Articles tagged with Memory Formation
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Researchers at University College London discovered that Alzheimer's disease disrupts the brain's 'memory replay' process, leading to impaired navigation and memory loss. The study found that even when mice were resting, their brains replayed recent experiences in an altered pattern, which had consequences on memory tasks.
Scientists found that blocking microglia prevents infant forgetting and improves memory in mice, suggesting a role for microglia in memory formation. Microglia inhibition also enhances engram cell activation, providing a functional explanation for enhanced memory recall.
Researchers at USC have identified four distinct layers of specialized cell types in the CA1 region of the mouse hippocampus, a structure vital for memory formation. This discovery changes our understanding of how information is processed in the brain and could explain why certain cells are more vulnerable in diseases like Alzheimer's ...
A new study demonstrates that long-term memory is formed by a cascade of molecular timers unfolding across brain regions. Key regulators promote memories into progressively more lasting forms or demote them until they are forgotten.
The team aims to build an anonymized database representative of the whole population by collecting two vivid memories from participants. The findings will inform new ways to help people remember in more detail and understand human memories across the lifespan.
A global study by the University of Jyväskylä found that our most emotionally resonant music comes from our teenage years, peaking around age 17. This 'reminiscence bump' helps explain why songs from adolescence remain meaningful even decades later.
A new study reveals that astrocytes, a type of glial cell, are responsible for stabilizing memories through repeated engagement. The researchers found that Fos activity in astrocytes only occurs during recall, and that these cells can be activated to produce stable memories.
Researchers found that paradise fish use a unique strategy called 'alternation' to investigate new areas, engaging working memory and previously thought to be characteristic mainly of mammals. Zebrafish and paradise fish provide complementary opportunities to study brain function.
Researchers found that map-making brain cells in the hippocampus are activated differently even when navigating a static environment, shedding light on how the brain processes spatial memories. The study's findings could have profound implications for understanding memory, learning, and aging.
The brain segments and organizes events into experiences by placing unique bookmarks on them, allowing us to revisit and learn from our lives. The lateral entorhinal cortex creates a signal that constantly drifts in a pattern never repeating itself, marking the beginning and end of an experience.
A 16-year study of over 10,000 individuals aged 50+ found that those with higher wellbeing were more likely to have better scores on memory tests. The association was independent of depressive symptoms and suggested that psychological factors affect brain health.
Researchers mapped dynamic cellular mechanisms of memory formation, storage and update, revealing new insights into encoding experiences in the brain. Memories are stored through biophysical changes in neuronal ensembles, which can be manipulated to induce recall.
A KAIST research team has identified a key neural pathway involved in forming fear memories triggered by psychological threats. The pIC-PBN circuit processes psychological distress and drives fear memory formation, offering a significant advance in understanding how psychological distress is processed.
Research at Duke University found that insight triggers a burst of activity in the hippocampus, leading to better memory retention. Participants who experienced 'aha!' moments recalled solutions far better than those without, with conviction levels doubling long-term memory.
Researchers at the Center for Genomic Regulation discovered a nine-letter microexon in DAAM1 exclusively in neurons that is critical for neuronal development and memory. Deleting this microexon in mice resulted in reduced learning spines and impaired memory function, with animals remembering roughly 40% less in standard memory tasks.
A harmful form of tau protein directly damages blood vessels in the brain, leading to inflammation and weakening the brain's protective shield. The discovery highlights the importance of focusing on early neurovascular changes mediated by tau to prevent or slow down damage to the blood-brain barrier.
Research reveals two parallel processes during post-learning sleep: reactivation of initial learning experience and emergence of new neurons encoding future memories. This study highlights the critical role of sleep in maintaining cognitive function and overall well-being.
Mind blanking is a common experience characterized by lapses in attention, memory issues, and cessation of inner speech. Studies have shown that it's associated with specific neural signatures and changes in arousal levels, leading to malfunctions in key cognitive mechanisms like memory and language.
Researchers at Trinity College Dublin have found that the brain forms memories of cold experiences and uses them to control metabolism. The discovery may lead to new treatments for conditions such as obesity and cancer, which are influenced by thermoregulation and metabolism.
Researchers developed a computational model that reproduces intricate protein structures at postsynaptic densities, crucial sites for learning and memory. The model reveals details on how these proteins organize into unique structures through liquid-liquid phase separation, enabling sustained activation of downstream signaling pathways.
A novel brain study uncovers the critical role of the HDAC5 enzyme in regulating gene expression and neuronal activity, which can trigger relapse in individuals with substance use disorders. The study highlights a new molecular target for developing novel treatments to reduce relapse risk.
A study published by the American Academy of Neurology found that heavy drinkers have an increased risk of brain lesions and signs of brain injury, including hyaline arteriolosclerosis and tau tangles. Heavy drinking was also associated with lower brain mass ratio and worse cognitive abilities.
Researchers found that immune molecule IL-17 influences brain regions to induce either anxiety in the amygdala or sociable behavior in the somatosensory cortex. This discovery highlights the interconnectedness of the immune and nervous systems.
Eventgoers use social media to capture special moments and construct narratives of their own lives, intersecting with communal narratives. This mediated memory work influences how they experience and remember live events, blurring the lines between the present and future.
Princeton neuroscientists pinpoint the central amygdala as the brain region responsible for forming lasting memories of food poisoning, which may shed light on PTSD and inform future clinical treatments. The study found that novel flavors can 'tag' specific brain cells to remain sensitive to illness signals.
A new study by UCL researchers found that people with visual Alzheimer's disease have a unique distribution of proteins and markers in their brain, leading to symptoms such as reading difficulties. In contrast, those with memory-led Alzheimer's disease have different protein patterns, resulting in symptoms like memory loss.
A new study by McGill University researchers sheds light on the disruption of calcium transport in the brain's AMPA receptors, linking it to autism and intellectual disability. The findings could pave the way for treatments targeting these receptors, offering hope for patients with related neurological disorders.
Groundbreaking research from the University of South Australia shows that any form of exercise can significantly boost brain function and memory across children, adults, and older adults. Regular exercise improves general cognition, memory, and executive function in both healthy individuals and those with clinical conditions.
Researchers at ISTA discovered that neural activity patterns during sleep reflect recently learned spatial memories and transform into those seen later upon awakening. This 'representational drift' phenomenon optimizes memory representations for long-term storage, allowing the brain to free up resources for new memories.
Researchers isolated precise location of memory overlap in cells using advanced imaging techniques in mice, showing that memories are stored in dendritic compartments. Linked memories consistently engaged the same groups of neurons and their dendritic branches.
Researchers at Yale University discovered that infants' hippocampi can encode memories in their earliest years, contradicting the long-held theory of infantile amnesia. The study found that increased hippocampal activity upon seeing a new image led to better recognition later on.
A new study from the University of Chicago suggests that patterns of activity in the brain continually reshape memories, even after learning has occurred. Researchers found that behavioral timescale synaptic plasticity (BTSP) is a key driver of this process, explaining the dynamic shifting of place cells in the hippocampus.
Researchers at UCL identified key brain regions involved in remembering words, finding shrinkage in the front and side of the brain linked to difficulty recalling words. Detailed MRI scans showed a dispersion network for creating and storing word memories, crucial for understanding epilepsy conditions.
A new brain-mapping technique identified memory-related brain cells vulnerable to protein buildup, a key factor in Alzheimer's disease. The study found that certain cell types in the hippocampus and cortex were more affected by tau buildup.
A study led by Dr. Rodrigo Quian Quiroga has confirmed that individual neurons represent concepts learned in any context, enabling abstract relationships and human intelligence. This finding contradicts previous research on animals, where memories were thought to be stored in different groups of neurons.
Researchers at USC Stem Cell discovered a gene called KCTD20 that suppresses glutamate toxicity, leading to enhanced tau protein clearance. This approach offers a promising therapeutic strategy for patients with tau-related neurodegenerative diseases, including Alzheimer's disease.
Researchers used fMRI to investigate how the brain processes ambiguous messages, finding that more complex tasks engage multiple brain regions. The study reveals that understanding others' thoughts and emotions contributes to successful performance, with greater flexibility in reasoning.
Researchers explore the connection between Alzheimer's and metabolic syndrome, finding links between insulin regulation, high blood pressure, and obesity. The study suggests that maintaining healthy blood fat levels may be crucial for brain health, paving way for potential therapeutic developments.
Researchers found that a rare genetic syndrome causes different damage mechanisms in male and female brains, affecting neurogenesis and energy production. The study suggests that the ADNP protein plays a crucial role in brain development and aging, with distinct functions in males and females.
Researchers tracked thousands of neurons as a mouse learned to navigate two virtual corridors, revealing distinct representations of each corridor. The study sheds light on cognitive map formation and may provide insight into memory disorders like Alzheimer's.
Researchers at University of British Columbia discovered a new brain cell type called 'ovoid cells' that play a central role in remembering and recognizing objects. These highly-specialized neurons activate when encountering something new, triggering the process to store objects in memory.
A new drug developed by the Centre for Addiction and Mental Health (CAMH) has shown significant promise in reversing memory loss in a mouse model of Alzheimer's disease. The drug, GL-II-73, selectively targets GABA receptors to restore brain function and repair damaged neural connections.
Researchers used fMRI data to uncover how the hippocampus coordinates memory processes by analyzing neural activity patterns. The study found that participants remembered scenes with lower novelty more accurately and that the hippocampus integrates diverse forms of novel information.
A recent study by Rei Akaishi at RIKEN CBS found that larger groups can actually promote greater cooperation. Participants in the 'prisoner's dilemma' game cooperated more frequently as group size grew, with brain scans showing increased activity in regions involved in prosocial behavior and memory processing. This challenges conventio...
UCSF researchers found that when brain cells of female mice express only a maternal X chromosome, their memory and cognitive skills deteriorate faster. This study could explain the variation in brain aging between the sexes and individual women.
A breakthrough study reveals a critical pathway linking synaptic activity to gene expression changes necessary for learning and memory. Researchers identified the activation of receptors and ion channels generating calcium signals that rapidly communicate from synapses to the nucleus.
A new computational model reveals how place cells in the hippocampus can store episodic memories, including those of events without a spatial component. The model proposes that grid cells form a scaffold that anchors memories and drives recall by connecting to sensory cortex.
The Cognitive Neuroscience Society conference will feature keynote addresses, award lectures, and symposia on various topics in cognitive neuroscience. Researchers will present the latest findings on sleep, emotional experiences, brain connectivity, and more.
A study published in Nature found that new memories are replayed and consolidated when the pupil contracts during non-REM sleep, while older memories are replayed when the pupil dilates. This micro-structure separates new learning from old knowledge, preventing 'catastrophic forgetting'.
Researchers at Tel Aviv University discovered the brain actively prevents learning both types of memory, leading to confusion. The brain prioritizes one type of learning over the other using a strategy to resolve conflicts.
A new study by Northwestern University researchers found that breathing rhythms coordinate hippocampal brain waves during sleep, strengthening memory consolidation. This synchronization is critical for proper memory formation and retrieval, with implications for treating disordered breathing during sleep, such as sleep apnea.
Researchers investigate how perturbed gene expression contributes to neurodegenerative disorders like Alzheimer's. Alternative polyadenylation, a mechanism regulating protein production, is being studied for its potential role in the disease.
The study found that slow electrical waves during deep sleep strengthen synaptic connections and make the neocortex more receptive to information. This enhances memory formation by creating a state of elevated readiness in the cortex.
Researchers uncover human hippocampal CA3 region's unique neural connectivity and synaptic properties. The team found that the human CA3 network codes information efficiently to maximize associations and memory storage, with sparser connections and more reliable synapses compared to mouse models.
Researchers found that weakly spatial cells gradually correlate their activity with other neurons to form a mental map, stitching together individual locations. Sleep aids in this process, refining neural network activity and consolidating memories.
Researchers Fernanda Morales-Calva and Stephanie Leal explored the three Ws of memory - what, where, and when - to understand why people remember certain things. They found that emotional content, personal significance, repetition, and attention can influence memory retention. The study highlights the importance of considering individu...
Researchers found a parallel pathway to long-term memory formation that bypasses short-term memory. Blocking short-term memory did not disrupt long-term memory retention.
Researchers at UCSF found a brain signature of resilience in mice that suggests a new way to treat severe depression. Stress changes activity in the amygdala, distinguishing resilient from less resilient mice. By stimulating neurons, the team improved decision-making and reduced ruminating in less resilient mice.
The study found decreased NMDA receptors in synapses and increased extrasynaptic membranes in Alzheimer's patients, suggesting neuronal toxicity-related activity. The novel protocol allows for precise analysis of these receptors in human postmortem brains, paving the way for new therapeutic approaches.
Researchers studied mossy fiber synapses in the hippocampus, a crucial region for memory formation and spatial navigation. They discovered that specific proteins play key roles in encoding and processing distinguishing features to trigger memory retrieval.