Researchers used flat worms to study the role of migrating stem cells in cancer. They found that regulatory genes controlling cell migration are also essential for planarian stem cells, providing a promising model for understanding human cancers.
Research reveals eight mental models used by teachers to construct STEM-based lesson plans, highlighting the need for better understanding of STEM education's value and online classroom design. Implementing teacher leadership techniques in digital classrooms also improves communication patterns.
A new study reveals that insulin is essential for preserving pluripotent stem cells' ability to become any cell type. Insufficient insulin leads to a specialized endoderm cell type, similar to early embryonic cells, suggesting potential importance in human development and pregnancy.
The University of Akron has launched a program called 'Zip to Industry' to explore the impact of job shadowing on STEM student retention. The project aims to provide paid job shadowing experiences for at-risk first-year STEM students to help them gain exposure to real-world work and develop skills needed to succeed.
Scientists at Temple University are exploring exosome-based treatments for heart disease using a $11.6 million NIH grant. Researchers aim to understand the regenerative capabilities of exosomes and develop novel therapies for patients with heart disease.
Researchers at USC found that TAZ can convey different signals to stem cells based on its location within the cell, affecting differentiation and self-renewal. This discovery provides a new tool for stimulating stem cells and has potential applications in regenerative medicine.
A new review examines the role of various stem cells in corneal wound healing, highlighting similarities and differences in the process. Stem cell transplantation may fine-tune wound healing and provide benefits for patients.
Lorenz Studer, a renowned stem cell biologist, has been awarded the prestigious Ogawa-Yamanaka Stem Cell Prize for his groundbreaking research on cellular reprogramming and human induced pluripotent stem cells. His work has advanced the therapeutic potential of stem cell-based therapies in Parkinson's disease.
Researchers found that US students perceive fewer communal opportunities in STEM careers than Asian students, who see them as essential. Emphasizing these communal aspects can close the cultural gap and increase interest in STEM fields.
Scientists at the University of California - Davis have discovered a way to steer neural stem cells transplanted into the rat brain towards specific locations using electric fields. This breakthrough opens up new possibilities for effectively guiding stem cells to repair brain damage and treat diseases such as stroke and injuries.
Stem-cell researchers have identified two distinct populations of leukemia stem cells that can lead to relapse in AML. The study, published in Nature, provides new insights into the cell types fated to relapse and may help accelerate the development of targeted therapies.
Researchers have discovered that Pramel7 protein is responsible for maintaining embryonic stem cells' perfect pluripotency. This discovery holds promise for developing treatments for complex bone fractures.
Researchers have found that brain regions can target specific pools of stem cells in the subventricular zone, stimulating them to divide and produce particular types of olfactory bulb neurons. This allows for the on-demand generation of specific neuron subtypes in the adult brain.
Researchers at Tel Aviv University discovered a molecular pathway involved in the toxic interaction between host cells and the immune system when using cardiac stem cells from patients with heart disease. The study suggests that these cells can develop inflammatory properties and exacerbate damage to the already diseased heart muscle.
Researchers identified BPTF as a protein essential for mammary stem cell maintenance and found that removing or inhibiting it causes stem cells to differentiate and die. This discovery provides hope for developing a drug that targets BPTF in breast cancer cells, potentially leading to the differentiation and death of these cells.
Researchers from Turku, Finland have discovered new information about the mechanisms regulating gene activity in human embryonic stem cells. The study sheds light on indirect genomic regulatory mechanisms that maintain gene expression and self-renewal of stem cells.
A recent study published in Nature Cell Biology identified a small RNA molecule, miR-199a, that helps maintain the activity of stem cells in both healthy and cancerous breast tissue. The microRNA promotes particularly deadly forms of breast cancer and inhibiting its effects could improve existing breast cancer therapies.
Researchers in China have made a breakthrough in developing a new approach to treat premature ovarian failure using female germline stem cells. The study found that mice with transplanted egg-making stem cells produced healthy pups without genetic malfunctions, opening up avenues for investigating human oogenesis in vitro.
Scientists have successfully generated blood-forming stem cells in the lab using pluripotent stem cells from patients' own cells. The advance opens up new opportunities to create immune-matched blood cells and potentially treat genetic blood disorders.
A recent study found that plant and animal stem cells exhibit similar interaction patterns, explaining why plant cells can reprogram more easily. Researchers developed mathematical equations to analyze protein interactions, revealing key differences in cellular flexibility.
UC Berkeley scientists have developed a new technique to track individual stem cells in the nose, uncovering clues that could help restore smell to those who have lost it. The team used single-cell RNA sequencing and statistical analysis to identify the molecules that trigger stem cell differentiation into specific cell types.
Research by the German Cancer Research Center found that vitamin A deficiency can lead to a loss of dormant stem cells in the bone marrow, impairing the immune system. The study suggests that understanding how vitamin A regulates these stem cells could lead to new cancer treatments.
Researchers at St. Jude Children's Research Hospital have identified trunk neural crest cells as key players in the development of blood-forming stem cells, which can produce any type of blood cell. This discovery may lead to new avenues for investigating stem cell biology and improving access to bone marrow transplantation.
Researchers at Karolinska Institutet have developed a new tool to distinguish between immature and mature embryonic stem cells. These cells hold great potential for replacing damaged tissue and understanding early embryonic development.
Human embryonic stem cells exist in two states: naïve and primed. Researchers have identified molecular flags on these cells, allowing them to track and investigate their transition. This approach has revealed new insights into the timing and coordination of gene activity changes during reprogramming.
Researchers have successfully rejuvenated old gut stem cells by restoring Wnt signaling, suggesting a potential pathway to target for clinicians. This breakthrough offers new insights into the role of Wnt proteins in controlling stem cell growth and pluripotency in the gut later in life.
A recent study conducted at The Mount Sinai Hospital found that certain genetic mutations are challenging to recreate in laboratory-produced stem cells. This limitation may hinder neuropsychiatric research, highlighting the need for researchers to carefully check for retained genetic elements in newly created stem cells.
Researchers at IRB Barcelona have discovered a new group of quiescent intestinal stem cells that are resistant to chemotherapy. These cells, estimated to be one in ten compared to active stem cells, play a crucial role in tissue regeneration and can produce any type of intestinal cell.
Researchers have identified adipose stem cells as a suitable alternative to bone marrow stem cells for treating orthopedic diseases and injuries in dogs. The study reveals that adipose stem cells exhibit similar functional properties to bone marrow stem cells, including tissue generation and immunomodulation, but grow at a faster rate.
Researchers at Lund University successfully reprogrammed old blood stem cells to function like those of younger individuals, revealing a potential new approach to treating age-related diseases. This breakthrough suggests that epigenetic changes, rather than DNA mutations, underlie the decline in blood cell function with age.
A team of researchers has identified a long-lived type of stem cell in the breast that grows mammary glands during pregnancy and may be linked to high-risk breast cancer. The discovery reveals new insights into how cancers arise from long-lived stem cells.
Researchers at the University of Freiburg have discovered how shoot stem cells form in plants, a process similar to animals. The transcription factor WOX2 regulates the balance between plant hormones cytokinin and auxin, allowing stem cells to maintain their unlimited potential for development.
Researchers at UCL and Heinrich Heine University have discovered the OCT4 gene essential for chemically reprogramming human amniotic stem cells. The process allows these cells to be rejuvenated and function like embryonic stem cells, providing a promising alternative for therapies and research.
A study led by NYU Langone researchers identified CD99, a protein-sugar molecule, as a potential therapeutic target for blood stem cell cancers like acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Antibodies against CD99 can selectively kill cancer stem cells while sparing normal blood stem cells.
Researchers have developed synthetic stem cells that mimic natural cardiac stem cells, promoting tissue repair and reducing risks of tumor growth and immune rejection. These cells are more durable, can be used off-the-shelf, and can tolerate harsh freezing and thawing.
Researchers define how genetic factors affect blood-forming stem cells' regenerative properties, accelerating or hindering their ability to restore the immune system. The findings highlight two molecular mechanisms that could be manipulated to increase hematopoietic stem cell regeneration.
Researchers compared three types of adult stem cells from 14 patients to determine their cardiac repair potential. Right atrial stem cells had the greatest protective effect on heart muscle cells, while ventricular stem cells promoted new blood vessel formation.
A new color-based labeling technique allows researchers to track the development and behavior of individual blood stem cells. The study reveals that these cells have a scripted set of responses and cannot make just any blood cell type.
A study analyzing brain tumor genomics on a single-cell level found evidence that cancer stem cells fuel the growth of oligodendrogliomas. Cancer stem cells were identified in human brain tumor samples and found to have distinct developmental signatures, suggesting they play a key role in tumor propagation.
A recent study published in Social Science Research found that women with STEM degrees who delayed marriage and family were not more likely to secure STEM employment than those who anticipated having children. The research, led by Cornell University demographer Sharon Sassler, analyzed data from the 1979 National Longitudinal Surveys o...
A Lund University research team identified high levels of reactive oxygen species in newly generated blood stem cells from pluripotent stem cells, damaging their function. The researchers developed a cocktail to reduce oxidative damage, resulting in over twenty times more blood stem cells that could grow.
A study found that corneal cells' softness indicates their potential for stem-like activity, enabling rapid and cost-effective enrichment of limbal stem cells. This biomarker could improve clinical success rates for corneal transplant patients with naturally low limbal stem cell percentages.
A new study reveals the cellular mechanisms that help human mesenchymal stem cells (hMSCs) retain their therapeutic properties when cultured in the lab. Mitochondria play a central role in this process.
Researchers used ECIS to track stem cell transformation into bone tissue cells, revealing age-related differences in conversion rates and calcium secretion. The study provides new insights into the potential of adipose-derived stem cells for osteoporosis treatment.
Researchers found that neural stem cells in the hippocampus use the Drosha protein to regulate their differentiation into specific cell types. The discovery challenges the long-held view that stem cell differentiation is controlled solely by the local environment.
Mesenchymal stem cells exhibit significant cell-to-cell variation in their capacity to survive upon implantation. The Tulane professor's three-year project aims to gain insight into the molecular mechanisms underlying this variation, with the goal of improving survival rates and advancing regenerative therapies.
Unproven stem cell therapies are on the rise for lung disease patients, despite promise of new treatments. Researchers warn that aggressive marketing and lack of regulation are exacerbating perceptions of these therapies.
The study reveals murky marketing practices and false advertising in the industry, with websites often making unsubstantiated claims about adult stem cells and targeting anti-aging/skincare applications.
A new study published in PLOS Computational Biology suggests that using a specific sub-type of human mesenchymal stem cells can reduce potential risks associated with this therapy. This finding could lead to improved treatment outcomes for heart failure patients, providing a safer alternative to existing therapies.
Researchers at the University of Basel discovered that the choroid plexus produces key signaling factors that regulate adult neural stem cells. As people age, these signals change, affecting stem cell behavior and leading to a decrease in new neuron formation.
Researchers discovered leukemia stem cells in fatty tissue of obese patients were more resistant to chemotherapy, using fatty acids as their energy source and actively signaling fat for lipolysis. This adaptation could help explain poorer outcomes in obese patients, potentially shedding light on new strategies to target cancer stem cells.
Researchers at Johns Hopkins University have discovered a protein that boosts the growth of damaged muscle tissue, potentially contributing to treatments for age-related muscle degeneration and diseases like muscular dystrophy. The protein, β1-integrin, promotes stem cell growth and restoration after muscle injury, with results showing...
Researchers found that a non-surgical treatment using patient's own bone marrow stem cells improved symptoms and increased physical activity in patients with angina. The treatment involved injecting a 'catalyst' molecule to stimulate stem cell migration into the bloodstream, followed by re-injection of harvested stem cells.
Scientists have created a four-step process to determine accurate signatures of human embryonic stem cells, relating them to precise developmental stages. The key steps involve analyzing transposable elements and DNA methylation state to assess pluripotency.
Researchers have discovered a genetic switch, microRNA mirR-125a, that can be used to increase the supply of stem cells from cord blood. This discovery could potentially increase the availability of stem cell transplants for cancer patients with no matching donors.
Scientists developed guidelines to evaluate laboratory-generated stem cells, finding that no current methods produce truly naïve embryonic cells. The new criteria may aid researchers in achieving this goal, which could benefit both basic research and medical applications of stem cells.
The University of Tennessee Institute of Agriculture has been awarded a $10,000 sponsorship to implement a Summer Camp STEM Experience during Junior 4-H camp in Columbia, Crossville, and Greeneville. The program aims to spark youth interest in STEM education through hands-on activities, including zip-lining, wildlife ecology, and archery.
Researchers have discovered a technique to improve the function of engineered organs and tissues by starving stem cells of glutamine, leading to more mature and functional endothelial cells. This method may prove useful for tissue engineering, particularly in the creation of functional blood vessels from human embryonic stem cells.
Researchers have concluded that reprogramming does not create differences between reprogrammed and embryonic stem cells. A thorough study showed that reprogrammed and embryonic stem cells are similar, with a list of 275 key genes that can present reprogramming results.
Researchers at ULB developed new methods to determine stem cell multipotency and unipotency with high confidence. The findings show that prostate cells are multipotent while mammary gland cells are unipotent, resolving a long-standing debate in the field.