Vaccine Research
Articles tagged with Vaccine Research
The liver’s immune cells might be the key to curing hepatitis B
Successful opening the largest BL3 and ABL3 special labs for the domestic universities and holding a symposium
Seasonal COVID-19 vaccination in 2025/26 reduced risk of illness by half in Canada
Needle-free flu vaccine aims to boost children’s immunity
LJI scientists take crucial step in developing world's first measles treatment
New study suggests ‘freedom framing’ more effective than mandates for vaccine-hesitant Americans
Review finds no direct link between aluminium adjuvanted vaccines and serious or long term health conditions
A systematic review of 59 studies found no association between aluminium-adjuvanted vaccines and serious or long-term health outcomes, including autism, type 1 diabetes, asthma, and myalgia. Persistent nodules or granulomas at the injection site were the most consistently documented reactions.
Cervical cancer: A growing gap between high- and low-income countries
A growing gap in cervical cancer incidence rates between high- and low-income countries threatens to escalate unless prevention efforts are increased. Researchers urge universal vaccination for girls and boys, as well as catch-up campaigns, to close the gap and prevent nearly 37 million cases of cancer by the end of the century.
Your nose is a battlefield
Researchers at La Jolla Institute for Immunology discovered that FluMist can trigger an immune response directly in nasal tissue, training immune cells to recognize and fight influenza virus infection. This response stays in the upper airways and cannot be detected via blood samples.
Where people get their news influences their beliefs about vaccines
A new Johns Hopkins University study reveals a significant link between following 'new right' media outlets and vaccine hesitancy. The research surveyed nearly 3,000 adults, finding that those who engage with these outlets are more than twice as likely to be hesitant about vaccines.
Scientists esteemed by public, with vaccine scientists seen as similar to scientists in general
A nationally representative survey found that nearly 7 in 10 people trust vaccine scientists to act in their best interests, similar to medical scientists and scientists in general. The public perceives vaccine scientists as credible, self-correcting, and unbiased, with their work benefiting society.
New study examines effectiveness of maternal RSV vaccination and nirsevimab in preventing and reducing severity of RSV-related illness in infants
A new study found that infants receiving maternal RSV vaccination or Nirsevimab after birth had significantly lower RSV infection rates and fewer severe complications. The study showed a high uptake of the vaccines among pregnant patients and newborns, leading to declining rates of RSV-related illnesses.
Researchers develop promising new vaccine against H5N1 bird flu
Researchers at the University of Nebraska-Lincoln have developed a promising new vaccine approach against highly pathogenic bird flu (H5N1) that demonstrates strong efficacy in both mice and dairy cattle. The vaccine platform protects against multiple H5N1 strains and generates immunity in both the bloodstream and respiratory tract.
Tumor vaccines in hepatocellular carcinoma: advances, challenges, and the path toward precision immunotherapy
Recent studies have explored tumor vaccine platforms, including peptide, dendritic cell, and nucleic acid-based vaccines. Personalized neoantigen vaccines are refining precision in HCC treatment, but challenges persist due to immunosuppressive tumor microenvironments and heterogeneity.
Study reveals new way to strengthen immunity against the flu
Researchers developed a new flu vaccine approach targeting specific but distinct regions of the influenza virus protein. This method broadened the immune response, leading to broader protection against various strains. The study's findings have implications for fighting other fast-changing viruses like COVID-19 and RSV.
We're taking a closer look at immune 'memory'
Researchers have found that COVID vaccines can train immune cells to remember the SARS-CoV-2 virus and protect against severe infection for years afterward. However, the continued spread of disease has scientists taking a closer look at how the immune system builds up immune memory over time.
Scientists uncover how vaccine adjuvants separate protection from reactogenicity
Researchers found that squalene-based adjuvants activate distinct pathways for vaccine protection and reactogenicity, including the role of IL-1β in enhancing efficacy and IL-1α in triggering local swelling. The study's findings could lead to safer vaccine design by targeting specific immune mechanisms.
Researchers uncover how obesity impairs vaccine response
Researchers found that obesity significantly impaired antibody production to a Pseudomonas aeruginosa vaccine in mouse models. The study suggests prioritizing tissue-resident immunity to boost protection against infections. Understanding this relationship addresses a significant gap in current vaccine research.
Trial assesses safety and effectiveness of two new TB vaccines
Two new TB vaccines, VPM1002 and Immuvac, demonstrate safety and effectiveness in preventing progression to active TB in latent infection, particularly in children. However, they do not offer general protection against all forms of TB or prevent weight-related mortality.
Immunogenicity and safety of an Escherichia coli-produced 9-valent HPV vaccine in adolescents compared with young women
A randomized, open-label bridging clinical trial was conducted to evaluate the immunogenicity and safety of a 9-valent HPV vaccine in adolescents aged 9-17 years compared to young women. The study found non-inferior immune responses with seroconversion rates comparable to those in young women receiving three doses.
Inequalities in childhood pneumococcal vaccine uptake persist in England despite schedule change
Persistent inequalities remain a major barrier to achieving universal protection against life-threatening infections. The study found that PCV booster retention has dropped in England since the schedule change, disproportionately affecting children in more deprived areas.
New vaccine strategy could help extend immunity against evolving viruses
Researchers at UW–Madison identified a way to program longer-lasting T cells, which can recognize more stable parts of viruses and offer a path to broader protection. The new strategy has the potential to provide longer-lasting immunity against respiratory infections like the flu and COVID-19.
New flu drug discovery could help fight future pandemics
Researchers have developed experimental compounds that block flu viruses by locking onto their surface enzyme, potentially improving treatments and pandemic preparedness. The new approach shows promise in stopping common types of flu virus, including H3N2 and bird flu strains.
Answering an urgent need
The Linda and Mike Mussallem Foundation has donated to USC's Keck School of Medicine to enhance clinical trials for individuals with Down syndrome at risk for Alzheimer's. This will increase domestic and international sites, accelerating the development of treatments specifically for this population.
Local immune coordination in the lung reveals a new layer of defense
Researchers discovered a new layer of defense in the lungs, where specialized immune cells coordinate a local response to viral infections. The study found that these cells produce a protein called HIF-1α, which activates neighboring immune cells to mount a coordinated defense.
New lipid nanoparticle design improves precision of mRNA vaccine delivery
Researchers redesigned a key component of lipid nanoparticles to steer particles toward lymph nodes, reducing off-target delivery. This advancement could make mRNA vaccines more efficient, potentially achieving strong immune protection at lower doses.
Engineered lipid nanoparticles reprogram immune metabolism for better mRNA vaccines
Researchers at the University of Pennsylvania developed lipid nanoparticles that modify immune metabolism to strengthen mRNA vaccines and reduce common side effects. The new lipid boosts the metabolism of immune cells, providing energy for the body's defenses while dialing down inflammatory signals.
Shingles vaccine drastically cuts risk of serious cardiac events
A recent study found that people with atherosclerotic heart disease who received the shingles vaccine had nearly half the rate of serious cardiac events compared to those who did not get vaccinated. The vaccine was associated with significant reductions in cardiovascular risk, including heart attacks, strokes, and death.
Vaccine gaps rooted in structural forces, not just personal choices: SFU study
A Simon Fraser University study found cultural, administrative, and governance barriers reinforce mistrust and limit vaccine access. Community-led clinics and trusted messengers can increase access and trust, but remain underfunded and excluded from decision-making.
Low-cost preventive measures could mitigate spread of bacteria causing neonatal mortality
A new study discovered that a multifaceted infection prevention and control intervention successfully disrupted a large and long-running bacterial outbreak of Klebsiella pneumoniae in a Zambian neonatal intensive care unit. The study found that low-cost measures, including IPC training, enhanced cleaning, and hand hygiene, reduced neon...
Contraceptive vaccine reduces fertility in animals to address wildlife overpopulation
A Purdue University-developed contraceptive vaccine reduces fertility in feral horses, deer, swine, and other animals, overcoming limitations of existing models. The vaccine, based on a male sperm protein, induces a long-lasting immune response and infertility in female mammals, with promising results for wildlife management.
Study finds natural fungal supplement improves COVID-19 vaccine response
A randomized, double-blind clinical trial found that a natural fungal supplement, FoTv, reduced short-term vaccine side effects and helped antibodies last longer in people who had not previously been exposed to COVID-19. The study suggests that FoTv may help strengthen vaccine protection without increasing side effects.
ACP advises all adults 75 or older get a protein subunit RSV vaccine
The American College of Physicians advises all adults aged 75 or older to receive a protein subunit Respiratory Syncytial Virus (RSV) vaccine, reducing the risk of severe illness and hospitalization. Adults aged 60-74 with comorbid conditions may also consider receiving the vaccine. The benefits outweigh the harms in this age group.
A step towards needed treatments for hantaviruses in new molecular map
Researchers at the University of Texas at Austin have created a high-resolution 3D map of the Andes virus, a crucial step towards developing vaccines and treatments against hantaviruses. The new structure allows for the design of effective vaccines and antibody therapies.
Novel vaccine protects against C. diff disease and recurrence
A novel vaccination approach cleared harmful gut bacterium Clostridioides difficile (C. diff) in an animal model of infection. The experimental vaccine protected against illness, death, tissue damage and infection recurrence through mucosal immunization.
Hospital analysers become the latest weapon against counterfeit drugs
A new study has shown that hospital analysers can accurately distinguish genuine liquid medical products from fakes, providing a low-cost screening tool to complement established methods. This breakthrough addresses a global health threat, with an estimated 10.5% of medicines worldwide being substandard or fake.
Batista Lab study reveals how local antibody feedback regulates B cell competition and promotes immune diversity
Researchers at Ragon Institute discovered that antibodies produced in germinal centers act as a 'brake' on selection, redirecting the immune system toward broader protection. Stronger-binding B cells suppress weaker ones targeting the same site, establishing a localized feedback loop.
HIV antibody opens up new approaches for vaccine development and combination therapies
A newly described HIV antibody targets the V3 glycan site in a different manner than previously known antibodies, remaining effective against virus variants that are resistant to classical V3 antibodies. This breakthrough supports antibody therapy combinations that neutralize the virus more effectively.
VALIDATE Network reaches 1,000 members across 80 countries, marking a milestone in global collaboration for vaccine research
The VALIDATE Network has achieved significant milestones in global collaboration for vaccine research, with over £3.5M in grants and £25.5M in follow-on funding secured. The network has supported over 86 novel publications and delivered online seminars and workshops to more than 3,400 attendees.
Scientific sleuthing solves vaccine side-effect
Researchers have identified a molecular trigger for rare blood clotting conditions after COVID19 adenovirus-based vaccines or natural adenovirus infections. The exact cause is now understood, allowing vaccine developers to adjust the adenovirus protein and prevent this extremely rare reaction.
HPV cancer vaccine slows tumor growth, extends survival in preclinical model
A new HPV cancer vaccine developed by Northwestern University scientists has shown promising results in a preclinical model. The vaccine's carefully organized structure dramatically enhances the immune system's ability to attack tumors, shrinking them and extending animal survival.
Could a treatment redirect the body’s anti-viral immune response to target cancer cells?
Researchers developed a PD-L1-binding antigen presenter that redirects antiviral antibodies to target cancer cells, transforming virus-specific immune memory into precision anti-cancer weapons. This strategy has significant potential for treating hard-to-treat cancers and represents a lower-cost, safer avenue for tumor immunotherapy.
Ethris and German Center for Infection Research (DZIF) announce strategic collaboration to develop mRNA-based vaccines
The partnership aims to develop next-generation mRNA vaccines with enhanced stability and targeted delivery, providing broader protection against emerging pathogens. This collaboration combines Ethris' mRNA technology platforms with DZIF's vaccine research expertise to accelerate the development of variant-ready vaccines.
Binghamton University researcher to lead $2.5 million project to create better avian flu vaccine
A team of researchers at Binghamton University is developing a new yeast-based solution for the production of better avian flu vaccines. The project aims to improve manufacturing, storage, and transportation efficiency compared to current options.
New vaccine platform promotes rare protective B cells
Researchers at MIT and Scripps Research Institute have developed a vaccine that generates a significant population of rare precursor B cells capable of evolving to produce broadly neutralizing antibodies against HIV. The DNA-VLP approach shows potential for inducing broadly neutralizing antibody responses against influenza as well.
Nasal vaccine combats bird flu infection in rodents
Researchers developed an intranasal vaccine that elicited strong immune responses and prevented infections in exposed animals, providing protection against upper respiratory infection and severe disease. The nasal vaccine was effective regardless of prior flu exposure, making it a promising tool in the fight against H5N1 bird flu.
New platform could develop vaccines faster than ever before
The new platform developed by UVA Health scientists can produce vaccines much faster, cheaper, and more easily than traditional approaches. The platform's proof-of-concept demonstrates its ability to produce highly immunogenic vaccines that can be manufactured at extremely low cost.
Vaccine against foot-and-mouth disease could deliver $1.3 billion a year in global livestock benefits
A new foot-and-mouth disease vaccine developed by Diamond Light Source is projected to deliver over $1.3 billion in annual benefits, transforming global livestock resilience. The vaccine's unique features, including heat stability and scalability, make it a game-changer for farmers worldwide.
Whooping cough vaccination during pregnancy strengthens the immune system in newborns
A study found that vaccinating pregnant women increases protection for infants against whooping cough, a highly contagious disease. The research team also showed that whole-cell pertussis vaccines provide longer-lasting protection than acellular vaccines, and recommends vaccination during pregnancy as a double-layered defense.
Mass General Brigham–developed cholera vaccine completes phase 1 trial
A single-dose oral cholera vaccine called PanChol has completed a phase 1 clinical trial with positive results, offering hope for combating the devastating disease globally. The vaccine was developed by Mass General Brigham and shows promise in preventing severe vomiting and diarrhea caused by Vibrio cholerae bacteria.
As flu cases surge, why don’t more people vaccinate?
A Cornell psychology professor argues that people make decisions based on intuition and core values rather than facts. Research found that considering the overall sense of risks and benefits (or
HPV vaccine can protect against severe lesions of the vulva and vagina
A new study published in JAMA Oncology found that the HPV vaccine can protect against severe precancerous lesions of the vulva and vagina. Vaccination before the age of 17 offers the strongest protection, with a 55% lower risk compared to unvaccinated women.
New white paper analyzes U.S. vaccine safety monitoring system
A new white paper by biostatistician Professor Jeffrey S. Morris analyzes the multicomponent US vaccine safety monitoring system, including VAERS and other components. The study suggests improvements to enhance the system's effectiveness and sustain a robust safety monitoring infrastructure.
AI tips off scientists to new drug target to fight, treat mpox
Researchers used AI to identify a new viral surface protein that triggers the production of neutralizing antibodies, offering a breakthrough for developing effective vaccines and antibody therapies. The discovery could also provide insights into treating smallpox, a related virus posing a bioterrorism risk.
Vaccines and the 2024 US presidential election
A survey study found that US voters generally support government role in ensuring safe vaccines, with high partisan divide among Trump and Harris supporters. Vaccine requirements for schools show similar support across parties.
Although public overwhelmingly supports hepatitis B vaccine for a newborn, partisan differences exist
A national survey of adults found that three-quarters support vaccinating newborns against hepatitis B, but Republicans are less likely to recommend the vaccine. The survey also found that most respondents believe the vaccine protects against liver disease, and there is little evidence justifying delaying vaccination.
Finnish study shows robust immune responses to H5N8 avian influenza vaccine
A Finnish study published in Nature Microbiology found that the MF59-adjuvanted A(H5N8) vaccine induced strong immune responses against the vaccine virus and heterologous H5 strains. The majority of participants developed seroprotective antibody levels after two doses, with significant increases in T-cell responses.
New organ-on-a-chip platform allows the testing of cancer vaccine efficacy in aging populations
A new organ-on-a-chip platform recapitulates age-dependent immune responses, allowing for more accurate testing of cancer vaccines in older adults. The platform reveals functional differences in immune responses between young and old lymphocytes, which are not detectable with traditional 2D cultures.
RSV vaccines could offer protection against asthma
Researchers have found that early-infancy RSV infection significantly increases the risk of developing childhood asthma, especially in those with family history of allergy or asthma. Protecting newborns against RSV could substantially reduce asthma cases later in life.