Articles tagged with Hematology
A phase 3 clinical trial found romiplostim significantly reduced chemotherapy dose delays and improved platelet counts in patients with gastrointestinal cancers who developed persistent low platelet counts during treatment. The therapy enables patients to maintain chemotherapy intensity, potentially preserving the integrity of cancer c...
A study by Yale School of Medicine found that 60% of physicians who treat sickle cell disease reported burnout, compared to 43% of those who do not. The data also showed that less job pride and less recreation time were associated with increased burnout.
A large venous thrombosis trial has found that apixaban is safer than rivaroxaban, with 3.3% of participants experiencing clinically relevant bleeding compared to 7.1% with rivaroxaban. This trial has significant implications for clinical practice and patient care.
A large registry study identifies a specific genetic mismatch linked to severe acute graft-versus-host disease (aGVHD) after cord blood transplantation, tripling the risk of life-threatening complications. Researchers found that a particular HLA combination in donors and recipients increased aGVHD risk by threefold.
A nationwide study found that periods can trigger severe pain in many women and girls with sickle cell disease, leading to emergency department visits and hospitalizations. The study's authors recommend a routine menstrual history screening as part of annual sickle cell care and connecting patients with reproductive health specialists.
A group of nerve cells in the brainstem has been identified as a stabilizing system for blood pressure, preventing fluctuations between daily activities. The study suggests that loss or dysfunction of these cells can lead to unstable blood pressure and is associated with conditions such as multiple system atrophy.
A study found that ultra-endurance running damages red blood cells, reducing their ability to carry oxygen and nutrients. The damage accelerates the aging and breakdown of these cells, with longer races leading to greater damage.
The National Comprehensive Cancer Network has published new guidelines for Pediatric Soft Tissue Sarcomas, highlighting the unique characteristics of this childhood cancer. The guidelines focus on rhabdomyosarcoma (RMS), a subtype with varying genetic changes that influence treatment outcomes.
The American Society of Hematology released guidelines for frontline and relapsed/refractory management of acute lymphoblastic leukemia (ALL) in adolescents and young adults (AYAs), outlining optimal approaches to treating high-risk patient populations. The guidelines highlight the need for additional research on immunotherapies and tr...
Researchers have developed an open-source pressure myography tool, HemoLens, which reduces the cost of vascular research to $750 from $40,000. The tool uses affordable manufacturing processes and customizable components, making it easier for researchers to study vascular function.
The American Society of Hematology released guidelines on the diagnosis of light chain (AL) amyloidosis, a rare and life-threatening disease of the bone marrow. The guidelines outline best practices for diagnosing the disorder, which typically takes about three years to diagnose.
A study published in EBioMedicine found changes in blood samples from almost 1,000 people hospitalized for COVID-19 may pinpoint patients at risk of long-term lung disease. The study identified elevated levels of certain molecules, which could lead to the development of simple blood tests to detect ongoing lung problems.
Researchers identify circulating extracellular vesicles produced in diseased kidneys as the culprit behind toxicity in the heart. The discovery could lead to the development of a blood test to identify patients at high risk for serious heart problems and novel treatments to prevent and treat heart failure.
A single dose of IV iron dextran is the most cost-effective treatment option for women with heavy menstrual bleeding and iron deficiency anemia. The study found that IV iron dextran improves quality of life and reduces costs compared to oral ferrous sulfate.
Researchers at Kanazawa University have developed a new combination therapy that combines CAR-T cell therapy with a SUMOylation inhibitor, which effectively suppresses MYC activity and slows the growth of Burkitt's lymphoma cells. The approach extends survival rates in mouse models by up to 80%.
Chromatin accessibility maps reveal that MDS stem cells gradually lose their normal identity and acquire characteristics typical of myeloid progenitors. A 'progenitor score' developed by the team tracks cell movement toward a progenitor-like state, correlating with disease severity and prognosis.
NEJM Clinician curates highly relevant clinical insights from over 150 peer-reviewed journals to give physicians clear guidance without the noise. The weekly publication delivers summaries and commentary in a concise, 30-minute read, helping healthcare providers stay informed and confident in their decisions.
Researchers present phase 1 study results of rapcabtagene autoleucel, a rapid CAR-T cell manufacturing platform that reduced production time to under two days. The treatment showed a manageable safety profile and promising antitumor activity, with complete remission rates ranging from 70% to 100% in patients.
Researchers at the University of Cincinnati present a new BTK degrader called Bexobrutideg, showing an 83% overall response rate in relapsed CLL patients. The treatment also shows efficacy in patients with CNS involvement and those with BTK mutations that none of currently approved BTK inhibitors are effective against.
Renuka Iyer, a leading oncologist with extensive experience in cancer care and research, has been appointed as the new Chief Medical Officer of the National Comprehensive Cancer Network. She will oversee the development of evidence-based guidelines for cancer prevention and treatment.
Researchers from Mass General Brigham Cancer Institute present promising new treatment options for acute myeloid leukemia, autoimmune bleeding disorders, and multiple myeloma. The studies show improved event-free survival, higher overall response rates, and better quality of life for patients treated with novel therapies.
Researchers from Penn Medicine will present data on latest advances in blood cancer and classical hematology research at the 67th American Society of Hematology Annual Meeting. The presentation includes updates on preclinical, clinical, and population-based research, as well as a multicenter Phase II study and a randomized phase III tr...
Serum markers such as NLR, PLR, ESR, LDH, ALP, creatine kinase-BB, SUA, CRP, and CA 15-3/27.29 have been linked to breast cancer diagnosis, prognosis, and therapeutic monitoring. These biomarkers offer affordable, non-invasive, and accessible diagnostic strategies for bridging the diagnostic gap in low-resource settings.
A new study found that engasertib reduced nosebleed frequency and duration in patients with hereditary hemorrhagic telangiectasia (HHT), a rare inherited bleeding disorder. The trial also showed improved symptoms and safety profile for the drug, paving the way for its potential use as a treatment option.
A recent study found that young donors (18-35 years old) with minor HLA differences can provide better survival rates and outcomes compared to older sibling donors. Additionally, gender and CMV status also play a role in donor selection.
Researchers have developed a system called CytoDiffusion that uses generative AI to study the shape and structure of blood cells. The system can accurately identify normal blood cell appearances and spot unusual or rare cells that may indicate disease, outperforming existing systems in tests.
A University of Delaware study uses robotic testing to gauge perception-based movement in stroke survivors, revealing hidden sensory losses. The researchers hope their findings will encourage clinicians to integrate precision testing into assessments, leading to a personalized medicine approach to treatment.
A new study by Carnegie Mellon University's Wood Neuro Research Group uses advanced brain imaging and a digital visualization tool to better understand how pain is processed in the brain for people with sickle cell disease. The team found that patients had reduced connectivity across key brain networks linked to pain perception, partic...
City of Hope experts will highlight advances in blood cancer research, cellular therapies, and precision medicine at the 2025 American Society of Hematology Annual Meeting and Exposition. The meeting will feature over 105 sessions covering topics such as CAR T cell therapy, transplant innovations, and precision medicine.
A biomarker study found that low placental growth factor (PlGF) levels can predict early-onset preeclampsia in pregnant women with sickle cell disease. The researchers identified a PlGF threshold of 87 pg/mL at 20-24 weeks as effective for predicting early-onset preeclampsia and late-onset preeclampsia, respectively.
Mikkael Sekeres has been elected to the Executive Committee of the American Society of Hematology (ASH), a four-year term starting after the 2025 ASH Annual Meeting. He will help strengthen the organization's mission in shaping the future of hematology.
Epithelioid hemangioendothelioma is a rare and potentially malignant vascular tumor that can be mistaken for benign conditions. A new case report highlights the diagnostic challenges raised by rare tumors and emphasizes the need for vigilant evaluation of slow-growing swellings.
The ASAP study found that transplantation as soon as possible does not provide a survival advantage over remission induction, but reduces hospital stays and chemotherapy exposure. Age and AML genetics are the most important risk factors influencing survival.
A new dual-imaging system simultaneously maps retinal structure and capillary oxygen levels in live mice, allowing researchers to study vision-threatening diseases like glaucoma and diabetic retinopathy. This non-invasive approach offers a powerful tool for elucidating local capillary values and tracking changes in retinal oxygenation.
Researchers at Northern Arizona University are developing a breakthrough tool to detect early signs of Alzheimer's disease. The new technology uses microvesicles in the blood to identify biomarkers indicating improved neuroplasticity, which can help track the disease's progression.
Researchers at Salk Institute and UC San Diego have identified a unique sugar called HSAT as a potential therapeutic target for slowing tumor progression and metastasis in pancreatic ductal adenocarcinoma. Boosting HSAT levels may slow the formation and spread of pancreatic cancer, leading to improved survival rates among patients.
A study published in The New England Journal of Medicine found that nearly 4 million children and adolescents were at higher risk of developing blood cancers due to radiation exposure from medical imaging. The researchers estimated that up to 10% of pediatric blood and bone marrow cancers may be attributable to radiation exposure.
Treatment with exagamglogene autotemcel (exa-cel) leads to clinically meaningful improvements in overall quality of life for patients with severe sickle cell disease and transfusion-dependent beta thalassemia. Patients experience substantial improvements in physical, social, functional, and emotional well-being, with sustained benefits...
The study found that only 16% of newly diagnosed patients with MDS on Medicare received HMAs during the period analyzed, with women and non-white patients being less likely to start treatment. The analysis suggests that making changes with existing therapies and administration can have a huge impact on improving outcomes in high-risk MDS.
St. Jude receives its third consecutive Magnet designation and first Magnet Designation with Distinction, recognizing its commitment to exceptional nursing care and patient outcomes. The hospital's nursing programs, including the Nurse Residency Program and Center of Advanced Practice, have contributed to its success.
A study found that immunoglobulin replacement therapy was ineffective in reducing serious infections requiring hospitalization among CLL patients. Despite increasing use of the therapy, infection rates remained high, highlighting a need for better clinical guidelines and evaluation of treatment duration.
A study from The University of Tokyo predicts HSC quality based on real-time cellular behavior using advanced imaging technology and machine learning. The researchers discovered previously hidden diversity within HSC populations and found that kinetic features could predict the expression levels of a key gene related to 'stemness'.
A new case report describes the use of extracorporeal blood filtration to treat stage IV poorly differentiated pancreatic adenocarcinoma. The patient experienced clinical improvement, reduced pain, and no signs of new tumor growth over 12 months of follow-up.
ADLM 2025 will tackle urgent topics like clinical AI integration and fake medical news, as well as leveraging genomics for personalized healthcare. The meeting also explores the health threat of plastics and microbiome medicine to combat diseases.
A new treatment approach using cyclophosphamide has been found to prevent most graft-versus-host disease in mismatched transplants. The study shows that 80% of patients are alive after a year, similar to outcomes seen in fully matched transplants.
A recent study found that blood cancer patients achieve good outcomes with a partial match drawn from the national public registry of donors when treated with cyclophosphamide. Survival rates at one year were comparable to those seen in other studies with fully matched donors.
The Association for Molecular Pathology (AMP) has announced the election results for 2026-2027 leadership positions, including President-Elect Yassmine M.N. Akkari and Secretary-Treasurer Jonathan A. Nowak. The newly elected leaders will drive AMP's mission to advance molecular diagnostics.
Nancy A. Speck has been recognized for her groundbreaking research on hematopoiesis and leukemogenesis, with a focus on the transcription factor complex core binding factor. Her work has provided critical knowledge to understand how certain blood cancers develop, leading to significant insights in embryonic blood cell formation.
The new guidelines aim to improve health outcomes by providing evidence-based recommendations for managing VTE in children. Direct oral anticoagulants are now recommended as a first-line treatment option in many cases.
Researchers have identified Clusterin as a novel marker capable of functionally categorizing aged HSCs. Clu-positive HSCs showed an increased propensity towards differentiating into platelets or myeloid cells, while Clu-negative HSCs maintained a balanced cell production approach typical of younger stages.
A new study published in the Journal of Child Psychology and Psychiatry reveals that childhood trauma significantly increases the likelihood of engaging in risky behaviors, including harmful alcohol consumption, smoking, and illicit drug use. The research also found an unexpected connection between trauma and cardiovascular health, wit...
Researchers at TUM developed an AI-powered algorithm to predict kidney damage in prostate cancer patients undergoing lutetium-177 PSMA therapy. Early detection could enable personalized treatment adjustments to prevent organ damage.
Patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) taking statin medications at the start of treatment had a significantly lower risk of dying from their cancer. Statin use reduced death rates by 61% compared to non-statin users.
A real-world study of 2,147 children with sickle cell disease found that hydroxyurea reduced emergency department visits by 0.36 fewer times per patient-year and hospital stays by 0.84 fewer days per patient-year. Improvements in hemoglobin concentration were seen only in patients who consistently took the medication.
Researchers have discovered a significant increase in inflammation and C-reactive protein levels in female patients with sickle cell disease during the follicular phase of their menstrual cycle. This finding may help identify potential targets for managing pain crises, particularly when combined with hormonal contraceptives.
A new machine learning model improves risk assessment for patients with myelofibrosis seeking a transplant, identifying high-risk patients with a 40% chance of dying within a year. The open-access model provides a practical tool for clinicians to enhance shared decision-making with their patients.
A new study found that white blood cells that remember past inflammation events are quick to overreact, raising the risk of blood clots. Researchers discovered that these immune cells, called myeloid cells, have increased blood-clotting activity long after the initial inflammatory event.
A team of researchers has identified a new chronic blood clotting disorder, VITT-like monoclonal gammopathy of thrombotic significance (MGTS), characterized by antibodies similar to those causing vaccine-induced immune thrombocytopenia and thrombosis (VITT). The disorder can lead to severe symptoms despite treatment with full-dose bloo...
A new case report reveals a rare and aggressive form of leukemia developing from donor cells nine years after a stem cell transplant. The disease, driven by genetic mutations in key genes, progresses despite intensive treatment and ultimately proves fatal.
A systematic literature review found no evidence to support a link between physical exertion without rhabdomyolysis or heat injury and sudden death in individuals with sickle cell trait. The review's findings refute the attribution of sudden death to SCT, a condition affecting over 100 million people worldwide.