Articles tagged with Urine
Researchers at Heinrich-Heine University Duesseldorf developed a laboratory-based model of acute kidney injury (AKI) using three-dimensional kidney organoids. They treated the organoids with a toxic substance to replicate processes such as inflammation and cell death, which are common in kidney diseases.
Researchers found that impaired kidney function is preferentially associated with cardioembolic stroke in a large cohort of patients. Low filtration rates and high urine protein levels predicted increased risk of cardioembolic stroke, disability, and mortality.
Researchers developed a novel electroanalytical technique that co-detects dopamine and uric acid in urine samples, overcoming interference from ascorbic acid. The technique uses a gold-containing ternary nanocomposite electrode, enabling simultaneous detection of low-level DA and UA under physiological conditions.
Researchers in Japan evaluated the cost-effectiveness of adding dipstick hematuria screening to a mass health check-up program. The study found that including routine testing for hematuria would promote early detection and treatment, leading to cost savings and improved patient outcomes. This cost-effective approach has the potential t...
Researchers found that dietary intake of flavan-3-ols activates brown adipose tissue, leading to increased heat production and fat burning. Long-term consumption of flavanol-rich foods may also lead to the development of a healthier metabolism.
Researchers identified four metabolites that indicate adherence to a Mediterranean diet, while ultra-processed foods consumption was associated with lower levels of these metabolites. The study's findings support public health efforts to recommend increased Mediterranean diet adoption and limiting ultra-processed food intake in childhood.
Researchers have discovered two proteins, IGF-1 and IGFBP5, in urine samples that are significantly lower after a concussion. These biomarkers could help diagnose concussion and monitor recovery. The study suggests that urine testing could be an early and inexpensive way to detect concussions.
Researchers have developed a highly sensitive immuno-CRISPR assay to detect acute kidney rejection in urine, potentially allowing for early diagnosis without invasive biopsy. The test uses CRISPR/Cas12a gene editing technology to identify biomarkers of rejection, such as CXCL9, with improved sensitivity compared to existing methods.
A new method measures glomerular filtration rate using D-serine clearance, showing strong correlation with GFR and lower bias than creatinine clearance. This could improve clinical practice and reduce dialysis patients.
Researchers at Shinshu University developed a novel detection principle for stimulants, including methamphetamine, using electrochemiluminescence (ECL) emission. The method allows for accurate and selective screening of stimulants with high sensitivity and selectivity.
Researchers have developed a simple, postal urine test that can detect signs of urothelial cancer in Lynch Syndrome (LS) patients, who are at high risk of developing tumors. The test uses cell-free DNA shed into the urine to identify DNA from tumor cells with characteristic microsatellite instability.
A new pilot study reveals a prostate cancer urine test can identify men with intermediate-risk disease, allowing them to opt for active surveillance instead of immediate treatment. The test assesses the amount of aggressive cancer in the prostate without needing a biopsy.
Researchers found that certain urinary biomarkers, including neutrophil gelatinase-associated lipocalin and kidney injury molecule-1, were associated with increased risk of severe acute kidney injury or death in patients hospitalized with COVID-19. These biomarkers may help identify patients at high risk for adverse kidney outcomes.
A research team from the University of Zurich has identified a common genetic variant in the AQP1 gene that affects treatment efficacy and patient survival on peritoneal dialysis. Patients carrying this variant have a higher risk of death, but researchers found a way to circumvent the problem using colloid osmotic agents.
A new study published in Prehospital and Disaster Medicine found that prehospital ketamine administration for excited delirium with concomitant cocaine intoxication significantly increases the risk of subsequent emergency department intubation. The study's findings suggest that cocaine may deplete excitatory neurotransmitters, leading ...
Researchers assessed diagnostic value of physical symptoms for urinary tract infections in children, finding only circumcision and diaper rash useful for ruling out UTI. They advise against restricting urine sampling to children with unexplained fever or specific features.
The article highlights the need for financial and technological support to enable effective interprofessional teams in primary care. The authors suggest training community members to serve their communities and exploring how diversity impacts patient care outcomes. They also advocate for innovative payment models that allow primary car...
Researchers from the National University of Singapore have identified three new urinary biomarkers that can detect consumption of ADB-BUTINACA, an emerging synthetic cannabinoid. The discovery will help boost global surveillance of synthetic cannabinoid abuse and aid in tackling the increasing abuse of this substance.
Researchers identified specific proteome features in COVID-19 patients' urine to distinguish between mild and severe cases. The study suggests that urine proteomics could be a valuable tool for early detection and prediction of COVID-19 progression.
Researchers from Tokyo University of Science developed a self-powered diaper sensor that monitors urine sugar levels, providing an alternative biomarker for blood sugar monitoring. The sensor uses a biofuel cell powered by glucose in the urine, detecting sugar levels within 1 second and simplifying caretaking tasks.
A large study found that people with hypertension or diabetes often lack a simple urine test for protein in the urine, despite being at high risk of chronic kidney disease. The researchers suggest widening albuminuria testing to detect early chronic kidney diseases and emphasize the importance of treatment.
A new study by researchers at Massachusetts General Hospital found that preoperative urinalysis screening for asymptomatic patients undergoing surgery has little or no benefit. However, the test may lead to unnecessary antibiotic prescriptions and exposure to potential harms, including Clostridium difficile infection.
This study suggests exploiting urine RNAs as diagnostic markers for bladder cancer, identifying novel marker candidates and validated amplicons. Deep transcriptome analysis of urine RNA revealed coding sequences, non-coding sequences, and circular RNAs, providing promising insights into bladder cancer diagnosis.
A pilot study found that patients with high cotinine levels were four times more likely to have their cancer return. The researchers aim to develop a simple urine test for cotinine to reduce invasive investigations for bladder cancer patients.
Researchers at Nagoya University have developed a simple urine test that can detect brain tumors with high accuracy, using microRNAs as biomarkers. The new device can extract more microRNAs from just a milliliter of urine than conventional methods, and shows promise for early diagnosis and treatment.
A study published in Hypertension reveals that vasopressin receptor stimulation leads to the short-term secretion of uromodulin into the urine in mice. Higher levels of uromodulin are associated with lower rates of urinary tract infections and kidney stones.
Wild African elephants highly attend to scent trails of dung and urine left by other elephants. Artificial elephant trails could divert them away from farms and villages, reducing conflicts with humans. The study's findings suggest an important role of smell in long-distance navigation for these animals.
Researchers found that urine protein biomarkers IL-1α, IL-1ra, and IL-8 can distinguish bladder cancer from controls with high accuracy. These markers also show promise in discriminating between different stages of the disease.
Researchers have developed a new urine test called ExoGrail, which shows how aggressive prostate cancer is and can reduce unnecessary biopsies. The test uses biomarkers to provide risk scores and identify patients who need invasive biopsies.
Dr. Jaeger's designation recognizes her high degree of experience with GreenLight Laser Therapy, providing effective relief from BPH symptoms like frequent urination and weak urine flow. The procedure is a minimally invasive outpatient solution with no incisions or impact on sexual function.
Researchers defined parameters for white blood cell counts in children's urine to diagnose and treat urinary tract infections (UTIs) more effectively. The new guidelines could help speed treatment, prevent complications, and reduce the risk of lifelong consequences like kidney scarring and hypertension.
A low-cost intervention using small prizes and incentives successfully reduced alcohol use among American Indian and Alaska Native adults diagnosed with alcohol dependence. Participants who received contingency management interventions were 70% more likely to abstain from alcohol than control participants.
A team of researchers developed an AI analysis method to diagnose prostate cancer from urine within twenty minutes with almost 100% accuracy. The technique utilizes multiple cancer factors in urine to enhance diagnostic accuracy innovatively.
A new study at Karolinska Institutet in Sweden has developed a urine test to identify and verify the type of asthma. The test uses lipid biomarkers to measure urinary metabolite levels of certain prostaglandins and leukotrienes, which are known mediators of asthmatic airway inflammation.
A mutation in the gene KCTD1 leads to kidney defects that can cause metabolic bone disease. The study reveals KCTD1's critical role in regulating electrolyte balance in the distal nephron.
Despite telehealth visits, fewer people began new medication treatment and less urine testing was conducted across all patients during the early months of the pandemic. The study found that established patients continued to receive needed care, but new patients who needed help might not have been getting it.
A University of Michigan-led study finds that urine diversion and recycling can significantly reduce greenhouse gas emissions, energy use, freshwater consumption, and the potential for algal blooms. The method also has lower environmental impacts than conventional wastewater treatment and fertilizer production methods.
A new study has identified fifty protein fragments, termed peptides, in the urine of patients with liver fibrosis, which could be used to develop a diagnostic urine test for the condition. The research team found that these peptides were accurately detected in 84.2% of liver fibrosis patients and 82.4% of those without the condition.
Researchers developed a risk-scoring calculation that adds blood and urine measures of kidney disease to the current standard method for assessing cardiovascular disease risk. The study found that adding these measures can result in large increases in cardiovascular disease-risk estimates among patients with severe kidney disease.
A new urine-based liquid biopsy test, UroCAD, has been developed to detect bladder cancer with higher sensitivity and similar specificity compared to traditional urine cytology. The test analyzes DNA copy number variants in urine exfoliated cells and shows promise for reducing the frequency of cystoscopy examinations.
Scientists at CNIC designed an algorithm that estimates cardiovascular risk in healthy middle-aged individuals based on variables like age, blood pressure, diet, and biomarkers. The EN-PESA algorithm provides a personalized risk profile for those with subclinical atherosclerosis or high short-term disease progression risk.
Researchers analyzed urine samples from 100 pregnant women to detect DINCH metabolites, finding concentrations in most samples but no evidence of hormone disruption. The study found higher concentrations in African American women compared to Caucasian women, highlighting the need for further research on potential disparities.
A membrane-based invention can concentrate virus content from urine or saliva samples, allowing for early detection of COVID-19. The technique is promising for pregnancy testing as well, with a sample analysis time of just five minutes.
A new study reveals significant variability in urine sediment test interpretations among nephrologists, emphasizing the need for standardized education and training to improve reliability. This variation can lead to misinterpretation and potential patient harm, necessitating a more standardized approach to diagnose kidney diseases.
A new study has found that measuring the ratio of two proteins in deceased donor urine can identify kidneys with a higher probability for successful transplantation and long-term survival. The researchers believe this biomarker could help reduce the number of discarded kidneys and increase the organ donation pool.
Scientists have discovered a rapid, inexpensive, and non-invasive method to track malignant melanoma using fluorescent molecules in urine samples. The technique allows doctors to diagnose and monitor the disease without requiring invasive biopsies.
A new analysis by Children's National Hospital researchers found that reducing proteinuria in patients with FSGS significantly slows declines in kidney function and extends time before kidneys fail. The study showed that even modest reductions in proteinuria have a positive impact on kidney health.
Researchers in Australia analyzed urine and wastewater samples to estimate changes in bisphenol exposure over six years. They found that urinary levels of BPA decreased, while BPS increased, with higher levels detected in younger age groups. In wastewater, BPA and BPS were consistently detected, with BPF also present in 29% of samples.
Research from Johns Hopkins Bloomberg School of Public Health found a link between elevated BPA levels and increased asthma symptoms in low-income children. The study also did not find a statistically significant association between BPS and BPF levels and asthma symptoms.
Researchers discovered that a urine test of bicarbonate can measure CFTR function in patients with cystic fibrosis. This test may predict the effectiveness of new treatments for the disease.
A new study suggests that a simple urine test could significantly improve the detection of adrenal cancer by detecting excess adrenal steroid hormones. The test was found to be more accurate than imaging tests in diagnosing cancerous adrenal masses, potentially reducing unnecessary surgeries and healthcare costs.
A study found that women taking MHT have a greater variety of beneficial bacteria in their urine, potentially creating conditions that discourage urinary infections. The study also showed that women with recurrent UTIs have fewer types of bacteria in their urine.
Researchers at the University of Alberta and Universidad Autónoma de Zacatecas developed a new method to analyze urinary metabolome in healthy newborns. The study provides reference data for 86 previously unmeasured chemicals in newborn urine, enabling more accurate diagnoses.
A surgeon demonstrated telesurgery using robotic technology and a 5G network, performing remote operations on a cadaver patient from 15 km away. This was the first public demonstration of remote surgery over 5G. Researchers also explored albumin-creatinine ratio for CKD screening, staging, and prognosis.
Researchers used cryo-electron tomography to reveal the molecular architecture of Uromodulin filaments, which form a fishbone-like structure that traps bacteria. The findings provide insights into Umod's role in protecting against urinary tract infections and its other physiological functions.
A new urine test measures diet quality and identifies an individual's unique 'fingerprint', providing insights into their nutritional needs. The test reveals associations between metabolites in urine and dietary intake of specific foods, nutrients, and health conditions.
A new urine-testing system inspired by nature can identify metabolites that cause kidney stones to form, enabling patients to receive results within 30 minutes. The test is more cost-effective and simpler than current methods, making it a promising solution for managing urinary stone disease.
A Stanford study reports a new smart toilet that monitors for signs of disease using motion sensing, video analysis, and molecular testing. The device can detect various biomarkers, including those for colorectal or urologic cancers, and is designed to provide precise, individualized health feedback.
Researchers find that urea in astronaut urine can be used to soften concrete, making it more pliable and resistant to extreme temperatures. The discovery could help reduce costs associated with transporting construction materials to the Moon.
Researchers found six substances with a strong link to bladder cancer in the urine of e-cigarette users, including carcinogens from combustion products and other tobacco products. The study's findings suggest that vaping may expose users to carcinogens similar to those found in cigarette smoke.