Researchers at Children's Hospital of Philadelphia found that dietary interventions can significantly alter outcomes in Hirschsprung disease, suggesting previously unknown mechanisms to improve care for children. The study discovered that a standard diet can induce microscopic and cellular changes in the colons of animal models, leadin...
Researchers have mapped cellular differences between two similar bowel diseases, identifying hidden immune activity that may explain why one carries a much higher risk of colon cancer. The study found that patients with PSC-associated IBD had a distinct microbiome and higher levels of immune activity even in the absence of inflammation.
Researchers found Campylobacter, Salmonella, Shigella, and Pseudomonas aeruginosa bacteria in 13%, 10%, 3%, and 12% of tanks, respectively, with elevated metal levels detected in metal tanks and poorly maintained systems. Regular maintenance and proper handling of rainwater systems are crucial to ensure water quality and public health.
Researchers analyzed data from 23 studies and found a strong association between ADHD and gastrointestinal symptoms, including constipation, IBS, and loss of bowel control. The study suggests that doctors treating people with ADHD should be alert to gut symptoms and consider referring patients to a dietitian or gastroenterologist.
A Swedish registry study found that IBD patients with multiple close relatives having colorectal cancer are significantly more likely to develop the disease. The study suggests that future cancer screening guidelines should consider the number of cancer cases in a patient's family.
A preliminary study by Weill Cornell Medicine investigators found that antifungal therapy can reduce IBD symptoms and improve the gut microbiome in patients with Candida overgrowth. The study compared the effects of two weeks of treatment with nystatin or fluconazole in 53 patients with mild-to-moderate Crohn's disease or ulcerative co...
Researchers have created a detailed map of childhood Crohn's disease before and after treatment, identifying specific cell signatures that predict disease severity and treatment outcomes. The study suggests that anti-TNF therapy may push the pediatric cell ecosystem towards more resistant disease.
A new study from the University of East Anglia found that people who swim in rivers and lakes are more than twice as likely to develop skin problems. Higher levels of bacteria linked to faecal pollution are also associated with an increased risk of stomach bugs. The study, which analyzed data from 2,368 volunteers, found that swimmers ...
Approximately 1 in 9 individuals in China will develop a digestive system cancer in their lifetime, with a staggering 1 in 12 succumbing to these diseases. The study reveals a profound 'risk transition' with colorectal cancer presenting the highest lifetime incidence risk.
A study found that dyadic coping partially explains the association between fear of cancer recurrence and depression among middle-aged and older survivors. The findings highlight the value of involving partners in psychological care to improve emotional well-being during cancer recovery.
Researchers combined AI, genetics, and gut microbiome analysis to shed light on intestinal fibrosis in Crohn's disease. They identified a shared set of 43 key genes linked to disease progression and found that bowel fibrosis is driven by ongoing immune activation, damage to the intestinal lining, and changes in gut bacteria.
A new review article discusses how artificial intelligence can predict disease trajectories and enable precision medicine strategies for inflammatory bowel disease. AI-based systems can standardize interpretation of endoscopic images, detect mucosal healing, and support recognition of dysplasia in patients with long-standing colitis.
Lehigh University researchers develop comprehensive mathematical model of the neural circuitry linking the gut and brain to regulate stomach function, opening new pathways for treating chronic digestive disorders through targeted vagus nerve stimulation. The digital twin could help accelerate therapy development and improve quality of ...
A multidisciplinary study has identified a novel biofilm regulatory protein called Biofilm Architecture Regulator (BatR) and its role in Pseudomonas aeruginosa infections. The discovery may lead to new targets for anti-infective treatments, including those for people with cystic fibrosis.
A new randomized clinical trial suggests that singing therapy provides greater short-term symptom relief and improved quality of life compared to diaphragmatic breathing exercises for people with supragastric belching. Structured singing therapy also resulted in higher response rates and more enjoyable experiences among patients.
Researchers developed a new mouse model that closely reproduces eosinophilic gastritis, identifying key immune pathways and mechanisms behind the disease. The study provides a biological explanation for therapies targeting IL-4Rα, suggesting potential improvements in treatment precision.
The center aims to address the structural gap in care delivery by offering advanced functional diagnostics, individualized treatment planning, surgical intervention, and long-term management. Led by Professor Sungsoo Park, it provides objective, precision-based diagnosis and tailored treatment strategies for patients with refractory GERD.
The partnership aims to streamline prior authorizations, appeals, and financial assistance, addressing delays or denials in accessing prescribed therapies. By combining AGA's clinical leadership with Forus's medication access platform, the collaboration seeks to enhance patient advocacy and access to effective treatments.
A new study found that specific gut bacteria from children with stunted growth can be passed to their offspring, causing inflammation and damage to the intestinal lining. The researchers identified Campylobacter concisus as a key contributor to this process, which may hold promise for future treatment and prevention strategies.
Researchers have found that oyster meat extract can effectively reduce TNF-α-induced intestinal inflammation by interrupting NF-kB signalling pathways and decreasing COX-2 enzyme expression. This natural supplement has potential as a sustainable solution for managing chronic inflammatory diseases.
A blood test may help identify which patients with colorectal cancer that has spread to the liver are most likely to benefit from chemotherapy after surgery. Patients with detectable circulating tumour DNA (ctDNA) who received adjuvant chemotherapy had markedly better outcomes, including a 93% reduction in recurrence.
The American Gastroenterological Association has launched a new professional development initiative for gastroenterology and hepatology advanced practice providers (APPs). The AGA APP GI Readiness and Credentialing program includes two pathways: the AGA Foundations Certificate for new APPs and the AGA GI Advanced Practice Certification...
A multi-omics study identifies the TNF-α/IL-1β/PGE₂ axis as a driver of mucus overproduction and colonic lesion formation in Cronkhite–Canada syndrome. The study reveals extensive epithelial remodeling, goblet cell hyperplasia, and an inflammatory colonic epithelial cell subset characterized by high expression of lipocalin-2.
Scientists discovered a natural microbial compound that protects the gut and supports future treatments for inflammatory bowel disease. UroA activates a protective pathway in intestinal epithelial cells, triggering the release of molecules associated with maintaining normal intestinal function and repairing the gut lining.
A new study found that beef protein worsens gut inflammation in mice with IBD, while pea protein shows protective effects. The research suggests that dietary protein source plays a key role in shaping gut health.
Scientists discovered a direct link between estrogen and gut inflammation in Crohn's disease. The study used zebrafish models to show that estrogen signalling plays a crucial role in maintaining normal gut health. This finding could lead to more personalized approaches to treatment, especially for females affected by the disease.
Researchers have identified a previously unknown genetic cause of Crohn’s disease and uncovered its link to inflammation through the RIPK1 pathway. This discovery may guide more precise treatments and improve patient matching based on unique biology.
Researchers discovered Paneth cell metaplasia can act as a protective response in ulcerative colitis by promoting healing and regeneration of the intestinal lining through REG3A. However, persistent changes may still carry risks, including increased cancer risk.
Researchers found that over-the-counter probiotics contain only 36 unique species of bacteria, with most common species being forms of Lactobacillus. The analysis suggests a lack of consistency in the combination of species used to support gut health and vaginal health claims.
Researchers found well-preserved bacterial communities in ancient middens, including species from human feces and animal hosts. The study suggests that these communities provide a unique glimpse into the daily life of Paleo-Inuit and old Norse, including their farming, seal hunts, and toilets.
Researchers at Institute of Science Tokyo have developed a novel culture system to produce stable, scalable, and low-cost clinical-grade intestinal organoids from patient biopsy samples. The innovative approach uses clinical-grade collagen and synthetic peptides to enhance growth and improve scalability.
Researchers have discovered a genetic marker associated with more severe IBD, enabling earlier treatment and monitoring for patients at risk. The study analyzed data from over 43,000 patients and found that a specific combination of genetic variants is linked to severe disease outcomes.
A study found that regularly assessing gastric residual volume in critically ill children being enterally fed significantly improved nutritional achievement at 72 hours. Not routine assessments every 6 hours had similar results, demonstrating noninferiority.
Researchers identified a driver of inflammatory bowel disease, a group of biologically distinct diseases driven by different underlying mechanisms. Autoimmune responses to interleukin-10 lead to uncontrolled inflammation in ~3.5% of IBD patients, carrying a genetic variant linked to severe disease.
Mazdutide, a GLP-1 receptor dual agonist, provides clinically meaningful weight reduction in Chinese adults with obesity. However, gastrointestinal adverse reactions are more common among those taking the drug compared to placebo.
A study published in Nature Communications reveals that phytic acid, found in plant-rich diets, activates a cellular regulator to maintain intestinal barrier function. This finding offers a promising natural solution for managing leaky gut and its link to chronic conditions.
A national analysis found that robotic-assisted cholecystectomy remained linked to increased bile duct injury risks despite growing use. The study suggests small differences in overall complication rates between approaches.
A new screening tool tests for microbial metabolites in urine to identify children at risk for autism, with 90% sensitivity and 100% specificity. The test may guide more targeted interventions, including approaches to restore a healthy gut microbiome.
Researchers at Cincinnati Children's Hospital Medical Center have developed a new method to produce large, functional human gut organoids with nerve cells, growing them twice as fast as previous methods. These organoids can now be used for patching damage or restoring diminished functions of the small intestine, stomach, or colon.
A phase 2 clinical trial found that 65% of patients receiving avatrombopag met key treatment goals, compared to 17% of those receiving placebo treatment. The oral medication has been shown to be effective in maintaining platelet counts needed to continue chemotherapy as scheduled.
A new study replicated patient- and sex-specific hallmarks of Inflammatory Bowel Disease (IBD) in a human organ chip, identifying stromal fibroblasts as key drivers of inflammation, fibrosis, and enhanced cancer risk. The model also recapitulated the impact of pregnancy hormones on IBD severity in female patients.
A study published in Nature Metabolism has found a crucial link between mitochondrial lipid deficiency and gut inflammation, revealing that cardiolipin plays a key role in maintaining immune homeostasis. The research suggests that targeting the metabolism of immune cells could be a new approach to treating inflammatory bowel diseases.
A new study reveals a correlation between body weight and gut microbiota composition, which can lead to gastrointestinal diseases. However, genetics also play a role in shaping the gut microbiome.
Researchers at the Sylvester Comprehensive Cancer Center presented several studies at ASCO 2026 exploring new treatment options for patients with advanced gastrointestinal stromal tumors (GISTs) and melanoma. These include velzatinib, a targeted therapy for GIST patients, and PRAME-directed T-cell receptor therapies for synovial sarcoma.
Researchers have developed a new combination therapy that shows promising results in treating patients with Crohn's disease and ulcerative colitis. The treatment, which combines two mechanisms of action, has been shown to improve clinical remission rates by more than 20 percentage points compared to existing therapies.
Researchers have developed a new class of biodegradable, all-metal microrobots that can penetrate tissue and deliver medications without causing damage. These microrobots demonstrate both strength and safety in testing on mice, paving the way for potential applications in drug delivery and biopsy procedures.
Research finds GADD45B induces MST1 expression by promoting DNA demethylation, exacerbating apoptosis and intestinal injury in I/R. GADD45B/TET1/MST1 axis may represent a viable therapeutic strategy for I/R injury.
Researchers at Vanderbilt University Medical Center discovered that enterotoxigenic Bacteroides fragilis reshapes intestinal cell metabolism to support its growth, causing diseases like diarrhea and colorectal cancer. The study provides new possibilities for intervention by targeting metabolic interactions between host and microbes.
Researchers from UH, Baylor College of Medicine and MD Anderson Cancer Center propose a new treatment approach for Crohn's disease by targeting the stress signal that fuels inflammation. They found that repurposing two existing cancer medications can promote natural repair and regeneration of the intestinal lining.
A new study suggests that eating late at night can disrupt bowel function and lead to constipation and diarrhea. Individuals who experienced high levels of chronic stress and ate more than 25% of daily calories after 9pm were more likely to report bowel problems, highlighting the impact of meal timing on gut health.
A national survey found significant disparities in IBS diagnosis across sex and racial groups in the US. Men and Black patients are less likely to receive a formal diagnosis compared to women and white patients, despite similar reported healthcare-seeking behavior and symptom severity.
A randomized trial found that duloxetine does not prevent painful neuropathy caused by oxaliplatin-based chemotherapy in patients with stage II or III colorectal cancer. The study suggests that duloxetine should only be used for managing existing neuropathy, not prevention.
A study led by UNICAMP researchers found that decreased bacteria in the large intestine affects nutrient absorption, particularly in older adults. The research showed a dual function of a previously thought mucus-secreting cell, which absorbs nutrients and regulates its abundance with gut microbiota signals.
Researchers at Aalborg University aim to identify biological changes driving disease development with a comprehensive pre-diagnostic study of early Crohn's disease. They will analyze thousands of blood samples from patients prior to diagnosis to develop a predictive model.
A meta-analysis of GLP-1 receptor agonist studies found potential safety signals for gastrointestinal side effects, while some evidence suggested a link to reduced respiratory disease risk. Further research is needed to confirm the latter association.
Researchers from Institute of Science Tokyo discovered a unique mechanism in which conventional stem cells can temporarily switch into a specialized regenerative state called revival stem cells, driving tissue repair. This process, known as fetal reversion, enables efficient regeneration without exhausting the stem cell pool.
Researchers found that metabolism of wheat fiber by intestinal bacteria generated bioactive anti-inflammatory metabolites, including polyphenols, which reprogrammed intestinal immune cells to suppress inflammation. The study suggests eating whole wheat foods may reduce one’s risk of developing inflammatory bowel disease (IBD).
A phase 3 clinical trial found romiplostim significantly reduced chemotherapy dose delays and improved platelet counts in patients with gastrointestinal cancers who developed persistent low platelet counts during treatment. The therapy enables patients to maintain chemotherapy intensity, potentially preserving the integrity of cancer c...
A new study suggests that early life stress during pregnancy and early childhood can lead to long-term digestive issues, including gut pain and motility challenges. The research found that early life stress can shape the development of gut-brain communication, contributing to gastrointestinal symptoms in both mice and humans.
A new experimental rat model reproduces creeping fat in Crohn's disease, characterized by mesocolic adipose tissue hyperplasia with macroscopic, histological, immunological, and molecular similarities to human disease. The model supports the hypothesis that intestinal microbiota contributes to remodelling of mesenteric adipose tissue.