Researchers found that Piezo1 and Piezo2 channels regulate odontoblast differentiation by modulating Wnt signaling, leading to decreased odontoblast height and impaired tooth development in mice. Exogenous supplementation of Wnt10a restored odontoblast differentiation, suggesting the channels' role in tooth development.
Researchers analyzed the make-up of oral microbes to detect signals associated with gastric and colorectal cancer, finding distinct signatures in patients with cancer. The study's findings could lead to the development of new, less-invasive screening tests for gastrointestinal cancers.
Lip cosmetics products are routinely ingested and absorbed through lip tissue, but existing frameworks were never designed to assess this dual-pathway exposure route. Researchers found significant gaps in testing and regulation, including inadequate absorption data and outdated ingestion assumptions.
Researchers developed a new approach to eliminate pathogenic bacteria like Porphyromonas gingivalis in periodontitis without harming healthy tissue. This therapy preserves beneficial oral microbes, reducing bone loss and improving oral microbiota in mouse models.
A study published in RMD Open found that specific oral microbiome imbalances may contribute to the development of hand osteoarthritis by influencing systemic inflammation and gut microbiome dysbiosis. The research suggests a potential role for the oral-gut microbiome axis in symptomatic hand arthritis pathogenesis.
A team of researchers discovered an epigenetic mechanism that protects tooth progenitor cells from mechanical stress, preserving tissue renewal. The study found that the enzyme KDM6B removes repressive chromatin marks, allowing genes to be active and preventing excessive activation of mechanosensitive ion channels.
Researchers have discovered a link between tooth aging and the decline of dental pulp stem cells' regenerative capacity. A unique subset of DPSCs, expressing NFATC1 protein, is essential for tooth regeneration. Eliminating this subset can lead to senescence and reduced ability to regenerate after injury.
Researchers at Leibniz Institute for Food Systems Biology found that bitter-tasting herbal extracts stimulate proton secretion in human gastric cells, with polyphenol-rich extracts showing the strongest effects. The study identified three human bitter taste receptor subtypes as key mediators of this response.
A systematic review found consistent evidence that snus causes gum recession, particularly with loose snus. White snus has virtually no studies on its long-term oral health effects, creating a significant knowledge gap.
Saliva plays a crucial role in protecting the mouth from apple juice's effects, which wear off within 10 minutes. The study suggests moderate consumption of fruit juice may not be as damaging as previously thought, but repeated exposure can overwhelm the mouth's natural repair mechanisms.
A new study from the University of Sydney found that poor oral health is significantly associated with higher instances of migraines and abdominal/pain in women. The research identified specific oral microbes correlated with certain pain conditions, including fibromyalgia.
A team of biologists has discovered an ancient neurohormone called bombesin that controls appetite in humans and other vertebrates. The study also found that bombesin-like neurohormones are present in starfish, revealing a common ancestor of appetite regulation dating back over half a billion years.
Researchers developed a novel approach using electrospun poly(Lactic-co-Glycolic Acid) membrane with autologous cells to treat oral mucositis, a painful side effect of chemotherapy. The study showed significant results, with ulcers healed completely within six days and reduced inflammation.
A study found a link between oral microbiome and dementia risk, with certain bacteria associated with better executive function. A nitrate-rich diet may favor beneficial oral bacteria, potentially delaying cognitive decline.
Researchers developed mucoadhesive films combining xyloglucan and green tea extract to treat oral mucositis, a painful inflammation caused by cancer treatment. The films demonstrated high strength and adhesion forces comparable to commercial products, showing promise as a novel treatment for oral mucositis.
Researchers from the Keck School of Medicine of USC found an association between levels of manmade “forever chemicals” in drinking water and certain digestive, endocrine, respiratory, and mouth and throat cancers. The study estimated that PFAS contamination contributes to 6,864 cancer cases per year.
A recent study has explored a new imaging approach that uses swept-source optical coherence tomography to visualize the upper airway with high precision. By integrating computational fluid dynamics, researchers were able to identify areas of turbulence and pinpoint obstruction sites, leading to more accurate diagnoses and treatment pla...
A pooled analysis of over a dozen studies found that drinking caffeinated coffee daily was associated with a 17% lower risk of head and neck cancer overall. Drinking decaffeinated coffee and tea also showed protective effects, with tea linked to a 29% lower risk of hypopharyngeal cancer.
A new study reveals dramatic changes to gut and mouth bacteria in people with chronic liver disease, correlating with increased antibiotic resistance and poor clinical outcomes. The findings suggest a need for personalized microbiome-based treatments and rapid diagnosis of infections to improve patient care.
A study by the University of Gothenburg found that unclear procedures and distribution of responsibilities among healthcare workers can lead to poor oral health in older adults in nursing homes. The researchers suggest that a more structured process can promote communication and awareness of good oral health practices.
A recent study published in the journal Microbiome found that lifestyle factors, such as diet and smoking habits, significantly impact the composition of beneficial bacteria in the mouth. The research team analyzed saliva samples from individuals representing different subsistence strategies in Nepal and discovered a correlation betwee...
Scientists develop artificial mouth with programmed tongue to simulate human oral processing, testing with soft foods such as cream dessert and chocolate mousse. The device accurately reproduces food properties like firmness and viscosity, offering a new tool for studying dynamics of food processing.
Researchers discovered that bottlenose dolphins use the open mouth facial expression to signal playfulness and that they mirror each other's expressions 33% of the time. This finding suggests that visual communication plays a crucial role in shaping complex social interactions in marine mammals.
A recent clinical trial found that an IV iron treatment called ferric carboxymaltose works faster and better than oral iron tablets in treating anaemia during pregnancy. The study showed improved haemoglobin levels and iron correction with the IV treatment, with comparable side effects.
A study by researchers at the University of Helsinki found that high rein tension can cause horses to open their mouths, indicating discomfort. Horse trainers should monitor horse behavior and adjust training to prevent mouth injuries.
A scoping review from the University of Gothenburg found that music-based movement therapy, known as the Ronnie Gardiner Method, can improve rehabilitation outcomes in individuals with brain disorders. The method has been shown to be challenging, motivating, and enjoyable for participants, leading to improved recovery and quality of life.
Researchers found two opportunistic bacteria significantly more abundant after three months of daily use, Fusobacterium nucleatum and Streptococcus anginosus. A decrease in Actinobacteria was also observed, crucial contributors to blood pressure regulation.
Researchers identified distinct differences between oral microbiomes of healthy patients and those with gastric cancer or pre-cancerous conditions. The findings suggest that oral bacteria could serve as biomarkers for gastric cancer risk, potentially leading to practice-changing tests and guidelines.
A new study has reconstructed the ancient giant salmon with tusk-like teeth, previously thought to be 'saber-toothed'. The teeth actually pointed sideways out of the fish's mouth, similar to a warthog. This discovery sheds light on the species' possible uses for these massive spikes.
Researchers found that statins altered macrophage response and suppressed inflammatory response in periodontal disease. The study suggests statins could improve gum health and reduce heart disease risk.
A new study finds that e-cigarette users with a limited smoking history experience similar DNA changes to specific cheek cells as smokers. The researchers also found that some smoking-related epigenetic changes remain more stable after giving up smoking, suggesting that e-cigarettes may not be completely safe.
A new study has discovered that Streptococcus anginosus bacteria play a significant role in causing stomach cancer. The research showed that S. anginosus infection led to gastric inflammation, cell damage, and the growth of stomach cancer cells, doubling tumour size and weight in some cases.
A new study found that low-level laser therapy (PBM) provides immediate pain relief for Burning Mouth Syndrome (BMS) patients, with a significant drop in pain scores after each treatment. The study also observed a cumulative effect of PBM on alleviating BMS symptoms, especially up to the third treatment.
Researchers from Osaka University discovered that a specific bacterial interaction causes the production of methyl mercaptan, a major contributor to bad breath. The interaction between Streptococcus gordonii and Fusobacterium nucleatum leads to increased methyl mercaptan production, which is driven by methionine metabolism.
Researchers from Osaka University found that gargling with an antiseptic mouthwash can reduce periodontitis-related bacteria in patients with type 2 diabetes. This simple method may improve the lives of people with periodontitis-linked diseases such as diabetes, dementia, and cardiovascular disease.
A new study found that one bacterial species, Streptococcus mitis, dominates in IPF patients not treated with antibiotics and is associated with better lung function and survival. This protective relationship does not apply to patients who received antibiotics.
A study conducted by Eurac Research Institute found that cigarette use alters the oral microbiome, leading to an increased risk of periodontitis and cardiovascular disease. Quitting smoking results in a gradual increase in aerobic bacteria, which can lead to improved blood pressure regulation.
A team of researchers has introduced a unique method that uses voice data to assist in revealing the covered parts of faces, overcoming challenges to facial recognition systems. Their approach demonstrates significant improvements in recreating critical facial areas like the mouth, nose, and overall face shape.
Researchers at University of California - San Francisco find that sense of taste signals brain to slow down eating. Using advanced techniques, they recorded brain activity in awake mice and found PRLH neurons controlled by mouth signals when eating normally, not gut signals as previously thought.
A new study found that consuming ultra-processed foods is associated with a higher risk of developing upper aerodigestive tract cancers. The study analysed data from 450,111 adults and found that eating more UPFs was linked to a 23% higher risk of head and neck cancer and a 24% higher risk of oesophageal adenocarcinoma.
A new study by an international team of researchers found that common oral infections and periodontal diseases are associated with inflammatory metabolic profiles. Oral infections were also predicted to cause future adverse changes in metabolic profiles.
Researchers studied over 100 noctilionoid bat species, finding that different dietary types drove modifications in tooth number, size, shape, and position. For instance, fruit-eating bats have shorter jaws with reduced middle premolars, while nectar-feeders have longer jaws with room for more teeth.
A dose-response meta-analysis of nine randomized trials found gefapixant to improve cough frequency, severity, and quality of life. However, it also led to increased taste-related adverse events compared to placebo.
University of Louisville researchers have received a five-year, $11.7 million National Institutes of Health grant to investigate the connection between microorganisms and disease. The study will focus on various chronic conditions, including Alzheimer's disease, heart disease, diabetes, periodontitis, and colorectal cancer.
A recent study has revealed how genetic and environmental factors interact to cause cleft lip or palate in a developing fetus. The research found that mutations in the e-cadherin gene combined with exposure to inflammatory risk factors during pregnancy can lead to cleft lip, which affects one in 700 live births.
A systematic review and meta-analysis found that SARS-CoV-2 infection significantly increases the risk of Bell palsy, whereas vaccination poses a lower risk. The Pfizer/BioNTech vaccine did not differ significantly from the Oxford/AstraZeneca vaccine in terms of BP incidence.
Acylceramides and protein-bound ceramides play a vital role in forming the oral barrier, similar to their function in the skin. Researchers found that these molecules protect against pathogens, chemicals, and allergens in mice.
Researchers at the Forsyth Institute have discovered a molecule naturally produced by the human host that targets and inhibits Fusobacteria, an opportunistic oral pathogen linked to colorectal cancer. The findings suggest a chemically modified version of this molecule could be used as a potential therapeutic to prevent colorectal cance...
Researchers at Flinders University discovered a previously unknown whale behavior, which may have been described in ancient Norse manuscripts. The
A new study from the Keck School of Medicine of USC found that vaping and smoking both cause significant DNA damage in oral epithelial cells. The frequency and duration of vaping were associated with increased levels of DNA damage, which is linked to chronic diseases such as cancer and inflammatory conditions.
Researchers developed a multimodal imaging-based tool, the active biopsy guidance system (ABGS), to improve oral cancer diagnosis. The ABGS provides clinically actionable direct visible guidance for biopsies, enhancing precision and potentially saving lives.
Research exploring cannabis and its impact on the oral microbiome found a link between frequent cannabis use and increased levels of bacteria Actinomyces meyeri in the mouth. The study suggests that this bacterial imbalance may contribute to neurological disease, such as Alzheimer's disease, and memory loss.
Current tobacco and electronic nicotine delivery systems use associated with increased risk of bleeding after brushing or flossing. Longitudinal studies highlight the importance of tobacco cessation counseling in clinical practice.
Researchers at Karolinska Institutet have identified the most common bacteria found in severe oral infections, shedding new light on the association between oral health and systemic diseases. The study found that certain bacterial infections can spread to other parts of the body, highlighting the importance of understanding the role of...
A new study published in Nature Human Behaviour found that mimicking facial expressions of actors or moving the corners of one's mouth to cheeks increases happiness. Researchers from Stanford University and UniSA tested three techniques, with two yielding noticeable results.
Researchers led by Osaka University found that Fusobacterium nucleatum produces polyamines through metabolic cross-feeding, creating favorable conditions for periodontal pathogens to grow and spread. This integration of a metabolic network within the oral microbiome may promote the development of periodontitis.
A recent scientific review suggests that the oral microbiome may hold key answers to pancreatic cancer development, diagnosis, and treatment. The study found a distinct association between oral microbiome patterns and pancreatic tumors, with certain disease-driving bacteria identified in both.
Researchers mapped neural networks in marmoset and macaque monkeys to find that multiple areas in the frontal lobe control vocalization, contradicting a long-held view. This discovery could lead to a better understanding of speech disorders such as stuttering and apraxia.
Researchers investigate plant-based meat substitutes to identify sensory weak points, finding muscle proteins emulsify fats and oils differently than plant proteins do. The study reveals fundamental differences in molecular structure and mouthfeel between meat and vegan sausages.
A new study will measure the effectiveness of oral hygiene in preventing non-ventilator hospital-acquired pneumonia (NVHAP) among hospitalized patients. NVHAP is the most deadly and costly type of hospital-acquired infection, affecting approximately one in 100 hospitalized patients.