A new study published in Cell Metabolism found that a low-protein, amino acid-supplemented 'longevity diet' improved cardiometabolic markers and reduced frailty and fat mass in mice. The diet was associated with longer healthy lifespan and better metabolic health in both mice and humans.
A new paper by over 20 protein experts examines widely held propositions about dietary protein, concluding that some science is insufficient or not robust enough to support certain claims. Key findings include the importance of protein quality, individual essential amino acids, and nuance in high-protein intake during weight loss.
Researchers found that D, L-buthionine-(S, R)-sulfoximine (BSO) replicates the anti-obesity effects of sulfur amino acid restriction without causing bone loss in male mice. The study suggests BSO as a promising tool for dissecting the beneficial versus deleterious axes of sulfur amino acid biology.
A groundbreaking study reveals how TRMT10A deficiency disrupts protein synthesis, synaptic structure, and function in the brain, leading to impaired cognitive abilities. Researchers found a significant decrease in specific tRNA levels, particularly those essential for initiating protein synthesis.
Researchers found that altering the starch, oil, and amino acid content of a broiler diet can help support healthy growth in coccidiosis-challenged birds. The optimal mix consists of 35.8% starch, 8.9% oil, and 101.3% recommended amino acids.
Researchers found that restricting methionine intake via a low-methionine diet or oral administration of recombinant methioninase-producing E. coli reversed old-age-induced obesity in mice, leading to significant weight loss after just 14 days.
Scientists have identified a molecular control centre responsible for processing newly formed proteins correctly when they leave the cell's protein factories. The ribosomal gatekeeper NAC ensures the excision of methionine from specific proteins, preventing cell death.
Dominique Higgins and his team found that a specialized diet can induce ferroptosis, a type of cell death, in glioblastoma cells, making chemotherapy drugs more effective. This approach has shown promise in animal models and is being explored as a potential treatment for brain tumors.
Researchers at Hokkaido University discovered itaconate's modulatory effect on T helper and T regulatory cells, potentially leading to new treatments for autoimmune diseases. The study found that itaconate inhibits Th17 cell differentiation and promotes Treg cell development, reducing disease symptoms in mice models.
Researchers found that cells exchanging amino acids and glycerol with each other lived up to 25% longer. The study suggests this collaborative exchange extends the lifespan of cells within a community as a whole.
A University of Illinois study shows rumen-protected lysine can improve uterine health in dairy cows during the transition period. The supplement reduced genes involved in inflammatory proteins and increased genes keeping the uterus clean, leading to less inflammation and improved reproductive outcomes.
Researchers at Tokyo Institute of Technology have revealed that zinc (Zn) content is essential for the methionine-mediated regulation of pluripotent stem cells (PSCs). The team developed a protocol to convert PSCs into insulin-producing β cells, overcoming diabetes treatment challenges.
Researchers found that suppressing an enzyme called MSRA, which fixes oxidative damage to proteins, sparks the metastatic spread of pancreatic cancer cells. The discovery suggests that similar switches may exist in other cancers and lays the groundwork for redox-based targeted therapies.
A study found that a methionine-deficient diet alters gene expression and DNA methylation in liver cells, increasing the risk of non-alcoholic fatty liver disease. A methionine-supplemented diet had the opposite effect, reducing the risk of liver damage.
Researchers at CIC bioGUNE identified microRNA 873 as a potential therapeutic agent for acute liver failure due to APAP overdose. The study found that anti-miR-873-5p treatment rescues the liver and extends the therapeutic window by 24 hours.
Researchers at the University of Kansas have discovered a promising new basis for active immunization against Alzheimer's disease. By injecting a recombinant methionine-rich protein into mice with the disease, they were able to improve short-term memory and learning abilities by up to 50%. The treatment also showed potential in reducin...
A study from the University of Pittsburgh found that methionine restriction can slow down the growth of difficult-to-treat brain tumors in children, known as diffuse midline gliomas. The researchers discovered that these tumors are uniquely dependent on methionine, an amino acid, and that depleting it can repress cancer cell growth.
Researchers at University of Cologne discovered that specific diets can safeguard against acute kidney injury in mouse models. The six tested diets showed overlapping changes in cysteine catabolism as a potential mechanism for organ protection.
A new diet that restricts methionine has shown promising results in improving biomarkers of metabolic health, potentially slowing the aging process. The palatable oxidized casein diet could be a solution to offset major components of metabolic disease.
Researchers propose a model of how caloric restriction contributes to yeast chronological aging delay by remodeling cellular metabolism. The study found that caloric restriction significantly lowers intracellular concentrations of methionine and S-adenosylmethionine, leading to a metabolic pattern of aging delay.
A study published in eLife found that selenium supplementation protects against diet-induced obesity in mice, reducing levels of energy-regulating hormones IGF-1 and leptin. The researchers also observed increased healthspan in yeast grown under selenium-supplemented conditions.
Researchers found that tumor cells increase SLC6A14 expression levels in response to methionine deprivation, leading to increased AMPK activation. Targeting both SLC6A14 and AMPK may drive unbalanced metabolism in starved tumor cells, promoting apoptosis.
Researchers applied CRISPRi technology to understand metabolic robustness in E. coli, revealing mechanisms that buffer enzyme knockdowns. The study identified specific buffering mechanisms across multiple metabolic pathways, paving the way for developing industrially useful microbes with controlled metabolism.
A new study found that tumor cells outcompete T cells for the amino acid methionine, impairing its function. Supplementing methionine can restore T cell function, suggesting a potential target for immunotherapy against more cancers.
Researchers at UC Santa Cruz have developed a new method for separating the stereoisomers of an oxidized amino acid, opening up new opportunities for studying its role in biological processes. The method uses supercritical fluid chromatography to purify the stereoisomers with high purity.
Lactococcus lactis bacteria use two amino acid transport systems to acquire methionine under low-methionine conditions. The choice of system is maintained over multiple generations, suggesting a strategy of bet-hedging or division of labor to adapt to changing environmental conditions.
Researchers found that significantly reducing dietary methionine slows the progression of inflammatory and autoimmune disorders like multiple sclerosis. Methionine fuels T cells, which can cause inflammation and damage if it lingers.
Research reveals that methionine in spider silk proteins increases flexibility, enabling close interactions between proteins. The discovery may enable the synthesis of novel biomaterials with improved stability.
Scientists have discovered that the natural amino acid methionine provides plasticity to spider silk proteins, increasing strength and elasticity. This finding has potential applications in industries such as aviation and textile production.
Researchers at Arizona State University discover that choline supplementation may help fight Alzheimer's disease in mice and their offspring. The study reveals that high choline intake during gestation and lactation improves spatial memory in subsequent generations, suggesting a transgenerational effect.
A recent study elucidates how methionine controls cell growth programs by setting into motion a metabolic program for cell proliferation. Methionine activates key nodes in metabolism that produce critical substrates and co-factors fueling the production of amino acids and nucleotides, critical for growth.
Researchers at Technical University of Munich have developed an enzymatic process to produce methionine from gaseous CO2, replacing the current petrochemical-based method. The new process requires just two enzymes and has a yield of 40 percent, compared to photosynthesis which uses 14 enzymes with only a 20 percent yield.
A study from Harvard T.H. Chan School of Public Health found that restricting the essential amino acid methionine triggered the formation of new blood vessels in skeletal muscle, suggesting improved vascular function may contribute to benefits of dietary restriction.
The study reveals a novel mechanism by which cancer cells become dependent on methionine, an essential amino acid. Researchers propose using existing drugs like sulfasalazine to trigger this dependency and induce cancer cell death.
A team of Rutgers scientists has discovered a way to increase the nutritional value of corn by inserting a bacterial gene that produces methionine, a key amino acid. This breakthrough could benefit millions in developing countries who rely on corn as a staple food, and significantly reduce worldwide animal feed costs.
Researchers have made a groundbreaking discovery, finding that an amino acid called methionine may play a crucial role in the development of schizophrenia. Excess methionine during pregnancy has been shown to alter fetal brain development, leading to changes in gene expression and potentially life-long consequences.
Researchers found that methionine supplementation can increase embryo survival in dairy cows and affect gene expression in ovarian follicles. Cows fed methionine had higher estrogen production and lower inflammation levels, potentially leading to faster heat cycles and improved fertility.
Chemists have developed a new technique called redox activated chemical tagging (ReACT) that selectively links chemicals to proteins. This method could transform the way drugs are developed, proteins are probed, and molecules are tracked and imaged.
A University of Illinois study found that supplementing Holstein cows' diets with methionine during prepartum and postpartum periods increased the number of lipid droplets in preimplantation embryos, allowing them to survive more stress. This may lead to lower embryonic death rates and improved pregnancy outcomes.
Researchers at Ohio State University Wexner Medical Center have identified altered metabolism of methionine and tryptophan as a driving force behind glioblastoma progression. Restricting dietary intake of these amino acids may slow tumor growth and improve treatment outcomes.
A low-methionine diet can increase the vulnerability of triple-negative breast cancer cells to targeted therapies. Researchers found that depriving cancer cells of methionine triggers an increase in a receptor on the cell's surface, making them more sensitive to treatments.
Researchers have discovered a genetic variant linked to an increased risk of stroke and cardiovascular disease. The study found that variants in the FOCM pathway, which regulates homocysteine metabolism, are associated with differences in methionine processing, highlighting potential new targets for disease prevention and treatment.
A research team at Ruhr-University Bochum has identified a new type of signalling mechanism in plant cells, involving the glutamate-like receptor AtGLR1.4. The receptor responds to multiple amino acids, including methionine, which is an essential nutrient for humans but can be produced by plants.
A new study published in the Journal of Economic Entomology reveals that methionine, a key amino acid essential for human nutrition, is effective against caterpillars threatening the U.S. citrus industry. Methionine disrupts an ion channel controlling nutrient absorption in larvae, leading to their death within two to three days.
Researchers at the University of Florida have discovered a key amino acid, methionine, that is effective in killing caterpillars threatening the US citrus industry. The discovery uses a genetically related surrogate and has potential applications for organic poultry production.
A study analyzing nearly 400,000 participants found that increased blood levels of vitamin B6 and methionine were associated with a reduced risk of developing lung cancer. The findings suggest these nutrients may play a role in inhibiting cancer development, offering potential for dietary modification to reduce cancer risk.
A diet rich in methionine, found in red meats and fish, may increase the risk of developing Alzheimer's disease by accelerating amyloid plaque formation. Research suggests that high levels of homocysteine, a byproduct of methionine breakdown, can lead to increased dementia risk.
A new study funded by the Wellcome Trust suggests that getting the correct balance of proteins in our diet may be more important for healthy ageing than reducing calories. Researchers found that varying the amount of amino acids in a diet can affect lifespan and fertility, with certain amino acids being crucial to maximising both.
Researchers discovered that cells use 'regulated errors' to create resistant proteins against damage, using the amino acid methionine to neutralize reactive oxygen species. This novel non-genetic mechanism allows every protein to get some protection, making it a crucial defense strategy.
A new study published in PNAS found that a B-vitamin deficiency can cause vascular cognitive impairment in mice. The research, conducted by researchers at Tufts University, used an experimental model to examine the effects of dietary B-vitamin deficiency on metabolic, cognitive, and microvascular changes.
Researchers have developed an enzyme inhibitor that targets betaine-homocysteine-S-methyltransferase (BHMT), slowing cancer growth by reducing methionine production. The BHMT inhibitors show promise as a potential treatment for cancer, with the possibility of enhancing efficacy when combined with other drugs.
Researchers at Rutgers University have created a new approach to increase protein content in corn without using genetically modified organisms (GMOs). The discovery has the potential to improve nutritional health in Third World countries where corn is a staple food.