Articles tagged with Rna
Researchers at the University of Pennsylvania developed lipid nanoparticles that modify immune metabolism to strengthen mRNA vaccines and reduce common side effects. The new lipid boosts the metabolism of immune cells, providing energy for the body's defenses while dialing down inflammatory signals.
Researchers discovered that PFK, a key sugar-processing enzyme, has a hidden function controlling cell division by unwinding RNA and promoting gene translation. The enzyme's ability to bind and unwind RNA was found to be crucial for cell cycle progression, with cells lacking PFK2 showing slowed growth and division issues.
A new RNA therapy has been developed to enhance the heart's own ability to protect and repair itself after a heart attack. The therapy, which involves injecting particles into the arm, significantly reduced scarring and improved heart function in lab experiments, offering a potential breakthrough for heart patients.
Researchers have synthesized long noncoding RNA molecules with anti-inflammatory properties, demonstrating a new paradigm in drug discovery. The team identified three lncRNA sequences that regulate inflammation and used them to create nanoparticles that reduced inflammation in human cell cultures and mice.
Researchers mapped GLP-1 expression in 25 brain regions in each sex, uncovering striking differences in key circuits. The atlas reveals sex-biased expression in certain medullary nuclei, with higher Glp1 densities and numbers of Glp1-expressing neurons in females compared to males.
Researchers have identified a crucial mechanism behind nonsense-mediated mRNA decay (NMD), which removes faulty transcripts to prevent incomplete protein production. The study reveals that the SMG5 and SMG6 proteins interact directly, forming an endonuclease that cuts through RNA in a targeted manner.
Researchers at UAlbany are developing a new technique using Raman spectroscopy to ensure mRNA is properly encapsulated in lipid nanoparticles, improving the safety and effectiveness of mRNA vaccines and therapeutics. The technique allows for instantaneous analysis without damaging the sample, enabling optimization of formulations.
MIT neuroscientists have found that two genetic mutations causing Rett syndrome compromise the structural integrity of developing blood vessels, leading to leaky vessels. Overexpression of miRNA-126-3p is responsible for the vascular defect, which can be rescued by reducing the miRNA's levels.
Researchers identified nine piRNAs linked to longevity, which could be detected through simple blood tests. The study suggests that these molecules may help predict survival and guide therapeutic targets for older adults.
Researchers identify nonsense-mediated mRNA decay (NMD) as a central mediator of neuronal migration and cortical lamination. The study reveals that UPF2, a core component of NMD machinery, is essential for proper neuron migration and brain development.
A study profiles mitochondrial circular RNAs in Peripheral Blood Mononuclear Cells from young and old human cohorts, revealing that circMT-RNR2 levels are depleted in older cohorts and are involved in promoting the TCA cycle. Loss of GRSF1 reduces circMT-RNR2 levels, decreasing mitochondrial TCA intermediates and accelerating cellular ...
Researchers at the Max Planck Institute for Brain Research discovered that stressed animal cells, including neurons, assemble inactive ribosomes into tightly linked pairs, known as disomes. This novel mechanism relies on a specific piece of ribosomal RNA called an expansion segment to form a precise RNA-RNA interaction.
Scientists have developed a technology that reveals which proteins are generated by individual brain cells. They mapped protein production across nearly 20,000 individual cells in the mouse hippocampus, finding surprising patterns and potential links to neurological conditions. The study sheds light on how translation affects memory ci...
Research reveals that nuclear speckles are essential for processing and exporting viral messenger RNAs from the nucleus, highlighting their critical role in viral infections. The study suggests that understanding how viruses interact with host cells can lead to new ways to treat and prevent viral diseases.
A research team has developed a 'SUPER' platform that utilizes synthetic small RNAs as add-on controllers for genetic switches. This technology enhances the performance and stability of gene regulatory devices by addressing the issue of 'leakage', where genes continue to express at low levels even in the 'OFF' state.
New diagnostic methods aim to detect RNA viruses with high sensitivity and specificity, overcoming the challenge of rapid evolutionary dynamics. The techniques include mutation-tolerant screening and precise mutation discrimination.
Scientists have identified a previously unknown molecular mechanism for initiating gene transcription in cells under stress. Using cryogenic electron microscopy, they observed how dinucleoside polyphosphate molecules bind to RNA polymerase, enabling the formation of alternative caps that protect cellular RNA.
Researchers found a progressive shift in RNA contents of sperm with age, potentially contributing to health risks of having kids later in life. The discovery may lead to improved fertility outcomes and diagnostic tools.
A study in mice found that paternal immune activation affects small RNAs in sperm, leading to changes in offspring phenotypes such as increased body size and impaired insulin sensitivity. The findings suggest a potential mechanism for intergenerational transmission of health disorders.
Flinders University researchers discovered a biological process that could explain some stillbirths and pave the way for early detection. The study found that molecules called circular RNAs build up in the placenta too quickly during pregnancy, compromising its ability to nourish the baby.
Researchers developed RNACOREX, a new open-source software tool that identifies gene regulation networks in cancer. The tool analyzes thousands of molecules simultaneously to detect key interactions, providing an interpretable molecular map that improves understanding of tumors.
Researchers discovered a tiny RNA molecule called PreS that helps viruses copy their DNA more efficiently and boost replication in bacterial cells. This discovery provides important insights for designing smarter phage-based therapies against antibiotic-resistant infections.
Researchers at UMass Amherst have developed a unique tool for studying RNA, allowing them to observe its behavior inside live cells. The three-color method uses glowing proteins that target specific parts of the RNA molecule, providing valuable insights into RNA's functions and how they impact cellular health.
Researchers at IIT identified a candidate molecule called Apt1 that enhances existing anticancer therapies by making tumour cells more vulnerable to chemotherapy drugs. The molecule slows DNA repair and impairs the interaction between RAD51 and BRCA2 proteins, inducing synthetic lethality in cancerous cells.
Researchers found that two proteins in the CCR4-NOT complex have opposing roles in controlling genetic messages, with one destabilizing and the other steadying mRNA. This balance is critical to gene regulation and understanding cellular differentiation, adaptation to environmental stimuli, and disease mechanisms.
A study from UMBC reveals a conserved RNA-protein interaction as a promising target for broad-spectrum enterovirus antivirals. The researchers found that a fusion protein called 3CD recruits proteins to assemble the replication complex, and targeting this interface could lead to universal drugs.
Researchers have discovered a small RNA molecule that plays a key role in controlling cholesterol production and the development of heart disease. The molecule, tsRNA-Glu-CTC, was found to boost SREBP2 activity, leading to higher cholesterol levels and increased risk of atherosclerosis.
A new study found that rising temperatures are driving changes in polar bear DNA, which may help them adapt to increasingly challenging environments. The researchers discovered that genes related to heat-stress, aging, and metabolism are behaving differently in polar bears living in southeastern Greenland.
Gerald M. Wilson, PhD, joins UMSOM as Chair of Biochemistry and Molecular Biology, bringing expertise in RNA biochemistry and cancer mechanisms. He aims to strengthen departmental capabilities and foster collaboration to advance research, education, and service.
Researchers developed an innovative treatment platform combining a multichannel 3D-printed bioactive scaffold with siRNA delivery for enhanced axon regeneration and improved motor function in spinal cord injury rats. The therapy addressed multiple pathological barriers, including insufficient intrinsic axonal regeneration, lack of dire...
Scientists capture unprecedented detail of a large RNA molecule assembling itself into a functional machine, overcoming kinetic traps. The research reveals the dynamic process, including subtle movements that prompt each domain to enter at precisely the right moment.
Researchers discovered that brain enzyme OTULIN regulates tau protein accumulation and has implications for treating neurodegenerative diseases. The study revealed OTULIN's role in controlling gene expression and RNA metabolism, suggesting a potential therapeutic target.
Scientists have cataloged hundreds of target sites and widely varying editing rates for RNA editing in more than 200 individual cells of tonic and phasic motor neurons. The study found that most sites were edited at rates between extremes, and that some edits altered proteins involved in neural communication and function.
The partnership aims to co-develop and evaluate next-generation self-amplifying RNA (saRNA) vaccines targeting seasonal and pandemic influenza. Apriori's Octavia platform will be combined with A*STAR IDL's saRNA delivery technology to develop improved H5 influenza vaccines that anticipate infection in humans.
A new study led by Prof. Maayan Salton and Dr. Tal Schiller found that gestational diabetes alters the placenta's genetic messages, causing hundreds of errors in protein synthesis. The key protein SRSF10 appears to contribute to this process, suggesting a potential therapeutic target for mitigating its effects.
Researchers have created a method for simultaneous imaging of DNA and RNA in living cells using harmless infrared light, allowing for high-precision detection of all stages of cell death. This breakthrough enables the early detection of cellular damage that leads to aging or death.
Researchers from the University of Edinburgh have identified a new mechanism of resistance to common antibiotics, targeting a special repair system possessed by certain bacteria. This discovery could aid efforts to combat antimicrobial resistance, one of the world's most urgent health challenges.
Researchers have discovered that stress hormones can silence crucial neuronal genes by interacting with long noncoding RNAs and the polycomb repressive complex 2. This mechanism may provide a new understanding of how stress affects gene expression, particularly in relation to synaptic function and calcium signaling.
Advanced molecular dynamics simulations model complex RNA structures with high accuracy, enabling potential applications in RNA-based therapies and drug design. The study successfully simulated the folding of diverse RNA stem loops, revealing a distinct folding pathway for challenging motifs.
Researchers at the University of Connecticut have developed two fast tests for early markers of Alzheimer's disease using CRISPR technology. The tests recognize microRNA molecules associated with Alzheimer's, allowing for quick identification in doctor's offices.
Scientists discovered queuine and preQ1, produced by gut bacteria, regulate protein synthesis in human cells. These bacterial metabolites promote cell growth and halt it, respectively. The study suggests using diet or microbiome composition to balance cell growth in cancer and prevent autoimmune diseases.
Scientists have characterized lipid nanoparticles' internal shape and structure, which correlates with how well they deliver therapeutic cargo. The research provides a blueprint for engineering more effective RNA therapies by matching LNP designs to specific therapies and tissues.
Researchers at UMass Amherst have developed a new tool, iConRNA, that provides an unrivaled look inside cells and can help solve the mystery of how devastating diseases develop. The tool resolves the balance of physical driving forces of phase separation and predicts how this balance is tuned under different cellular situations.
Researchers at Hebrew University of Jerusalem have created a new type of drug molecule that can precisely destroy TERRA, an RNA molecule helping certain cancer cells survive. The discovery paves the way for a new generation of RNA-based cancer treatments targeting genetic roots rather than symptoms.
Researchers developed a new diagnostic test, CAARRD, to detect ribonucleic acid (RNA) at room temperature, increasing sensitivity and reducing complexity. The test uses special 'anti-tag' CRISPR sequences to block the activity of the Cas13a enzyme, allowing for faster and more affordable detection of viral RNAs such as HIV.
Researchers have developed a new mRNA vaccine technology using albumin-recruiting lipid nanoparticles to deliver vaccines precisely to lymph nodes, avoiding liver toxicity. The approach outperformed traditional delivery systems in laboratory tests, producing strong antitumor T-cell responses and high levels of neutralizing antibodies.
Researchers developed a novel RNA-based therapy using lipid nanoparticles to silence a gene causing ceramide buildup in the liver, reducing inflammation and scarring. The treatment shows promise for millions of patients worldwide and could eventually benefit those with heart disease, obesity, and diabetes.
Scientists have created a novel method to synthesize all 21 types of transfer RNA (tRNA) simultaneously in a test tube using the tRNA array method. This breakthrough allows for precise control over protein synthesis and has significant implications for the development of artificial molecular systems with self-reproducing capabilities.
A new mRNA vaccine has stopped allergens from causing immune reactions and inflammation in mice, instructing the immune system to respond more appropriately. The vaccine is tailored to encode proteins from different allergens, offering a flexible solution to treat seasonal pollen allergies, food sensitivities, and asthma.
Researchers developed an mRNA vaccine that suppresses abnormal blood vessel growth in mouse models of age-related macular degeneration. The vaccine is as effective as current therapies and offers a convenient alternative to frequent eye injections.
Researchers at UCLA Health Jonsson Comprehensive Cancer Center identify IGF2BP3 as a master switch linking cancer metabolism and RNA regulation in leukemia cells. The protein shifts energy breakdown and RNA modifications to support cell survival and multiplication.
Researchers have developed a system to selectively switch off the key molecule of NMD, allowing them to observe its function in human cells with unprecedented precision. The study reveals that NMD not only prevents errors but also acts as an important regulator of gene activity.
Researchers have devised a method to safely and temporarily 'switch off' and then 'turn on' ribonucleic acid (RNA) inside cells using disulfide-containing chemical groups. This strategy could potentially open new avenues in more precise RNA-based therapeutics and gene editing.
Researchers at SMART Alliance for Research and Technology developed a powerful tool to scan thousands of biological samples and detect transfer ribonucleic acid (tRNA) modifications, which help control cell growth and response to diseases. The tool opens up new possibilities for disease research, diagnostics, and treatment development.
Cells use a stopwatch-like mechanism to measure the length of messenger RNA (mRNA) tails, achieving molecular accuracy in vital processes like gene expression. The discovery reveals that two proteins, CPAC and Nab2, set the tail's length by timing their interaction, with the final length determined by a race between their speeds.
Researchers discovered that disordered regions enhance specific RNA interactions in FUS protein-RNA complexes, revealing a breakthrough strategy for nucleic acid binding. The study suggests that intrinsically disordered regions actively contribute to the RNA-binding mechanism.
Scientists have developed a new approach to analyze proteins in individual cells during blood cell formation, bypassing mRNA intermediates. This study reveals the correlation between mRNA levels and protein expression, shedding light on the role of essential proteins in maintaining stem cell populations.
Researchers at the University of Waterloo have developed a novel method using modified M13 bacteria to deliver targeted gene therapies for genetic disorders. This approach shows promise as a cost-effective alternative to current methods, which can be expensive and trigger toxic side effects.
Researchers have identified a previously unknown molecular mechanism behind chemoresistance in acute myeloid leukemia (AML), a type of blood cancer. The study found that a protein called RUNX1C plays a key role in this process, and blocking its activity with RNA-targeting tools can improve chemotherapy's effectiveness.
Researchers used machine-learning models to design nanoparticles that can deliver RNA to cells more efficiently. The approach accelerated the identification of optimal ingredient mixtures in lipid nanoparticles, leading to better delivery vehicles for RNA vaccines and mRNA therapies. This could dramatically speed up the development of ...