Articles tagged with Neurodegenerative Diseases
Researchers found that excessive glucose chains induce neuronal death and cause Lafora disease by disrupting glycogen levels. This discovery may lead to new treatment strategies for other neurodegenerative diseases.
Researchers found that defects in protein glycosylation, a process adding sugars to proteins, promote inflammation and neurodegeneration in MS. A dietary supplement similar to glucosamine may correct these defects and treat both short-term and long-term symptoms.
Researchers identify pur alpha protein as key player in FXTAS, a neurodegenerative disorder caused by CGG repeats in the FMR1 gene. The protein's sequestration leads to toxic brain aggregates and movement problems.
A four-year study investigates how dietary iron is used by cells, addressing endemic iron deficiency affecting 80% of the world's population. The researchers aim to understand cellular iron metabolism, a key process impacted in various human diseases.
Researchers identify mutations in moonlighting enzyme dihydrolipoamide dehydrogenase (DLD) that contribute to the reduction of frataxin production, leading to increased severity of Friedreich's ataxia. The study suggests DLD as a potential target for therapies of this condition.
U of MN researchers have shown that early brain development is tied to the severity of adult-onset neurodegenerative diseases like spinocerebellar ataxia type 1. The study suggests doctors may be able to target treatment to coincide with critical times in development.
Researchers found that imatinib can block the development of disease in a mouse model of rheumatoid arthritis, providing hope for a new treatment. Additionally, studying adrenomedullin's effect on female mice revealed that reduced expression may severely decrease fertility. Meanwhile, a study on TNF-alpha discovered that it decreases e...
Scientists at Duke University Medical Center have identified a gene defect linked to hereditary spastic paraplegia, a rare nervous system disease with no cure. The discovery could lead to the development of drugs targeting the defective gene and provide insights into other neurodegenerative diseases.
The American Institute of Ultrasound in Medicine has awarded a New Investigator Award to Dr. Elisa Konofagou for her groundbreaking work on treating neurodegenerative diseases using ultrasound-induced blood-brain barrier opening. Seven nominees presented their research, showcasing the diverse applications of ultrasound technology.
Researchers have developed a new classification system for myosins, increasing the number of subclasses from 18 to 24. This allows for better understanding of each myosin's function and its evolutionary links with other proteins.
Researchers Phillipe Besnard and colleagues pinpoint CD36 as the sensor for lipid detection in the oral cavity. They show that lingual stimulation of CD36 influences behavioral and digestive physiology. The findings suggest a potential pathway mediating fat taste, which may contribute to obesity risk through feeding dysregulation.
Researchers identified mutations in the sialin protein, responsible for transporting sialic acid out of lysosomes. The study found that even milder forms of the disease involve reduced transport activity and potential therapeutic targets.
Researchers discovered that replenishing depleted neurosteroid hormone allopregnanolone significantly delayed neurological deficits and doubled the lifespan of mice with neurodegenerative disease. The treatment was particularly potent when administered early in life and showed promise for delaying symptom onset and progression.
Scientists have identified genetic mutations in heat shock proteins linked to Charcot-Marie-Tooth disease, a debilitating disorder affecting peripheral nerves. The study's findings hold promise for developing new therapies and improving diagnosis.
A new study suggests that a caspase-inhibiting drug could help delay ALS symptoms and prolong life. Researchers found that mice treated with zVAD-fmk lived 22% longer than untreated littermates, providing proof of principle for this potential treatment.
The Drosophila genome sequence completion reveals nearly two-thirds of genes known to cause human disease are present in the genome. This achievement demonstrates the value of basic research using Drosophila in combating human disease.
Researchers discovered the exact cellular site where the leprosy-causing bacterium attacks peripheral nerves. The findings point to a way of treating leprosy in its early stages and have tremendous ramifications for understanding nerve damage in other neurodegenerative diseases like muscular dystrophy and multiple sclerosis.
Scientists have mapped a defective gene responsible for hereditary amyotrophic lateral sclerosis (ALS) to chromosome 9, bringing closer the isolation of the gene and potential treatment options. The gene is suspected to be linked to similar neurodegenerative disorders, with symptoms appearing in childhood but never being fatal.
A team of scientists discovered a special protein that encases copper to transport it through the cell and deliver it to specific enzymes. The finding provides clues to toxic mechanisms of other metals and rare diseases related to copper metabolism.
Researchers have identified a gene responsible for late infantile Batten disease, a devastating genetic disorder that affects about 300 children in the US. The CLN2 gene codes for an enzyme that degrades proteins and its discovery may lead to effective treatment and new insights into the aging process.