifying IBD and distinguishing ulcerative colitis from Crohn's disease.
Researchers found that over-the-counter probiotics contain only 36 unique species of bacteria, with most common species being forms of Lactobacillus. The analysis suggests a lack of consistency in the combination of species used to support gut health and vaginal health claims.
Researchers at Institute of Science Tokyo have developed a novel culture system to produce stable, scalable, and low-cost clinical-grade intestinal organoids from patient biopsy samples. The innovative approach uses clinical-grade collagen and synthetic peptides to enhance growth and improve scalability.
Researchers identified a driver of inflammatory bowel disease, a group of biologically distinct diseases driven by different underlying mechanisms. Autoimmune responses to interleukin-10 lead to uncontrolled inflammation in ~3.5% of IBD patients, carrying a genetic variant linked to severe disease.
A new study has found that standard antibody-based tests can fail to detect all gluten residues in barley beer, leading to concerns about the safety of gluten-free products. Researchers developed a new mass spectrometry method to identify celiac disease-active peptides, which were found in some 'gluten-free' beers.
Researchers create detailed cell map to identify genetic and cellular drivers of IBD, finding that many genetic effects occur in immune cells and epithelial cells. The study demonstrates the power of single-cell sequencing and genetics to unlock disease mysteries.
A study published in Nature Communications reveals that phytic acid, found in plant-rich diets, activates a cellular regulator to maintain intestinal barrier function. This finding offers a promising natural solution for managing leaky gut and its link to chronic conditions.
Researchers identified ST8Sia6, an immune-regulating molecule, as a potential explanation for treatment-resistant IBD. The study found that the absence of ST8Sia6 led to increased inflammation in preclinical models.
Researchers at Vanderbilt University Medical Center discovered that enterotoxigenic Bacteroides fragilis reshapes intestinal cell metabolism to support its growth, causing diseases like diarrhea and colorectal cancer. The study provides new possibilities for intervention by targeting metabolic interactions between host and microbes.
Researchers from UH, Baylor College of Medicine and MD Anderson Cancer Center propose a new treatment approach for Crohn's disease by targeting the stress signal that fuels inflammation. They found that repurposing two existing cancer medications can promote natural repair and regeneration of the intestinal lining.
Researchers found that vitamin D supplementation was associated with increased levels of immunoglobulin A and decreased levels of immunoglobulin G, indicating a more balanced immune response. The study also observed changes in immune signaling pathways and increased activity of regulatory immune cells.
A new experimental rat model reproduces creeping fat in Crohn's disease, characterized by mesocolic adipose tissue hyperplasia with macroscopic, histological, immunological, and molecular similarities to human disease. The model supports the hypothesis that intestinal microbiota contributes to remodelling of mesenteric adipose tissue.
Researchers identified a link between clonal hematopoiesis of indeterminate potential (CHIP) and IBD severity. Using a drug called APX3330, the team reduced inflammation and restored colon health in mouse models.
The study found that terminal ileum intubation significantly increases the diagnostic yield for inflammatory bowel disease, anemia, abdominal pain, and chronic diarrhea. Routine ileal biopsy is recommended during colonoscopy for patients with abnormal mucosal findings or red-flag symptoms.
Researchers found that mice without the ANGPTL4 gene were protected from intestinal inflammation and colon tumors due to altered macrophage behavior. The study suggests that early-life inflammatory events can shape long-term immune programming, providing resistance to future challenges.
A study by NYU researchers found that children with Crohn’s disease have a unique microbiome signature, characterized by more pro-inflammatory and less protective bacteria. This could lead to personalized treatments for pediatric Crohn’s disease.
A global study found that a group of bacteria, CAG-170, consistently appeared in high numbers in the gut microbiomes of healthy individuals. This species has the capacity to produce Vitamin B12 and break down carbohydrates, suggesting it plays a crucial role in maintaining human health.
A randomized clinical trial found that time-restricted feeding reduced Crohn's disease activity by 40% and halved inflammation in adults with the condition. Participants practicing intermittent fasting also showed notable improvements in blood markers of inflammation and immune health, including lower levels of leptin.
A long-term study of over 2,500 individuals found that two out of three adolescents with IBS no longer met the criteria by adulthood. Factors such as sleep, mental wellbeing, gastrointestinal disorders, and family history played a role in the persistence of symptoms.
Researchers at UC Riverside find that faulty gene PTPN2 increases susceptibility to harmful bacteria like AIEC, leading to gut inflammation and IBD. The studies suggest that restoring PTPN2 function or using medications like JAK inhibitors may help control harmful bacterial growth.
Insilico Medicine presents three abstracts at the 2026 Crohn's & Colitis Congress highlighting clinical, preclinical safety, and efficacy data for ISM5411. The first-in-human Phase 1 results show no serious adverse events or deaths reported, with a favorable pharmacokinetic profile supporting gut restriction.
Research reveals that fat located near the colon contains an unusually high number of inflammatory fat cells and immune cells, suggesting a unique function in communicating with the immune system in the gut region. This tissue may be an adaptation to the gut microbiome and could contribute to amplifying or sustaining inflammation.
Researchers developed a tool to measure gut inflammation levels using luminescent reporting, detecting high levels of granzyme A enzyme in inflamed gut tissue. The new technique shows promise for accurate IBD diagnosis and monitoring, reducing invasive procedures.
Researchers develop a novel approach to precisely encapsulate individual probiotics into microgels, enhancing survival and targeted delivery in the gastrointestinal system. The study demonstrates improved therapeutic efficacy in treating IBD using this technology.
A new study found that bowel preparation procedures for colonoscopies can disrupt the gut environment, making mice more susceptible to infection and inflammation. The researchers hope to understand whether these procedures may put people with inflammatory bowel disease (IBD) at risk of exacerbation.
Researchers identified a novel natural decoy receptor, IL-17REL, that plays a protective role in inflammatory bowel disease. The decoy receptor suppresses downstream inflammatory genes and improves colitis in mice, suggesting its therapeutic potential.
The Crohn's & Colitis Foundation survey found that 18% of young adults with IBD work extra hours to afford care, while over 1 in 3 lack confidence in navigating insurance. The study highlights the need for targeted educational resources and policy attention to improve equitable access to care.
Researchers developed a soft, wireless implant that modulates the splenic nerve to restore immune balance in patients with chronic inflammatory diseases. The device showed excellent biocompatibility and reduced inflammation in a rat model of chronic colitis.
A new international study found significant changes in gut bacteria at the onset of inflammatory bowel disease (IBD), a condition that affects the digestive system. The study reveals a loss of beneficial anaerobic bacteria and an increase in oxygen-tolerant bacteria, which may trigger inflammation.
Colectomy and liver transplantation alter disease behavior in IBD-Associated PSC, highlighting unique risks and challenges. PSC patients face heightened cancer risk after colectomy, while transplant reshapes risks of de novo IBD and recurrent PSC.
A multinational study found PSC prevalence among Asian IBD patients to be markedly lower than in Western countries, associated with more favorable clinical outcomes. The proportion of asymptomatic PSC cases has increased due to improved imaging modality detection, allowing for early-stage diagnosis and reduced liver transplantation rates.
The coralME tool creates detailed genome-scale models of metabolism, gene and protein expression from large amounts of data. The models uncover how microbes respond to certain nutrients and predict what nutrients favor the formation of undesired products.
The American Gastroenterological Association has released an updated clinical guideline on the pharmacological management of moderate-to-severe Crohn’s disease, recommending early use of high-efficacy therapies to improve patient outcomes. The guideline organizes treatments by efficacy to simplify decision-making for gastroenterologist...
Renowned gastroenterologist Jean-Frédéric Colombel, MD, will deliver the 31st Anatomy Lesson on November 20, exploring Mount Sinai's pioneering work in IBD prevention and treatment. His presentation aims to highlight the growing problem of immune diseases, including Crohn's disease.
Research from the University of Gothenburg has identified two bacteria that can produce bioactive serotonin, a key player in bowel movements and brain function. These findings suggest new avenues for treating functional gastrointestinal disorders like IBS.
Researchers analyzed 659 posts on Reddit to better understand the role of social media in managing inflammatory bowel disease. The study found that patients use social media to track symptoms, manage medications, and cope with stress.
Double negative T cells (DNT cells) play an indispensable role in suppressing intestinal inflammation, acting as antigen-presenting cells. Their impaired function may contribute to the pathogenesis of Crohn’s disease, suggesting they could be a potential therapeutic target.
Researchers at uOttawa are developing an AI tool to provide personalized dietary strategies for people living with inflammatory bowel disease (IBD). The project aims to match specific types of carbohydrates to individual patients' unique gut microbiomes.
A UCLA Health study found that taking an 8-strain probiotic daily reduces the risk of pouchitis, a common inflammatory condition. However, the treatment's cost-effectiveness depends on the patient's likelihood of flare-ups, with benefits only seen in patients with frequent relapses.