A new study published in Cell Metabolism found that a low-protein, amino acid-supplemented 'longevity diet' improved cardiometabolic markers and reduced frailty and fat mass in mice. The diet was associated with longer healthy lifespan and better metabolic health in both mice and humans.
SourceUniversity of Southern California·JournalCell Metabolism·TypeExperimental study·DateJun 23, 2026
A new paper by over 20 protein experts examines widely held propositions about dietary protein, concluding that some science is insufficient or not robust enough to support certain claims. Key findings include the importance of protein quality, individual essential amino acids, and nuance in high-protein intake during weight loss.
SourceNational Pork Board·JournalCritical Reviews in Food Science and Nutrition·TypeCommentary/editorial·DateJun 8, 2026
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Researchers found that D, L-buthionine-(S, R)-sulfoximine (BSO) replicates the anti-obesity effects of sulfur amino acid restriction without causing bone loss in male mice. The study suggests BSO as a promising tool for dissecting the beneficial versus deleterious axes of sulfur amino acid biology.
SourceImpact Journals LLC·JournalAging-US·TypeNews article·DateMar 13, 2026
A groundbreaking study reveals how TRMT10A deficiency disrupts protein synthesis, synaptic structure, and function in the brain, leading to impaired cognitive abilities. Researchers found a significant decrease in specific tRNA levels, particularly those essential for initiating protein synthesis.
SourceKumamoto University·JournalNucleic Acids Research·TypeExperimental study·DateSep 27, 2024
Researchers found that altering the starch, oil, and amino acid content of a broiler diet can help support healthy growth in coccidiosis-challenged birds. The optimal mix consists of 35.8% starch, 8.9% oil, and 101.3% recommended amino acids.
SourceUniversity of Illinois College of Agricultural, Consumer and Environmental Sciences·JournalPoultry Science·DateMar 4, 2024
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Researchers found that restricting methionine intake via a low-methionine diet or oral administration of recombinant methioninase-producing E. coli reversed old-age-induced obesity in mice, leading to significant weight loss after just 14 days.
SourceImpact Journals LLC·JournalAging-US·TypeExperimental study·DateJun 27, 2023
Scientists have identified a molecular control centre responsible for processing newly formed proteins correctly when they leave the cell's protein factories. The ribosomal gatekeeper NAC ensures the excision of methionine from specific proteins, preventing cell death.
SourceUniversity of Konstanz·JournalScience·DateJun 22, 2023
Dominique Higgins and his team found that a specialized diet can induce ferroptosis, a type of cell death, in glioblastoma cells, making chemotherapy drugs more effective. This approach has shown promise in animal models and is being explored as a potential treatment for brain tumors.
SourceUniversity of North Carolina Health Care·JournalNature Communications·DateApr 7, 2023
Researchers at Hokkaido University discovered itaconate's modulatory effect on T helper and T regulatory cells, potentially leading to new treatments for autoimmune diseases. The study found that itaconate inhibits Th17 cell differentiation and promotes Treg cell development, reducing disease symptoms in mice models.
SourceHokkaido University·JournalNature Communications·TypeExperimental study·DateMar 14, 2023
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Researchers found that cells exchanging amino acids and glycerol with each other lived up to 25% longer. The study suggests this collaborative exchange extends the lifespan of cells within a community as a whole.
SourceCharité - Universitätsmedizin Berlin·JournalCell·TypeExperimental study·DateJan 6, 2023
A University of Illinois study shows rumen-protected lysine can improve uterine health in dairy cows during the transition period. The supplement reduced genes involved in inflammatory proteins and increased genes keeping the uterus clean, leading to less inflammation and improved reproductive outcomes.
SourceUniversity of Illinois College of Agricultural, Consumer and Environmental Sciences·JournalJournal of Dairy Science·DateSep 19, 2022
Researchers at Tokyo Institute of Technology have revealed that zinc (Zn) content is essential for the methionine-mediated regulation of pluripotent stem cells (PSCs). The team developed a protocol to convert PSCs into insulin-producing β cells, overcoming diabetes treatment challenges.
SourceTokyo Institute of Technology·JournalCell Reports·TypeExperimental study·DateJul 19, 2022
Researchers found that suppressing an enzyme called MSRA, which fixes oxidative damage to proteins, sparks the metastatic spread of pancreatic cancer cells. The discovery suggests that similar switches may exist in other cancers and lays the groundwork for redox-based targeted therapies.
SourceUniversity of California - Berkeley·JournalMolecular Cell·TypeExperimental study·DateJun 28, 2022
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A study found that a methionine-deficient diet alters gene expression and DNA methylation in liver cells, increasing the risk of non-alcoholic fatty liver disease. A methionine-supplemented diet had the opposite effect, reducing the risk of liver damage.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalFood and Chemical Toxicology·DateJun 15, 2022
Researchers at CIC bioGUNE identified microRNA 873 as a potential therapeutic agent for acute liver failure due to APAP overdose. The study found that anti-miR-873-5p treatment rescues the liver and extends the therapeutic window by 24 hours.
SourceCIC bioGUNE·JournalAntioxidants·TypeExperimental study·DateMay 4, 2022
Researchers at the University of Kansas have discovered a promising new basis for active immunization against Alzheimer's disease. By injecting a recombinant methionine-rich protein into mice with the disease, they were able to improve short-term memory and learning abilities by up to 50%. The treatment also showed potential in reducin...
SourceUniversity of Kansas·JournalAntioxidants·DateMay 3, 2022
A study from the University of Pittsburgh found that methionine restriction can slow down the growth of difficult-to-treat brain tumors in children, known as diffuse midline gliomas. The researchers discovered that these tumors are uniquely dependent on methionine, an amino acid, and that depleting it can repress cancer cell growth.
SourceUniversity of Pittsburgh·JournalNature Cancer·DateApr 14, 2022
Researchers at University of Cologne discovered that specific diets can safeguard against acute kidney injury in mouse models. The six tested diets showed overlapping changes in cysteine catabolism as a potential mechanism for organ protection.
SourceUniversity of Cologne·JournalTranslational Research·TypeExperimental study·DateMar 21, 2022
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A new diet that restricts methionine has shown promising results in improving biomarkers of metabolic health, potentially slowing the aging process. The palatable oxidized casein diet could be a solution to offset major components of metabolic disease.
SourcePennington Biomedical Research Center·JournaliScience·DateMay 20, 2021
Researchers propose a model of how caloric restriction contributes to yeast chronological aging delay by remodeling cellular metabolism. The study found that caloric restriction significantly lowers intracellular concentrations of methionine and S-adenosylmethionine, leading to a metabolic pattern of aging delay.
SourceImpact Journals LLC·JournalOncotarget·DateMay 17, 2021
A study published in eLife found that selenium supplementation protects against diet-induced obesity in mice, reducing levels of energy-regulating hormones IGF-1 and leptin. The researchers also observed increased healthspan in yeast grown under selenium-supplemented conditions.
Researchers found that tumor cells increase SLC6A14 expression levels in response to methionine deprivation, leading to increased AMPK activation. Targeting both SLC6A14 and AMPK may drive unbalanced metabolism in starved tumor cells, promoting apoptosis.
SourceImpact Journals LLC·JournalOncotarget·DateMar 1, 2021
Researchers applied CRISPRi technology to understand metabolic robustness in E. coli, revealing mechanisms that buffer enzyme knockdowns. The study identified specific buffering mechanisms across multiple metabolic pathways, paving the way for developing industrially useful microbes with controlled metabolism.
SourceMax-Planck-Gesellschaft·JournalCell Reports·DateNov 24, 2020
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A new study found that tumor cells outcompete T cells for the amino acid methionine, impairing its function. Supplementing methionine can restore T cell function, suggesting a potential target for immunotherapy against more cancers.
SourceMichigan Medicine - University of Michigan·JournalNature·DateSep 2, 2020
Researchers at UC Santa Cruz have developed a new method for separating the stereoisomers of an oxidized amino acid, opening up new opportunities for studying its role in biological processes. The method uses supercritical fluid chromatography to purify the stereoisomers with high purity.
SourceUniversity of California - Santa Cruz·JournalChemistry - A European Journal·DateApr 9, 2020
Lactococcus lactis bacteria use two amino acid transport systems to acquire methionine under low-methionine conditions. The choice of system is maintained over multiple generations, suggesting a strategy of bet-hedging or division of labor to adapt to changing environmental conditions.
SourceUniversity of Groningen·JournalNature Communications·DateMar 5, 2020
Researchers found that significantly reducing dietary methionine slows the progression of inflammatory and autoimmune disorders like multiple sclerosis. Methionine fuels T cells, which can cause inflammation and damage if it lingers.
SourceVan Andel Research Institute·JournalCell Metabolism·DateFeb 4, 2020
Research reveals that methionine in spider silk proteins increases flexibility, enabling close interactions between proteins. The discovery may enable the synthesis of novel biomaterials with improved stability.
SourceJohannes Gutenberg Universitaet Mainz·JournalNature Communications·DateNov 4, 2019
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Scientists have discovered that the natural amino acid methionine provides plasticity to spider silk proteins, increasing strength and elasticity. This finding has potential applications in industries such as aviation and textile production.
SourceUniversity of Würzburg·JournalNature Communications·DateSep 26, 2019
Researchers at Arizona State University discover that choline supplementation may help fight Alzheimer's disease in mice and their offspring. The study reveals that high choline intake during gestation and lactation improves spatial memory in subsequent generations, suggesting a transgenerational effect.
SourceArizona State University·JournalMolecular Psychiatry·DateJan 8, 2019
A recent study elucidates how methionine controls cell growth programs by setting into motion a metabolic program for cell proliferation. Methionine activates key nodes in metabolism that produce critical substrates and co-factors fueling the production of amino acids and nucleotides, critical for growth.
SourceNational Centre for Biological Sciences·JournalMolecular Biology of the Cell·DateJan 4, 2019
Researchers at Technical University of Munich have developed an enzymatic process to produce methionine from gaseous CO2, replacing the current petrochemical-based method. The new process requires just two enzymes and has a yield of 40 percent, compared to photosynthesis which uses 14 enzymes with only a 20 percent yield.
SourceTechnical University of Munich (TUM)·JournalNature Catalysis·DateJul 26, 2018
A study from Harvard T.H. Chan School of Public Health found that restricting the essential amino acid methionine triggered the formation of new blood vessels in skeletal muscle, suggesting improved vascular function may contribute to benefits of dietary restriction.
SourceHarvard T.H. Chan School of Public Health·JournalCell·DateMar 22, 2018
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The study reveals a novel mechanism by which cancer cells become dependent on methionine, an essential amino acid. Researchers propose using existing drugs like sulfasalazine to trigger this dependency and induce cancer cell death.
SourceLudwig Institute for Cancer Research·JournalScience Signaling·DateDec 19, 2017
A team of Rutgers scientists has discovered a way to increase the nutritional value of corn by inserting a bacterial gene that produces methionine, a key amino acid. This breakthrough could benefit millions in developing countries who rely on corn as a staple food, and significantly reduce worldwide animal feed costs.
SourceRutgers University·JournalProceedings of the National Academy of Sciences·DateOct 9, 2017
Researchers have made a groundbreaking discovery, finding that an amino acid called methionine may play a crucial role in the development of schizophrenia. Excess methionine during pregnancy has been shown to alter fetal brain development, leading to changes in gene expression and potentially life-long consequences.
SourceUniversity of California - Irvine·JournalMolecular Psychiatry·DateAug 15, 2017
Researchers found that methionine supplementation can increase embryo survival in dairy cows and affect gene expression in ovarian follicles. Cows fed methionine had higher estrogen production and lower inflammation levels, potentially leading to faster heat cycles and improved fertility.
SourceUniversity of Illinois College of Agricultural, Consumer and Environmental Sciences·JournalTheriogenology·DateApr 17, 2017
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Chemists have developed a new technique called redox activated chemical tagging (ReACT) that selectively links chemicals to proteins. This method could transform the way drugs are developed, proteins are probed, and molecules are tracked and imaged.
SourceDOE/Lawrence Berkeley National Laboratory·JournalScience·DateFeb 9, 2017
A University of Illinois study found that supplementing Holstein cows' diets with methionine during prepartum and postpartum periods increased the number of lipid droplets in preimplantation embryos, allowing them to survive more stress. This may lead to lower embryonic death rates and improved pregnancy outcomes.
SourceUniversity of Illinois College of Agricultural, Consumer and Environmental Sciences·JournalJournal of Animal Science·DateMay 16, 2016
Researchers at Ohio State University Wexner Medical Center have identified altered metabolism of methionine and tryptophan as a driving force behind glioblastoma progression. Restricting dietary intake of these amino acids may slow tumor growth and improve treatment outcomes.
SourceOhio State University Wexner Medical Center·JournalClinical Cancer Research·DateMar 31, 2016
A low-methionine diet can increase the vulnerability of triple-negative breast cancer cells to targeted therapies. Researchers found that depriving cancer cells of methionine triggers an increase in a receptor on the cell's surface, making them more sensitive to treatments.
SourceUniversity of Wisconsin-Madison·JournalClinical Cancer Research·DateJul 14, 2015
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Researchers have discovered a genetic variant linked to an increased risk of stroke and cardiovascular disease. The study found that variants in the FOCM pathway, which regulates homocysteine metabolism, are associated with differences in methionine processing, highlighting potential new targets for disease prevention and treatment.
SourceNIH/National Human Genome Research Institute·JournalPLOS Genetics·DateMar 20, 2014
A research team at Ruhr-University Bochum has identified a new type of signalling mechanism in plant cells, involving the glutamate-like receptor AtGLR1.4. The receptor responds to multiple amino acids, including methionine, which is an essential nutrient for humans but can be produced by plants.
SourceRuhr-University Bochum·JournalScience Signaling·DateJun 25, 2013
A new study published in the Journal of Economic Entomology reveals that methionine, a key amino acid essential for human nutrition, is effective against caterpillars threatening the U.S. citrus industry. Methionine disrupts an ion channel controlling nutrient absorption in larvae, leading to their death within two to three days.
SourceEntomological Society of America·JournalJournal of Economic Entomology·DateJan 19, 2012
Researchers at the University of Florida have discovered a key amino acid, methionine, that is effective in killing caterpillars threatening the US citrus industry. The discovery uses a genetically related surrogate and has potential applications for organic poultry production.
SourceUniversity of Florida·JournalJournal of Economic Entomology·DateJan 17, 2012
A study analyzing nearly 400,000 participants found that increased blood levels of vitamin B6 and methionine were associated with a reduced risk of developing lung cancer. The findings suggest these nutrients may play a role in inhibiting cancer development, offering potential for dietary modification to reduce cancer risk.
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A diet rich in methionine, found in red meats and fish, may increase the risk of developing Alzheimer's disease by accelerating amyloid plaque formation. Research suggests that high levels of homocysteine, a byproduct of methionine breakdown, can lead to increased dementia risk.
A new study funded by the Wellcome Trust suggests that getting the correct balance of proteins in our diet may be more important for healthy ageing than reducing calories. Researchers found that varying the amount of amino acids in a diet can affect lifespan and fertility, with certain amino acids being crucial to maximising both.
Researchers discovered that cells use 'regulated errors' to create resistant proteins against damage, using the amino acid methionine to neutralize reactive oxygen species. This novel non-genetic mechanism allows every protein to get some protection, making it a crucial defense strategy.
SourceUniversity of Chicago Medical Center·JournalNature·DateNov 25, 2009
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A new study published in PNAS found that a B-vitamin deficiency can cause vascular cognitive impairment in mice. The research, conducted by researchers at Tufts University, used an experimental model to examine the effects of dietary B-vitamin deficiency on metabolic, cognitive, and microvascular changes.
SourceTufts University, Health Sciences Campus·JournalProceedings of the National Academy of Sciences·DateSep 2, 2008
Researchers have developed an enzyme inhibitor that targets betaine-homocysteine-S-methyltransferase (BHMT), slowing cancer growth by reducing methionine production. The BHMT inhibitors show promise as a potential treatment for cancer, with the possibility of enhancing efficacy when combined with other drugs.
SourceUniversity of Illinois at Urbana-Champaign, News Bureau·JournalJournal of Medicinal Chemistry·DateJul 6, 2006
Researchers at Rutgers University have created a new approach to increase protein content in corn without using genetically modified organisms (GMOs). The discovery has the potential to improve nutritional health in Third World countries where corn is a staple food.
SourceRutgers University·JournalThe Plant Journal·DateJun 4, 2002