Researchers found that genetic modifications are unlikely to conquer Earth due to natural resistance. Gene drives, like CRISPR/Cas9, can spread quickly but will eventually be outcompeted by natural selection.
The modified Atkins diet has been shown to reduce seizure frequency in children with Doose syndrome by at least 50%. In a recent study, 83% of children experienced this significant reduction, making it an effective treatment option for families affected by this rare form of epilepsy.
A new study from the University of Adelaide found that women's attitudes towards genetically modified (GM) foods are influenced by multiple factors, including science background and values. Women with scientific backgrounds used evidence to support their stance, but others saw 'unknown' risks, leading to a lack of trust in science.
Researchers from Boston University School of Medicine have discovered an efficient way to generate thyroid cells using genetically modified embryonic stem cells. The findings, published in Stem Cell Reports, are the first step towards developing a protocol using human stem cells to model thyroid disease and develop therapies.
The release of genetically modified insects for pest control could lead to contamination in organic crops, harming farmers and eroding consumer confidence. International trade could be disrupted if detected contaminants are met with import bans.
Researchers created a genetically modified rat model of autism and intellectual disability to study Phelan-McDermid syndrome. The study found that oxytocin improved social memory, attention, and nerve cell activity in the rat model.
Researchers at Stanford University and the University of Tokyo successfully transplanted functional mouse islets into diabetic mice, reversing their condition with minimal immunosuppression. The study suggests a potential approach to generate genetically matched human organs in large animals.
Researchers created genetically modified fruit flies containing reconstructed ancient genes to study the evolutionary effects of genetic changes. They found that the accepted wisdom about the molecular causes of the flies' evolution is incorrect, challenging a classic example of adaptation.
Researchers genetically modified mosquitoes to resist infection from dengue virus, boosting their natural ability to fight the disease. The findings could be a prelude to developing a strategy to eliminate the threat of dengue.
Researchers genetically engineered Aedes aegypti mosquitoes to resist dengue fever virus by altering the JAK/STAT pathway, resulting in a 78-83% reduction in viral copies. The modified mosquitos had normal lifespans but produced fewer eggs.
Researchers have created a genetically induced obesity model in fruit flies, shedding light on the brain's 'fullness' signal. The model highlights a hormone called unpaired 1, which plays a crucial role in regulating eating behavior and weight gain.
A clinical trial with human volunteers has found a next-generation malaria vaccine to be well-tolerated and stimulate an appropriate immune response. The vaccine uses genetically attenuated parasites that are incapable of multiplying in the human liver but effectively stimulate the immune system.
Researchers at PNNL have chemically modified sawdust to make it exceptionally oil-attracting and buoyant. The material absorbs up to five times its weight in oil and stays afloat for at least four months, ideal for cleaning oil spills in the Arctic.
A modified rabies virus expressing a protein from the MERS virus protects mice against both diseases. The dual compound could lead to an effective human vaccine for Middle East Respiratory Syndrome and prevent its spread in camels.
Researchers successfully developed a vaccine against influenza using genetically modified live virus that activates the immune system but cannot replicate in healthy cells. The new vaccine proved effective in mice, guinea pigs, and ferrets, offering an antibody response comparable to existing vaccines.
A new survey by Pew Research Center reveals a divide among Americans regarding the health effects of organic produce, genetically modified foods, and eating healthy. While some believe organics are healthier, others see no difference or consider GM foods worse for health.
Researchers used CRISPR/Cas9 to remove an enzyme that regulates the diabetes-associated TXNIP gene, leading to reduced cell death and increased insulin production in genetically modified pancreatic beta cells. The study also found that histone acetyltransferases play a crucial role in regulating the TXNIP gene.
Researchers developed genetically engineered T cells armed with a fusion inhibitor to disrupt HIV's entry process. The C34 peptide was shown to be potent and effective against diverse HIV strains, including those resistant to existing drugs.
Researchers have identified a way to manipulate photosynthesis in plants to increase light-harvesting ability and biomass production. The modified plants outperformed controls by 11-14% under fluctuating light conditions, with greater leaf area and plant height.
A global GMO crop ban would raise food prices by 0.27-2.2% and add nearly a billion tons of CO2 to the atmosphere. This would lead to negative environmental consequences, including forest and pasture conversions that release stored carbon.
Researchers investigate how queuine, produced by gut bacteria, affects breast cancer risk and growth. High levels of queuine-modified tRNAs may speed up protein production in rapidly dividing cancer cells.
A portable device enables medical staff to genetically modify blood stem cells at a lower cost and with reduced staffing requirements. The technology has the potential to make gene therapy more accessible to patients in developing countries, reducing the need for expensive clean rooms.
A modified HIV-1 virus can integrate into the genome of the parasitic flatworm Schistosoma mansoni, a major species of schistosomiasis-causing flatworm. This finding could aid research into potential new treatments for schistosomiasis and related neglected tropical diseases.
Researchers at USC Fertility found modified natural cycle IVF to be a cost-effective fertility method, saving up to $7,000 per live birth compared to conventional IVF. This approach takes less time and is gentler on the body, making it more accessible to younger patients.
Ferns are inaccurately depicted as extreme inbreeders in most biology textbooks, but research suggests this is not the case. New study co-authored by KU researcher Christopher Haufler reveals that ferns use outbreeding to produce genetic variation, contrary to long-held assumptions.
A study by Dartmouth Health found that children genetically predisposed to obesity overeat when exposed to TV food ads. The study showed a significant increase in calorie consumption among children who watched food commercials compared to those who watched toy ads.
A modified casting technique resulted in comparable functional outcomes to surgery at 6 months, while reducing wound complications and intervention costs. The study found no significant differences in quality of life, pain, or mobility between the two groups.
Rice University scientists are building a tool to detect and quantify genetically modified organisms (GMOs) in the environment. The technology uses light transmission spectrometry to identify DNA or proteins from engineered crops and animals, which can have unintended consequences on ecosystems.
Researchers found that increasing satellite cell numbers can increase muscle regeneration and stifle degeneration. Muscles with genetically modified TEAD1-expressing fibers showed a six-fold increase in satellite cells, allowing for faster repair after injury.
Researchers identify peptide allatostatin A in Drosophila that regulates feeding behavior and promotes sleep, with effects comparable to human galanin receptor. The study provides insights into the complex interactions of hunger, sleep and digestion.
Scientists describe a multi-step method to produce broadly neutralizing antibodies in genetically engineered mice, which can recognize multiple HIV mutations. This approach offers a starting point for developing an HIV vaccine that could prevent infection or cure the systemic illness.
Researchers have developed genetically modified male flies that produce only males when mating, suppressing New World screwworm fly populations. The technique could increase the efficiency of sterile insect technique programs and provide a cost-effective solution for controlling livestock pests in tropical regions.
A Case Western Reserve University researcher proposes a framework to address ethical questions surrounding potentially revolutionary research on part-human, part-animal embryos. The researcher suggests prioritizing animal welfare while enabling scientific progress in areas of biomedical importance.
Researchers developed a new technique using modified strains that consume xenobiotic nutrients, allowing them to outcompete other microorganisms. This method enables mass biofuel production without the use of antibiotics, which is poised as a more sustainable energy source.
Researchers at Institut Pasteur have created a live, genetically attenuated vaccine for Plasmodium that triggers a potent immune response and provides long-term protection against malaria. The vaccine uses a mutated gene that boosts the production of an IL-6 cytokine, resulting in a strong cellular and humoral response.
Scientists have developed a new vaccine that stimulates both innate and adaptive immune responses, allowing the body to remember and attack cancer cells. The treatment, called aAVC, uses modified foreign cells that promote the maturation of dendritic cells, key coordinators of the immune response.
Genetically modified tobacco plants lacking jasmonates are more susceptible to insect and vertebrate attacks, with a significant impact on reproductive ability. Rabbits prefer to feed on these plants, peeling the stems and reducing flower production, highlighting the importance of nicotine in plant defense.
Researchers found that blocking acetylcholine in genetically modified mice caused Alzheimer's-like pathology, highlighting the importance of this neurotransmitter for brain health. The study suggests that targeting one of the affected messenger RNA pathways may lead to a reversal of dementia progression.
A study found that genetically raised CRP levels are linked to a reduced risk of schizophrenia. The researchers also discovered associations between elevated CRP and increased risks for arthritis, bipolar disorder, and high blood pressure.
Researchers have designed a new approach to treating B cell malignancies by targeting specific B cell markers with modified T cells. The treatment showed promising results, resulting in complete remission in two patients and stable disease in four others.
A new study from Washington University in St. Louis finds that genetically modified Golden Rice is still years away from field introduction due to scientific challenges. The research suggests that GMO opponents have not been the problem, but rather the rice's inability to yield well and meet its nutritional goals.
Physicists at Lomonosov Moscow State University propose a theoretical model for analyzing the conformational behavior of hydrophobically modified polymer gels in solution. The model explains experimentally observed phenomena and reveals new ways to control gel susceptibility, promising applications in drug delivery systems.
Researchers have modified microalgae to produce complex molecules using sunlight, enabling efficient production of pharmaceutical compounds. The method offers a sustainable and renewable energy-based solution for producing chemicals, potentially replacing traditional methods that rely on plants or yeast.
A new study has found that certain sugars produced by the body play a crucial role in the development of colitis and colon cancer. The researchers genetically modified mice to lack these sugars, revealing that their mucous layer vanished and they developed colitis and a form of colon cancer.
A study by Fatima Maia and her team found that modifying household utensils can increase autonomy and self-esteem among patients with leprosy. Patients reported feeling joyful using modified tools like toothbrushes, pens, and mugs, while also experiencing frustration with remaining limitations.
Researchers at Queen Mary University of London have developed a modified flu virus that can re-sensitize resistant pancreatic cancer cells to chemotherapy. The virus enhances the efficacy of the drug by preventing cancer cells from repairing themselves, leading to increased cell killing with lower doses.
Researchers have identified a core component of a conotoxin from marine snail venom that retains its pain-relieving properties after simplification. This modified conotoxin successfully treated pain in a laboratory rat model similar to human irritable bowel syndrome.
Researchers found that genetically modified cord blood cells carrying VEGF and GDNF transgenes can promote tissue sparing, axonal regeneration, and motor function recovery in rats with spinal cord injuries. The study suggests these cells may be a promising strategy for enhancing posttraumatic spinal cord regeneration.
A new study shows that genetically modified pig hearts developed by US and LMU researchers can survive for more than 2½ years when transplanted into baboons. The findings demonstrate a promising breakthrough in xenotransplantation, with potential implications for human organ transplantation.
Scientists at EMBL have increased the efficiency of gene therapy tool Sleeping Beauty, which is being trialed for therapies targeting B-cell leukaemias and lymphomas. The enhancement results in a 30% increase in efficiency and aims to improve patient outcomes.
The researchers genetically modified cyanobacteria to produce enzymes for basic and fine chemicals, utilizing photosynthesis to supply energy. This approach shows promising potential for industrial applications by reducing unwanted by-products and increasing selectivity.
Cornell University has received a $4.8 million USAID grant to improve genetically engineered eggplant production in Bangladesh and the Philippines. The project aims to increase farmers' livelihoods by reducing yield losses and improving food security.
A Northwestern University study shows that engaging environment can alleviate depression in genetically depressed rats, suggesting that nurture can override nature. The study found that psychotherapy and behavioral activation therapy can change blood biomarkers for depression, potentially leading to more precise treatment.
Researchers at NC State University have genetically engineered green bottle fly larvae to produce and secrete human growth factor-BB, a molecule that promotes cell growth and wound healing. The modified maggots show promise for cost-effective wound treatment that could save people from amputation.
Researchers at the University of Tokyo discovered that calcium ions control sleep duration in mice by regulating the inflow and outflow of calcium ions into neurons. This finding has implications for understanding and treating neurodegenerative diseases associated with sleep disorders.
A study of over 30,000 women found that genetically elevated maternal body mass index and blood glucose levels are associated with higher offspring birth weight. In contrast, elevated maternal systolic blood pressure is linked to lower birth weight.
Scientists have developed a modified form of CRISPR that can silence genes in stem cells more efficiently and precisely than the original CRISPR-Cas9 system. This new technology allows for flexible gene suppression and reversal, enabling versatile investigations into genetic diseases.
Scientists have developed a genetically modified lime that produces anthocyanins, resulting in unique leaf pigmentation, flower coloration, and fruit pulp colors. The discovery opens up opportunities for new citrus fruits, ornamental plants, and potentially health-beneficial fresh produce.
Researchers have found a modified protein that can reverse liver fibrosis and cirrhosis in lab rats. The protein, TRAIL, was coated with a polymer to extend its half-life, allowing it to effectively kill activated hepatic stellate cells and reduce signs of fibrosis.
Kyoto University engineers have developed genetically modified E. coli that produce thebaine, a morphine precursor, 300 times more efficiently than yeast. This breakthrough could lead to the production of painkillers from microbes with low regulatory risk.