Side Effects
Articles tagged with Side Effects
Clinical trial aims to address vaginal complaints after breast cancer diagnosis
A clinical trial aims to evaluate whether laser therapy reduces vaginal dryness caused by breast cancer treatment. The study, REVITALIZE, plans to enroll approximately 250 women with a history of breast cancer who experience moderate to severe vaginal dryness.
Penn researchers use AI to surface unreported GLP-1 side effects in Reddit posts
Researchers identified patient-reported symptoms associated with GLP-1s, including menstrual changes, fatigue, and temperature-related complaints, that may not be fully captured in clinical trials or drug labeling. Nearly 4% of Reddit users reported reproductive symptoms, and fatigue was the second most common complaint.
Antidepressant unable to prevent chemotherapy-associated nerve damage
A randomized trial found that duloxetine does not prevent painful neuropathy caused by oxaliplatin-based chemotherapy in patients with stage II or III colorectal cancer. The study suggests that duloxetine should only be used for managing existing neuropathy, not prevention.
Cancer treatment: Understanding risks and side effects
Researchers used machine learning methods to identify safe time windows for outpatient stem cell therapy in multiple myeloma patients. The study found that this approach can predict adverse events and enable more precise risk assessment.
Elinzanetant reduces severity and frequency of hot flushes and night sweats, regardless of type of hormone treatment breast cancer patients receive
A new analysis shows elinzanetant effectively relieves moderate-to-severe vasomotor symptoms (VMS) associated with endocrine therapy, regardless of the type of hormone treatment. The drug reduces VMS frequency and severity by blocking a protein that triggers these symptoms.
Radiotherapy rather than surgery may help reduce risk of lymphoedema in patients with breast cancer: results from pilot study
A pilot study found that axillary radiotherapy may be as effective as surgery in killing cancer cells while reducing the risk of painful swelling. The trial compared radiotherapy to axillary lymph node dissection and found similar cancer outcomes, but lower rates of lymphoedema after radiotherapy.
Understanding GLP-1 signaling: A path to better therapies
A new study finds that a novel GLP-1 receptor agonist, Exendin-4-Phe (Ex-Phe-1), preserves glycemic control while reducing malaise and vomiting behaviors in preclinical models. The compound uses biased agonism to selectively activate certain signaling pathways, achieving desired effects without triggering others.
FAU study: Tiny worm offers clues to combat chemotherapy neurotoxicity
Researchers used Caenorhabditis elegans to model chemotherapy-induced neurological dysfunction and tested two compounds for improved recovery. Both sildenafil citrate and Resveramorph-3 significantly reduced seizure-like behaviors and duration, suggesting their potential as therapeutic candidates.
Study explores why some drug therapies are ineffective for brain tumor patients
Researchers at the University of Plymouth investigate why drugs used to treat other tumours are ineffective against NF2-related schwannoma and meningioma tumours. They explore repurposing clinically tested cancer drugs to target MDR mechanisms, which may lead to effective therapies for patients with these tumours.
Best foot forward – chemo care should include podiatry
A new study from the University of South Australia found that up to 50% of patients are missing out on vital foot care after chemotherapy, despite irreversible nerve damage being a common side effect. Podiatry services can prevent falls, ulcerations, pain, and improve mobility in cancer survivors with CIPN.
Low-dose THC reduces side effects of HIV treatment
A new study from Texas Biomedical Research Institute found that low-dose THC significantly reduced side effects and inflammation caused by HIV and antiretroviral therapy. The treatment also increased serotonin levels, lowered cholesterol and toxic bile acids, and improved cardiovascular health.
Human Organ Chip technology sets stage for pan-influenza A CRISPR RNA therapies
A new human lung alveolus chip model enables investigation of viral replication, inflammatory responses, and genetic off-target effects of a novel pan-influenza CRISPR therapy. The study achieved significant reductions in virus load and host inflammatory response after a single administration.
Major cosmetic injection survey finds safety gaps
A recent survey of 919 UK adults who received botulinum toxin injections found alarming differences in the quality of care and advice given. Despite existing requirements for qualified prescribers, many participants reported not receiving written consent forms or being informed of potential complications.
How does chemotherapy disrupt circadian rhythms?
Research reveals that chemotherapy impairs molecular and behavioral measures of the primary biological clock found in the brain. In a study on female mice, paclitaxel treatment disrupted circadian rhythm-related gene expression and behavioral adaptations to light challenges.
Illinois analysis aims to ease GI symptoms for cancer patients
Researchers found that specific nutrient supplements like amino acids, probiotics, and herbs like ginger can effectively reduce nausea, vomiting, and diarrhea. Dietary counseling also showed promise in reducing common GI side effects. Oral nutritional supplements, however, did not demonstrate benefits in easing symptoms.
Study identifies genes that can predict response to immunotherapy in melanoma patients
A recent study identified four genes associated with treatment resistance to immunotherapy in melanoma patients. The genes, CD24, NFIL3, FN1, and KLRK1, were found to be linked to mechanisms of immune evasion and suppression of the inflammatory response. Patients with high expression of these genes had significantly lower overall survi...
Botox mitigates debilitating dry mouth in prostate cancer patients receiving radiopharmaceutical therapy
A dual-protective approach using Botox and an anti-nausea patch significantly reduces salivary gland toxicity in prostate cancer patients undergoing PSMA-targeted radiopharmaceutical therapy. This strategy led to a 30% decrease in PSMA uptake by the salivary glands without affecting the treatment's cancer-fighting efficacy.
UT Health San Antonio Multispecialty and Research Hospital pioneers use of new non-opioid painkiller after surgery
The UT Health San Antonio Multispecialty and Research Hospital is the first in Texas to approve use of suzetrigine, a new non-opioid medication for post-surgical pain. This medication targets the peripheral nervous system, avoiding opioid-related side effects.
Real-world evidence links long-term use of oral and inhaled steroids to adrenal insufficiency
Research reveals individuals taking oral steroids for over 3 months are 6 times more likely to be diagnosed with adrenal insufficiency than those treated with non-steroidal anti-inflammatory drugs. Long-term users of inhaled steroids also face increased risk without hospitalisations.
Probiotic supplementation may help reduce chemotherapy side effects in breast cancer
A new study suggests that multi-strain probiotics can alleviate chemotherapy-related side effects such as fatigue, nausea, and weakness. Probiotics have been shown to improve blood urea nitrogen levels and enable patients to perform daily activities more independently.
Exercise can counter detrimental effects of cancer treatment
Regular exercise can reduce side effects of cancer treatment, such as heart damage, nerve damage, and brain fog. It also improves psychological wellbeing, sleep quality, and overall quality of life in people with cancer.
Couple satisfaction linked to fewer cognitive issues with chemo
A study found that satisfying intimate relationships and general social support can reduce cognitive problems experienced by breast cancer patients undergoing chemotherapy. The research suggests that couples therapy could be a helpful option for partnered patients, while oxytocin levels decreased significantly during treatment.
AACR: HER2 targeted therapy shows promise in previously treated lung cancers
A Phase Ia/Ib trial found that zongertinib demonstrated clinical benefits for patients with advanced HER2-mutant non-small cell lung cancer, particularly those with specific HER2 mutations. The treatment showed a 71% objective response rate and manageable side effects.
AACR: Topical gel relieves painful skin rash side effect caused by targeted therapy for colorectal cancer
A clinical trial found that LUT014, a topical BRAF inhibitor, significantly reduced the severity of acne-like skin rashes caused by targeted therapy for colorectal cancer. Patients who received LUT014 had improved quality of life and were able to continue receiving their cancer treatment with reduced side effects.
AACR: Topical treatment offers relief from painful skin rash caused by targeted cancer therapy
A novel topical BRAF inhibitor gel called LUT014 has been shown to significantly reduce the severity of an acne-like rash in patients undergoing anti-EGFR therapies for colorectal cancer. The treatment's safety and effectiveness have been confirmed, offering a potential solution to managing this common side effect.
Cinnamon could affect drug metabolism in the body
A study published in Food Chemistry: Molecular Sciences found that cinnamaldehyde in cinnamon activates receptors controlling medication clearance, raising concerns about potential interactions. Researchers recommend consulting a doctor before using cinnamon as a dietary supplement to avoid rapid clearance of prescription medicines.
Patient with rare cancer first in U.S. to be treated with groundbreaking, highly accurate proton beam arc therapy
A patient with adenoid cystic carcinoma was successfully treated with step-and-shoot proton arc therapy at Corewell Health William Beaumont University Hospital. The treatment showed minimal side effects, including only light skin discoloration, and the patient remains cancer-free.
Hyperbaric oxygen treatment provide long-term relief for radiation-induced injuries
Hyperbaric oxygen treatment has been shown to provide long-term relief for patients with late radiation-induced injuries, improving symptoms of urinary incontinence, bleeding, and severe pain. The treatment can lead to the healing of chronic injuries and allow patients to live a fully normal life.
Researchers may have solved decades-old mystery behind benzodiazepine side effects
A research team has identified a key protein suspected to be involved in benzodiazepine-related inflammation, which could inform strategies to improve benzodiazepine drug design and treat inflammation-related conditions. The findings may lead to new treatments for diseases such as Alzheimer's, arthritis, and multiple sclerosis.
Evaluating different types of GOSE scores among patients treated in trauma centers in the US
Researchers evaluated different types of Glasgow Outcome Scale Extended (GOSE) scores among US trauma center patients. They found that GOSE-All scores capture the combined effect of brain and extracranial injuries, while GOSE-TBI scores exclude extracranial injury effects.
Most COVID-19 treatments found to be free of serious side effects in analysis of U.S. studies
The study analyzed 54 U.S. studies and found no significant association with serious adverse events for oral antivirals like Paxlovid or monoclonal antibodies. Actemra was associated with infection and low white blood cell counts, while transfusions of convalescent plasma were linked to internal bleeding and blood clots.
Studies shows new class of antibiotic is effective in tackling MRSA
A new class of antibiotic has been shown to be effective in treating MRSA infections, with a daily dose of epidermicin NI01 demonstrating equal efficacy to the current standard of care. The findings justify further pre-clinical development and could lead to new gel-type therapies for skin infections.
Researchers identify safer pathway for pain relief
A team of scientists at the University of Florida has developed a new drug compound that selectively targets delta opioid receptors, providing pain relief without the dangerous side effects associated with opioids. The study's findings offer a promising approach to developing safer pain treatments, which could also be applied to treati...
Test predicts which patients with prostate cancer are most likely to develop long-term side effects from radiation therapy
A UCLA study validates the predictive power of PROSTOX, a genetic test that uses microRNAs to identify patients at higher risk of developing long-lasting urinary side effects from radiation therapy. The test helps doctors and patients choose safer treatment options, reducing the burden of long-term complications.
New study investigates effects of ADHD medications on the heart
A new study published in The Lancet Psychiatry found that ADHD medications have small but significant effects on blood pressure and heart rate. While there were concerns about the side effects of these medications, the study suggests that their benefits outweigh the risks.
Testing patients for just three genes could help prevent three quarters of avoidable side effects of certain medications
A study found that genetic variants in three genes (CYP2C19, CYP2D6, SLCO1B1) can lead to adverse reactions in up to 75% of cases. This could allow for personalized prescribing and reduce ADRs by three quarters.
Citrus remedy squeezes out dry mouth for cancer patients
A natural citrus oil, when combined with a lipid formulation, may effectively relieve dry mouth in cancer patients. The new formula has demonstrated improved solubility and bioavailability compared to pure limonene.
Waterjet surgery for an enlarged prostate can offer relief, without compromising sexual enjoyment
The WATER III trial shows that waterjet surgery can better preserve ejaculation function compared to standard laser surgery. The technique has similar outcomes and can be performed with robot assistance, reducing waiting times for men with urinary problems caused by an enlarged prostate.
Study confirms safety and efficacy of higher-dose-per-day radiation for early-stage prostate cancer
A new study confirms that a shorter, higher-dose-per-day radiation course is as effective as conventional radiotherapy for treating early-stage prostate cancer without increasing side effects. The study found similar cancer control rates and fewer gastrointestinal issues with the new approach.
Low doses of antibiotic work just as well as higher ones to treat rare type of chronic hair loss
Researchers found that lower doses (20mg) and higher doses (100mg) of doxycycline were equally effective in treating lymphocytic scarring alopecia, a rare skin condition causing permanent hair loss. The low-dose regimen resulted in fewer side effects and no compromise on efficacy or anti-inflammatory benefit.
Researchers find possible link between medication and unexpected blood clots
A study from Aarhus University found a possible link between JAK inhibitor medication and unexpected blood clots. The researchers identified a potential mechanism behind the side effect, which could lead to the development of safer medications.
New test helps doctors predict a dangerous side effect of cancer treatment
Researchers at Kyushu University have discovered a way to predict a potentially life-threatening side effect of cancer immunotherapy before it occurs. By analyzing cerebrospinal fluid, they identified specific proteins associated with an immune response that can affect the central nervous system after therapy.
Children poisoned by the synthetic opioid, fentanyl, has risen in the U.S. – eight years of national data shows
Fentanyl poisoning among US children has surged by 924% and 1,506% for teens aged 13-19 over the past eight years. Parents are advised to be vigilant about hidden fentanyl risks and know the signs of overdose symptoms to save their children.
Chemo-immunotherapy approach shows potential benefit in patients with advanced HPV-negative head and neck cancer
A Phase 2 clinical trial found that a neoadjuvant chemo-immunotherapy regimen achieved a 53% deep response rate, exceeding historical data with chemotherapy alone. The treatment approach led to impressive survival outcomes and fewer toxic side effects in patients with advanced HPV-negative head and neck cancer.
Facial thread lifting: Complications, causes and prevention
A recent report in The Journal of Craniofacial Surgery highlights the importance of anatomical factors in minimizing risks and optimizing outcomes of facial thread lifting. The report outlines techniques such as reticular cutis gathering and pinching to enhance procedural safety and results.
Substantial portion of cancer patients in early trials access drugs that are later approved
A new study found that nearly 20% of cancer patients in middle-stage drug trials receive treatment that later gets FDA approval. This has important implications for drug development and clinical trial recruitment.
Rare side effect of cancer immunotherapy
A rare case of T cell lymphoma developed in a patient with multiple myeloma nine months after CAR-T cell therapy. Genetic alterations in the patient's haematopoietic cells played a role in tumour development, highlighting the importance of genetic predispositions for potential side effects.
Lancet article details drug’s lack of benefit for head and neck cancer
A recent Lancet article revealed that durvalumab combined with radiation therapy offers no benefits for patients with head and neck cancer who cannot receive cisplatin. However, a new clinical trial is underway to test the use of a heavy metal to enhance radiation therapy, providing potential new options for these patients.
Pusan National University researchers develop self-protecting nanoparticles for effective treatment of colorectal cancer
Researchers at Pusan National University have developed a novel drug delivery system that uses nanoparticles to target and kill colorectal cancer cells. The system, which involves encapsulating cancer cell-activated nanoconjugates in an alginate matrix, can selectively deliver drugs to tumor cells while minimizing side effects.
Robot faster than physicians at spotting side effects
A new study at the University of Gothenburg found that a software robot can detect side effects faster than physicians during amiodarone treatment for cardiac arrhythmia. The robot also recommends appropriate intervals between lab tests, aligning with standard practices and reducing unnecessary testing.
Breast cancer treatment advances with light-activated ‘smart bomb’
New cyanine-carborane salts show promise in eradicating metastatic breast cancer tumors with minimal side effects. The therapy targets specific proteins in cancer cells, allowing for precise killing of diseased cells while sparing healthy tissue.
Does pain affect cancer survivors’ use of non-opioid substances?
A recent study published in CANCER found that pain is associated with a greater likelihood of tobacco and cannabis use among cancer survivors. Pain also exacerbates treatment-related side effects and worsens health outcomes.
Updated drug information handout outdoes FDA’s version
Researchers developed a one-page medication handout that quantifies a drug's risk and benefits, improving patient understanding and decision-making. The study compared this handout with the FDA's version and found it to be more effective in conveying complex information.
Study explores whether dietary supplement could provide first effective treatment for cirrhosis
A new trial will test whether taking HMB can improve patients' physical function and quality of life. The BOOST study aims to recruit 124 patients with cirrhosis and measure its effects on liver disease, mental wellbeing, and physical function over 24 weeks.
Testing the effect of thousands of compounds on cellular metabolism
A new method of testing the metabolic effects of thousands of active substances at the same time has been developed by researchers at the University of Basel, providing valuable insights into the modes of action of known medications. The study reveals previously unknown mechanisms and potential side effects.
Fewer than 1% of U.S. clinical drug trials enroll pregnant participants, study finds
A study by Brown University researchers found that only 0.8% of clinical drug trials involving women aged 18-45 included pregnant participants, while 75% excluded them. This gap in research leaves critical questions about medication safety and efficacy unanswered for maternal and child health.
Commonly prescribed medications increase fall risk and related injuries in people with COPD
A new study published in the COPD Foundation journal found that people with chronic obstructive pulmonary disease (COPD) are at a higher risk of falls and related injuries when taking commonly prescribed medications. The likelihood of falls increases relative to the number of fall-risk increasing drugs used.
Scientists uncover rapid-acting, low-side-effect antidepressant target
A new study reveals that delta opioid receptor agonist KNT-127 has a rapid and effective antidepressant effect with minimal side effects. The research highlights the molecular mechanisms underlying its action, including mTOR signaling pathways and Akt activation in the medial prefrontal cortex.
Bioengineered yeast microbes as targeted drug delivery systems
Engineered yeast cells can form cooperative groups that perform complex tasks and self-regulate in response to external signals. This approach enables precise production of therapeutic compounds, reducing waste and increasing treatment efficacy.