Articles tagged with Digital Publishing
A rare case of high-grade laryngeal leiomyosarcoma was successfully treated with extended laryngectomy, left neck dissection, and adjuvant chemotherapy. Complete surgical excision remains the cornerstone of therapy, while multidisciplinary-guided adjuvant treatment may benefit selected high-grade or high-risk patients.
Research suggests that aging immune systems compromise the body's ability to control Mycobacterium tuberculosis during treatment with rifampicin and isoniazid. The study identified age-associated immune abnormalities linked to impaired bacterial clearance, including chronic inflammatory signaling and mitochondrial dysfunction.
A new editorial proposes the use of agentic AI systems to address cancer-related malnutrition, a prevalent issue affecting up to 80% of patients. These systems aim to coordinate multiple functions simultaneously and support ongoing clinical decision-making throughout treatment.
A new editorial provides guidance on writing constructive peer reviews, emphasizing key takeaways such as 'picking battles' and maintaining professional courtesy. The guidance aims to elevate scientific data quality while mitigating impacts on authors' reputation and mental wellbeing.
The publisher achieved a 35% reduction in supply chain emissions through sustainable digital publishing, plastic-free packaging, and optimized book supply chains. Taylor & Francis trained over 70,000 researchers in low-income regions to publish their work, enhancing access to research and knowledge.
A new research paper presents a practical diagnostic approach for detecting high-grade serous ovarian carcinoma using a low-cost, portable color sensor device. The method tracks inorganic phosphate generated during nucleic acid amplification, producing a visible green signal that correlates with the amount of amplified DNA.
The BHARAT study, led by the Indian Institute of Science, is a groundbreaking initiative that integrates clinical, molecular, lifestyle, and environmental data from diverse demographic groups in India. The study aims to develop population-specific biological aging signatures and predictive models tailored to Indian populations.
A rare case of a small bowel GIST harboring concurrent KIT exon 9 duplication and SDHC mutation showed a strong response to high-dose imatinib, despite the presence of the SDHC mutation. Integrated molecular interpretation is crucial in GIST management.
The study reveals that human TERT is only compatible with non-human primate cells, while other species show limited or no telomere lengthening. This highlights the importance of using suitable preclinical models for telomerase-based therapies.
Researchers identified stage-specific gene expression changes that occur during cellular senescence, revealing an early immune-activating response and a shift in cellular priorities. This study offers new insight into the molecular mechanisms of aging and highlights potential therapeutic strategies for delaying age-related decline.
Dr Hendricks-Sturrup brings expertise in biomedical research, bioethics, and policy to lead the editorial board. Her experience will focus on disseminating high-quality research globally.
A new review found that lifestyle behaviors like physical activity and diet can positively modulate the gut microbiome of cancer patients, but these effects are often influenced by non-modifiable variables. The study also highlighted the role of intrinsic patient characteristics in shaping microbial composition.
A new hypothesis proposes that introducing Hydra-like gene expression patterns into rotifers could delay senescence and extend healthspan. The study focuses on conserved molecular pathways, including FoxO, which plays a central role in maintaining stem cell function and cellular resilience.
A recent study has found that epigenetic clocks are associated with cognitive impairment and dementia, but only specific epigenetic markers related to smoking exposure are linked to neurodegenerative changes. The study suggests that measures of epigenetic age acceleration capture different aspects of biological aging.
A rare case of mucinous ovarian carcinoma was reported in a postmenopausal woman, initially misdiagnosed as a pelvic abscess due to nonspecific symptoms and radiologic features. The diagnosis was confirmed after advanced imaging and tumor marker assessment. Early recognition is crucial for timely diagnosis and effective treatment of th...
The 12th ARDD meeting emphasized the importance of reversing biological age and identifying molecular mechanisms that can be targeted to modify them. Researchers presented new biomarkers and AI-designed proteins to develop novel therapeutics, with a focus on integrated, multi-targeted therapeutic strategies.
A rare scalp reaction resembling erosive pustular dermatosis was identified in a lung cancer patient treated with amivantamab following cranial radiotherapy. The reaction appeared to be related to impaired wound healing due to dual inhibition of EGFR and MET signaling pathways.
A new gene catalogue provides comprehensive insights into premature aging disorders, highlighting the central role of genome maintenance and DNA repair pathways. The catalogue organizes genetic and clinical information for 56 syndromes and 160 distinct clinical entities, offering a valuable framework for future research.
Research finds PDX1 gene plays a tumor-promoting role in human PCa cells by influencing metabolic pathways. The study identifies PDX1 as differentially hypermethylated in prostate cancer tissues, contributing to its aggressive characteristics.
The extension of the partnership aims to refine SnapShot's performance for live manuscript submission, providing enhanced author feedback and guidance on data sharing. The collaboration also focuses on iterative product development, expanding assessment graphs to accommodate additional data policies.
Oncology services are often excluded from emergency health priorities, resulting in delayed diagnosis and treatment interruptions. Vulnerable populations, including women and children, face advanced disease stages due to delays in care.
The study found that ATF5 plays a critical role in coordinating mitochondrial quality control and adaptive stress signaling in skeletal muscle. Absence of ATF5 resulted in increased muscle fatigability and elevated ROS production, highlighting its importance in maintaining muscle function with age.
The study found that immune checkpoint inhibitors significantly improved key clinical outcomes, including disease-free survival and distant metastasis-free survival. However, no clear improvement in overall survival was observed across studies, highlighting the need for careful patient selection and monitoring.
The article highlights the urgent need to modernize scientific record with AI-powered discoveries trapped in a predigital system. Top-tier research universities face $10-15 million annual subscription expenditures, while author-facing processing charges range from $5,000 to over $11,000 per article.
Treatment with i.v. furosemide plus HSS significantly decreased serum levels of inflammatory biomarkers IL-6, sST2, hsTnT, galectin-3, and NT-proBNP. The study found that this combination therapy modulated some miRNA expression and was associated with reduced miR181b expression compared to furosemide alone.
A new review analyzes how glioma classification research has evolved across clinical, molecular, and social domains. The study highlights the prominent role of DNA methylation profiling and advanced imaging techniques in molecular biomarker-based classification models, while finding social factors to be relatively scarce.
The COCOON trial found that a structured dermatologic prophylaxis regimen reduced moderate-to-severe dermatologic adverse events by half, with fewer grade ≥3 events and treatment discontinuations. This approach could improve tolerability and maintain dose intensity for EGFR-mutant non-small cell lung cancer patients.
The renewed agreement allows eligible researchers at participating UK institutions to publish unlimited articles across JMIR's portfolio of journals without APCs. This simplifies the publication workflow and increases equity for researchers at all career stages.
Researchers found that older adults exhibit higher BOLD variability in cerebellar lobule VIIIb and greater modulation across task conditions. This modulation predicts performance in an age-dependent manner, with increased modulation linked to better performance in older adults.
Between 2021 and 2024, government organizations accounted for around one-tenth of the estimated $336 million spent on advertising to news websites publishing health misinformation. Pharmaceutical companies also made notable contributions.
Researchers found that targeting MD2 could reduce tumor growth in a mouse model of prostate cancer bone metastasis. High MD2 expression was associated with metastasis, immune suppression, and increased resistance to PARP inhibitor therapy.
Dr Amy Shirong Lu joins JMIR Serious Games as Editor-in-Chief with extensive research on digital health technologies and their impact on physical activity and cognitive health.
Researchers found that the three-drug combination increased autophagosome formation and autophagic flux in uveal melanoma cells, killing them via enhanced autophagy. The study suggests a potential therapeutic approach for treating metastatic uveal melanoma, particularly in liver-targeted disease.
A new study published in Aging-US found that plant-based dietary patterns are associated with slower epigenetic aging. The research analyzed data from two large cohorts and found that higher intake of plant foods was linked to decelerated biological aging.
The company has announced an expansion of its innovative diamond open access (OA) model, Collective Pathway to Open Publishing, through agreements with Jisc in the UK and CAUL in Australasia. Six new journals will make their 2026 volumes open access without charging authors an article publishing charge.
JMIR Publications and the University of Nevada, Las Vegas announce a new Flat-Fee Unlimited Open Access Publishing Agreement. The agreement eliminates financial obstacles for researchers, reducing administrative workload for library staff and ensuring research findings are available via immediate open access in JMIR's high-impact journ...
The review emphasizes surgical excision as the cornerstone of curative treatment, with recommended margins depending on tumor risk stratification. Reconstruction should be individualized according to defect size, anatomic subunit involvement, and patient factors.
A systematic review of experimental studies found exergames to be associated with better mood outcomes, including reductions in tension and depressive symptoms. The evidence base remains small and heterogeneous, but the study calls for longer-term interventions and larger samples to determine the durability of benefits.
Over 11,000 Cambridge Scholars eBooks are now globally accessible through the Taylor & Francis eBooks platform. The partnership expands the reach of Cambridge Scholars titles, enhancing visibility and discoverability for rigorous academic scholarship.
A study found CREB5 regulates basal and SCL transcriptional programs and tumor-forming phenotypes in prostate cancer, suggesting a central role in aggressive prostate cancer. Disrupting CREB5-regulated pathways may improve therapeutic responses in advanced disease.
Researchers developed two neural network models predicting human biological age based on blood biochemistry and gut microbiota. The models demonstrated high predictive accuracy and explainability, holding potential for monitoring intervention effects in clinical trials.
A novel method for monitoring on-treatment disease burden in high-grade serous ovarian cancer uses tumor-informed breakpoints-spanning ddPCR, detecting superior sensitivity and specificity compared to real-time PCR. The approach may enable sensitive and specific detection of minimal residual disease and early relapse detection.
Dr. Sara Simblett brings expertise in digital health innovation, patient engagement, and technology integration to JMIR Neurotechnology. Her research focuses on improving access, quality, and outcomes of care through digital interventions.
Impact Journals is exhibiting at the AACR Annual Meeting 2026 in San Diego, showcasing recent publications and discussing collaboration opportunities. The meeting highlights the latest advances in cancer science and medicine, with a focus on research impact, ethical standards, and scientific integrity.
Researchers found that D, L-buthionine-(S, R)-sulfoximine (BSO) replicates the anti-obesity effects of sulfur amino acid restriction without causing bone loss in male mice. The study suggests BSO as a promising tool for dissecting the beneficial versus deleterious axes of sulfur amino acid biology.
A new study found that MYC amplification in metastatic prostate cancer is associated with reduced tumor immunogenicity, making it harder for the immune system to detect and attack the tumor. This reduction in immunogenicity was linked to poorer progression-free survival outcomes in patients with MYC-amplified tumors.
A new study reveals that p38 MAPK plays a key role in epigenetic regulation of fibrotic genes in lung fibroblasts, particularly in senescent cells. Pharmacological inhibition of p38 MAPK significantly reduced α-SMA and Col3A1 expression, suggesting a potential therapeutic target for treating age-related fibrotic diseases like IPF.
JMIR Publications has partnered with the University of Turku to provide unlimited open-access publishing, eliminating financial barriers and administrative hurdles for researchers. The partnership offers APC waivers for corresponding authors affiliated with the university, allowing them to publish in prestigious titles at no cost.
Prince of Songkla University and Taylor & Francis have partnered for a new open access agreement, supporting PSU's sustainable development mission and research impact. The partnership provides access to over 2,000 journals and eBooks, enabling PSU researchers to publish and share their work globally.
A new case report describes a large, calcified solid pseudopapillary neoplasm of the pancreatic head, emphasizing the importance of multidisciplinary evaluation and long-term follow-up for monitoring recurrence. The case underscores the diagnostic value of integrating imaging, histopathology, and immunohistochemistry.
A new metabolic theory proposes that a decline in glycolytic ATP production is the fundamental mechanism limiting lifespan. Species with an optimal rate of decline survived, suggesting that maintaining a stable glycolytic flux may support repair processes and tissue regeneration. The authors propose testing this hypothesis through expe...
A recent study found that higher IL6 levels are associated with increased mortality, while genetically higher IL6R levels reduce all-cause mortality through cardiovascular mechanisms. The researchers suggest that IL6R antagonism may be a potential strategy for preventing cardiovascular disease.
The article discusses recent advances in chimeric antigen receptor T-cell (CAR-T) therapy, highlighting its promise and remaining challenges. Next-generation CAR designs aim to improve specificity and reduce on-target/off-tumor toxicity, while addressing access disparities and equity issues.
A study profiles mitochondrial circular RNAs in Peripheral Blood Mononuclear Cells from young and old human cohorts, revealing that circMT-RNR2 levels are depleted in older cohorts and are involved in promoting the TCA cycle. Loss of GRSF1 reduces circMT-RNR2 levels, decreasing mitochondrial TCA intermediates and accelerating cellular ...
A mathematical model suggests paths forward to stabilize peer review, as rising submissions imperil the process. The study identifies key factors contributing to the strain on peer reviewers.
A new study examines the mechanisms, clinicopathological features, and management strategies of GI toxicity induced by targeted cancer therapies. The authors highlight the importance of close collaboration between oncologists, gastroenterologists, and pathologists to ensure accurate diagnosis.
Researchers developed a new single-cell transcriptomic clock called Tictock to measure aging in specific immune cells. The study found that COVID-19 and HIV alter T cell composition and accelerate the biological age of naïve CD8 T cells, while long-term antiretroviral therapy stabilizes T cell proportions.
Researchers highlight polyploidy-induced senescence as a coordinated biological program that may drive aging, tissue repair, and cancer risk. Polyploidization in healthy tissues could help maintain organ structure and barrier integrity, but its instability can promote chromosomal instability and malignant transformation.
A case report investigates a woman's development of acute lymphoblastic leukemia and lymphoblastic lymphoma after receiving her second dose of the Pfizer-BioNTech COVID-19 mRNA vaccine, highlighting potential genetic and molecular mechanisms involved in disease pathogenesis.
Researchers found that an experimental compound SB-216 reduced the growth of pancreatic ductal adenocarcinoma cells by inhibiting oncogenic microtubules and mitochondrial function. This approach may reduce cancer cell adaptation and survival.