Articles tagged with Exosomes
Extracellular vesicles from liver cells can elicit a 'lipid counterstorm' that counters the effects of cytokine storms in mice. The treatment shows promise for treating inflammatory conditions such as sepsis, coagulopathy and colitis.
By coating extracellular vesicles with metal ions, cells can recognize and capture their own vesicles more strongly, improving liquid biopsies and aiding in drug delivery, rejuvenation, and more. This technique amplifies signals indicating cancer cells by a factor of 10,000, making single cells detectable even in large samples.
Studies in Drosophila complement mammalian systems to uncover EV biogenesis and function, revealing conserved molecular pathways. The review highlights diverse physiological functions of EVs across species, including development, metabolism, immunity, and cancer progression.
A comprehensive review reveals how phospholipid asymmetry governs EV surface charge, providing a unified framework for classification, functional understanding, and standardization in nanomedicine. The study highlights the importance of membrane lipid composition and surface charge in determining EV function.
Exosome-based therapies harness the power of microRNAs to activate hair follicle stem cells, promoting hair growth. Key findings include the identification of pro-anagen and inhibitory microRNAs that regulate Wnt/β-catenin, Shh, and HIF-1α pathways.
Researchers from Xi'an Jiaotong-Liverpool University have developed a nanoparticle-based system to produce exosomes, which are being explored as a new type of medical treatment. The system enables the efficient production of engineered exosomes with improved efficiency, scalability and stability.
Researchers have discovered that vesicles generated from cell-surface protrusions can deliver active proteins and genome-editing enzymes far more efficiently than conventional extracellular vesicles. This natural delivery system may enable the development of safer and more precise strategies for genome editing, regenerative medicine, a...
Scientists found that CtBP2 levels decrease with age, but are higher in long-lived individuals. This biomarker may estimate the degree of aging and overall health status.
The 2-day conference focuses on bridging the fields of mitochondrial biology, microbiome research, and extracellular vesicle science to advance translational innovation. Experts will discuss EVs as core messengers in intercellular communication and their potential therapeutic applications.
Researchers found that exosomes from senescent cells and circulatory exosomes carry molecular signatures associated with biological aging and cellular senescence. These signatures include proteins, lipids, and microRNAs linked to inflammation, oxidative stress, and tissue remodeling.
Researchers will explore the intersection of mitochondria and microbiota through extracellular vesicles for diagnostics, targeted drug delivery, and regenerative medicine. The conference aims to accelerate scientific progress by building bridges between disciplines.
The interplay between exosomes and metabolic reprogramming shapes breast cancer progression and resistance. Targeting this axis offers novel diagnostic and therapeutic strategies, including exosome-based liquid biopsy techniques and combination therapies.
Exosomes carry tumor-derived DNA, RNA, and proteins, enabling a liquid biopsy platform. They enhance diagnostic specificity and sensitivity, and play dual roles—mediating drug resistance and serving as therapeutic vehicles. Exosomal cargo predicts metastatic potential and survival.
The University of Texas MD Anderson Cancer Center has been awarded $21.4 million by CPRIT to support cancer research efforts and faculty recruitment. The institution is grateful for the continued funding, which will help advance future potential breakthroughs in cancer treatment.
Researchers at MD Anderson Cancer Center present promising results from clinical trials in three minisymposia abstracts. The studies explore personalized vaccine combination therapy for colorectal cancer, radiotherapy to avoid toxicities of systemic treatments for kidney cancer, and engineered exosomes to silence mutant KRAS in pancrea...
The researchers developed a platform technology that stably attaches functional substances to the surface of exosomes without structural damage or functional degradation. This approach enables the production of tailored exosomes for targeted cancer treatment, improving anticancer efficacy.
Researchers developed a next-generation exosome-based combination therapy to effectively treat metabolic dysfunction-associated steatohepatitis (MASH). The therapy regulates metabolic abnormalities, inflammation, and fibrosis simultaneously by attaching FGF21 and miRNA-223 to the surface of exosomes.
Researchers at MD Anderson Cancer Center have discovered that adding copper-loaded agents to radiotherapy can overcome radioresistance in preclinical models of thoracic cancer. A novel blood-based biomarker, OSMR, has also been identified in patients with acute myeloid leukemia (AML), which shows prognostic potential and can help ident...
Scientists at Virginia Tech have developed a method to produce, store, and deliver exosomes containing wound-healing compounds for targeted drug delivery and diagnostics. The breakthrough process improves stability for up to a year at room temperature, enabling mass production and commercial implementation.
A novel therapeutic strategy for superbug infections has been discovered using the siRNA-AGO2 complex. This complex inhibits bacterial gene translation by delivering AGO2-loaded siRNA into bacterial cytoplasm, downregulating resistance genes and converting multidrug-resistant bacteria into methicillin-sensitive ones.
HCC-derived exosomes reprogram immune and stromal cells to create an environment conducive to tumor growth. Exosome engineering holds promise for targeted therapies that enhance the efficacy of existing treatments.
A team of researchers has identified an 18-digit code within a protein called Wnt7a that allows it to attach itself to exosomes, enabling targeted delivery of proteins throughout the body. This discovery has major implications for the development of new therapies for diseases such as Duchenne muscular dystrophy.
Researchers developed LIFES, a living interface that secretes bioactive exosomes with tunable contents and miRNA cargoes, promoting neurovascular remodeling. This technology mimics native physiological processes, overcoming existing strategies' limitations.
Researchers will explore the role of exosomes in delivering regenerative compounds, while also investigating olfactory receptors' unexpected functions in skin health. The conference aims to slow or reverse skin aging through novel approaches to mitochondrial function and microbiota balance.
A team of bioethicists and legal scholars call for clear and concise regulations on exosome-based treatments due to the lack of scientific evidence and existing regulatory frameworks. These unproven interventions can cause serious harm to patients, highlighting the need for stronger protections.
Researchers have identified a 'forcefield-like' defense system in solid tumors, which uses small extracellular vesicles to block nanoparticle-based therapies. The study found that tumor cells release sEVs carrying proteins that block the activity of cytotoxic T cells and intercept nanoparticles like a decoy.
Scientists developed exosomes with increased cholesterol content to enhance siRNA delivery efficiency and safety. Cholesterol-rich exosomes improved targeting ability and delivery via membrane fusion, leading to better gene expression regulation.
Researchers from National Cancer Centre Singapore have successfully used exosomes to target squamous cell cancer tumours resistant to EGFR-TKIs. The study found that exosomes carrying a specific protein can increase sensitivity to TKIs in both lab and mouse models, providing new therapeutic solutions for patients with poor prognosis.
Researchers at the Lewis Katz School of Medicine will investigate how injured heart cells communicate with other cells throughout the body using microvesicles known as exosomes. The study aims to understand how specific molecules, such as microRNAs, facilitate communication pathways between cells in the heart and vasculature.
A new study published in Nature Biomedical Engineering shows that targeted cancer treatment using antibody-displaying extracellular vesicles reduces tumour growth and improves survival in mice. The treatment has the potential to be used against other diseases and cancer types, offering a more effective and fewer side effects compared t...
Small extracellular vesicles from young blood have been shown to dramatically extend lifespan, rejuvenate whole-body physiology, and reverse age-related degenerative changes in mice. The study demonstrates that these vesicles stimulate the expression of PGC-1 through their miRNA cargoes, ultimately improving mitochondrial functions.
A faulty beta-catenin gene helps tumours evade immunity by stopping tumor cells releasing message-containing cargoes called exosomes. Silencing mutant-beta-catenin could be a viable therapeutic strategy to trigger immune cell infiltration and increase tumour-to-immune cell communication.
Researchers at Duke University have developed a new diagnostic platform that uses sound waves to spin an individual drop of water up to 6,000 revolutions per minute. The technique separates tiny biological particles within samples to enable new diagnostics based on exosomes.
A Husker research duo has won a $25,000 prize in the NIH’s Targeted Genome Editor Delivery Challenge. They will advance development of universal milk exosomes capable of transporting gene editors to any location in the body, overcoming a significant challenge in using gene editing to treat disease.
Cancer stem cell-derived exosomes (CSC-Exos) are essential for communication between CSCs and other cells in the tumor microenvironment, contributing to cancer progression. The editorial highlights their potential as a novel clinical tool for diagnosis, prognosis, prevention of tumor recurrence, and therapeutic strategy
Researchers discuss recent advances in blood-based liquid biopsies for prostate cancer interrogation, highlighting key biomarkers like CTCs, ctDNA, and exosomes. The studies suggest that these approaches can aid in predicting tumor recurrence, improving treatment response, and evaluating prognosis.
Researchers developed a novel 'pseudo cell' formulation using self-healing microcapsule-loading exosomes to treat diverse vitreoretinal diseases. The treatment demonstrated therapeutic benefits in both murine and nonhuman primate models, offering potential for improved patient compliance.
Jinglei Ping, a UMass Amherst engineering professor, has received a $1.9 million grant to investigate a new method of regulating exosome traffic using electronic signals. This approach aims to control cell communication in cancer and heart disease research.
A new clinical trial has shown that infusing immune cells from living donors into recipients before transplantation may reduce the need for lifelong immunosuppressant medication. The treatment involves infusing donor-derived regulatory dendritic cells, which help the recipient's immune system distinguish between foreign and self-cells.
Defective exosomes in diabetic patients drive inflammation and impair wound healing. Researchers identified alterations in exosome cargo and release that compromise wound healing in diabetes. New exosome-focused therapies may promote healing of chronic wounds.
Researchers at Sylvester Comprehensive Cancer Center are working on a new urine test to detect prostate cancer, reducing the need for invasive biopsies. They will use exosomes, small extracellular vesicles, as a promising new biomarker and collaborate with Exosome Diagnostics.
Researchers at Nagoya University have discovered three new biomarkers for high-grade serous ovarian carcinoma using membrane proteins and polyketone-coated nanowires. The study reveals that small extracellular vesicles containing these proteins can be used to detect ovarian cancer, potentially leading to personalized medicine.
Researchers found that leukemia cells use messenger particles to navigate and release molecular cargo at distant sites, driving cancer metastasis. A potential therapeutic strategy involves targeting these particles with an antibody drug that blocks E-selectin activity.
Using mice, researchers successfully converted scar tissue back into functioning cardiac muscle using RNAs and exosomes, offering new hope for reversing heart attack damage. The study also sheds light on the aging process's impact on cellular reprogramming.
A simple blood test for ALS has been developed using microRNA analysis, which can accurately identify patients with the disease. The test uses a unique protein called L1CAM to concentrate diagnostic particles from extracellular vesicles in the bloodstream.
Researchers found that senescence-associated exosomes (SA-EXOs) from MSCs induce fibrosis and activate invasive characteristics in neighboring cells via the TGF-β pathway. SA-EXOs play a large role in cancer-related fibrosis, and their unique miRNA content influences myofibroblast phenotypes.
Extracellular vesicles from immune cells have been shown to activate the immune system in mice with skin cancer, rendering them sensitive to checkpoint inhibitor therapy. The treatment improved survival rates when used in combination with checkpoint inhibitors.
Researchers at Kyoto University discovered METTL16's role in DNA repair and erythropoiesis, a process generating 200 billion new red blood cells daily. Tiny methyl groups on specific mRNAs play a pivotal role in this process, involving mechanisms mediated by RNA-binding proteins.
Researchers at Hokkaido University have developed a biosensing technology to detect amyloid β build-up in the brain from biomarkers in blood samples. The Digital ICA TM technology can detect Aβ-binding exosomes in mice, increasing with age and disease progression.
A new CAPSTONE study aims to identify inflammatory biomarkers associated with positive and poor outcomes in patients after intracerebral hemorrhage (ICH) strokes. By analyzing patient blood and plasma samples, researchers hope to develop targeted treatments to prevent long-term brain degeneration.
Exosomes have been identified as possible vehicles for virus transmission, and a recent study found that the saliva protein exportin 6 plays a crucial role in this process. The researchers isolated exosomes from the saliva of insect vectors and showed that they can transport plant virions into rice plants.
Researchers have developed a new labeling technique to analyze exosomes from specific cell types, providing insights into their role in both health and disease. The technique allows for the identification of protein cargo and RNA in exosomes, enabling the study of cellular communication and potential monitoring of response to treatment.
Extracellular vesicles and exosomes are membrane-bound vesicles that facilitate intercellular exchange of proteins, lipids, and genetic material. They will be highlighted in upcoming events focusing on mitochondrial quality control, skin ageing, and microbiota.
Scientists have developed a smart contact lens that can capture and detect exosomes, nanometer-sized vesicles found in bodily secretions, which hold promise for cancer diagnostics. The lens was designed to bind to antibodies capturing exosomes found in tears, offering a potential platform for non-invasive cancer screening.
The 13th Annual Meeting on Skin Challenges 2022 will highlight the roles of extracellular vesicles in skin ageing and age-related diseases. Therapeutic strategies and anti-ageing potential of these vesicles from various sources, including stem cells and commensal bacteria, will be addressed.
Researchers developed a nanomembrane system called iTEARS that can quickly analyze tears for disease biomarkers. The system enables more efficient and less invasive molecular diagnoses for various diseases, including dry eye disease and diabetic retinopathy.
Researchers developed an inhalable COVID-19 vaccine that targets the lungs specifically and effectively, allowing for self-administration via an inhaler. The vaccine prototype, RBD-Exo, elicited production of antibodies specific to the SARS-CoV-2 spike protein in rodent models, offering a promising solution to improve vaccine delivery.
A study by researchers at Uppsala University found that crocodiles can regenerate their hair cells due to the activation of support cells and efferent nerves. This discovery may lead to new treatments for people with impaired hearing, who affect over 1.2 billion worldwide.
A UT Southwestern study reveals that RNA exosomes are crucial for B cell development, which is critical for the immune system's ability to fight infection. The findings also explain why patients with a rare disease associated with RNA exosome deficiency experience immunodeficiency and recurrent infections.
Researchers have used cryo-EM to visualize the structure of a protein assembly called Nuclear Exosome Targeting (NEXT) Complex, which plays a crucial role in degrading faulty or unwanted RNA molecules. This breakthrough could help understand how defects in RNA degradation pathways contribute to diseases like cancer and cystic fibrosis.