A new study published in the Journal of Vascular and Interventional Radiology found that kidney-sparing embolization is associated with lower rates of acute kidney injury and in-hospital mortality compared to nephrectomy in patients with high-grade kidney injuries. The study analyzed 849 cases and found that embolization reduced in-hos...
A nasal spray treatment has shown to provide rapid and effective pain relief for children in emergency departments, with 86.2% of children experiencing reduced pain 30 minutes after treatment. The treatment was well-tolerated with mild side effects, offering a simple and effective option for treating children in the emergency department.
E-scooter trauma admissions increased 92% from 2021 to 2023, with young riders sustaining more severe injuries. Helmet use was documented in only 12% of cases, and nearly two-thirds of injured riders under 16 sustained major injuries. Researchers call for increased caution and awareness among e-scooter riders, particularly children.
Researchers developed a gene-delivery system that converts reactive astrocytes into functional neurons, improving motor recovery in mice and rats. The system, TRANsCre-DIONE, selectively targets scar-forming cells and reprograms them into neurons, which generate nerve impulses and receive signals from other neurons.
A new system for anatomical guidance in ultrasound helps novice users locate the correct views more reliably during trauma examinations. The system combines a predictive anatomical model with real-time imaging and mixed-reality guidance to aid probe placement and movement.
A targeted quality improvement campaign by University of Cincinnati emergency medicine physicians safely reduced unnecessary head and cervical spine CT scans in low-risk trauma patients, saving patients $6.2 million in healthcare costs and avoiding significant radiation exposure. The campaign, which included continuing education sessio...
Researchers identified a natural antibody, anti-NMDAR1, that may protect the brain after traumatic brain injury, reducing the risk of depression and PTSD. The study found that Marines with higher levels of the antibody had lower depression and PTSD symptoms after a TBI.
A portable handheld terahertz three-dimensional spectral scanner has been developed to diagnose burn wounds and predict wound-healing outcomes. The device uses an asynchronous optical sampling system to achieve short scan times and can acquire three-dimensional spectroscopic images in the terahertz range.
A national study of over 230,000 pediatric trauma patients found that signs of hemodynamic instability may appear earlier than current standards indicate, highlighting the need for more accurate blood pressure thresholds. The study suggests that clinicians may need to recognize and respond to signs of circulatory instability at higher ...
New research from Texas A&M University suggests that younger brains may be more vulnerable to post-traumatic epilepsy after traumatic brain injury, despite their flexibility to adapt. Older brains showed fewer signs of epilepsy but were vulnerable to neuroinflammation, circuit remodeling, and memory loss.
UVA researchers James Stone and Matthew Panzer contributed to the NATO guidelines, which provide practical recommendations to protect service members from blast-related brain injuries. The guidelines aim to reduce soldiers' risk of suffering blast-related brain injuries by balancing immediate protection with a roadmap for future research.
A new study investigates the effects of a multimodal intervention combining individualized neuromodulation with functional training on supraspinal functional characteristics and sensorimotor function in individuals with chronic ankle instability. The intervention, which includes transcranial direct current stimulation and functional co...
A new University of Pittsburgh study found that low-frequency deep brain stimulation improves control of facial and tongue muscles involved in speaking and swallowing after traumatic brain injury. The treatment showed small but significant improvements in word intelligibility for one participant with TBI.
A new paper by the American College of Surgeons Committee on Trauma recommends making automatic crash notification (ACN) and advanced automatic crash notification (AACN) systems standard safety features in every new vehicle. These systems can provide critical information to emergency responders, such as the vehicle's location and poten...
A global study suggests that traumatic brain injury causes vary widely worldwide, with motor vehicle crashes being the biggest single cause globally. The study found that causes of traumatic brain injury differ by country, with high rates of ground-level falls among older adults in wealthier countries.
A clinical trial found that refrigerated platelets stored for up to 21 days are just as effective as room-temperature platelets in treating bleeding patients. This discovery could extend the lifespan of platelets by nearly 4-fold, reducing waste and improving access to lifesaving therapy.
A cross-sectional study in US traffic fatalities found a significant association between major music album releases and increased traffic fatalities, potentially attributed to distracted driving. The study suggests that online music streaming through smartphones may contribute to this risk.
Researchers from Hebei Medical University review current evidence on prolonged disorders of consciousness (pDOC) management. They propose a brain communication network model to explain how brain injury leads to long-term unconsciousness, identifying key brain electrical signaling activity measures for diagnosis and treatment.
Studies in Pakistan's trauma registry found that traumatic brain injuries are associated with high death and disability rates long after the initial injury, even in moderate cases. Patients remain vulnerable during hospital discharge transition.
Patients with severe traumatic brain injury in resource-limited settings are at higher risk of mortality. The study highlights the need for improved acute and postdischarge care to reduce mortality rates.
A recent study published in the Emergency Medicine Journal found nearly 500 children were injured by e-scooters between 2019 and 2024. Most injuries occurred due to falls or collisions with vehicles, highlighting the need for clearer public health messaging and regulation.
The US FDA has cleared Eve, the first self-balancing personal exoskeleton, enabling eligible adults with spinal cord injury to walk and perform daily activities hands-free. Participants reported improvements in health status, psychological well-being, and quality of life, demonstrating substantial clinical relevance.
A qualitative study reveals multilayered health care barriers faced by Afghan refugee women in the US, including displacement-related trauma and sociocultural norms. Culturally sensitive public health interventions are needed to improve healthcare access for these women.
Researchers examine how chronic stress, trauma, and violence shape physical health and well-being across the lifespan. The editorial highlights a special issue of 16 empirical papers synthesizing research on childhood adversity, protective factors, and biological embedding of trauma over time.
Adults with type 2 diabetes have a high risk of fragility fractures, but new research found GLP-1 receptor agonists reduce this risk by 21% compared to DPP-4 inhibitors. The largest reductions occurred in hip, femur, and spine fractures.
A cohort study identified risk factors for bacterial infection after firearm injury and found an association between bacterial infection and increased mortality among US adults. The study assesses the impact of firearm injuries on health outcomes in this population.
A preliminary study found that people taking Prozac after a traumatic injury reported fewer PTSD symptoms and lower pain levels in the year following their injury. The study suggests that preventative medical interventions could reduce the formation of post-traumatic stress disorder symptoms.
Researchers describe microneedles as a minimally invasive platform for precision health, offering timely progress in multifunctional systems for wearable devices and intelligent healthcare. Despite challenges to be overcome, the technologies hold promise for more precise, convenient, and individualized healthcare solutions.
A recent study published in JAMA finds that nicotine e-cigarettes are an effective treatment for smoking cessation. The research suggests that e-cigarettes can help reduce the harms of cigarette smoking and support evidence-based pharmacologic treatment for smokers seeking to quit.
This study analyzed 9845 Ukrainian refugee children aged 5 and under in Southern Poland, identifying 5 distinct health care utilization profiles. The findings suggest that refugee-hosting countries must prioritize emergency and inpatient care following a crisis to rapidly adapt health care resources.
A new Global Burden of Disease study found that people are spending more years living with chronic disease and disability as global life expectancy increases. The analysis revealed that high-income countries face the widest morbidity gaps, while women consistently live longer but spend more years in poor health.
Global road injury rates declined by 38.3% for new cases and 32.3% for deaths between 1990 and 2023, but progress was uneven across income groups. Low- and middle-income countries bear the greatest burden, with nearly six times higher mortality rates than high-income countries.
Researchers at Texas A&M University have found a way to intervene early in traumatic brain injuries using a natural, gut-derived chemical that prevents post-traumatic epilepsy from taking root. The treatment reduced brain inflammation, improved memory and mood, protected brain cells, made seizures both rarer and harder to trigger.
A specific subgroup of neutrophils signals the immune system to dial down its response, allowing regeneration. The study shows that the fine regulation of inflammation is crucial for healing and that unleashing the right signals can reactivate nerve regeneration.
A scoping review suggests astrocytic dysfunction may precede neuronal degeneration in CTE. Astrocytes' dysregulation contributes to the development of CTE's characteristic features through mechanisms including astrogliosis, disrupted waste clearance pathways, and chronic neuroinflammation.
Pedestrian deaths in New York State show that nearly half involved substance use, leading researchers to call for more public health messaging on walking while under the influence. Substance use is particularly concerning when combined with alcohol, increasing cognitive impairment and neurocognitive deficits.
Glial cells play critical roles in determining brain recovery after TBI, and researchers have identified ways to selectively modulate their functions. The study highlights the importance of coordinated cellular behavior and suggests that targeting glial responses could lead to effective therapies.
Recent studies suggest that p16INK4a+ cells, previously thought to be non-beneficial due to their association with aging, actually contribute to tendon regeneration. These mesenchymal cells produce collagen and factors promoting new blood vessel and nerve growth, crucial for normal tendon function.
A nationwide China study analyzed 695,142 hospitalized patients and identified eight life-stage pathogen profiles, three co-detection networks, and marked male predominance in bacterial and fungal infections. The study found distinct shifts in microbes across infancy to old age, accompanied by sex disparities.
A new study published in the Canadian Medical Association Journal found that older adults discharged from hospital with a new prescription for sedatives are at increased risk of falls, further need for acute hospital care, and death within 30 days. The study looked at over 1.86 million adults aged 66 years and older and found a 20% hig...
A new study by Northwestern Medicine found that patients with severe injuries from car crashes are 70% less likely to be transferred to another hospital in states with no-fault insurance laws. This is because policies guarantee reimbursement for trauma care, incentivizing hospitals to keep and treat seriously injured patients.
Researchers discovered biomarkers indicating overactivity and dysfunction in the immune system, which can lead to chronic critical illness. Identifying these markers could allow doctors to intervene earlier, leading to shorter ICU stays and improved patient outcomes.
Researchers developed a pH-triggered nanocomposite that synchronizes the release of therapeutic agents, combating bacterial biofilms and oxidative stress. The platform accelerates healing and promotes tissue repair in infected wounds.
The University of Louisville has opened an expanded Pediatric NeuroRecovery Center, featuring state-of-the-art facilities and increasing treatment capacity by 33%. The center provides life-changing therapies to children with spinal cord injuries, accelerating recovery and expanding access for those in need.
A study published in the Canadian Medical Association Journal found that female patients with traumatic brain injuries are 26% less likely to be admitted to specialized trauma centers than males. This disparity persisted even after adjusting for factors like age, severity of injury, and other health conditions.
A new study by UC San Francisco found that women with HIV are more likely to die from preventable trauma-related conditions like substance use and mental illness. The researchers say these causes are largely missing from official death records, highlighting the need for broader goals in HIV care beyond just controlling the virus.
Researchers at UC Riverside link immune signaling to disrupted brain function and cognition after concussion, finding a crucial link between TLR4 and MMP-9. Blocking these pathways may limit changes in brain circuits and improve long-term neurological outcomes.
A recent study published in JAMA found that high-dose intravenous vitamin C did not reduce mortality and persistent organ dysfunction in patients with severe burn injury. Instead, the treatment may be harmful, suggesting alternative approaches for managing burn-related complications.
Adults with lower measured glomerular filtration rates had a higher risk of all-cause mortality, kidney failure, and major adverse cardiovascular events. Lower GFR values were also associated with increased hospitalization for heart failure and acute kidney injury.
A new monitoring system, NeuroSense, tracks cerebrospinal fluid at the bedside for faster intervention in intensive care units. The system detects biomarkers of infection and flow rate, enabling early warning of complications and better treatment decisions.
A cohort study found that introducing immunity in US nursing homes was associated with lower overall staffing and staff-to-resident time. During the COVID-19 pandemic, many states adopted immunity from tort liability for harms to nursing home residents.
Scientists have created a miniature circuit that mimics the brain and spinal cord connection, showing that previously thought irreversible nerve damage can be reversed. The researchers found that blocking specific genes in mature neurons restored axon regrowth ability.
A national analysis found that robotic-assisted cholecystectomy remained linked to increased bile duct injury risks despite growing use. The study suggests small differences in overall complication rates between approaches.
Researchers found that a high arm slot and torso tilt put the most demand on the UCL, but make mechanical changes could help pitchers reduce injury risk. The study reveals that controlled pitching delivery can minimize elbow stress and produce lower speeds.
Researchers from Zhejiang University present a comprehensive overview of stem cell-based strategies for treating traumatic brain injury. The study explores the therapeutic effects of stem cells, exosomes, and biomaterial scaffolds in promoting brain repair and functional recovery.
A new study published in the British Journal of Sports Medicine found that children who received early, tailored care experienced significant improvements in recovery from concussion. The intervention combined education, physiotherapy, and psychological support, resulting in a 62.5% full recovery rate compared to 37% for those receivin...
Researchers develop an AI framework to accurately predict RNA splicing and isoform usage, addressing the need for better management strategies in patients with Hutchinson-Gilford Progeria Syndrome. The study highlights the importance of multidisciplinary coordination and prompt decision-making in this high-risk population.
A nationwide trial found that giving whole blood or its component parts to patients with severe bleeding before arriving at the hospital is equally effective. The study, which included over 1,000 patients, also showed no difference in outcomes between newer and older blood within a certain time frame.
Children and adolescents in Gaza who suffered penetrating traumatic brain injury during armed conflict experienced substantial morbidity and mortality. Survivors often endured neurological impairments and long-term psychosocial challenges.
A study by University of Pennsylvania researchers found that 75% of individuals meeting TES criteria did not have CTE pathology at autopsy, highlighting the risk of misdiagnosis and potential mental health impacts. The proposed criteria may miss some people with CTE while incorrectly identifying others who do not have the disease.