Articles tagged with Rna Transcripts
Scientists at Georgetown University have found that ezrin's closed form binds to RNA, influencing gene translation and supporting cancer cell growth. The discovery may lead to new treatments for osteosarcoma and other ezrin-dependent cancers.
Researchers mapped GLP-1 expression in 25 brain regions in each sex, uncovering striking differences in key circuits. The atlas reveals sex-biased expression in certain medullary nuclei, with higher Glp1 densities and numbers of Glp1-expressing neurons in females compared to males.
A team of researchers at VCU Massey Comprehensive Cancer Center has discovered an innovative way to use a drug already approved in treating irregular heartbeat to selectively target specific functions of enzymes in lymphoma, effectively killing cancer cells and reducing tumor growth with little to no toxicity. The study found that RBF4...
Researchers identify circulating extracellular vesicles produced in diseased kidneys as the culprit behind toxicity in the heart. The discovery could lead to the development of a blood test to identify patients at high risk for serious heart problems and novel treatments to prevent and treat heart failure.
A new study by researchers from Rice University has uncovered a mechanism by which the identity of nucleotides following a given nucleotide in DNA affects transcription accuracy. The discovery offers insight into hidden factors that influence transcription accuracy and may improve synthetic and therapeutic RNA.
Researchers discovered novel COVID-19-specific chimeric RNAs in whole blood of patients, differing between symptomatic and asymptomatic cases. These chimeric RNAs have an additional layer of transcriptional control and may serve as valuable biomarkers for early-stage viral infection.
The InSTAnT Toolkit allows scientists to investigate cellular processes by identifying proximal pairs of RNA transcripts, revealing sets of molecules that work together. This technology provides accurate and reproducible findings, shedding light on the complex interactions within cells.
Researchers developed an algorithm to analyze high-resolution spatial data from Seq-Scope and other technologies, called FICTURE. This enables scientists to see how and where a gene is expressed at microscopic resolution, improving our understanding of gene expression.
A new proteomics study explores the relationship between protein and transcript levels in young-adult and old mice bones. The research identifies key targets associated with bone mineral density and aging, shedding light on protein-specific changes that occur with age.
Researchers from Japan have discovered that Exportin-5 interacts with a broader spectrum of RNAs, including tRNAs, miRNAs, lncRNAs, and specific mRNAs. This study sheds light on the unique roles of Exp5 in RNA export within Drosophila cells.
Scientists have mapped the global repertoire of genes that determine the male or female sexual fates in Plasmodium falciparum malaria parasites. This study reveals key regulators of gene expression during development and identifies novel candidate 'driver' genes, shedding light on the complex biology of malaria transmission.
Researchers at Osaka University have developed molecules that can correct improper splicing of a vital tumor suppressor gene in neuroendocrine cancers. The study demonstrates that these splice-switching oligonucleotides can significantly reduce viable cancer cells and tumor size in mice, suggesting a novel therapeutic approach for intr...
Researchers from Tokyo Medical and Dental University used long-read RNA sequencing to decode genetic intricacies and disease links. The study identified novel isoforms, cell-type-specific splicing patterns, and disease-linked transcripts associated with immune-related diseases.
Research finds that immune cells in older adults are similar to those in newborns and children, but less effective at recognizing infected cells. The study, published in Nature Immunology, suggests that tailored vaccines and therapies could be developed for different age groups based on the unique characteristics of killer T cells.
In people with Rett syndrome, nerve cells have a mechanism called transcriptional buffering to partially compensate for genetic changes. This process helps maintain healthy RNA levels and acts as a defence against genetic variations, suggesting a potential new molecular mechanism in human cells.
A new toolkit enables researchers to map individual RNA data to a more diverse 'pantranscriptome', addressing reference bias and increasing the accuracy of gene expression mapping. This approach builds on pangenomics, allowing for the comparison of an individual's genome to genetically diverse cohorts of reference sequences.
A recent study has identified common and unique cellular processes in six neurodegenerative diseases, providing new insights into the underlying causes of these conditions. The research used machine learning analysis to compare RNA markers in whole blood samples from patients with distinct diseases, revealing eight shared themes across...
Researchers have mapped RNA diversity in human tissues at unprecedented depth, discovering tens of thousands of novel transcripts. The study used long read sequencing to catalog the genetic code's transcripts, shedding light on how genetic and environmental differences affect gene regulation.
A new study demonstrates that glyphosate successfully crosses the blood-brain barrier and enhances TNF-α levels in mice. The herbicide is linked to increased production of soluble beta amyloid and reduced neuron viability, suggesting potential hazards to neurological health.
Researchers have created stem cell models that mimic the genetic disorder, revealing the role of WASP protein in regulating RNA splicing and finding potential therapeutic targets. These findings could lead to new treatments for Wiskott-Aldrich syndrome, a devastating immune deficiency disorder.
Researchers at EMBL discovered how messenger RNA molecules bind to and regulate the enzyme ENO1, which breaks down glucose. This riboregulation process can determine cell growth and differentiation, with potential implications for understanding cancer.
Researchers found microbes influence which genes are used for fat digestion and absorption, leading to changes in epithelial cells. The study also showed microbes promote lipid absorption and impact systemic processes like weight gain.
The Tabula Sapiens Consortium has unveiled a massive digital atlas that maps gene expression in nearly 500,000 cells from 24 human tissues and organs. The atlas provides unprecedented insights into human health and disease, offering new avenues for therapies and treatments.
Researchers have uncovered a collaboration between RNA decay and chromatin regulating complexes that work together to control the levels of transposable element RNAs, preventing genetic instability. The study reveals an unprecedented mechanism of transcriptional and post-transcriptional regulation.
Researchers developed long-lived biological computers using RNA, which can persist inside cells. Unlike DNA-based devices, these RNA circuits are dependable and versatile, enabling continuous production in living cells.
Researchers at the University of Cologne's Institute of Organic Chemistry have created a novel method for producing synthetic messenger RNA (mRNA) with site-specifically introduced non-natural nucleotides. This approach allows for better therapeutic applications and study of cellular processes.
Scientists from Tokyo Institute of Technology have developed a genetically encoded probe to visualize active transcription sites in living cells. The probe successfully identified phosphorylated Ser2 in RNA polymerase II, allowing for the localization of elongation phase transcription sites in real-time.
A study has identified a specific protein, PHF3, that plays an important role in transcription and modulates the reading process of DNA. The absence of PHF3 or its binding site SPOC may lead to neuronal production defects, which could be linked to autism and glioblastoma.
Researchers at DTU Health Tech have invented a one-pot assay, NISDA, for rapid detection of SARS-CoV-2 RNA without the need for enzyme-based methods. The assay detects low concentrations of RNA in 30 minutes and has shown high accuracy and sensitivity.
Researchers developed a new model, MultiRM, that can predict the 12 most desirable RNA modifications for large-scale prediction. The approach integrates multiple tasks into a single prediction task, providing a more comprehensive view of epitranscriptomes and discovering underlying mechanisms.
This study suggests exploiting urine RNAs as diagnostic markers for bladder cancer, identifying novel marker candidates and validated amplicons. Deep transcriptome analysis of urine RNA revealed coding sequences, non-coding sequences, and circular RNAs, providing promising insights into bladder cancer diagnosis.
Researchers have built a comprehensive catalogue of human non-coding RNAs using three sequencing methods. The project uncovered thousands of novel non-coding RNA genes and found correlations between RNA abundance and regulatory functions.
CSU researchers have observed early RNA transcription dynamics by recording where, when, and how RNA polymerase enzymes kick off transcription. The breakthrough technology has far-reaching potential, including sharpening understanding of basic biological processes and unveiling genetic underpinnings of certain diseases.
A new RNA detection method, BOLORAMIS, overcomes limitations of previous technologies to analyze RNA molecules in their native cellular environment. The study demonstrates high specificity and sensitivity, enabling the analysis of multiple RNAs simultaneously.
The Galej group has discovered the structure and arrangement of the proteins comprising Integrator's catalytic core, revealing a network of multiple subunits interacting with each other. This complex is involved in the transcription attenuation process and plays a crucial role in regulating gene expression.
The Integrator protein complex plays a crucial role in regulating gene expression by terminating non-productive transcription. This mechanism ensures the production of wasteful transcripts is limited while maintaining thousands of transcription start sites for potential functional genes.
RNA molecules have been found to play a key role in regulating their own production through feedback loops. This discovery provides insight into the complex process of transcription, where proteins and DNA interact to create messenger RNA molecules. The research suggests that low levels of RNA encourage droplet formation, while high le...
New research reveals that Rho protein 'hitchhikes' on RNA polymerase for the duration of transcription, cooperating with other proteins to eventually coax the enzyme through structural changes. This process refutes traditional understanding of how Rho stops gene expression.
Researchers developed scVelo to estimate RNA velocity with an AI-based model, allowing them to study dynamic populations and understand cellular development and gene activity. This enables better understanding of disease progression and cell signaling, paving the way for personalized treatments.
Fatah Kashanchi and Lance Liotta investigate cannabidiol's impact on reducing HIV-1 transcription and extracellular vesicle release, which may lead to decreased virus production and neuroinflammation. The study aims to define the mechanisms behind cannabinoid-mediated EV production reduction.
A new study reveals that nuclear RNAs are sorted using a two-layered targeting mechanism, where NEXT and PAXT complexes work together to degrade non-functional transcripts. This process prevents deleterious accumulation of non-functional RNAs in cells.
The study analyzed data from over 1000 donors of more than 25 cancer types, studying whole genomes and tumour transcriptome data. Researchers identified diverse mechanisms of cancer genome alterations, including gene fusions, which can be used for disease diagnosis.
A Belgian-American research team has uncovered a new mechanism of neurodegeneration in Charcot-Marie-Tooth disease, revealing that tRNA synthetases can interfere with gene transcription in the nucleus. This discovery could lead to new therapeutic approaches for CMT patients.
Researchers identified a disruptive relationship between excess nuclear RNA levels and PRC2 function, highlighting the importance of balancing nuclear RNA levels. Excess pA+ RNA hampers PRC2 function through sequestration from DNA.
Flipons are sequences that alter DNA conformation, enabling cells to dynamically modify gene expression. This adaptable coding allows cells to change their response to environmental stressors, such as oxidative stress, which promotes Z-DNA flipon formation.
Scientists have made new discoveries about transcription, a fundamental process in all living cells. Researchers used advanced imaging techniques to study transcription at the scale of individual genes, revealing unexpected drivers of cellular individuality.
A study published in PLOS Biology analyzed RNA transcripts from a 14,300-year-old canid preserved in Siberian permafrost, providing evidence that RNA from ancient animals may be well-preserved. The analysis revealed tissue-specific transcriptomes in the ancient wolf, with many liver-specific transcripts matching modern samples.
A new CRISPR platform, RESCUE, has been developed to target RNA edits that were not previously possible. The system allows for precise modifications of cytosine bases in RNA transcripts, enabling the treatment of devastating diseases affecting the brain.
A protein complex, Ccr4-Not, has been shown to recruit factors that mark RNAPII with ubiquitin, triggering its degradation and clearing the jam. This process is essential for normal cell function and preventing diseases associated with DNA damage.
A team of researchers has made a breakthrough in understanding how transcription is terminated, revealing key components and mechanisms involved. The study used gene editing approaches to identify the molecular torpedo that stops RNA polymerase, shedding new light on this fundamental biological process.
The new software, called Scallop, can reconstruct complete RNA transcripts from fragments of RNA sequences with improved accuracy. This advancement will help scientists better understand the regulation of gene expression.
Researchers at Arizona State University have developed an early blood test for Alzheimer's disease that can detect the disease before symptoms appear. The test distinguishes between Alzheimer's, Parkinson's, and healthy controls by analyzing RNA transcripts in white blood cells.
A team of researchers at Penn State University has discovered a new pathway for nonstandard RNA transcription using high-resolution crystal structure. This finding provides insights into the mechanism of reiterative transcription, which plays a key role in controlling gene expression.
Researchers at the University of Pennsylvania have identified a new mechanism by which RNA molecules are degraded in plants, occurring co-translationally with translation. This process is linked to gene regulation and may play a role in stress response.
Researchers at UT Austin developed an enzyme that accurately proofreads RNA for the first time, increasing precision in genetic research and potentially improving medicine. The new discovery may enhance diagnoses made based on genomic information, leading to more accurate medical outcomes.
A new approach has been devised to map the transcriptome, revealing RNA variants that were largely invisible to previous techniques. The study identified complex splice variants in mammals, which are strikingly common and likely have roles in gene regulation across tissues and human diseases.
Researchers discovered how elongin A morphs between roles as facilitator and destroyer in response to stress and DNA damage. This understanding sheds light on diseases like cancer where genes are improperly turned on or off.
Researchers used single-cell transcriptogenomics to study the cell's defense mechanisms and found that DNA-directed RNA transcription can exclude ENU-mutated alleles, preventing them from being expressed. This novel mechanism may provide a new approach to understanding aging and disease.
Researchers have filled in details on how an enzyme, MOV10L1, protects sperm integrity by producing RNA molecules essential to development. The discovery could lead to a form of reversible male contraception by disrupting piRNA production.
Researchers developed a new genetic control mechanism using synthetic RNAs that can turn genes on and off. The breakthrough could lead to the creation of RNA-only genetic circuits with diagnostic capabilities.