Arthritis

Ultrasound has potential to alter how the brain responds to pain

Discovery could point to new treatments for cardiovascular disease, arthritis, Crohn's and other inflammatory diseases

A protein interaction between iNOS and IRG1 has been identified as a key regulator of the immune response. This discovery could lead to new treatments for conditions such as cardiovascular disease, arthritis, and Crohn's disease.

Do drugs that similarly combat a disease have differing effects on quality of life?

Researchers found that patients taking TNF inhibitors reported better energy levels and mood, while those on IL-6 and JAK inhibitors showed improved physical functioning. This suggests different drug classes offer distinct advantages across quality-of-life domains.

Weight-loss drugs may affect arthritis directly in the joints - new study finds

A new study from Aarhus University reveals that weight-loss drugs containing GLP-1 hormone may influence joint inflammation in arthritis patients. The study found that high doses of GLP-1 in medication could have a dual effect, both through weight loss and by increasing levels in the joints.

City St George’s partners with Paradigm Biopharmaceuticals to investigate mechanism of osteoarthritis pain drug candidate

City St George's, University of London, is partnering with Paradigm Biopharmaceuticals to test a potential treatment for osteoarthritis. The partnership aims to investigate the mechanism of action of pentosan polysulfate sodium (iPPS) on bone marrow lesions, which are linked to pain in osteoarthritis.

Researchers identify potential disease marker, therapeutic target for cats with osteoarthritis

A study found that elevation of artemin could serve as a disease marker and potential therapeutic target for osteoarthritis in cats. The researchers confirmed that TRP channels commonly associated with osteoarthritis pain were expressed and functional in healthy cat DRG neurons, and increased artemin blood concentrations were correlate...

Exercise harder, not just longer, to reduce risk of disease and death

Research found that people who spend a higher proportion of their total physical activity doing vigorous activity have substantially lower risks of all eight serious health conditions. The benefits of vigorous activity remained even when the amount of time was modest.

Gut health supplement relieves arthritis pain, finds new study

A new study found that a prebiotic fibre supplement reduced pain, improved grip strength, and lowered pain sensitivity in people with knee osteoarthritis. The supplement, inulin, improved grip strength and reduced pain sensitivity, measures linked to how the nervous system processes pain.

LOXL2 enzyme discovery offers new hope for jaw arthritis

Researchers have discovered the protective role of LOXL2 protein in preventing cartilage damage and inflammation in temporomandibular joint osteoarthritis. The enzyme helps suppress inflammatory pathways, reducing cell death and preserving cartilage viability even under inflammatory conditions.

Collagen benefits skin but not performance - study

A comprehensive study of collagen supplements found benefits in skin elasticity, hydration, and osteoarthritis symptoms. However, there were no meaningful improvements in sports performance or muscle recovery, dispelling some myths surrounding its use.

New molecular maps of bone could transform early osteoarthritis detection

Researchers used advanced imaging to uncover early molecular changes in bone associated with osteoarthritis. The study found that subchondral bone beneath damaged cartilage showed strong upregulation of specific collagen fragments, suggesting that disease-related bone changes begin earlier than previously recognized.

New study: Immune cells linked to Epstein-Barr virus may play a role in MS

Researchers found that certain types of CD8+ killer T cells are more abundant in people with MS and target the EBV virus, indicating the virus may trigger an immune response leading to progressive neurological damage. The study suggests that interfering with EBV could have a significant impact on other autoimmune diseases.

Early treatment can delay rheumatoid arthritis for years

A new study by King's College London found that early treatment with abatacept can delay rheumatoid arthritis (RA) onset in people at high risk for several years. The benefits persist even after treatment has stopped, potentially reducing the number of years people live with symptoms and complications.

Physical therapy research highlights arthritis’ toll on the workforce — and the path forward

Research highlights arthritis' toll on the workforce, with nearly 10 million Americans aged 18-64 experiencing limitations. Overall health and socioeconomic factors are significant contributors to work-related challenges.

cPLA2 inhibition with fexofenadine protects cartilage in degenerative joint disease

The study demonstrates that fexofenadine reduces cartilage degradation, inflammation, and senescence in mice models for OA and IVDD. Pharmacological inhibition of cPLA2 preserves cartilage structure and improves behavioral outcomes.

New antibodies developed that can inhibit inflammation in autoimmune diseases

Two first-in-class antibodies, C01 and C04, have been developed to inhibit inflammation in autoimmune diseases by blocking the high-affinity IgG receptor FcγRI. The antibodies were discovered using a unique immunization method and exhibit higher affinity for FcγRI than human IgG.

UMC Utrecht researchers receive grant to develop predictive model for juvenile dermatomyositis

Researchers at UMC Utrecht are developing a predictive model to accurately predict disease progress in juvenile dermatomyositis. The Interferon Score aims to identify which children can safely reduce medication and which require intensified treatment.

Insight into how sugars regulate the inflammatory disease process

Scientists have discovered that immune cells shed their glycocalyx layer to move into tissues, changing the understanding of inflammatory skin diseases like psoriasis. This finding may lead to new approaches in developing drugs targeting immune cell movement and treating infections and inflammatory diseases.

UH pharmacy researcher provides new hope in managing diabetic ketoacidosis

A University of Houston researcher identifies a protein that may reduce high ketone levels in diabetic patients, potentially improving health outcomes. The study also shows that the protein promotes muscle ketolysis and running capacity in mice.

Arthritis pain rising: How state policies matter

A study by UT Arlington researchers found that state welfare policies affect joint pain trends, with states like Colorado and Hawaii seeing significant increases. In contrast, Texas saw a decrease in the educational gap despite increased pain prevalence, highlighting the need for targeted interventions.

GLP-1 drugs shown cost-effective for knee osteoarthritis and obesity

A study by Mass General Brigham researchers found that tirzepatide offers greater value than semaglutide for most patients with knee osteoarthritis and obesity. Bariatric surgery provides the best option from a clinical and economic perspective for eligible and willing patients.

Immune ageing detected in the earliest stages of rheumatoid arthritis before clinical diagnosis gives hope for early intervention

A new study from the University of Birmingham has found that immune ageing may be a driver of rheumatoid arthritis rather than a consequence of the disease. The research detected features of immune system ageing in the earliest stages of RA, even before clinical diagnosis, suggesting that early intervention is possible.

‘Artificial cartilage’ could improve arthritis treatment

Researchers have developed an artificial cartilage material that responds to pH changes in the body, releasing anti-inflammatory drugs precisely where and when needed. This approach could improve arthritis treatment outcomes by continuously delivering pain-relieving medication.

Study suggests no link between antibiotic exposure and autoimmune diseases in children

A large-scale study published in PLOS Medicine found no association between early life antibiotic exposure and the development of autoimmune diseases in children. Researchers analyzed data from over 4 million Korean children and discovered no increased risk of Type 1 diabetes, Juvenile idiopathic arthritis, or other autoimmune conditions.

Study reveals spinning could reduce NHS waiting lists for physiotherapy treatments

A new study by Bournemouth University reveals that spinning can improve recovery outcomes and reduce clinical time needed for physiotherapy treatment compared to standard care. The cycling and education classes prove more cost-effective, contributing to reducing NHS waiting times for hip osteoarthritis patients.

Surgical procedure slows progression of knee osteoarthritis

A clinical trial found that high tibial osteotomy (HTO) reduces knee joint damage and improves pain and function in patients with knee osteoarthritis and bowed legs. HTO alters the way people walk, lessening further joint damage, reducing pain, and improving quality of life.

Rheumatoid arthritis and muscle wasting: New review points to overlooked complications

Researchers explore the biological mechanisms of myopenia in RA, finding it affects individuals of all ages, with notable muscle mass loss without concurrent fat loss. The review highlights the diagnostic and therapeutic relevance of myopenia in RA, emphasizing the importance of early detection and tailored management strategies.

First of its kind study for children with arthritis reveals possible new disease targets

A groundbreaking study has uncovered the unique architecture of cells and signals inside the joint as inflammation takes hold in children with arthritis. The research provides a new way forward for understanding this condition, which affects over 10,000 children in the UK.

The hidden drawbacks of HIV: treatment regimens may exacerbate risk of knee arthritis

Researchers investigated the link between HIV treatment regimens and osteoarthritis development, revealing that certain medications like lopinavir can exacerbate OA in the knee. The study's findings have important implications for people living with HIV, highlighting the need to carefully consider treatment options.

Potential to prevent and treat a common type of inflammatory arthritis advanced by the identification of new genetic links

Researchers have identified two genes, RNF144B and ENPP1, that cause calcium pyrophosphate deposition disease in Americans of European and African descent. This discovery opens up promising new avenues for targeted prevention and treatment of CPPD disease, which is currently lacking effective options.

Knee arthritis made worse with steroid injections

Researchers found corticosteroid injections accelerated structural knee degeneration, while hyaluronic acid injections slowed down damage. The study challenges common clinical practice and suggests alternative pain management strategies for patients with osteoarthritis.

R. Rex and Carrol Parris make $10 million gift to launch USC Longevity Research Accelerator at Keck School of Medicine

The USC Parris Longevity Accelerator aims to develop early interventions for age-related diseases, including osteoarthritis and cardiovascular disease, through AI-driven diagnostic tools and targeted therapeutics. The initiative could lead to therapies that preserve mobility and restore strength in older adults.

Breakthrough provides new hope for patients with knee osteoarthritis

Scientists at Henry Ford Health + Michigan State University Health Sciences have identified a circulating microRNA called miR-126-3p as a mechanistic biomarker of knee osteoarthritis. This discovery may lead to the development of blood tests for early detection and therapeutics for slowing or stopping disease progression.

Scientists urge earlier diagnosis and treatment of psoriatic arthritis to prevent permanent damage

A new study from the University of Bath reveals that delays in diagnosing and treating psoriatic arthritis often result in irreparable damage to joints. Early diagnosis and effective treatment can prevent this damage and improve physical function and quality of life for patients with PsA.

People with COPD and arthritis have an increased risk of death

A new study found that people with chronic obstructive pulmonary disease (COPD) and arthritis have a significantly increased risk of death compared to those with only arthritis. The research analyzed data from over 11,000 individuals in the US and discovered a strong association between COPD and mortality rates in people with arthritis.

Adults abused as children twice as likely to develop health and mental health conditions

A new study published in Child Maltreatment found that adults who experienced childhood physical and sexual abuse had double the odds of developing health and mental health conditions. The presence of a protective adult in the home was associated with better long-term health outcomes among children who experienced abuse.

New research reveals how the body clock regulates inflammation

Researchers at RCSI University of Medicine and Health Sciences have discovered that macrophages, a type of immune cell, work differently throughout the day due to the body's internal clock. This daily rhythm determines when immune cells are most efficient at detecting threats and mounts a response.

How new therapies are revolutionizing the treatment of juvenile idiopathic arthritis

Researchers analyzed medical trends for the most common childhood rheumatic disorder, finding that newer biologic and targeted therapies surpassed traditional treatments. The study revealed a significant decline in conventional therapy use and an increase in biologic therapies, particularly adalimumab.

Youth with chronic childhood arthritis empowered to overcome barriers

A new intervention will be developed by University of South Australia researchers to help young people with chronic childhood arthritis overcome barriers to physical activity and mental wellbeing. The VITAL Project aims to validate, understand, and empower activity in people with Juvenile Idiopathic Arthritis, reducing pain invalidatio...

Protein blocking bone development could hold clues for future osteoporosis treatment

A team of researchers discovered a protein that blocks bone-forming cells by preventing them from maturing. The study found that the protein CLEC14A reduces bone formation, while its absence leads to increased mineralized bone tissue.

Medical imaging breakthrough could transform cancer and arthritis diagnosis

A new hand-held scanner can generate highly detailed 3D images in seconds, paving the way for earlier disease diagnosis. The technology uses laser-generated ultrasound waves to visualize subtle changes in blood vessels, helping inform patient care and diagnose conditions like cancer and cardiovascular disease.

Med school scientist receives prestigious NSF award for inflammation research

Associate Professor Justine Tigno-Aranjuez received a $1 million NSF CAREER Award to study the impact of the NOD2 pathway on inflammation. Her research aims to understand how lipid mediators are produced and how they influence inflammation.

Shedding light on how oral bacteria can aggravate rheumatoid arthritis

A recent study has revealed that oral bacteria, specifically Aggregatibacter actinomycetemcomitans, can exacerbate rheumatoid arthritis. The study found that the infection led to increased inflammation and joint damage in animal models.

Immune cell regulator discovery could lead to treatments for arthritis and severe COVID

Researchers have discovered a new regulator affecting immune cells, which could lead to treatments reducing inflammation in diseases such as arthritis and severe COVID-19. The study found that the regulator, MICL, plays a key role in regulating inflammation in these diseases.

Crnic Institute clinical trial shows JAK inhibitor improves multiple autoimmune conditions in patients with Down syndrome

A clinical trial shows that JAK inhibitors improve autoimmune conditions such as alopecia areata, atopic dermatitis, and psoriasis in people with Down syndrome. The study also observed improvements in arthritis and decreased biomarkers of autoimmune thyroid disease.

New safety checklist aims to prevent side effects in patients with arthritis

Researchers developed a comprehensive safety checklist to prevent severe side effects from antirheumatic drugs. The checklist helps doctors determine if patients have comorbidities that limit medication use, enhancing patient safety for those treated for inflammatory rheumatic diseases.

Older adults want to cut back on medication, but study shows need for caution

A new University of Michigan study found that over 82% of Americans aged 50-80 take one or more prescription medications, with 80% open to stopping certain drugs. However, researchers stress the importance of personalized guidance for deprescribing older adults, particularly those taking medication for cardiovascular disease or diabetes.

Scientists discover new T cells and genes related to immune disorders

Researchers have discovered several rare types of helper T cells associated with immune disorders such as multiple sclerosis and rheumatoid arthritis. The study found that genetic variants in bidirectional enhancer DNA are linked to specific immune-mediated diseases, including inflammatory bowel disease.

People who care for loved ones with arthritis carry an economic burden

A Griffith University study reveals that informal carers of loved ones with arthritis incur a significant economic burden, losing around $1,000 per week in earnings. By 2030, this figure is expected to rise to $576.9 million, highlighting the need for improved support systems and policies to alleviate this financial strain.

Self-administered acupressure for probable knee osteoarthritis in middle-aged and older adults

A randomized clinical trial found self-administered acupressure to be efficacious and cost-effective in reducing knee pain and improving mobility in middle-aged and older adults with probable osteoarthritis. The treatment also showed significant benefits in terms of quality of life.

Morris Animal Foundation-funded researchers develop early osteoarthritis detection tool

Researchers developed a questionnaire to identify signs of osteoarthritis in horses, aiming to facilitate earlier treatment. The tool was found beneficial for 88% of participants, who appreciated its simplicity and ease of use, helping owners better manage their horse's pain.

Joints that could heal themselves? Researchers could get there in five years

A team of scientists from CU Boulder, Anschutz Medical Campus and CSU is developing non-invasive therapies for osteoarthritis, including a healing shot and annual infusion. They hope to begin trials in human patients within 3.5 years.

Discovery of proteins associated with the progression of dialysis-related amyloidosis

A study by Dr. Yamamoto et al. discovered 200 types of proteins, including β2-m, adsorbed onto blood purification devices in dialysis patients. These proteins, such as lysozyme, are involved in amyloid fibril formation and may contribute to the disease progression.

IL-17 promotes IL-18 production in osteoarthritis synovial fibroblasts via…

Researchers found significantly higher levels of IL-18 expression in osteoarthritis patients and cells compared to healthy controls. IL-17 promoted IL-18 production through the MEK/ERK/miR-4492 axis, indicating potential therapeutic targets for OA treatment.

Autoimmune disease and pregnancy

A study published in Lancet eClinical Health found pregnancy outcomes for pregnant individuals with autoimmune disease vary greatly depending on the specific condition and individual factors. Research highlights the importance of considering comorbidities when discussing autoimmune disease and pregnancy.

Most Canadians with arthritis and disabling chronic pain are in excellent mental health

A new study by researchers at the University of Toronto found that most Canadians with arthritis and debilitating chronic pain are free of all psychiatric disorders, including depression. More than half achieve excellent mental health, characterized by daily happiness, high social well-being, and freedom from anxiety and depressive dis...

MU study shows how brucellosis — which can jump from animals to humans — impacts the brain

A new MU study highlights the protective role of innate lymphoid cells and interferons in reducing neurological effects of Brucellosis. The findings could lead to improved diagnostics and therapies for neurobrucellosis, a condition that can cause long-term neurological complications.

Tool predicts a patient’s risk of developing psoriatic arthritis

A new tool called PRESTO identifies patients with psoriasis at high risk of developing psoriatic arthritis. The tool uses a mathematical model to estimate a patient's risk based on factors such as age, sex, family history, and disease severity.

Significant variations in hip fracture health costs and care between NHS hospitals and regions, study finds

A new study by the University of Bristol highlights significant variations in healthcare spending and care delivery across NHS hospitals following hip fracture. The research found that patients who received timely orthogeriatrician assessment and physiotherapy had lower costs and reduced risk of delirium.

Does brepocitinib benefit patients with psoriatic arthritis?

A phase IIb trial found brepocitinib superior to placebo in reducing signs and symptoms of psoriatic arthritis after 16 weeks. Response rates were maintained or improved through week 52, with mostly mild or moderate side effects.