Articles tagged with Genomes
A new DNA test has been developed to identify the genetic causes of inherited muscle disease, offering hope for diagnosis and treatment for thousands of Australians. The test, which uses long-read sequencing, screens over 300 genes and detects complex genetic changes that older tests miss.
A global study of over 700 bacterial genomes found that 87% of the bacteria from dogs and cats belonged to strains identified in humans. The study also revealed high levels of antibiotic resistance, with nearly half of animal-derived samples carrying genes resistant to clinically important antibiotics.
A new study reveals that cohesin, a protein complex, prevents local mixing of compact active genome domains in living human cells. This domain organization helps maintain proper gene regulation. The study challenges the simple textbook view of chromatin and provides a revised view of euchromatin.
A new study reveals that a single gut bacterium, Bifidobacterium pseudocatenulatum (BP), and its metabolite 5-aminovaleric acid betaine (5-AVAB), can alleviate multiple hallmarks of aging and extend healthy lifespan in mice. This finding suggests a simple yet powerful strategy for promoting healthy aging.
A new study using clinical aging clocks reveals distinct aging transitions in men and women, with men experiencing a metabolic transition at 35-45 years and women at 55-65 years. The study also found that several metabolic factors contribute to aging and that some effects are partially reversible.
A research team assembled the first haplotype-resolved genome of monk fruit, tracing its origin and genetic diversity. The study found that low genetic diversity reflects ancient climate-driven population decline rather than severe domestication.
Researchers assembled two complete genome assemblies of Plasmopara viticola, uncovering dynamic genome architecture and revealing nearly 90% effector genes exist as duplicated clusters. Structural variations drive effector diversification, with local duplications and rearrangements creating hotspots for gene duplication and deletion.
The partnership aims to develop genomic tools addressing large-scale problems in health and the environment, combining research strengths across UC San Diego's departments. The collaboration will accelerate discovery and drive real-world impact, leveraging CRISPR technology and microbiome-editing tools.
Researchers Dfam and Repbase collaborate to create a unified open platform for transposable element annotation, providing decades of expertly curated data freely available. The integration will support large-scale genome annotation, evolutionary research, and biomedical applications.
A new European alliance aims to build a continent-wide system using genomics for protecting biodiversity, combining DNA barcoding and genome sequencing. The initiative will enable efficient collaboration and interoperability in biodiversity research.
A team of scientists has produced two complete telomere-to-telomere genome assemblies for cowpea, providing a stronger genomic foundation for research and trait discovery. The study reveals previously unannotated centromeric genes and chromosome regions linked to subspecies divergence.
Researchers at the University of Guelph developed a faster way to identify potential drug targets against Candida albicans using CRISPR interference. The new system reduced the time from laboratory discoveries to clinical applications by years, focusing on hundreds or thousands of genes simultaneously.
Scientists have discovered a new rare genetic disease caused by a mutation in the RPN1 gene, which affects glycosylation and leads to protein instability. The disease, now termed RPN1-CDG, is characterized by neurodevelopmental issues and has expanded the number of genes associated with OST complex diseases.
A multi-institution research team has developed a comprehensive genetic library for the soybean cyst nematode, which could help renew resistance and profitability for soybean growers. The pangenome allows for population genetic analysis to understand how nematodes are overcoming resistance.
Research from Salk Institute scientists shows that DNA's dynamic folding process affects gene regulation and expression, with specific regions unfolding at different rates to regulate cell type-specific functions.
Urbanization may be shaping the spotted lanternfly's spread into new environments by allowing them to adapt to heat, pollution, and pesticides. The insects' genetic diversity is lower in the US compared to China, but they are still adapting to local climate conditions.
Researchers introduce a framework linking biochar's internal structure to its performance in various applications. The physical genome framework unifies scattered findings and encourages future studies measuring multiple properties.
Researchers created detailed maps of the human genome's three-dimensional organization across time and space, revealing how genes interact and fold as cells function. The study provides a powerful framework for predicting which genes are likely to be affected by pathogenic variants.
Researchers at Arizona State University introduce powerful tools to analyze microbial family trees and biological data, strengthening microbiome research, disease tracking and environmental monitoring. The new software library scikit-bio provides a foundation for analyzing large biological datasets.
The new PLAMseq technique enables simultaneous analysis of chromatin-associated proteins and their location in the genome, opening up new avenues for researching human diseases. This breakthrough could lead to a better understanding of epigenetic mechanisms underlying diseases such as cancer and neurological disorders.
A recent study found extensive antibiotic resistance in Haemophilus influenzae, a type of bacteria causing up to 200 million childhood infections. Despite this, the team discovered surprisingly little genetic variation, suggesting a universal vaccine targeting shared features could be developed.
A collaborative research team analyzed historical museum specimens of the Asian honeybee, revealing a significant decline in genetic diversity and a potential link to pesticide use. The study suggests that pesticide exposure may be driving rapid evolutionary changes in the species.
Researchers at Charité – Universitätsmedizin Berlin have developed a method to predict the effects of mutations in yeast by analyzing the proteome. The study reveals that small genetic mutations can have significant impacts on cell growth, especially under altered conditions.
A 'genomic-first' approach can identify rare genetic disorders earlier and more frequently than standard genetic testing driven by clinical symptoms. The study found that a majority of participants with associated genetic variants did not have matching diagnoses in their electronic health records.
A renowned geneticist, Dr. Martin Alda, has made a groundbreaking discovery that bipolar disorder is composed of multiple genetically distinct disorders, transforming treatment approaches worldwide. His research also highlights the importance of combining basic research with clinical observations to advance psychiatric care.
A new study reveals that Indonesian cattle breeds carry a unique blend of zebu and banteng genetics, making them more genetically diverse than other breeds. This diversity could lead to improved disease resistance, productivity, and greenhouse gas emissions in cattle farming.
A reference-quality genome assembly of the human RPE-1 cell line has been produced, resolving centromeres and enabling accurate analysis of structural and regulatory variation. This milestone in functional genomics provides a matched, high-quality genome for one of biology's most important model systems.
Researchers found that children with stable gut microbiomes tend to have better growth outcomes. The study created the first-ever pediatric undernutrition microbial genome catalog, which can predict and prevent malnutrition. This discovery opens the door to new diagnostics and therapeutics for addressing global child stunting issues.
The Earth BioGenome Project aims to create a digital library of DNA sequences to preserve and protect life on Earth. With over 2,200 scientists in 88 countries, the project is making discoveries that could help assure food security and advance medicine.
A team of researchers from the University of Ottawa has developed a new workflow to study autophagy, a fundamental cellular mechanism that preserves cell health by recycling and degrading worn-out components. The study reveals novel signaling mechanisms regulating autophagy in response to numerous disease-related stress conditions.
Dr. Rentería's Australian Parkinson's Genetics Study (APGS) includes nearly 20,000 volunteers, generating a comprehensive genetic database to understand Parkinson's disease variability. He incorporates wearable sensors and digital biomarkers to address clinical heterogeneity.
Researchers have finally pinned down the genomic, epigenomic, and cellular landscape of the enigmatic arrow worm, connecting its unique genetic markup to specialized cell-types. The study reveals an unprecedented rate of gene genesis and duplication, as well as a unique method of chromosomal organization.
An international team reconstructs the genetic interactions of populations in the Southern Caucasus over time, showing a mostly constant ancestry profile. Evidence of migration from neighboring regions is also found, with notable instances of cultural adoption and genealogical links to Central Eurasian Steppe populations.
Despite using a large genetic dataset, scientists were unable to find a definitive explanation for the formation of distinct great white shark populations in the southern Indo-Pacific Ocean. A study published in Proceedings of the National Academy of Sciences suggests that genetic divergence began around 7,000 years ago.
Researchers at Salk Institute launched a machine learning framework called ShortStop to explore overlooked DNA regions and discover microproteins with potential roles in disease. The tool identified 210 new microprotein candidates in lung cancer data, including one validated target for therapeutic treatment.
ADLM 2025 will tackle urgent topics like clinical AI integration and fake medical news, as well as leveraging genomics for personalized healthcare. The meeting also explores the health threat of plastics and microbiome medicine to combat diseases.
A new study has reconstructed two 4000-year-old genomes from Mycobacterium lepromatosis, a rare pathogen that caused Hansen's Disease in the Americas. The discovery challenges historical records of leprosy's impact on population health and its origins in the continent.
A new study combines ancient DNA with dietary evidence and linguistics to paint a vivid picture of pre-colonial coastal communities in Papua New Guinea. The research highlights the influence of migrations and interactions on genetic makeup, supporting previous studies on the settlement of remote islands.
The Hong Kong Bauhinia Genome Project has completed a decade-long effort to sequence the DNA of Hong Kong's floral emblem, revealing 28 complete chromosomes and solving the species' parentage. The project's T2T genome assembly provides insights into genetic mechanisms underlying its vibrant blooms and ecological adaptability.
The study reveals that Phoenician culture spread primarily through cultural transmission and assimilation, with little direct genetic contribution from Levantine ancestors. Punic sites showcased a highly heterogeneous genetic profile, with individuals having both Sicilian-Aegean and North African ancestry.
The study reveals that eukaryogenesis occurred abruptly at a critical gene length of 1,500 nucleotides, marking the emergence of the eukaryotic cell. This phase transition was algorithmic, driven by the tension between increasing gene length and protein complexity.
A new study deciphers ancient DNA from the Green Sahara, providing critical insights into the African Humid Period and its impact on human migration. The research reveals a unique genetic lineage that remained isolated for thousands of years, highlighting North Africa's heritage.
Scientists have released new high-quality genome sequences for two critically endangered pangolin species, revealing genetic vulnerabilities and extinction risks. The research provides essential information for rescue operations and focusing on the best ways to conserve these unique animals.
Researchers mapped yerba mate's genome, discovering an ancestor that duplicated its genome 50 million years ago. This event led to the evolution of caffeine biosynthesis in yerba mate and coffee through convergent pathways. The study provides opportunities for creating plant varieties with new characteristics.
A new study reveals that bacteria species in Lake Mendota rapidly evolve over time, responding to changing seasonal conditions. The researchers found that hundreds of separate species would return almost fully to near copies of their genetic predecessors after a thousand or so generations of evolutionary pressures.
Researchers developed a new tool called SigRM to analyze single-cell epitranscriptomics data, enabling the study of RNA modifications in individual cells. This can provide valuable insights into gene regulation and its impact on health and disease, particularly in complex conditions like cancer.
The study of turtle genomes provides crucial information for the development of effective conservation strategies and the understanding of the evolution of sex chromosomes. Researchers have identified a novel three-dimensional chromatin conformation in both lineages, allowing for centromere-telomere interactions.
A team of scientists at Gladstone Institutes has developed a new method that enables them to make precise edits in multiple locations within a cell—all at once. They created a tool using molecules called retrons to efficiently modify DNA in bacteria, yeast, and human cells.
Researchers combined DNA markers from two genotyping systems to improve genomic predictions and GWAS for 24 fruit traits. The results showed increased accuracy and detection power when using combined datasets, suggesting benefits to leveraging historical data.
A new Research Training Group will investigate the evolution of nuclear genomes in organisms using different forms of reproduction, including asexual and sexual reproduction. The group aims to better understand the dominance of sexual reproduction in nature through empirical analysis of changing and evolving genomes.
Researchers have developed a new gene-editing system called multiplexed orthogonal base editors (MOBEs) to tackle complex diseases. MOBEs enable simultaneous installation of multiple point mutations across the genome, reducing the risks associated with traditional gene-editing tools like CRISPR-Cas9.
A team from Korea University College of Medicine has discovered the evolutionary process of glioblastoma recurrence through proteogenomic analysis, providing potential therapeutic avenues. They found that recurrent tumors undergo neuronal transition and BRAF protein kinase activation, leading to resistance to standard treatments.
Researchers created GraSSRep and rhea, tools that outperform current methods for handling repeats and structural variants in metagenomic data. These methods use self-supervised learning and graph neural networks to analyze microbiome data, offering new insights into biological processes and potential applications in antibiotic resistance.
A new screening system enables researchers to investigate sperm cell development and health at the molecular level, identifying a crucial gene Rd3 for maintaining sperm integrity during development. The study uses CRISPR technology to disrupt genes in living animals, revealing its significance in regulating oxidative stress.
Scientists mapped genetic blueprints for 51 vertebrate species, including cats, dolphins, and birds, using novel algorithms and computer software. This discovery has huge implications for understanding human health and evolution, as it allows researchers to compare complete genomes and identify DNA sequence divergence.
A team of scientists sequenced the full genome of a sea cucumber collected at a hydrothermal vent, revealing expanded gene families involved in DNA repair and iron metabolism. The research provides valuable insights into the unique adaptations of marine animals to survive in extreme environments.
Researchers use genomic surveillance to identify distinct sexual networks for syphilis transmission in England, highlighting the presence of drug resistance. The study reveals information beyond standard epidemiological surveillance data, aiding public health strategies to break transmission chains.
A biologist at Binghamton University has developed a new method to uncover the parent species of hybrid plants and animals. By examining genomic patterns within these hybrids, researchers can identify distinct ancestries and determine the order in which chromosomes were inherited from their progenitor species.
Researchers, led by Elizabeth King, aim to develop a knowledge base on complex genetic traits using fruit fly models. The project seeks to address the scientific knowledge gap in this field by focusing on interconnectedness among multiple factors.
Three Amazonian Morpho butterfly species have been sequenced for the first time, revealing genetic differences that maintain reproductive isolation despite sympatry. The study found Z-chromosome rearrangements and genetic divergence among gene copies, suggesting a role in speciation.