Articles tagged with Immunization
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A recent study found that respiratory syncytial virus (RSV) hospitalizations are associated with a higher risk of cardiorespiratory events, with some conditions experiencing elevated risks up to 180 days after admission. The findings highlight the importance of increasing RSV immunization in adults to mitigate this risk.
A population-based surveillance study found both maternal RSV vaccine and nirsevimab effective in protecting infants from RSV hospitalizations. The studies results show that these products reduced RSV-associated hospitalization rates in newborns and infants under 11 months by up to half compared to previous seasons.
A study published in JAMA found that nirsevimab was associated with lower risks of RSV-related hospitalization and severe outcomes compared to maternal vaccination with the RSVpreF vaccine. These findings suggest a potential benefit for passive infant immunization with nirsevimab in reducing RSV-related complications.
Revising newborn hepatitis B vaccination guidelines may lead to increased perinatal infections, according to infectious disease experts. The study estimates that revoking the policy could result in a significant number of new infections.
A new study suggests that expanding seasonal immunization access could minimize off-season RSV epidemics, with higher rates of hospitalizations in urban areas compared to rural communities. Providing year-round access to RSV immunization would be more risk-averse and minimize risks of large seasonal outbreaks.
Two new Cochrane reviews show that HPV vaccines are effective in preventing cervical cancer and pre-cancerous changes, especially when given to young people before they are exposed to the virus. Girls vaccinated before the age of 16 were found to be 80% less likely to develop cervical cancer.
The American College of Physicians (ACP) has issued new influenza vaccine practice points that recommend standard-dose trivalent or quadrivalent vaccines for healthy adults aged 18-64, and high-dose trivalent or quadrivalent vaccines for those 65 years old. The guidelines aim to prevent seasonal epidemics caused by highly infectious fl...
In response to rising RSV cases, ECDC advises policymakers and public health authorities on effective ways to mitigate the impact of RSV disease in infants. Immunisation interventions, including long-acting monoclonal antibodies and maternal vaccines, can prevent severe illness and hospitalization.
A European study found that long-acting monoclonal antibody immunisation effectively prevented hospitalisation due to RSV infection among children under two years old. The overall immunisation effectiveness was 79%, with a decline in protection over time, highlighting the need for ongoing monitoring.
Leading experts urge universal hepatitis B vaccination for all newborns in the US, citing a 95% decline in infant infections since 1991. The policy has prevented an estimated one million hospitalizations and 90,000 deaths.
A recent study found that 90% of people in BC's Lower Mainland have detectable antibodies against measles, indicating high vaccine coverage and population protection. However, the study also found lower immunity rates among older adults, with only 75% of those aged 20-39 having measurable antibodies.
The National Association of School Nurses reaffirms its commitment to school immunization requirements, citing the life-saving role of vaccines. The updated position statement recommends eliminating vaccine exemptions except in medical contraindications, emphasizing the importance of timely and complete vaccinations.
A Dutch study found that vaccination coverage among children declined faster in households with lower income and those not attending daycare. The study, which analyzed over 2 million children, identified sociodemographic factors contributing to the decline, including parental education and migration background.
A new study models the impact of MMR vaccination strategies on measles outbreaks in Texas, highlighting the critical role of improving immunization rates. The findings suggest that increasing vaccine coverage can significantly reduce the risk of large-scale measles outbreaks.
The IMPACT-CETR aims to develop preventive strategies against antibiotic-resistant pathogens Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae. The project seeks to harness immunity in these bacteria to prevent infections and reduce the emergence of resistance.
A recent study found a sharp increase in hospitalisations for pertussis among children and adolescents in Tuscany, Italy, between 2016 and 2024. The study emphasizes the critical role of timely vaccination administration to prevent further cases and hospitalisations.
The American College of Cardiology recommends flu, COVID-19, RSV vaccinations and others for adults with heart disease to reduce risks of infection, hospitalization, and death. Vaccination has been shown to be highly effective in reducing these risks, yet only 30% of primary care physicians assess patients' vaccination status.
A new study finds reported conflicts of interest on CDC vaccine panels had been at historic lows for years before Kennedy's dismissal. The type of conflict typically considered most concerning, income from vaccine makers, was virtually eliminated among panel members.
The new book explores organoid bioengineering, using pluripotent and adult stem cells to create models for various organs. It discusses breakthroughs in personalized cancer care and large-scale production protocols supported by advanced tools like 3D printing and genome editing.
A modeling study finds that COVID-19 vaccination is more cost-effective for individuals aged 65 and above, with favorable results across different parameter input scenarios. The study's findings support the Advisory Committee on Immunization Practices' decision to recommend vaccination with the 2023-2024 mRNA vaccines.
Despite improvements in childhood immunization coverage, many African countries are unlikely to meet global targets by 2030. The study found that socioeconomic inequalities persist in coverage, with significant gaps between wealth quintiles.
The European Centre for Disease Prevention and Control (ECDC) emphasizes the need for high immunization coverage to protect European populations from diseases like measles and polio. Vaccination remains a crucial tool in public health, with recent data showing a tenfold surge in reported measles cases in the EU/EEA.
Scientists at Sanford Burnham Prebys developed a new method of generating antibodies by fusing two immune system proteins, enabling the creation of stable monoclonal antibodies. This breakthrough has potential applications in diagnosing and monitoring diseases such as lupus and cancers.
The reemergence of dengue virus serotype 3 (DENV-3) in Brazil could worsen fresh outbreaks as the population is not immunized against this serotype. Researchers found a rise in DENV-3 cases since late 2023, with 31 blood samples testing positive for the virus.
Researchers created new proteins using AI that bind to and neutralize deadly snake toxins, providing a safer alternative to traditional antivenoms. The study's results show an 80-100% survival rate in mice, offering potential benefits for people in developing countries.
The study utilized biocompatible polymethyl methacrylate microspheres for controlled antigen delivery, demonstrating improved immunogenicity of tetanus toxoid. Microsphere formulations showed significant immune response, with optimal polymer concentrations required to meet I.P. requirements.
Researchers developed biocompatible polymethyl methacrylate microspheres for controlled antigen delivery. The formulation resulted in efficient uptake by macrophages and other antigen-presenting cells, eliciting a notable immune response.
Early data from Luxembourg's national immunisation campaign against severe respiratory syncytial virus (RSV) in 2023 showed a decline in hospitalisations, especially among infants under six months old. The authors attributed this to the administration of a monoclonal antibody, nirsevimab, shortly after birth. Additionally, the mean age...
A study analyzed Google Trends data to assess the impact of immunization and the COVID-19 pandemic on varicella cases in Europe. The research found a significant decrease in chickenpox cases across the region, suggesting suppressed transmission during the pandemic.
CHOP researchers have identified variants of a chaperone molecule that can enhance the loading of peptides across different HLA types, which could be used in cell therapy and immunization applications. The study found that chicken-derived TAPBPR proteins can react with multiple HLA allotypes and stabilize the empty MHC-I groove, boosti...
Researchers developed a new prototype treatment using a human antibody that neutralizes neurotoxins from African and Asian elapid snakes, with potential for broader cross-reactivity. The treatment showed promising results in preventing death from venom envenoming in mice.
There were significant increases in HPV vaccine administration among commercially insured adults aged 27 to 45 following the Advisory Committee on Immunization Practices' recommendation change in 2019. This trend is attributed to shared decision-making between patients and clinicians.
Researchers attribute low vaccination rates in children to misconceptions about vaccine safety and Covid-19 vaccines. Misinformation about vaccine safety predicts reluctance to vaccinate both adults and children.
Researchers found that a 'slow delivery, escalating dose' vaccination strategy can prompt B cells to spend months mutating and evolving their antibodies, leading to more effective long-lasting vaccines. This breakthrough has implications for vaccines against pathogens like influenza, malaria, and SARS-CoV-2.
A new study found that individuals with low confidence in the importance of vaccination are five times more likely to remain unvaccinated. Rural areas and those with lower socioeconomic status also had higher prevalence of non-vaccination across all regions.
A population-based retrospective cohort study found that COVID-19 vaccination during pregnancy is not associated with an increased risk of preterm birth, small for gestational age at birth, or stillbirth. The study concluded that COVID-19 vaccination during pregnancy can inform evidence-based decision-making about its safety.
A large Canadian study found no association between Covid-19 vaccination during pregnancy and increased risks of preterm birth or stillbirth. The study analyzed data from over 85,000 births and concluded that vaccination is effective against Covid-19 in pregnant individuals and their newborns.
A new study found that countries with greater universal health coverage had smaller declines in childhood immunization coverage during the COVID-19 pandemic. Countries with a high UHC index had an average childhood immunization coverage rate of 92.7% compared to 86.2% in those with lower UHC indices.
The UK's Joint Committee on Vaccination and Immunisation advises that COVID vaccines should be offered to 5–11-year-old children, but deem immunization as non-essential. Dr Hamid Merchant explains why current vaccines are not suitable for children due to efficacy and safety concerns.
A new study analyzing 8 cohorts of COVID-19 patients found that antibody responses in previously infected individuals were relatively stable, providing protection from reinfection unless the new infection was the Omicron variant. Vaccination also boosted protection, with rapid immune responses observed even after a single vaccine dose.
Two projects aim to vaccinate 40,000 and 60,000 people in Ethiopia against cholera, using the OCV vaccine developed by IVI. The mass vaccination campaign will also establish a disease monitoring system to strengthen local public health capabilities.
Researchers found that a single mRNA vaccine booster shot can provide the same level of protection as three doses, making it a promising investment for resource-poor countries. The study suggests that this strategy could benefit billions of people worldwide and help combat emerging COVID-19 variants.
A new grant will help Missouri parents make informed decisions about vaccinating their children against various diseases. The grant aims to provide factual, evidence-based information to address common concerns and promote public health outcomes.
The 100-year-old BCG vaccine has been found to protect newborns and young infants against multiple bacterial and viral infections, including COVID-19. The study identified changes in metabolite and lipid profiles that correlate with innate immune system responses.
Researchers at the University of Kansas have discovered a promising new basis for active immunization against Alzheimer's disease. By injecting a recombinant methionine-rich protein into mice with the disease, they were able to improve short-term memory and learning abilities by up to 50%. The treatment also showed potential in reducin...
A study across eight European countries found that conventional vaccination campaign messages are ineffective due to factors like low health literacy and conspiracy theories. The research suggests a need for targeted messaging strategies tailored to specific groups and communication channels.
Researchers analyzed nearly 100,000 pregnancies and found no association between COVID-19 vaccination and poor birth outcomes. The study provides further evidence on the safety of mRNA vaccines for pregnant individuals.
Researchers at Karolinska Institutet in Sweden have developed a novel strategy to identify potent miniature antibodies, so-called nanobodies, against emerging SARS-CoV-2 variants. The approach led to the discovery of multiple nanobodies that effectively blocked infection with different SARS-CoV-2 variants.
A booster dose of the Pfizer/BioNTech vaccine significantly increases antibodies against SARS-CoV-2, reversing a drop in immunity after two doses. In subjects given CoronaVac or Oxford-AstraZeneca vaccines, the booster raised immunity by a factor of 25 and 7, respectively.
Researchers found that infants and toddlers had significantly higher levels of antibodies against SARS-CoV-2 compared to adults. Children under 4 years old had the highest levels of RBD and neutralizing antibodies, indicating a strong immune response.
A study found that maternal immunization against respiratory syncytial virus (RSV) can reduce antimicrobial prescribing among young infants. The research, based on a blinded, multi-country trial, showed that infants of mothers assigned the RSV F vaccine experienced fewer antimicrobial prescription courses over the first 90 days of life.
A single dose of nirsevimab protected healthy infants from medically attended lower respiratory tract infections caused by RSV with 74.5% efficacy. This breakthrough results suggest a broad immunization approach is needed to mitigate the global burden of RSV on infants and healthcare services.
The WHO European Region has seen significant success in diphtheria immunization, with high coverage rates and only a few reported cases. However, suboptimal surveillance systems and inadequate laboratory capacity may contribute to the persistence of sporadic cases.
A University of Ottawa group is conducting research to equip healthcare professionals with resources to aid patients in French-speaking minority settings make informed decisions about COVID-19 vaccines. The project aims to address language barriers and combat patient disinformation.
A study by MedUni Vienna found that dual-vaccinated and recovered individuals have virtually no protection against infection with the current Omicron variant of SARS-CoV-2. However, a third Corona vaccination provides partial blockade of Omicron.
A study published in PLOS Medicine found that the COVID-19 pandemic led to an increase in the uptake of childhood immunizations in Scotland. Researchers analyzed data from over 439,000 vaccine invitations and found higher immunization rates during lockdown periods compared to pre-pandemic years.
The new schedule includes revised guidance on the hepatitis B vaccine for adults aged 60 years and older, as well as simplified recommendations for pneumococcal vaccinations. The updated schedule also recommends co-administration of COVID-19 vaccines with other vaccines.
A global study highlights inadequate information from healthcare professionals and lack of sensitivity leading to child vaccine hesitancy. Expectant parents are seeking alternative sources due to concerns about adverse reactions and long-term side effects, with some fearing measles as a minor childhood illness.
A Phase II trial will investigate a prime-boost regimen using two different COVID-19 vaccines, with the goal of expanding access to vaccines in Africa. The study aims to demonstrate the safety and efficacy of a mixed schedule of COVID-19 vaccines.
A modelling study suggests COVID-19 certification increases vaccine uptake in countries with below-average vaccination coverage. In six countries, certification was linked to a significant uptick in anticipation of restrictions and continued increases after introduction.