Articles tagged with Atherosclerosis
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Researchers have discovered how Mycoplasma pneumoniae obtains essential lipids from the human body and targets fat-rich tissues. The bacterium uses the P116 protein to capture cholesterol and other lipids, allowing it to survive and colonize tissues beyond the lungs.
Researchers have discovered a small RNA molecule that plays a key role in controlling cholesterol production and the development of heart disease. The molecule, tsRNA-Glu-CTC, was found to boost SREBP2 activity, leading to higher cholesterol levels and increased risk of atherosclerosis.
A recent study published in JAMA Cardiology found that high blood pressure during adolescence can increase the risk of atherosclerosis in middle age. The study analyzed data from over 15,000 men and found that even mild hypertension at age 18 was associated with an increased risk of cardiovascular disease.
A mouse study by University of California, Riverside scientists suggests microplastic exposure may accelerate the development of atherosclerosis in males. The study found microplastics dramatically worsened plaque buildup in male mice, but not females.
Researchers at Karolinska Institutet have developed a system to classify individuals into different risk groups for atherosclerosis based on genetic data. The study identified four distinct risk groups, with one specific gene variant linked to increased cardiovascular risk in those with high predicted risk.
Researchers developed a new model to predict risk of subsequent cardiovascular events in patients with ASCVD, outperforming current guidelines. The novel scoring tools use readily available clinical factors and blood assays, enabling easier, faster clinical translation.
Researchers at Beihang University have made new progress in understanding the relationship between collagen fiber arrangement and pathological calcification in atherosclerosis. The study found that CFA disruption is closely linked with inflammatory responses, SMC phenotype switching, osteogenic gene expression, and vascular calcificati...
A multidisciplinary panel published in the Journal of Pediatrics advocates for accelerated diagnosis of familial hypercholesterolemia, a life-threatening genetic condition. Universal lipid screening is recommended to identify affected children at high risk of heart disease decades earlier than those without the condition.
Graz researchers investigate homocysteine's impact on the aorta, finding elevated levels lead to stiffer and less elastic vessels. This discovery contributes to understanding of cardiovascular diseases like atherosclerosis.
A new luteolin nanomedicine is designed to deliver the fat-clearing compound precisely to atherosclerotic plaques, boosting fat clearance and improving artery stability. The treatment reduces plaque size, lipid burden, and inflammation, making it more stable and reducing the risk of rupture.
A team of researchers created a 3D-bioprinted model of stenotic brain blood vessels to study the effects of abnormal flow patterns on endothelial cells. The model successfully replicated physiological conditions, including upregulation of inflammatory markers.
This review systematically maps miRNA-mediated dysregulation of the AGE/RAGE pathway in MetS, revealing widespread but understudied miRNA dysregulation across adipose tissue, liver, and immune cells. Prioritizing poorly studied receptors and multi-pathology miRNAs could accelerate targeted therapies for MetS.
Researchers found that certain antiviral genes become less active with age in people with lupus, leading to fewer inflammatory proteins. This reversal of 'inflammaging' may explain why symptoms improve in some older patients, allowing them to approach healthy aging.
A study published in Menopause journal found that four components of the Life's Essential 8 tool, including sleep quality, are key drivers of future cardiovascular risks. Healthy sleep, defined as 7-9 hours per night, may contribute to women's heart health and longevity.
A study of 273,770 individuals with cardiovascular disease found that increasing lipoprotein(a) levels significantly increases the risk of subsequent cardiovascular events. Treatment with high-impact LDL-C lowering therapies may help reduce this risk.
A multicenter study found that radiologically unstable plaque, particularly intraplaque hemorrhage, significantly increases the risk of ischemic stroke and ocular symptoms in patients with symptomatic mild carotid stenosis. Surgical intervention, such as carotid endarterectomy, may be a protective factor for these patients.
Researchers successfully treated atherosclerosis and fatty liver disease using DT-109 in nonhuman primates, which has potential as a dual therapy for two common conditions. The compound reduced the formation of atherosclerotic plaques and stopped critical processes that lead to vascular calcification.
Researchers at UCL developed a new scoring system, CAR, to identify patients with narrowed carotid arteries who can be effectively treated with optimised medical therapy. The study found low rates of recurrent strokes and heart attacks among patients treated with medication alone.
Swedish researchers have identified 20 genetic variants associated with an increased risk of atherosclerosis, a leading cause of cardiovascular disease. The study used advanced imaging techniques to examine millions of genetic variants, providing new insights into the disease process and potential ways to prevent it.
Researchers studied mRNA length variations during atherosclerosis progression in mice, discovering shorter mRNAs as the disease advances. The findings suggest alternative splicing mechanisms may play a role in generating diverse mRNA sequences related to the disease.
A new study found that artificial sweetener aspartame triggers insulin spikes leading to blood vessel inflammation in mice, which can contribute to atherosclerosis and increased risk of heart attacks and stroke. The researchers identified an immune signal called CX3CL1 that plays a key role in this process.
A study found that 77.9% of lung cancer patients had detectable atherosclerosis on CT scans, with smoking being the most prominent cardiac risk factor. The results suggest using concurrent coronary calcium scoring to aid in identification and earlier intervention for these patients.
Researchers found that olpasiran significantly lowers lipoprotein(a) levels by over 95% and reduces oxidized phospholipids, which promote atherosclerosis. The study also showed no significant effects on inflammatory markers.
Cadmium induces hyaluronan synthase 3 expression via the c-Jun N-terminal kinase–c-Jun pathway, leading to increased hyaluronan synthesis. This process accelerates atherosclerosis progression in vascular endothelial cells.
Researchers discovered that people with hereditary high cholesterol (FH) in Denmark are now living as long as the general population, with average life expectancies increasing from 50 to 78 years. However, they are still diagnosed with cardiovascular disease seven years earlier than those without FH.
The ACC Advancing the Cardiovascular Care of the Oncology Patient conference will provide clinicians with tools to improve cardiovascular care of cancer patients. Key sessions will include discussions on pulmonary tumor thrombotic microangiopathy, AI and technology in cardio-oncology.
Researchers found that IGFBP6 levels are diminished in atherosclerotic plaques and serum from patients with coronary artery disease, suggesting it as a potential therapeutic target. Overexpression of IGFBP6 reversed pro-inflammatory effects induced by disturbed flow and tumor necrosis factor.
The summit features live case demonstrations, interactive debates, hands-on training, and the latest evidence-based practices in structural heart care. Attendees will witness innovation in action, exploring breakthroughs in surgical techniques, transcatheter interventions, and personalized treatment strategies.
Despite decreased aspirin use among adults with low and higher ASCVD risk, many patients with limited benefit to treatment continue taking aspirin. The study highlights the need for better understanding of individual risk factors to improve treatment decisions.
Researchers discovered a brain functional connectome phenotype related to multiple cerebrovascular disease markers that contributes additively to cognitive decline and neurodegeneration alongside Alzheimer's disease. The study highlights the role of cerebrovascular disease in reshaping our understanding of dementia.
Researchers at Lund University Diabetes Centre have mapped out differences in the atherosclerotic process in people with type 2 diabetes. The study found that high blood sugar levels can lead to reduced ability to form protective connective tissue in atherosclerotic plaques, increasing cardiovascular risk.
A new study maps genetic traits to cellular composition of atherosclerotic plaques, predicting future stroke or heart attack risk. The research improves risk assessment and treatment for patients with atherosclerosis.
Zerlasiran, a small-interfering RNA targeting hepatic synthesis of apolipoprotein(a), significantly reduced time-averaged lipoprotein(a) concentrations by over 80% during 36 weeks of treatment. This finding has potential implications for the treatment of atherosclerotic cardiovascular disease.
A new version of the MESA heart disease risk score that doesn't include race predicts heart disease risk just as well as the original score. The study aims to assess the implications of including race in clinical risk prediction models and broaden their potential use.
A large multi-ethnic study found that work-related stress was associated with unfavorable cardiovascular health metrics, including lower odds of average and optimal health scores. The study's authors emphasize the need for longitudinal research on stress mechanisms and workplace interventions to improve employee well-being.
A team of researchers has identified the activation of the YAP/TAZ pathway as a major contributor to atherosclerosis in patients with Hutchinson-Gilford progeria syndrome. This discovery sheds light on the vascular problems faced by HGPS patients and opens up potential new avenues for treatment.
A new study published in the Journal of the American College of Cardiology found that subclinical atherosclerosis is independently associated with the risk of dying from any cause. The study also showed that monitoring the progression of atherosclerosis can improve the prediction and prevention of death from any cause.
A study published in JACC demonstrates that subclinical atherosclerosis burden and progression independently predict death from any cause. Asymptomatic individuals with high carotid plaque burden and coronary artery calcification are at increased risk of mortality.
A study finds that cardiometabolic indicators like metabolic syndrome and diabetes impair coronary microvascular function, increasing cardiovascular risk. The presence of subclinical atherosclerosis also contributes to altered microvessel function.
A study by Columbia University's Mailman School of Public Health found that metal exposure is associated with the progression of plaque buildup in arteries, comparable to traditional risk factors like smoking and diabetes. Metal levels in urine were found to increase coronary calcification over time, with higher levels linked to a grea...
Researchers developed a breakthrough nanoparticle technology that offers an effective solution to diagnose and treat atherosclerosis in a non-invasive manner. The innovative theranostic approach can target atherosclerotic plaques and deliver therapeutic agents directly to inhibit the progression of atherosclerosis.
A new study published in the journal JCI Insight found that male mice fed high-cholesterol diets have increased cardiovascular disease risk in their female offspring. The researchers used a novel method to study sperm small RNA and discovered altered molecules that affect gene expression in early embryonic stem cells.
A study published in JAMA finds that balloon angioplasty plus aggressive medical management reduces the risk of any stroke or death within 30 days. The treatment approach may be effective for symptomatic intracranial atherosclerotic stenosis, but with consideration for increased stroke risk after balloon angioplasty.
Researchers discovered that high cholesterol levels at a young age can be a significant risk factor for atherosclerosis. Fluctuating levels of cholesterol were found to cause the most damage and may increase the risk of heart attack even in those taking statin medication.
High levels of lipoprotein (a) found in 20-34% of Polish patients with heart disease or at risk. Lp(a) measurements may be crucial in preventing cardiovascular diseases and atherosclerosis progression.
The AHA PREVENT equations could reduce eligibility for statin and antihypertensive therapy among 15.8 million US adults due to lower atherosclerotic cardiovascular disease risk predictions. This change may impact treatment guidelines and recommendations.
Researchers at Wake Forest University School of Medicine have been awarded a five-year, $27 million grant from the National Institute on Aging to study the connections between heart health and brain health. The study will examine how cardiovascular disease contributes to Alzheimer's disease and other dementias.
A Swedish researchers have created a questionnaire test that quickly identifies individuals at high risk of heart attack. The test has been shown to be as accurate as blood tests and blood pressure measurements, detecting 65% of those at the highest risk of cardiovascular disease.
Scientists have created mirror-image cyclodextrins in the laboratory, which could make it easier to formulate and deliver complex medications. These discoveries may also lead to improved treatment of cardiovascular diseases caused by atherosclerotic plaques.
A study using induced pluripotent stem cells has revealed that inflammation triggered by retrotransposons and interferon signaling causes atherosclerosis in Werner syndrome patients. The researchers propose targeting the interferon signaling pathway as a potential treatment for reducing stroke and heart attacks.
A new risk equation could lead to a significant reduction in statin prescriptions, with 28.3 million adults potentially eligible instead of 45.4 million under current guidelines. The PREVENT equations incorporate recent insights into the biology of cardiovascular disease and remove race as a factor.
A recent Cleveland Clinic-led study found that high levels of the sugar alcohol xylitol are associated with an increased risk of cardiovascular events like heart attacks and strokes. The research team identified a link between xylitol consumption and elevated platelet activity, which can lead to blood clots and thrombosis.
A study found that ACS, elevated HbA1c and TG levels, and higher SYNTAX scores are risk factors for the progression of native coronary atherosclerosis after PCI. Higher rates of hyperuricemia and acute coronary syndrome were also observed in patients with progressive disease.
Research finds insulin levels correlate with triglycerides, ApoB, non-HDL cholesterol, and free cholesterol in women with atherosclerotic coronary disease. The study suggests these laboratory-associated flags indicate early coronary atherosclerosis in both diabetic and non-diabetic women.
A Danish-Spanish collaboration is launching the REACT initiative to develop early detection and prevention methods for atherosclerosis. The project aims to identify new means to detect atherosclerosis at earlier stages and at a younger age, enabling precision treatment and prevention.
A new study published in Journal of the American Geriatrics Society found that greater community mobility is significantly associated with better cognitive function in individuals aged 52 and older. The association was strongest among those at low risk for atherosclerotic cardiovascular disease.
Cardiovascular biomarkers strongly associated with cardiovascular events and mortality. Adding biomarkers to established risk factors improved heart failure and mortality prediction, but only slightly enhanced atherosclerotic disease risk prediction.
Researchers found transformed smooth muscle cells driving atherosclerosis by proliferating and resisting cell death, suggesting potential treatment with anticancer therapies. A common cancer drug reduced plaque size in mouse models, but further studies are needed for clinical translation.
A new genetic testing procedure identifies patients at high cardiovascular risk due to clonal haematopoiesis and carotid artery stenosis. This allows for early detection of increased mortality and a personalized cardiovascular risk profile, enabling therapy adaptation and prevention of atherosclerotic disease progression.
A study of 26,000 US participants found that both individual- and area-level social determinants contribute to cardiovascular disease risk. The findings suggest that these factors should be considered in future risk assessment tools, especially for Black individuals.