Articles tagged with Heart Ventricles
Dr. Tim Allerton's research focuses on heart failure with preserved ejection fraction (HFpEF), a condition affecting millions of Americans. His team aims to determine how declining hydrogen sulfide levels contribute to muscle function and exercise capacity in patients with HFpEF.
A new study found that a simple angiogram scoring system can identify patients whose heart muscle is still alive even when a major artery has been completely blocked. This breakthrough could change how cardiac patients are treated and help doctors make faster, more informed decisions.
Researchers identified a key protein called PERM1 that is restored in patients whose hearts recover after left ventricular assist device (LVAD) support. PERM1 regulates energy production and contractile function in heart cells, and its normalization is associated with improved cardiac function.
A new study from CU Anschutz researchers found that regular physical activity can significantly lower post-ablation atrial fibrillation recurrence risk. Adults who engaged in moderate exercise for 30 minutes three times a week had markedly lower rates of AF recurrence compared to those who were less active.
Researchers have developed a non-invasive method to estimate blood oxygen levels in heart failure patients using standard cardiac MRI. This breakthrough could spare thousands from undergoing risky tube procedures, allowing for safer and more frequent monitoring.
A new study from the University of Copenhagen enables researchers to investigate the cause of heart diseases by analyzing thousands of proteins in heart tissue. This groundbreaking method reveals molecular patterns characteristic of heart diseases.
Researchers developed a simpler way to identify patients with suspected cardiac sarcoidosis at increased risk of sudden cardiac death. CMR phenotyping can help determine which patients would benefit from an implantable cardioverter-defibrillator for primary prevention, improving decision-making in clinical practice.
Researchers at University of East Anglia developed 4D flow MRI scan to diagnose aortic stenosis more accurately and reliably than current ultrasound techniques. The technology offers more accurate measurements of blood flow through heart valves, leading to better prediction of when patients need surgery.
Scientists have discovered that early-life cardiac injury in parents can alter heart development and function in offspring, leading to improved cardiac remodeling and increased blood ejection volume. This finding suggests a potential long-term impact on cardiovascular health.
A new mechanical heart pump, BrioVAD, is being tested against the current standard, HeartMate 3, in a national study. The trial aims to enroll 780 participants with advanced heart failure and will compare the two devices head-to-head.
The American Heart Association has launched a new three-year initiative to standardize HCM systems of care and support better management of the disease. The initiative aims to overcome gaps in care for hypertrophic cardiomyopathy, leading to delayed treatment, increased risk of complications, and preventable death.
A new AI program, PanEcho, has been developed to interpret echocardiography videos independently, reducing wait times and improving timely medical care. The program demonstrated accuracy in estimating continuous echocardiographic parameters and quantifying left ventricle dimensions and function.
Research explores relationship between cardiac metabolism dysfunction and heart failure in the elderly, revealing potential therapeutic targets for improved cardiac outcomes. The study highlights the critical role of Pdk4 and MIF in cardiac metabolism, suggesting innovative treatments to manage interconnected cardiovascular conditions.
Researchers compared human hearts with those of great apes, discovering a more compact muscle structure in humans, related to greater cardiac function. This finding supports the hypothesis that human heart evolved to meet higher demands of human physiology, such as larger brain size and physical activity.
A new study found that inter-atrial shunts improve symptoms and outcomes in heart failure patients with reduced left ventricular ejection fraction (LVEF), but worsen outcomes in those with preserved LVEF. The device reduces high pressures in the left atrium, causing shortness of breath and hospitalizations.
Researchers have developed an injectable hydrogel that mitigates damage to the right ventricle of the heart in children with hypoplastic left heart syndrome. The treatment, made from cardiac extracellular matrix, improves heart function and slows tissue scarring, potentially increasing patient survival time.
Researchers developed a test to predict which heart attack patients are likely to experience dysfunction after receiving mechanical pumps. The test measures pulmonary vascular compliance and its adaptability, helping doctors prevent right ventricle failure.
A Phase 2B clinical trial, led by City of Hope, found that carvedilol may improve heart health markers and reduce the risk of heart failure in childhood cancer survivors. The study suggests that carvedilol could benefit long-term survivors and those who are highly adherent to the treatment.
The new robotic replica, called RRV, can mimic healthy and diseased states, allowing scientists to test cardiac devices and therapies. The model can also be used to study the effects of mechanical ventilation on the right ventricle and develop strategies to prevent right heart failure.
Researchers at Temple University Health System report that the BASHIR Endovascular Catheter reduces blockages in lung arteries and correlates with improved right ventricle function, suggesting better survival outcomes. The catheter also shows significantly lower bleeding rates compared to other devices.
Despite its cost-effective prevention for recurrent events, cardiac rehabilitation remains inaccessible to many due to lack of social support, particularly in poorer countries. Home-based rehabilitation and comprehensive lifelong healthy behavioral programs may help address these barriers.
Researchers at ETH Zurich found that targeting deep sleep with brief tones increases heart contractions, improving cardiovascular function. This leads to increased blood flow and a more efficient pumping mechanism.
Researchers at the University of Alabama at Birmingham have developed a modified messenger RNA that can temporarily induce cardiomyocyte cell division, leading to reduced infarct size and improved heart function. The treatment has shown promise in mouse and pig models without increasing the risk of deadly arrhythmias.
Researchers at Harvard developed a fiber-infused ink that allows 3D-printed heart muscle cells to align and contract like human heart cells, enabling the creation of functional heart ventricles. The innovation can be used to build life-like heart tissues with thicker muscle walls, paving the way for regenerative therapeutics.
A long-term analysis reveals that approximately one-third of CTEPH patients also have left heart disease, which can worsen breathing symptoms and requires more comprehensive diagnostic approaches. The study suggests that treatment options for both conditions may overlap, necessitating further research to find effective therapies.
A new study shows that transcatheter mitral valve repair significantly reduces hospitalizations by almost 50 percent and death by nearly 30 percent in heart failure patients with severe mitral regurgitation. The procedure, using Abbott's MitraClip system, improves symptoms, reduces hospitalizations, and leads to longer survival.
The procedure requires thorough pre-procedural evaluation and assessment of anatomical and hemodynamic data. Long-term results indicate that TPVR can effectively restore RVOT function, while improving survival rates and reducing the need for reintervention across age groups. Vigilant testing is recommended to avoid rare but serious com...
A new study found that a specific genetic mutation can protect the heart from the damaging effects of high blood pressure, unlike in other individuals. The researchers discovered that this mutation leads to overactive phosphodiesterase 3A enzyme production, but unexpectedly does not cause cardiac hypertrophy or heart failure.
University of Toronto researchers develop a lab-grown model of the human left heart ventricle made with living heart cells. The bioartificial tissue construct beats strongly enough to pump fluid inside a bioreactor and offers new possibilities for studying heart diseases and testing potential therapies. Future work aims to increase the...
A team of researchers has successfully created complex artificial tissue models, including a full-scale human heart model, using focused rotary jet spinning. This method enables the creation of intricate details and spatially varying alignment, rivaling biological tissues in mechanical behavior.
A study of over three million patients found that post-operative atrial fibrillation increases the risk of hospitalization for heart failure. The risk is present regardless of whether surgery was performed for a heart condition, and can be as high as doubling in non-heart-related conditions.
A new study published in the European Heart Journal shows that MRI is superior to echocardiography for diagnosing heart failure and predicting patient outcomes. The research found that MRI can accurately measure left ventricular filling pressure, leading to improved diagnosis and reduced need for invasive assessments.
The study found significant improvements in blood flow through the heart and quality of life at one year, with all 36 patients achieving a reduction in tricuspid regurgitation severity. Longer follow-up is needed to determine how well the device continues to perform.
Researchers have discovered that bioprosthetic heart valve patients develop an immune response against foreign sugars in the valves, leading to calcification and deterioration. By genetically engineering these sugars out of the valves, durability can be increased, offering a potential solution for patients.
Recent clinical trials showed promising results with cardiosphere-derived cells, improving heart parameters in patients with Duchenne muscular dystrophy. Researchers investigate using cell-derived products like exosomes to boost endogenous repair pathways, while aiming to reverse cardiomyocytes' proliferation limitations.
A new AI-based computer algorithm created by Mount Sinai researchers can identify subtle changes in electrocardiograms to predict heart failure. The algorithm was 94% accurate at predicting healthy ejection fractions and 87% accurate at detecting weakened hearts, offering a promising alternative to traditional diagnosis methods.
A new study found that leaving an atrial communication at biventricular repair of unbalanced AVSD is associated with reduced long-term survival. The study included 581 patients and showed a significant difference in five-year survival rates between those with and without atrial fenestration.
A study found a significant association between rapid decreases in resting heart rate from childhood to adulthood and larger left ventricle, higher blood pressure, and increased cardiovascular risk. Exercise might help intervene in individuals with such trajectories.
Empagliflozin improves heart function, reduces dilation and hypertrophy of the left ventricle, increasing ejection fraction. The medication also enhances exercise capacity and quality of life in patients with heart failure, leading to reduced hospitalization rates.
Researchers identified coronary microvascular dysfunction as a precursor to later heart disease and possible death in patients with chronic kidney disease. The study found that CMD was associated with abnormal mechanics of the left ventricle and clinical risk of adverse cardiovascular outcomes.
A team of engineers at MIT has developed a bionic 'heart' to test prosthetic valves and other cardiac devices, reducing the need for animal testing and increasing design efficiency. The device combines real heart tissue with soft artificial muscles to mimic the natural beating motion of a human heart.
Researchers developed a cardiac MRI method to predict mortality risk in PAH patients. By monitoring right ventricular function, doctors can provide targeted therapies and measure their effectiveness.
Researchers have shown that gene transfer therapy can improve left ventricle function and glucose disposal in mice with diabetes. A single injection of a hormone called urocortin 2 increased heart function and reduced blood sugar levels, offering a potential new treatment for cardiovascular disease.
Mesoblast's MPC-150-IM heart failure product candidate is being studied in a randomized trial combining cell injection with corrective surgery in children under five with hypoplastic left heart syndrome. The trial aims to promote cardiac growth and regeneration, improving quality of life and longevity.
D-transposition of the great arteries is a cyanotic congenital heart disease affecting 3-5% of CHDs, with surgical management evolving to anatomic repair. Clinicians must closely monitor patients through adulthood and beyond for long-term outcomes.
Researchers present a case study of an asymptomatic patient with severe mitral regurgitation who underwent successful repair. The study emphasizes the importance of timely intervention to avoid irreversible left ventricular dysfunction and improve patient outcomes.
Smoking has been linked to an increased risk of developing heart failure in African Americans, with hospitalizations for heart failure nearly three times more likely among current smokers. The study found that smoking a pack or more per day for 15 years was associated with twice the risk of heart failure compared to non-smokers.
Researchers found that splenic leukocytes play a key role in resolving inflammation after a heart attack, coinciding with cardiac repair. The study highlights the need to investigate macrophage-derived specialized proresolving mediators in heart failure.
A new study introduces a holistic 3D numerical simulation model of the human heart, taking into account the mutual interaction between blood flow and individual components. The model reveals complex effects of heart strings on the mitral valve, shedding light on potential strategies for preventing cardiac problems.
Researchers found that a fatty acid-derived bioactive molecule called lipoxin improved heart function after a heart attack by inducing the resolving immune response. Lipoxin treatment also reduced left ventricle and lung mass-to-body-weight ratios, improving ejection fraction, and decreased kidney inflammation.
Researchers found that a diabetes medication, linagliptin, can protect against stiffening of the left ventricle of the heart in overweight female mice fed a Western diet. The treatment suppressed oxidative stress, inflammation, and fibrosis, reducing the risk of cardiovascular complications associated with obesity and Type 2 diabetes.
Researchers developed a new metric to predict blood clots in the left ventricle, which is more accurate than current methods. The E-wave propagation index can be calculated using standard diagnostic tools and clinical procedures, and has been validated with data from patients who experienced post-heart attack blood clots.
The SCAI 2016 Mullins Lecture by Andrew Redington discusses breakthrough advances in cath lab treatments for the failing subpulmonary right ventricle. The lecture highlights the tremendous opportunity for interventional cardiologists to develop new treatment options for their patients.
A new study from Intermountain Medical Center and Johns Hopkins Hospital found that abdominal obesity, or having an apple-shaped body, is a strong predictor of serious heart disease in diabetic patients. Waist circumference was also shown to be a stronger predictor of left ventricular dysfunction than total body weight or BMI.
The study provides information that can be incorporated into clinical assessments for the prevention of cardiac emergencies in basketball players. The analysis reveals that left ventricular cavity sizes in NBA players are larger than in normal adults, but proportional to body size.
A comprehensive analysis of 526 NBA players reveals larger left ventricular cavity sizes, but not necessarily indicative of increased risk. Most athletes have normal left ventricular ejection fractions, with African American athletes showing increased wall thickness and mass compared to white athletes.
Current practice of testing athletes at rest may miss signs of right ventricular dysfunction that can lead to sudden death. A new study shows that exercise echocardiography can detect changes in the right ventricle's functioning during physical activity, providing a potential diagnostic tool for cardiologists managing athletes.
A new study by SEPTAL-CRT found that mid-septal RV lead placement in heart failure patients undergoing CRT results in similar outcomes compared to the conventional apical position. The study showed no differences in clinical outcome or implantation success rates between the two groups.
Research associates high traffic-related air pollution exposure with increased right ventricular mass and volume, linking it to a higher risk of heart failure and cardiovascular death. The study found that participants exposed to higher levels of nitrogen dioxide had greater right ventricular changes.
Researchers tracked premature babies into their 20s and found that those born prematurely had a smaller but heavier right ventricle with thicker walls and less pumping capacity. The earlier the birth, the greater the impact on right ventricle size and function.