Articles tagged with Brain Lesions
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A clinical prediction model called the Goliat score can estimate the risk of acute complications in patients with minor and moderate traumatic brain injuries. The model, developed by researchers at UOC and IRBLleida, uses easily accessible variables to predict neurological or cardiorespiratory complications and mortality within 48 hours.
A new randomized clinical trial found that training the less-impaired arm significantly improved movement coordination, speed and control in chronic stroke survivors. The study showed that motor skills in the less-affected arm can be improved even years after a stroke occurs.
Researchers at Mount Sinai found chronic traumatic encephalopathy (CTE) rare among individuals with isolated brain injuries. The study, published in the Journal of Neuropathology & Experimental Neurology, analyzed postmortem brain tissue from 47 donors and revealed that CTE is more common in those with extensive repetitive head impacts.
A new study found that damage to the medial prefrontal cortex (mPFC) makes people more likely to be influenced by other people's impulsive decisions. The researchers also discovered that this type of brain damage is linked to increased impulsivity, even before being influenced by someone else.
Researchers at University of Turku discovered a new biomarker that correlates the thickness of inflammatory cell rim surrounding brain lesions with disease severity and speed. The wider the rim, the more aggressively the disease advances, allowing for earlier treatment identification and evaluating drug candidates.
A team of researchers at UCL has identified key brain regions essential for logical thinking and problem-solving. They used lesion-deficit mapping to study patients with brain lesions caused by stroke or tumors and found that damage to the right frontal lobe impaired reasoning skills.
Researchers have identified specific brain structures that regulate political passion, finding damage to the prefrontal cortex increases intensity and amygdala decrease it. The study suggests emotion plays a role in shaping expressed political beliefs rather than determining ideology.
A new MRI technique has been successfully used to treat adults with drug-resistant epilepsy, allowing doctors to offer life-changing surgery to patients. The parallel transmit 7T scanner identified previously unseen structural lesions in nine patients, confirming the effectiveness of the treatment option.
Researchers at the National Institutes of Health (NIH) have created a four-dimensional brain map that reveals how lesions similar to those seen in human MS form. The findings provide insight into early disease state changes and could help identify potential targets for MS treatments and brain tissue repair.
Studies identified 153 cases of psychosis caused by brain lesions, which connected to a common circuit in the hippocampus. The circuit, including the rostromedial prefrontal cortex, is a promising target for transcranial magnetic stimulation therapy, potentially improving symptoms in patients with schizophrenia.
Researchers used single-cell sequencing to characterize different cell types in brain lesions and identify subpopulations involved in disease progression. The study provides a cellular view of focal cortical dysplasia, a malformation leading to drug-resistant epilepsy.
The InteReg project aims to create interactive biomaterials that instruct cells to regenerate after brain or spinal cord injuries, potentially treating MS and other neurological disorders. The project, funded by the Carl Zeiss Foundation, brings together experts in biology, chemistry, medicine, and polymer research.
A Baycrest study reveals that degeneration of the thalamus, a brain area distinct from stroke lesions, contributes to post-stroke symptoms. Innovative non-invasive treatments targeting this area may improve or reverse these life-altering consequences.
Researchers at University of Pittsburgh discover that deep brain stimulation instantly improves arm and hand strength and function weakened by traumatic brain injury or stroke. The therapy stimulates the motor thalamus, a key relay hub of movement control, and significantly improves activation of muscles and grip force.
Researchers at Brigham and Women's Hospital have identified a specific brain circuit that may protect against post-traumatic stress disorder (PTSD) in veterans with traumatic brain injury. The study suggests using neurostimulation therapies on this circuit could treat PTSD, offering a new potential non-invasive treatment option.
A new study reveals that more than half of strokes causing ataxia are located outside the cerebellum but affect a specific brain network. This discovery changes our understanding of ataxia's neural mechanisms and may lead to safer treatments for patients.
A clinical trial found that fish oil supplements slowed neuronal integrity breakdown in older adults with the APOE4 gene variant, a risk factor for Alzheimer's disease. The study showed no benefit for all older adults, but suggested omega-3 fatty acids may be useful for prevention.
A recent study found that high cumulative BMI is associated with smaller brain volume, larger white matter lesions, and abnormal microstructural integrity in adults. Maintaining a healthy BMI below 26.2 kg/m² is suggested for better brain health.
The themed issue highlights advances in nosology, covert consciousness assessment, neuromedical morbidity, neurorehabilitation evaluation, and medicolegal challenges. Patients with severe brain injuries may have better prognoses than previously believed, but require careful assessment due to high misdiagnosis rates.
Researchers found that low-dose X-ray irradiation reduced lesion size and reversed motor deficits in TBI and ischemic stroke mice, demonstrating its potential as a therapeutic strategy. The treatment also accelerated substantial motor function recovery and promoted brain rewiring after stroke.
A phase III study found that selpercatinib significantly improves cancer progression-free survival in patients with NSCLC and RET gene translocations. The therapy also demonstrated efficacy in treating intracranial lesions, a common challenge in advanced NSCLC.
A study published in Neurology found that white matter hyperintensities in former football players are associated with greater vascular risk factors, brain shrinkage, and other markers of dementia. The study suggests that brain scans may be a promising tool to study the long-term effects of repetitive head impacts.
Researchers found that former football players with medical and mental health conditions like depression and anxiety are at higher risk of receiving an unverified CTE diagnosis. The study highlights the need for accurate diagnoses and access to proven treatments.
Researchers highlight microvascular contributions to white matter injury in Alzheimer's disease, sparking calls for exploration of connections between AD, WM injury and cerebral small vessel disease. The study emphasizes the critical need to define mechanisms and diagnostic features of mixed vascular and AD neuropathological change.
Researchers developed a molecular test to identify brain tumors by analyzing genetic material in cerebrospinal fluid. The Real-CSF test correctly identified 67% of cancerous and 96% of noncancerous brain lesions, outperforming standard cytology methods.
Researchers at Brigham and Women's Hospital linked MS brain lesions to memory problems by mapping white matter lesion locations in people with MS. The study found that lesions intersecting with a previously derived memory circuit centered on the hippocampus were associated with memory issues.
A new geometric deep learning model called GFCN has been developed to detect stroke lesions in brain imaging scans. The model leverages rich geometric information to segment brain tissue and achieves higher segmentation performance than other neural network architectures.
The University of Texas Health Science Center at San Antonio has developed an AI algorithm that can accurately count brain lesions on MRI scans in seconds. This tool helps neuroradiologists evaluate patients' brain diseases at earlier stages and identify the most significant lesions associated with stroke and small-vessel disease.
A new study by investigators from the Brigham and Women’s Hospital found that lesions associated with epilepsy are connected to a common brain network, suggesting the brain connections disrupted by the lesions are key. This discovery may have clinical implications for predicting epilepsy risk and targeting treatments.
Researchers developed an innovative imaging approach using two-photon microscopy to analyze retinal microcirculation, revealing significant changes in blood flow that may indicate brain diseases. The study suggests that microcirculation in the retina could serve as a promising predictor of cerebrovascular diseases.
Researchers at Brigham and Women's Hospital identified distinct brain network connections for visual and motor anosognosia, as well as a shared network for awareness of deficits. The study found that the hippocampus and precuneus play a key role in memory-based recognition of neurological deficits.
A recent meta-analysis shows that amino acid PET can accurately differentiate between recurrent brain metastases and treatment-related changes. This technology has the potential to reduce unnecessary invasive procedures and overtreatment in patients with cancer.
A new study published in JAMA Network Open found that intensive blood pressure treatment significantly reduces the risk of adverse cerebrovascular events such as stroke. Participants with hypertension who received intensive treatment showed reduced white matter lesions and improved blood flow, indicating better overall brain health.
A study published in Brain found that disconnecting nerve pathways in the brain can lead to improved seizure freedom in patients with frontal lobe epilepsy. The research, involving 47 patients, revealed that cutting these connections resulted in 88% of patients being seizure-free after three years.
A new study published in Neurology shows that younger brain age is associated with superior post-stroke outcomes, suggesting a potential biomarker for stroke rehabilitation. The research team used multi-site data sets and 3D brain structural MRIs to analyze the relationship between brain age and stroke recovery.
Researchers discovered a novel waste removal factor, CDNF, that treats brain haemorrhage by accelerating lesion resolution, reducing brain swelling, and improving functional outcomes. The treatment also alleviates cell stress and promotes scavenging by immune cells, leading to better recovery.
A study found that over 80% of American adults with type 2 diabetes meet the criteria to use GLP-1 RAs or SGLT2is, but only a small percentage are using them. The medications have a substantially higher cost than current first-line treatments, making it difficult for patients to access them.
A new study has mapped the parts of the brain that support fluid intelligence, a key feature of human cognition. The research found that patients with damage to the right frontal regions performed poorly in tasks requiring problem-solving and reasoning.
Researchers found that individuals who underwent hemispherectomy surgery at a young age can still recognize differences between pairs of words or faces with remarkable accuracy. The study, published in PNAS, sheds light on brain plasticity and its limitations.
A new study has identified two distinct brain networks associated with risk and resilience in depression. The salience network is linked to increased depression symptoms, while the default mode network is linked to decreased depression symptoms. These findings may lead to new treatments for depression using neuromodulation therapies.
A Kessler Foundation study found a relationship between rate of cognitive fatigue in MS and microstructural brain changes, particularly in white matter tracts and basal ganglia. The study's findings hold promise for advancing clinical interventions for disabling fatigue.
A study from UniSA researchers found associations between metabolic profiles and adverse brain findings, including lower hippocampal and grey matter volumes. People with metabolic profiles linked to obesity were more likely to have higher accumulation of iron in the brain.
A study found that high blood adenosine levels at 15 days of life correlated with white matter lesions and brain injury in very low birth weight premature infants. Adenosine may play a role in oligodendrocyte maturation and neuronal development, suggesting its potential as a biomarker for complications of prematurity.
Researchers have developed a new MRI methodology called Correlation Tensor Imaging (CTI) that can analyze stroke lesions with unprecedented accuracy. This technology may predict individual outcomes and guide treatment, improving patient care.
A study published in Neurology found that higher blood pressure in later life is associated with signs of brain aging and brain lesions, including infarcts and tangles linked to Alzheimer's disease. The risk of brain lesions increases by 46% for those with one standard deviation above the average systolic blood pressure.
Researchers found that atrophied brain lesions, rather than new or expanding lesions, predict disability progression in multiple sclerosis. The study suggests that the disappearance of brain lesions into cerebrospinal fluid may be a more accurate indicator of disease worsening.
Research finds brain lesions associated with increased risk of criminal behavior, specifically impacting the moral decision-making network. The study analyzed MRI and CT scans of individuals with brain lesions, revealing a strong correlation between lesions in the same brain network as those with criminal behavior.
Research reveals that brain lesions affecting a specific network involved in moral decision-making are more common among individuals exhibiting criminal behavior. This finding highlights the potential link between brain dysfunction and crime, but also emphasizes that genetic, environmental, and social factors play important roles.
A novel study has identified new biomarkers of multiple sclerosis pathogenesis, revealing a central role for interferon gamma in brain inflammation. The research found that high serum interferon gamma levels activate astrocytes, triggering an inflammatory response and promoting the migration of autoreactive T lymphocytes into the brain.
A study published in Annals of Internal Medicine found that even very small brain lesions (less than 3 mm) detected by MRI triples the risk for stroke and death in asymptomatic patients. Having both small and larger lesions increases the risk to eight-fold, highlighting the importance of considering all lesion sizes in clinical practice.
A new study found that reducing B cell levels can significantly decrease brain lesions and disease activity in people with relapsing-remitting MS. The research showed that maintaining B cell levels below a threshold of 32-64 cells per microliter resulted in an annualized rate of less than one new brain lesion per year.
A study found that migraine can cause long-lasting changes in brain structure, including increased risk of brain lesions, white matter abnormalities, and altered brain volume. Migraine with aura is associated with a higher risk of these changes compared to those without aura.
A new study published in Neurology suggests that high-altitude flying increases the risk of brain lesions. The research found that pilots had nearly four times the volume and three times the number of brain lesions as non-pilots, with lesions evenly distributed throughout the brain.
A weekly stress management program for patients with multiple sclerosis prevented the development of new brain lesions, a marker of the disease's activity in the brain. The study showed that stress management therapy reduced two types of new brain lesions common in multiple sclerosis.
Researchers have discovered a new mouse model for Multiple Sclerosis, using diabetic mice to replicate the disease's relapsing and remitting symptoms. This breakthrough may lead to the development of more effective treatments that turn temporary recovery into permanent repair.
A study published by the American Academy of Neurology found that brain lesions associated with dementia contribute to mild memory loss in older adults. The study of 350 Catholic nuns and priests revealed a gradual decline in memory until the last four to five years of life.
Research found that 18-month-old gesturing in brain-injured children can predict later vocabulary delays; the study suggests that gesture may be a diagnostic tool for identifying children who will experience persistent language delay. The findings have both therapeutic and diagnostic implications.
A study published in Neurology found that smoking is associated with an increased risk of brain lesions and brain shrinkage in people with multiple sclerosis (MS). Smokers with MS had nearly 17% more brain lesions and 13% larger ventricles compared to non-smokers.
A study found that elderly individuals with growing white matter changes were more likely to develop persistent cognitive impairment and dementia. Researchers followed 49 participants for an average of 9.5 years, tracking brain scans and thinking skills tests.
A study published in JAMA Network reveals a strong association between midlife migraines with aura and an increased prevalence of brain lesions in older age. Women were more likely to develop cerebellum-related lesions, suggesting a potential link between migraine with aura and brain function.