Researchers discovered a novel brain mechanism that links anxiety and depression, showing unique cellular mechanisms activate as one pathology progresses into another. The 'switch' involves astrocytes and cytoskeletal mechanisms, which may be targeted for new classes of psychotropic drugs.
SourceSt. Petersburg State University·JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry·DateOct 2, 2020
MarrowQuant, a new digital pathology software, can quantify bone marrow components in histological images without bias. The tool builds maps based on values to complement images, potentially re-examining historical sample collections and old clinical trials.
SourceEcole Polytechnique Fédérale de Lausanne·JournalFrontiers in Endocrinology·DateSep 28, 2020
Researchers found a connection between contact sports participation and chronic traumatic encephalopathy (CTE) leading to sleep dysfunction. The study revealed that tau pathology in brainstem nuclei is more strongly associated with sleep symptoms than Lewy body pathology, suggesting a new link between CTE and REM sleep behavior disorder.
SourceBoston University School of Medicine·JournalActa Neuropathologica·DateSep 16, 2020
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Drs. Dennis Lo, Karen Mann and Ronald Przygodzki are recognized for their pioneering work in non-invasive prenatal testing and cancer detection using circulating nucleic acids. Their innovations have created a paradigm in prenatal medicine and advanced the field of molecular diagnostics.
A study using iPSC technology reveals astrocytes' role in PD pathology, including altered alpha-synuclein production and disrupted calcium homeostasis. The findings suggest LRRK2 and GBA mutant astrocytes contribute to PD progression.
SourceUniversity of Eastern Finland·JournalScientific Reports·DateSep 7, 2020
Research shows that air pollution from ozone levels damages the scent of flowers, deterring moths. However, when given a chance, moths quickly learn that even polluted floral odors may lead to nutritious nectar rewards. This learning ability is crucial for moths to adapt to changing environments.
SourceMax Planck Institute for Chemical Ecology·JournalJournal of Chemical Ecology·DateSep 4, 2020
A meta-analysis of NHP studies reveals that AAV gene therapy often causes DRG pathology with no clinical effects, prompting preclinical safety evaluations before clinical trials. The study's findings have the potential to streamline the development process for new vectors.
SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalHuman Gene Therapy·DateSep 2, 2020
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
A critical EPA insecticide study on chlorpyrifos was found to have been based on incomplete data, leading to an incorrect safe exposure limit. Researchers argue that this oversight had significant public health implications and potentially allowed approvals for unsafe uses of the chemical.
SourceUniversity of Washington·JournalEnvironment International·DateAug 18, 2020
The American Chemical Society's 'Talented 12' program recognizes early-career researchers tackling difficult global challenges. This year's class includes innovators in chemistry, biobased building blocks, and faster reagents. They will be featured in this week's issue of CEN.
A preliminary analysis of 300+ COVID-19 patients treated with convalescent plasma suggests the treatment is safe and effective. The results show that patients who received plasma early in their illness had a lower mortality rate compared to those who did not.
SourceHouston Methodist·JournalAmerican Journal Of Pathology·DateAug 12, 2020
A new study proves that the McKee CTE staging scheme accurately represents the progression of tau pathology in CTE, correlating with clinical dementia and age at death. Researchers found five brain regions with increasing p-tau pathology that conform to CTE stage, age, and years of football play.
SourceBoston University School of Medicine·JournalActa Neuropathologica·DateAug 10, 2020
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Researchers at Yokohama National University have developed a novel light-based reaction that yields high numbers of a key chemical component. The method uses green visible light to selectively reorganize chemical components, resulting in the production of multisubstituted cyclobutanes with high efficiency and cost-effectiveness.
SourceYokohama National University·JournalOrganic Letters·DateAug 3, 2020
A team of researchers has developed a computational model to describe the motion of molecular motors, shedding light on how they generate unidirectional motion. The study found that molecular motors follow a
SourceNational Institutes of Natural Sciences·JournalThe Journal of Physical Chemistry B·DateAug 3, 2020
Researchers have discovered a way for chemical reactions to accelerate Brownian diffusion by sending long-range ripples into the surrounding solvent. This finding challenges the traditional view of molecular motion and chemical reaction being decoupled.
SourceInstitute for Basic Science·JournalScience·DateJul 30, 2020
The American Chemical Society names BASF the number one chemical company for 2019, followed by Sinopec and Dow/DuPont, in its annual Global Top 50 list. The report shows a decline in earnings due to trade tensions and poor automotive performance.
SourceAmerican Chemical Society·JournalChemical & Engineering News·DateJul 29, 2020
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
A team of researchers at UC Riverside used machine learning to understand what chemicals smell like, predicting how any chemical will smell to humans. This breakthrough technology has vast applications in the food, flavor, and fragrance industries, including discovering new flavors and insect repellents.
SourceUniversity of California - Riverside·JournaliScience·DateJul 28, 2020
Researchers at the University of Bristol have identified a novel protein pathway in several human neurodegenerative diseases, including Huntington's disease. Abnormal expression of SAFB1 was found to be associated with spinocerebellar ataxias and polyglutamine expansion, offering new potential diagnostic markers and therapeutic targets.
SourceUniversity of Bristol·JournalBrain Pathology·DateJun 30, 2020
Researchers at Lund University have developed a 3D model of human hippocampal tissue from induced pluripotent stem cells, allowing for the study of early cellular dysfunction in Alzheimer's disease. The study found that patient-specific pathology differs between individuals with extreme symptomatology.
SourceLund University·JournalStem Cell Reports·DateJun 28, 2020
A recent study by the University of Kentucky's Sanders-Brown Center on Aging has identified a previously under-recognized form of dementia, quadruple misfolded proteins (QMP), linked to TDP-43 proteinopathy. The study found that about 20% of participants with dementia had QMP, resulting in the most severe dementia cases.
SourceUniversity of Kentucky·JournalJAMA Neurology·DateJun 26, 2020
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
A new study in The American Journal of Pathology reports that gene expression analysis of lung explant tissue can accurately differentiate pulmonary arterial hypertension (PAH) from pulmonary veno-occlusive disease (PVOD). This molecular approach promises to facilitate clinical diagnostics and develop novel target-specific intervention...
SourceElsevier·JournalAmerican Journal Of Pathology·DateJun 15, 2020
Researchers paired hyperspectral sensors with machine learning and molecular assays to differentiate between late blight clonal lineages. They found that accuracy increased at early stages of infection before symptoms appeared, suggesting a link to pre-symptomatic effector expression differences.
SourceAmerican Phytopathological Society·JournalPhytopathology·DateJun 9, 2020
Researchers at Hokkaido University have successfully synthesized a non-natural fluorinated amino acid using a novel computer-assisted method. The Artificial Force Induced Reaction (AFIR) method predicts feasible reaction pathways, significantly reducing synthesis time and cost, with yields of up to 99.99%.
SourceHokkaido University·JournalChemical Science·DateJun 8, 2020
Researchers at the University of Bern have discovered how Clostridium perfringens causes fatal intestinal bleeding in piglets. The toxin attaches to CD31, a key molecule on endothelial cells, leading to cell death and damage to blood vessels.
SourceUniversity of Bern·JournalCell Host & Microbe·DateJun 4, 2020
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Extracellular vesicles play a key role in the pathology of malaria vivax by promoting parasite adhesion to human spleen fibroblasts. The study found that EVs induce the expression of ICAM-1 on fibroblast surfaces, serving as an anchor for parasite-infected red blood cell adherence.
SourceBarcelona Institute for Global Health (ISGlobal)·JournalNature Communications·DateJun 2, 2020
A recent study published in the American Journal of Pathology found that convalescent plasma therapy is a safe treatment option for patients with severe COVID-19 disease. The therapy showed significant improvement in 76% of patients, with no adverse side effects caused by the plasma transfusion.
SourceHouston Methodist·JournalAmerican Journal Of Pathology·DateJun 2, 2020
A new framework for assessing and managing serious spinal pathologies has been developed by the International Federation of Orthopaedic Manipulative Physical Therapists (IFOMPT). The framework provides a clinical-reasoning pathway to recognize red flags in spinal injuries and disease, enabling early identification and management.
SourceJOSPT, Inc. d/b/a Movement Science Media·JournalJournal of Orthopaedic and Sports Physical Therapy·DateMay 27, 2020
A groundbreaking study published in iScience has created a detailed 3D map of the intracardiac nervous system (ICN), the 'little brain' of the heart. The researchers used novel imaging techniques to reveal previously unknown complexity and diversity of molecular identities among neurons.
SourceThomas Jefferson University·JournaliScience·DateMay 26, 2020
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
The Chemical Checker tool uses a similarity principle to analyze over 1M compounds and identify potential treatments for diseases. It has been used to reposition approved drugs for Alzheimer's disease and identify substitutes for expensive biologics.
SourceInstitute for Research in Biomedicine (IRB Barcelona)·JournalNature Biotechnology·DateMay 19, 2020
Researchers at the Dalian Institute of Chemical Physics found clear quantum interference in the H + HD reaction, verifying that Nature plays dice. The study reveals a new roaming mechanism, which occurs only 0.3% of the time, and highlights the complexity of chemical reactions.
SourceChinese Academy of Sciences Headquarters·JournalScience·DateMay 14, 2020
The Association for Molecular Pathology (AMP) has released consensus recommendations to aid in the design, validation and interpretation of clinical genotyping tests for predicting warfarin response. The guidelines define a minimum set of pharmacogenetic alleles for inclusion in clinical warfarin sensitivity genotyping tests.
SourceAssociation for Molecular Pathology·JournalJournal of Molecular Diagnostics·DateMay 5, 2020
Researchers have seen the initial step in light-driven chemical reactions, where a molecule's electron cloud balloons out before atomic nuclei respond. This direct observation paves the way for studying chemical bonds forming and breaking in real-time.
SourceDOE/SLAC National Accelerator Laboratory·JournalNature Communications·DateMay 1, 2020
Researchers studied Aegean wall lizards on predator-free islands and found they rapidly developed new chemical signals distinct from their source population. This change occurred after only four generations and offers a unique opportunity to understand animal communication.
SourceWashington University in St. Louis·JournalJournal of Animal Ecology·DateApr 21, 2020
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
Researchers discovered significant chemical differences between PM1 and PM2.5 aerosol species, affecting particle acidity and water content predictions. These findings are crucial for accurately modeling air pollution in highly polluted regions, where the distinction is critical.
SourceInstitute of Atmospheric Physics, Chinese Academy of Sciences·JournalGeophysical Research Letters·DateMar 9, 2020
Researchers developed oscillating catalyst technology that accelerates chemical reactions without side reactions, improving performance and cost-efficiency. This breakthrough has the potential to reduce waste by thousands of tons annually and transform the way chemicals are manufactured.
SourceUniversity of Minnesota·JournalChemical Science·DateMar 4, 2020
A study has described the pathology of SARS-CoV-2, or COVID-19, for the first time in its early phase. The research reveals edema, proteinaceous exudate, and inflammatory cellular infiltration in patients with COVID-19 pneumonina.
SourceInternational Association for the Study of Lung Cancer·JournalJournal of Thoracic Oncology·DateFeb 27, 2020
Researchers developed a new strategy to control both target chemical production and microbe propagation, boosting muconic acid yield. The Parallel Metabolic Pathway Engineering approach allows for independent utilization of sugars for microbe growth and target chemical production.
SourceKobe University·JournalNature Communications·DateFeb 25, 2020
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
A recent animal study found that adding L-serine to the diet of vervets exposed to cyanotoxin BMAA significantly reduced signs of ALS-like pathology. The study provides a promising model for understanding ALS development and potential treatments.
SourceUniversity of Miami Miller School of Medicine·JournalJournal of Neuropathology & Experimental Neurology·DateFeb 24, 2020
An interdisciplinary team from KU Leuven has mapped out the technological and economic viability of replacing petroleum with wood in the chemical industry. The research suggests that a biorefinery using wood can produce chemicals with lower CO2 emissions, making it a more sustainable alternative.
A recent study by the Keck School of Medicine found that vapers and smokers exhibit similar epigenetic changes in their genome, which can cause genes to malfunction. These chemical alterations are commonly found in human cancer and other serious diseases.
SourceKeck School of Medicine of USC·JournalEpigenetics·DateFeb 12, 2020
Researchers at ORNL developed a multitask convolutional neural network to extract key information from cancer pathology reports. The AI tool can complete multiple tasks simultaneously, reducing processing time by an average of five times compared to single-task models.
SourceDOE/Oak Ridge National Laboratory·JournalJournal of the American Medical Informatics Association·DateFeb 12, 2020
Nikon Monarch 5 8x42 Binoculars
Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
Researchers developed a hybrid microscope that combines optical and infrared measurements with machine learning algorithms to create digital biopsies. The hybrid microscope closely correlates with traditional pathology techniques and outperforms state-of-the-art infrared microscopes in terms of resolution, consistency, and coverage.
SourceUniversity of Illinois at Urbana-Champaign, News Bureau·JournalProceedings of the National Academy of Sciences·DateFeb 12, 2020
Scientists at Argonne National Laboratory have experimentally detected the transition state in chemical reactions, a hidden aspect that controls product formation. This breakthrough could improve industrial processes and lead to the synthesis of new life-saving drugs.
SourceDOE/Argonne National Laboratory·JournalProceedings of the National Academy of Sciences·DateFeb 3, 2020
Researchers developed a Noncontact Catalysis System (NCCS) to accelerate chemical reactions using gold nanoclusters as intermediaries, enabling independent reactions of normally incompatible substances. This breakthrough could lead to more versatile, efficient, and cost-effective industrial chemical production processes.
SourceNorthwestern University·JournalScience Advances·DateJan 31, 2020
The Mark Foundation Center for Advanced Genomics and Imaging at Johns Hopkins University aims to develop innovative solutions for cancer immunotherapy. The center will utilize a combination of tools from astronomy image analysis, pathology, computer science, cancer genomics, and immunogenomics.
SourceThe Mark Foundation for Cancer Research·DateJan 27, 2020
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Scanning Raman picoscopy enables visualization of vibrational modes and direct construction of molecule structures. Researchers achieve Ångström-resolved imaging, correlating local vibrations with constituent groups to assemble molecules in real space.
SourceScience China Press·JournalNational Science Review·DateJan 21, 2020
The American Chemical Society forecasts a year marked by environmental improvements, such as reducing plastic use and recycling. Regulatory actions are also expected, including updated chemical risk assessments and classification of PFAS as hazardous materials.
SourceAmerican Chemical Society·JournalChemical & Engineering News·DateJan 15, 2020
A recent study published in Nature Communications used AI to analyze pathology images from human cancer patients and identified new features relevant to cancer prognosis. The AI's predictions were found to be more accurate than those made by human pathologists, with a higher accuracy rate when combined with human-established criteria.
Researchers recommend simplifying air quality testing methods to improve accuracy in simulating atmospheric chemical reactions and reducing pollution. A combination of bottom-up and top-down techniques can help achieve more accurate results.
SourceTaylor & Francis Group·JournalJournal of the Air & Waste Management Association·DateDec 17, 2019
Researchers found that standard pathology tests provide better information on likely outcome and best treatment options for patients with bladder cancer than molecular subtyping techniques. The study suggests that more study is needed before molecular subtypes are used to guide patient care.
SourceMedical College of Georgia at Augusta University·JournalThe Journal of Urology·DateDec 13, 2019
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
A new AI algorithm, ConvPath, uses artificial intelligence to classify cell types and quantify spatial distributions in tumor tissue. This allows pathologists to obtain accurate cancer cell analysis in a faster way.
SourceUT Southwestern Medical Center·JournalEBioMedicine·DateDec 9, 2019
A new report recommends that researchers use expert reviews and computational Big Data approaches to select high-quality chemical probes. The report highlights the value of resources like the Chemical Probes Portal, which provides assessments on 192 chemical probes for 181 different proteins of interest.
SourceInstitute of Cancer Research·JournalFuture Medicinal Chemistry·DateNov 28, 2019
Diascopic LLC is developing an AI-powered diagnostic platform for detecting tuberculosis (TB) using digital pathology tools. The platform has shown promising results in five African clinical locations, securing $225,000 in Small Business Innovation Research funding from the National Institute of Health.
SourceChristine Coolick Creative Services, LLC·DateNov 26, 2019
Research from Johns Hopkins University found that chemical herders can amplify strong breaking waves, dispersing oil slicks into the water column. This makes effective burning difficult in open oceans, but less effective when combined with weaker waves.
Researchers found that inflammatory processes triggered by the NLRP3 inflammasome play a key role in emerging tau pathology, a hallmark of neurodegenerative diseases like Alzheimer's. The study suggests that modulating the immune response could be a promising approach for treating these conditions.
SourceDZNE - German Center for Neurodegenerative Diseases·JournalNature·DateNov 20, 2019
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
A team of researchers at Penn State developed a way to control the direction of self-propelled protocells using enzymes that catalyze chemical reactions. The protocells can move towards or away from specific chemical signals, enabling targeted drug delivery and reducing the amount of medication required.
SourcePenn State·JournalNature Nanotechnology·DateNov 18, 2019
Scientists cultivate chemical reactions similar to those found on Earth, using a novel strategy to study the origin of life. The system appears to consume its raw materials, forming feedback loops and self-propagating networks.
SourceUniversity of Wisconsin-Madison·JournalLife·DateNov 14, 2019
The American Chemical Society has identified 10 emerging start-ups revolutionizing the field of chemistry, from pharmaceuticals to green chemistry processes. These companies are addressing global issues such as microcontaminant removal, sustainable materials, and climate change.
SourceAmerican Chemical Society·JournalChemical & Engineering News·DateNov 13, 2019
A recent study by Cold Spring Harbor Laboratory has made significant strides in understanding the role of proteins called TDP-43 in ALS. The researchers found that TDP-43 aggregates in nerve cells can cause a toxic effect, leading to paralysis. This discovery opens up new avenues for developing effective treatments and therapies.
SourceCold Spring Harbor Laboratory·JournalCell Reports·DateOct 29, 2019
A study of 526 older adults found that hospitalizations accelerated cognitive decline, especially for those with more brain pathology. The research suggests that having Alzheimer's-related changes in the brain is bad enough, but being hospitalized adds insult to injury.
SourceRush University Medical Center·JournalAnnals of Neurology·DateOct 22, 2019
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
Research reveals a connection between Alzheimer's disease and metabolic disturbances, including glucose resistance and abnormal sleep patterns. Introducing ApoE2 into cells expressing ApoE4 may reduce metabolic deficiencies, supporting cellular functions and energy metabolism in the brain.