Epigenetics
Articles tagged with Epigenetics
UT MD Anderson shares latest research breakthroughs
Researchers at UT MD Anderson Cancer Center have made significant advancements in targeted therapy treatments for advanced lung cancer and early-stage classical Hodgkin lymphoma. The studies showcase high response rates with novel combination therapies and a new understanding of how an enzyme affects infertility and cancer progression.
Chinese Medical Journal article explores the mechanism of GADD45B in intestinalischemia/reperfusion
Research finds GADD45B induces MST1 expression by promoting DNA demethylation, exacerbating apoptosis and intestinal injury in I/R. GADD45B/TET1/MST1 axis may represent a viable therapeutic strategy for I/R injury.
AI method tackles one of science's hardest math problems
Researchers developed a new framework, 'Mollifier Layers,' to tackle challenging inverse PDEs. This advance could benefit fields such as genetics and weather forecasting by inferring hidden forces that produce observable patterns.
Researchers identify how enzyme affects infertility and cancer progression
A specific region of Dicer must be activated to achieve proper cell division and reproduction, a discovery that sheds light on the regulation of this enzyme's critical role in both cancer biology and fertility. This finding opens new avenues for studying how small epigenetic changes contribute to disease.
New research shows how blood sugar-regulating cells change in type 2 diabetes
Researchers mapped epigenome changes in cells that regulate blood sugar levels, finding patterns differ between people with and without type 2 diabetes. Epigenetic alterations impact insulin-producing beta cells, leading to impaired energy production and reduced insulin release.
The past informs the future: BTI's Eric Richards named a 2026 Guggenheim Fellow
Dr. Eric Richards, a professor at BTI, has been awarded a 2026 Guggenheim Fellowship to investigate Daniel MacDougal's pioneering work on ovarial injection experiments in plant genetics. He aims to use archival research and modern DNA sequencing to determine if MacDougal's protocol actually created mutations.
Study finds each protein in the epigenome produces a different pattern of gene expression
A new study found that every type of epigenome protein produces a distinct pattern of gene expression, surpassing the on/off switch functionality. This discovery has significant implications for cellular engineering, enabling more dynamic control over cellular behavior and potential applications in biomanufacturing and bioproduction.
A molecular movie captures cancer’s great escape from targeted therapy
A new study reveals that cancer cells may begin escaping therapy much earlier, triggered by a stress response that drives them into a temporary drug-tolerant state. Researchers identified an early molecular trigger: NF-κB, which acts as a regulator of cellular stress and survival.
Epigenetic changes at birth are associated with an infant’s microbiome and neurodevelopment
A study found that epigenetic changes present at birth can impact an infant's gut microbiome development during their first year. The researchers also identified specific epigenetic changes and gut microbes associated with signs of autism spectrum disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD).
UT MD Anderson shares latest research breakthroughs
Researchers at UT MD Anderson have made significant advancements in cancer care, including a blood-based biomarker for cancer risk in people with Lynch Syndrome and a new target to sensitize pancreatic tumors to immunotherapy. The studies also identified a strategy to overcome radiation therapy resistance in lung cancer.
Linker histone H1 acts as a liquid-like “glue” for chromatin
A recent study reveals that linker histone H1 binds to nucleosomes and creates a dynamic, flexible network that condenses chromatin. This new understanding suggests that chromatin behaves like a liquid-like 'glue' rather than a rigid structure.
Researchers find new target to sensitize pancreatic tumors to immunotherapy
A study published in Cancer Research has identified DPY30 as an epigenetic target that can sensitize pancreatic tumors to immunotherapy. By modulating DNA replication stress, DPY30 promotes the addition of activation signals at stressed replication forks, supporting cancer cell survival and proliferation.
Brain mechanisms may vary depending on how long alcohol use occurs
Research in mice reveals direct gene regulation by alcohol metabolites, with varying effects on brain regions and exposure durations. Short-term exposure influences more genes and epigenetic programs compared to lengthy exposure.
How inflammation may prime the gut for cancer
A study in mice reveals that chronic intestinal inflammation can lead to epigenetic 'memories' that promote colon cancer. Researchers found that even seemingly healed gut tissues retain molecular scars from earlier inflammation, making it easier for cancer to take hold.
Well-fed penguins live longer but age faster — much like modern humans
Researchers found that penguins living in zoos with regular food access and limited physical activity age faster, but live longer than those in the wild. The study reveals a link between zoo conditions and accelerated aging mechanisms.
Registrations open for São Paulo School of Advanced Science in Obesity
The São Paulo School of Advanced Science in Obesity will provide graduate students and early career researchers with a two-week training program on obesity research and prevention. The school will feature renowned keynote speakers and cover topics such as epidemiological aspects, genetic nutrition, epigenetics, and emerging preventive ...
The writing on the genes and the tumor’s power grid
Recent discoveries have shed light on gene expression control in tumor growth, revealing the critical role of epigenetic marks and genomic imprinting. The findings have significant implications for cancer treatment, as they suggest that disrupting the tumor's access to neural signaling may halt its growth.
This epigenetic switch could be targeted by new cancer therapies
Researchers found that a small region of the PRC2 complex, called the SBD, is crucial for its function and can be targeted by cancer inhibitors. The SBD's absence halts the growth of aggressive lymphomas and normalizes gene expression, mimicking the effects of powerful clinical cancer inhibitors.
Scientists identify the gatekeeper of retinal progenitor cell identity
Researchers discovered Setd8 enzyme preserves retinal progenitor cell flexibility, enabling potential regenerative vision therapies. The study highlights a potential target for repairing damaged retinas, with implications for regenerative medicine and ophthalmology.
Balancing two genomes as one: Epigenomic coordination stabilizes polyploid rapeseed
Researchers found that regulatory features of homoeologous genes become increasingly similar after polyploidization, reducing expression divergence between duplicated gene pairs. Epigenomic convergence directly contributes to transcriptional balance, while genomic structure and cis-regulatory evolution jointly buffer subgenomic conflict.
Do certain circulating small non-coding RNAs affect longevity?
Researchers identified nine piRNAs linked to longevity, which could be detected through simple blood tests. The study suggests that these molecules may help predict survival and guide therapeutic targets for older adults.
Worrying about aging may actually age women faster
A study by NYU School of Global Public Health found that anxiety about aging contributes to accelerated epigenetic aging, with greater concern about declining health having the strongest association. This can lead to physical decline and increased risk of age-related diseases.
Cancer’s Achilles’ heel: Monash researchers discover how to ‘switch off’ cancer genes for good
Researchers at Monash University have discovered a way to permanently switch off cancer-causing genes, potentially leading to shorter treatment periods and reduced side effects. The breakthrough uses epigenetic therapy, targeting specific proteins that keep cancer-promoting genes switched on.
Study identifies PARG as a new target to enhance chemotherapy in colorectal cancer
A study led by researchers from the Germans Trias i Pujol Research Institute has identified PARG as a new target to enhance chemotherapy in colorectal cancer. Inhibition of PARG significantly increases the cytotoxic effect of chemotherapy, leading to enhanced cell death and apoptosis in different colorectal cancer models.
Shingles vaccine linked to slower biological aging in older adults
A new study found that shingles vaccination is associated with lower inflammation, slower epigenetic aging, and overall slower biological aging in older adults. Vaccination showed benefits even four years after the initial dose.
DFG funds brain development research at MPZPM with half a million euros
The German Research Foundation (DFG) has funded a three-year project to investigate epigenetic memory in nerve cells. The goal is to understand how gene expressions are preserved via epigenetic regulation, which plays a key role in learning ability, memory function, and healthy brain development.
UMass Chan scientists annotate largest map yet of human genome’s regulatory switches
Researchers have created a comprehensive map of the DNA sequences that control gene expression in human cells, identifying 2.37 million potential regulatory elements. This registry reveals previously unrecognized classes of elements and illuminates how noncoding genetic variation contributes to cell type-specific traits.
4D Nucleome Consortium produces detailed models of the 3D genome over time in cells
The study created a critical framework for understanding the architecture of the genome and its association with gene function in cells. The 4DN Consortium integrated data from over a dozen techniques to compile an extensive catalogue of looping interactions between genes and regulatory elements.
Number and timing of children linked to biological aging
The study found that women with two to three children tend to live the longest, while those with an above-average number of children have shorter lifespan. Pregnancies between ages 24 and 38 were also linked to more favorable aging patterns.
Searching for the centromere: diversity in pathways key for cell division
A research team at The University of Osaka has identified a parallel pathway involving CENP-C for centromere specification and function. This process is vital for ensuring chromosomes are structured and genes are expressed appropriately.
Disaster-related prenatal maternal stress has epigenetic outcomes
A narrative review reveals that disaster-related prenatal maternal stress can lead to epigenetic modifications in offspring, affecting child health outcomes. Epigenetic markers show promise for shaping interventions to mitigate the effects of stress on health outcomes.
High levels of protein drive tumor immune suppression in head and neck cancer
Researchers discovered that high levels of protein BATF2 drive tumor immune suppression in head and neck cancer. Glutamine in the tumor microenvironment silences BATF2, affecting the STING signaling pathway and overall immune response.
From fungi to brain cells: one scientist's winding path reveals how epigenomics shapes neural destiny
Dr. Maria Margarita Behrens' work deciphers the molecular signatures defining every human brain cell type, shedding light on neural development and psychiatric disorders. Her single-cell epigenomic atlases will enable researchers to target specific cell types with unprecedented precision.
Skeletal muscle epigenetic clocks developed using postmortem tissue from an Asian population
A new study introduced epigenetic clocks in skeletal muscle from an Asian population, identifying DNA methylation sites associated with age and developing accurate age prediction models using NGS and SBE. The findings offer a reliable method for estimating age and its potential applications in forensic science.
Younger biological age may increase depression risk in older women during COVID-19
Research found that older women with younger biological ages were more likely to experience increased depressive symptoms during the pandemic. The study suggests that this may be due to reduced social connections and daily routines, which can affect mental health.
Chromatin accessibility maps reveal how stem cells drive myelodysplastic progression
Chromatin accessibility maps reveal that MDS stem cells gradually lose their normal identity and acquire characteristics typical of myeloid progenitors. A 'progenitor score' developed by the team tracks cell movement toward a progenitor-like state, correlating with disease severity and prognosis.
Brain resilience science reshapes psychiatry from treating illness to building strength
Dr. Eric J. Nestler's research has fundamentally reshaped global understanding of addiction and depression by focusing on resilience rather than pathology. His laboratory identified distinct molecular, cellular, and circuit changes in resilient brains that maintain normal behavioral function despite exposure to drugs or stress.
Pitt and UPMC study finds epigenetic signature of pediatric traumatic brain injury, paves way for precision recovery tools
Researchers at Pitt and UPMC Children's Hospital discovered a biomarker of complicated pediatric traumatic brain injury, which may serve as dynamic indicators of post-injury recovery. The study found that children with TBI had a different epigenetic profile compared to those with orthopaedic injuries.
Researchers identify the molecular mechanisms linking early-life environments with memory
Researchers identified a molecular mechanism linking early-life environments with memory by activating AP-1, which regulates genes involved in neuronal plasticity and learning. Early-life experiences produce long-lasting modulation of AP-1 activity, boosting gene networks that strengthen neuronal connections.
DNA shape and rigidity regulate key players of gene expression
Researchers at the University of Texas M. D. Anderson Cancer Center discovered that inflexible DNA within nucleosomes regulates the positioning of INO80, a chromatin remodeling complex. This unique mechanism allows INO80 to position itself on the surface of nucleosomes at the right location.
Shapeshifting cancers’ masters, unmasked
Cancer researchers at Cold Spring Harbor Laboratory have identified key proteins that determine the behavior of two hard-to-treat carcinomas, pancreatic cancer and tuft cell lung cancer. These findings could lead to new therapies targeting specific vulnerabilities in these cancers.
Epigenetic changes regulate gene expression, but what regulates epigenetics?
Scientists at the Salk Institute have discovered a new mode of epigenetic targeting in plant cells, where specific DNA sequences guide DNA methylation patterns. This finding has major implications for understanding epigenetic regulation and could inform future strategies for epigenetic engineering.
DNA methylation patterns in newborns point to susceptibility to schizophrenia
Researchers identified distinct epigenetic signatures in cord blood linked to increased schizophrenia and other neurodevelopmental conditions. Newborns with higher genetic susceptibility showed differences in DNA methylation patterns, especially in immune-related regions.
Researchers reveal intricate control system for key immune gene
Researchers at Gladstone Institutes and UCSF have identified the genetic switches that regulate FOXP3 levels in human and mouse cells. In humans, multiple enhancers work together to keep FOXP3 active, while a repressor keeps it off in conventional T cells. This discovery has important implications for developing immune therapies.
New “ultra-mild” sequencing method fixes long-standing flaws in cancer DNA methylation tests
A novel methylation analysis method, called UMBS-seq, achieves both accuracy and gentleness, unlocking more reliable cancer biomarker detection. The method outperforms existing methods for 5-methylcytosine detection with low input DNA, preserving DNA integrity.
Protein arginine methyltransferase 5 (PRMT5) in solid tumors- A review
PRMT5 promotes proliferation, metastasis, therapy resistance, and an immunosuppressive tumor microenvironment in various solid malignancies. Targeting PRMT5 with inhibitors has shown promising therapeutic effects in several cancers.
The “MDME Axis”: A new view on how microbial metabolites epigenetically shape host health
Microbial metabolites from the gut microbiome influence gene expression, cellular function, and host health. The MDME axis proposes a unified theoretical framework explaining this complex dialogue.
New high-efficiency gene editing method enhances speed and reduces costs in biomedical research
A new gene editing technique, P3a mutagenesis, achieves near 100% success in creating precise DNA mutations. This method simplifies protein engineering, accelerating biomedical research and reducing costs.
Maternal type 1 diabetes may protect children through epigenetic changes
A new study found that maternal type 1 diabetes is associated with specific epigenetic marks in the child, which affect immune function and expression of genes involved in autoimmune diseases. These changes appear to protect against islet autoimmunity, a precursor to type 1 diabetes.
N6-methyladenosine methylation emerges as a key target for treating acute lung injury
Acute lung injury is characterized by diffuse inflammation and intractable hypoxemia, with N6-methyladenosine methylation playing a crucial role in its pathogenesis. The review synthesizes findings from multiple studies, highlighting the dynamic nature of m6A methylation and its associated proteins.
UC Riverside scientist recognized by American Federation for Aging Research
Huimin Zhang, a UC Riverside assistant professor, has received a $150,000 grant to study the role of HELIOS in epigenetic regulation of T cell aging and TFH cell differentiation. Her research aims to understand how aging affects the immune system and develop new vaccines and therapies to restore immune vitality in older adults.
Lactylation in gynecological malignancies: a bridge between lactate metabolism and epigenetic therapy
Lactate accumulation drives lactylation, a critical post-translational modification promoting tumor proliferation, metastasis, and therapy resistance. Emerging strategies targeting lactate production, transport, and lactylation hold significant anticancer potential.
Switching memories on and off with epigenetics
Researchers develop CRISPR-based tools to epigenetically silence or boost memory gene Arc, demonstrating its direct impact on memory expression and storage. This breakthrough offers new avenues for exploring memory processing disorders in humans.
Global platform for pandemic preparedness to be established at DTU National Food Institute
The Global Pathogen Analysis Platform (GPAP) will enable low- and middle-income countries to conduct research and surveillance of infectious diseases independently. The platform aims to prevent disease outbreaks from developing into pandemics by detecting genetic sequences of potential pathogens.
Epigenetic “scars”: Unveiling how childhood trauma affects our genes
A recent study identifies molecular markers in children and adolescents that link childhood maltreatment to long-term brain alterations and mental health outcomes. The researchers found four DNA methylation sites associated with child maltreatment, including the 'master switch' gene FOXP1, which regulates brain development.
Genetics pioneer transforms global depression research through multi-omics discoveries
Dr. Amin's transformative insights reshape international understanding of depression genetics, identifying novel therapeutic targets and biomarkers for diagnosis and treatment. Her systemic disease model challenges traditional views of depression as a brain disorder.
Air pollution can contribute to obesity and diabetes
Long-term exposure to fine air pollutants like PM2.5 can impair metabolic health by disrupting the normal function of brown fat through complex epigenetic changes. The study identified two enzymes, HDAC9 and KDM2B, as key drivers of this process.
Study finds restoring order to dividing cancer cells may prevent metastasis
Researchers discovered that an enzyme called EZH2 drives triple negative breast cancer cells to divide abnormally, enabling them to spread. Inhibiting EZH2 with drugs like tazemetostat restored order to dividing cells and thwarted the spread of TNBC cells.
Does early-life cellular activity influence cancer and aging?
Telomeres, which cap chromosomes, are inherited from parents in a parent-of-origin effect, with mothers contributing short telomeres and fathers long ones. This process is linked to cancer risk and aging, and researchers hope to study it further using human genome sequencing.