A study found that combining omega-3 and low-dose acetylsalicylic acid (ASA) was comparable to antibiotics in treating severe periodontitis, reducing the need for antibiotics. The treatment combination showed significant benefits, with patients experiencing a similar rate of deep pocket reduction as those receiving antibiotics.
A study of 5,500 individuals aged 50+ found that both conditions alone increase the risk of death, but together it more than doubles. Abdominal obesity and vitamin D deficiency create a vicious cycle, exacerbating chronic inflammation and impairing bodily functions.
A phase 3 clinical trial found that adding high-dose vitamin D to standard treatment did not improve progression-free survival in patients with metastatic colorectal cancer. Median progression-free survival was 11.8 months with high-dose vitamin D compared to 10.3 months with standard dose.
Research suggests that inhaled vitamin D can protect against dust, pollution, and pathogens in the lungs, potentially improving outcomes for those with chronic lung disease. Human clinical trials are needed to confirm these findings and explore the therapeutic benefits of direct lung delivery.
SourceCOPD Foundation·JournalChronic Obstructive Pulmonary Diseases Journal of the COPD Foundation·TypeCommentary/editorial·DateJun 25, 2026
A recent study of over 1,800 infants in Sweden found that most young children have sufficient vitamin D levels, but intake was too low for some. The research also explored the climate impact of foods providing vitamin D, concluding that plant-based alternatives are a climate-friendly source.
Researchers found that a vitamin D analog reduced fibroblast activation and increased T cell infiltration in pancreatic tumors, improving chemotherapy responses and progression-free survival. Patients with high vitamin D receptor expression also had longer overall survival.
A systematic review of 69 trials involving over 153,000 adults found that calcium, vitamin D, or combined supplements have little to no effect on fracture prevention. The findings suggest that routine supplementation may not be necessary, and instead focus should be on interventions like balance and resistance exercise.
Patients with breast cancer and low vitamin D levels experienced moderate to severe postoperative pain, while those with sufficient vitamin D levels reported less pain. Vitamin D deficiency was also associated with increased opioid consumption and nausea.
A post hoc analysis of a randomized clinical trial found high-dose vitamin D3 supplementation in pregnancy to be positively associated with visual memory, verbal memory, and flexibility among offspring at age 10. This strengthens evidence on the association between prenatal vitamin D exposure and childhood cognition.
A new analysis of a major clinical trial found that vitamin D supplementation reduced diabetes risk in prediabetic adults with certain variations in the vitamin D receptor gene. The study suggests personalized medical care could delay or prevent diabetes onset for millions of Americans living with prediabetes.
A study published in Neurology Open Access found that higher vitamin D levels in middle age are associated with lower levels of tau protein in the brain, a sign of dementia. The study suggests an association between vitamin D levels and lower tau burden, but highlights the need for further research.
A large randomized trial found that high-dose vitamin D3 did not reduce COVID-19 infection severity, but may impact long COVID outcomes. Researchers observed a promising signal that vitamin D supplementation could reduce long COVID symptoms, warranting further research in larger populations.
A recent study found that adults with heart disease who took vitamin D doses tailored to their individual needs reduced their risk of another heart attack by more than half. The study also showed that supplementation appeared beneficial for preventing heart attack specifically.
Researchers found that vitamin D receptor deficiency disrupts autophagy and promotes epithelial-mesenchymal transition, leading to endometrial fibrosis. Vitamin D or VDR-targeted therapy may serve as a promising approach for preventing or treating intrauterine adhesion.
A study published in the journal Bone found a clear link between osteomalacia and a fivefold increased risk of emergency caesarean sections or vacuum-assisted delivery. Vitamin D deficiency is a key underlying cause of osteomalacia, which may influence labor outcomes and increase the need for urgent obstetric interventions.
Research found that taking vitamin D2 supplements lowers the body's concentration of vitamin D3, which is essential for bone and immune health. Vitamin D3 has been shown to have modifying effects on the immune system, potentially fortifying against viral and bacterial diseases.
A new study by the Environmental influences on Child Health Outcomes (ECHO) Cohort suggests that higher vitamin D levels during pregnancy may be associated with better cognitive test scores in children. Children of Black mothers, in particular, showed strongest association between vitamin D and cognitive development.
Researchers found that vitamin D supplementation reduces liver inflammation and fibrosis in patients with chronic liver disease by upregulating the TXNIP gene in ductular cells. The study provides new insights into the underlying mechanisms of liver diseases and offers a potential therapeutic target for improving outcomes.
A study published in PLOS One found a clear link between low vitamin D levels and an increased risk of being hospitalized by COVID-19. However, no association was found between low vitamin D and the risk of catching COVID-19.
Researchers investigated the effects of vitamin D3-loaded nanoemulsion on adaptive behavior and language performance in children with ASD. The study found improved core manifestations and receptive and expressive language abilities, suggesting a potential therapeutic benefit for children with ASD.
A clinical trial found that vitamin D3 nanoemulsion significantly improved core symptoms of autism spectrum disorder in children, including language development and adaptive behavior. The nanoemulsion form was shown to be more effective than conventional oral supplementation.
Researchers found that vitamin D supplementation helps maintain telomeres, protective caps at the ends of chromosomes that shorten during aging. This suggests a promising role in slowing a pathway for biological aging and preventing age-related diseases.
A new study from the University of Bath found that regular, moderate-intensity exercise preserves vitamin D levels in overweight and obese individuals. The study showed that exercise completely maintained the body's active form of vitamin D, which plays a key role in supporting bone health and the immune system.
Researchers at the University of Florida have discovered a vitamin D nasal spray that significantly reduces nasal inflammation and improves sense of smell in mice. This study suggests a new potential treatment for humans suffering from loss of smell due to inflammation, which is often caused by cigarette smoke or COVID-19.
A new study suggests that paricalcitol may help manage chronic kidney disease (CKD) in dogs by reducing renal secondary hyperparathyroidism and proteinuria. The treatment showed promise in stabilizing proteinuria, but raised questions about potential long-term effects on CKD progression.
Pacific children are not meeting daily recommended intakes for key micronutrients, leading to associations with childhood obesity and acanthosis nigricans. The study highlights excessive sodium intake across the region, posing cardiovascular health risks.
A recent study led by Heike Bischoff-Ferrari found that taking omega-3 fatty acids slowed down biological aging across several epigenetic clocks by up to four months. The combination of omega-3, vitamin D, and strength training proved to be even more effective in slowing down the biological aging process.
A new study led by Penn State researchers found that low vitamin D levels during the first trimester of pregnancy are associated with higher rates of preterm birth and decreased fetal length. Pregnant women with low vitamin D concentrations were four times more likely to experience a preterm birth compared to those with sufficient levels.
SourcePenn State·JournalAmerican Journal of Clinical Nutrition·TypeData/statistical analysis·DateFeb 3, 2025
A pooled data analysis of 132 studies involving 52,501 participants found that 45% of people with type 2 diabetes have a micronutrient deficiency. Vitamin D was the most common deficiency, affecting 60.5% of those with the condition.
Researchers from the University of Eastern Finland found that high-dose vitamin D supplements over five years had no impact on type 2 diabetes development among those without prediabetes. The Finnish Vitamin D Trial revealed no statistically significant difference in disease incidence between groups receiving different doses of vitamin D.
The Endocrine Society's 2024 guidelines for Vitamin D testing and supplementation have been criticized for being too restrictive, with limited benefits for healthy individuals. The new guidelines recommend limiting supplementation to specific risk groups and advise against routine 25-hydroxyvitamin D testing in healthy individuals.
A new study from the University of Leeds found that eating oily fish, fruits, cereals, and drinking moderate amounts of beer can lower the risk of rheumatoid arthritis. The research suggests that a tailored diet approach may be more effective for people with autoimmune diseases.
A new tool, ViDDPreS, has been developed to assess vitamin D deficiency in young Japanese women. The study found that excessive sun protection measures are causing severe vitamin D deficiencies among this population.
A recent study found that vitamin D supplementation can decrease blood pressure in older adults with obesity and those with low vitamin D levels. High doses of vitamin D did not provide additional health benefits compared to the recommended daily dose.
New research led by the University of Southampton found that vitamin D supplements during pregnancy increase children's bone mineral density in mid-childhood. Children born to mothers who received extra vitamin D supplementation had stronger bones and were less likely to break them.
A McGill University study reveals that vitamin D deficiency early in life can lead to a higher risk of autoimmune diseases like Type 1 diabetes. The research found that an aging thymus causes the immune system to become less effective, increasing the risk of misdirected immune cells attacking healthy tissues.
Research presented at American Academy of Pediatrics 2024 National Conference & Exhibition found that low Vitamin D levels correlate with longer healing times in pediatric fracture patients. Patients with low Vitamin D levels took up to two months longer to show signs of healed fractures, compared to those with normal vitamin D levels.
A double-blind randomized phase 3 clinical trial found no additional benefits from high-dose vitamin D3 when added to standard chemotherapy for patients with untreated metastatic colorectal cancer. However, a potential benefit was observed for left-sided disease patients.
A systematic review and meta-analysis of 99 randomized controlled trials found that vitamin D supplementation reduces systolic and diastolic blood pressure, total cholesterol, and fasting blood glucose in various populations. The benefits were most pronounced in non-Western groups, individuals with low baseline vitamin D levels, those ...
A study published in Science Advances reveals that germ cells drive sex-dependent lifespan differences in vertebrate animals. Removing these cells led to similar lifespans in males and females of the turquoise killifish species. Vitamin D was also discovered to have a role in improving longevity, with supplementation extending life spans.
The IOF position paper emphasizes the need for population-specific vitamin D approaches, considering factors like diet, skin pigmentation, and supplement use. The authors also highlight the importance of standardized measures of 25(OH)D in future studies.
The Endocrine Society recommends healthy adults under the age of 75 take the recommended daily allowance of vitamin D. This guideline exceeds IOM recommendations for children and pregnant people, whereas individuals over 75 years old may benefit from higher doses.
The Endocrine Society will unveil new research on male birth control and anti-obesity medications during ENDO 2024 news conferences. The society's Vitamin D Clinical Practice Guideline is also being shared publicly for the first time, featuring discussions on its recommendations.
Researchers, led by Masako Suzuki, aim to understand the effect of dysregulated vitamin D metabolism on preterm infant kidney development. They will study the genome and transcriptome to gain insights into how vitamin D affects podocyte differentiation during preterm development.
Researchers analyzed data from over half a million UK participants to develop individualized estimates of ambient UVB levels, revealing key predictors of vitamin D status. The study highlights the need for personalized vitamin D supplementation guidelines based on ethnicity, age, sex, and other factors.
The Women's Health Initiative study found that hormone therapy is beneficial for treating moderate-to-severe hot flashes and night sweats in early menopause, while a low-fat dietary pattern may reduce breast cancer mortality. Calcium and vitamin D supplements do not support fracture prevention for all postmenopausal women.
Menopausal hormone therapy is appropriate to treat vasomotor symptoms in early menopause without contraindications. WHI evidence does not support routine supplementation with calcium plus vitamin D or a low-fat diet for preventing fractures and breast/colorectal cancer, respectively.
Researchers found that vitamin D encourages the growth of a type of gut bacteria in mice which improves immunity to cancer. Mice given a diet rich in vitamin D had better immune resistance to experimentally transplanted cancers and improved responses to immunotherapy treatment.
A randomized controlled trial found that co-administration of probiotic and vitamin D supplements improved MoCA scores and increased the percentage of patients with normal cognition in individuals with schizophrenia. The study suggests that probiotics may be a novel way to treat mental disorders by regulating gut microbiota.
A 20-year analysis found that calcium and vitamin D supplements reduced cancer mortality by 7%, but increased cardiovascular disease mortality by 6% in postmenopausal women. The study suggested that cancer incidence depends on pre-supplementation status, while CVD mortality is higher among supplement users.
Researchers discovered that the vitamin D/vitamin D receptor pathway protects enterocytes during aging, reducing ISC proliferation and centrosome amplification. This study provides insights into the molecular mechanisms underlying healthy aging in Drosophila.
Researchers found evidence of seasonal vitamin D deficiency in ancient teeth, indicating that latitude and sunlight exposure played a major role. The study's findings provide insight into how past populations developed the disease, shedding light on its history and potential causes.
A study published in PLOS ONE suggests that childhood vitamin D deficiency was widespread in industrialized England during the 18th and 19th centuries. Analysis of teeth from 25 individuals reveals a high incidence of VDD, with males affected more frequently than females, possibly related to social dynamics.
A survey study found a lower rate of overall fractures among living kidney donors, yet an increased incidence of vertebral fractures after 25 years following donation. Treatment with dietary supplements may help alleviate these issues and patient morbidity.
A recent study found that nearly all pregnant women have low levels of essential vitamins and minerals, with some developing deficiencies in late pregnancy. Supplementing with over-the-counter multivitamins significantly reduced nutrient deficiencies before and during pregnancy.
A major clinical trial found that vitamin D supplements had no effect on fracture risk or bone strength in children with vitamin D deficiency. The study, which included over 8,800 schoolchildren aged 6-13, boosted vitamin D levels but did not prevent fractures.
A review of 15 years' worth of data found that prenatal vitamin D supplementation reduced rates of asthma and wheezing in children compared to standard prenatal multivitamin. Vitamin D levels during pregnancy were associated with a 50% reduction in asthma and wheezing.
New research suggests that vitamin D supplements can reduce the risk of peripheral neuropathy in patients undergoing paclitaxel treatment. The study found that patients with vitamin D deficiency were more likely to experience severe neuropathy, and that inducing vitamin D deficiency caused similar symptoms in a mice model study.
A new commentary suggests that vitamin D supplementation can improve survival outcomes for patients with digestive tract cancers, particularly those with a high-risk genetic makeup. The study found that patients with antibodies to control the production of mutated p53 protein saw improved survival rates when taking daily vitamin D3 sup...
A large study found a significant link between vitamin D levels and psoriasis severity, with lower levels associated with greater severity. The research suggests that a vitamin D-rich diet or oral supplementation may provide benefits for individuals with psoriasis.