Articles tagged with Interneurons
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A study in mice confirms the presence of two molecules that enable precise connection between inhibitory interneurons and target excitatory neurons. This link regulates information processing and maintains balance in brain circuits, with implications for understanding neuronal disorders such as schizophrenia and autism.
A mouse study by Okinawa Institute of Science and Technology researchers has found that acetylcholine release is essential for breaking habits and enabling new choices to be made. The study's findings may help understand diseases such as Parkinson's disease, addiction, and obsessive-compulsive disorder.
A study found that rats' impulsive behavior and risky decision-making are shaped differently in males and females based on the timing of neural stimulation. The results highlight the importance of considering biological sex when developing treatments for disorders related to impulsivity and addiction.
Researchers at OIST investigate the neural basis of social hierarchy in male mice, identifying brain cells involved in determining dominance. The study found that the 'loser effect' is attributed to activity of certain brain cells, called cholinergic interneurons, and has implications for understanding human social behaviors.
Researchers found distinct effects of single disease-causing gene variants across different brain regions, pointing to hippocampal disruptions as a key factor in cognitive problems beyond seizures. This study provides an early step toward understanding why current treatments often fall short and may help identify new therapies.
A study found that evaluators' musical experience influences the sight-over-sound effect, reducing its impact for those with auditory expertise. The study used Japanese high school brass band competitions and found no significant evidence of the effect in musicians, but a stronger presence in non-musicians.
Researchers found that inhibitory neurons called parvalbumin interneurons reduce activity before a learned reward zone is reached, clearing the way for excitatory neurons to strengthen their bonds and reinforce learning. This finding challenges traditional ideas about neural activity and learning.
Researchers analyzed brain tissue from individuals with severe Tourette syndrome and identified three key changes: altered gene activity, regulatory element modifications, and interneuron loss. These findings provide unprecedented insights into the disorder's biology and may explain why individuals experience involuntary movements and ...
The Open Brain Institute launches a groundbreaking platform to simulate and study digital brains, empowering researchers to explore brain complexity and diseases. With its virtual neuroscience laboratories, the OBI enables global collaboration and access to cutting-edge virtual labs.
Researchers have identified parvalbumin interneurons as the key players in encoding pain intensity and driving gamma oscillations. The findings suggest PV interneurons in S1 as a promising target for therapeutic interventions to treat chronic pain, providing new insights into nociceptive processing and its relationship with GBOs.
Researchers created a whole-brain atlas to visualize regions of the brain connected to V1 interneurons, a group of cells necessary for movement. The findings provide a framework to further understand the anatomical landscape of the nervous system and how the brain communicates with the spinal cord.
Researchers at Texas A&M University have discovered that chronic alcohol use alters brain signaling pathways, specifically targeting cholinergic interneurons. This impairment affects learning and adaptability, critical components of cognitive flexibility.
A new brain-mapping neurotechnology called Single Transcriptome Assisted Rabies Tracing (START) has been developed to map the brain's intricate neuronal connections. The technique combines two advanced technologies to resolve cortical connectivity at the resolution of transcriptomic cell types, enabling the identification of distinct p...
A study of 30 volunteers found that a poor diet can lead to changes in neurotransmitters and grey matter volume, commonly associated with depression and anxiety. Adhering to a Mediterranean-style diet was shown to prevent these changes.
A new study uses computational modeling to understand how ketamine affects individual neurons, leading to changes in brain network function. The model predicts that ketamine can disinhibit network activity by shutting down certain inhibitory interneurons.
Researchers discovered that MEIS2 plays a critical role in activating genes necessary for the formation of inhibitory projection neurons, vital for motion control and decision-making. A MEIS2 mutation found in patients with intellectual disability disrupts these processes.
The study investigates how different genes related to autism spectrum disorders affect the brain's neural circuits, resulting in heightened sensitivity to sounds. The researchers aim to identify a potential biomarker for sensory hypersensitivity and develop treatments using optogenetics and minocycline.
A newly developed labeling method allows for visualization of intraregional synaptic connections between inhibitory interneurons and excitatory engram cells. Researchers have identified the role of inhibitory interneurons in memory expression, suggesting that they suppress fear expression by inhibiting fear engram cells.
A study in mice finds that two proteins, MAP6 and Kv3.1, interact to control movement, memory, and anxiety. Disrupting this interaction can lead to behavioral changes, including hyperactivity and impaired memory, highlighting potential new targets for schizophrenia treatment.
Researchers identify somatostatin-positive interneurons as crucial in maintaining cognitive function, and their dysfunction leads to impaired memory and learning. The study uses a toxin to ablate these cells, resulting in mice exhibiting cognitive deficits similar to those seen in aging humans.
Researchers identified dozens of genes implicated in neurodevelopmental disorders, which have similar effects on brain function. The study uses a new method to sort defective genes by their function, accelerating drug development for these disorders.
A new approach to PTSD treatment may involve targeting cerebellar inhibitory interneurons, which play a critical role in fear memory formation. The research found that these interneurons drive fear memory consolidation via learning-induced HCN plasticity.
Researchers at Texas A&M University found that substance use impairs cognitive flexibility by inhibiting specific neurons. Chronic cocaine or alcohol use alters the local inhibitory brain circuit, leading to decreased cognitive flexibility and increased risk of academic deficits and lower quality of life.
Researchers have discovered that inhibitory neurons can transmit information over long distances in the prefrontal cortex, allowing for adaptive changes in behavior. This synchronization of gamma oscillations is associated with the realization of new rules and enables cognitive flexibility.
Researchers have identified α5-GABAARs on interneurons as key receptors regulating memory formation in the hippocampus. Selectively knocking out these receptors from interneurons impaired spatial memory, while leaving pyramidal neurons unaffected.
A recent study found that antidepressant fluoxetine facilitates the erasure of learned fear responses and enhances spatial learning in mice. The TrkB receptor in Parvalbumin interneurons is primarily responsible for this increased plasticity, suggesting a new target for treating psychiatric diseases.
A study by University of Bonn elucidates a key mechanism in the brain where neurons fine-tune their sensitivity to incoming signals. Special nerve cells called interneurons play an essential role, sending inhibitory action potentials to reduce sensitivity.
A Brazilian-American research team has identified a subtype of inhibitory interneurons that can gauge speed with great precision. These neurons are more stable than excitatory neurons and may be linked to spatial memory and the ability to remember routes or locations.
The study reveals that somatostatin neurons act as highly coordinated subpopulations throughout the cortex, with local networks tailored to specific cognitive processes. This finding highlights the specialized roles of somatostatin neurons in different brain regions.
Researchers at UCLA have developed a roadmap detailing how stem cells become sensory interneurons, which enable sensations like touch and pain. The study identifies protocols for producing all types of sensory interneurons in the laboratory, paving the way for cell therapies to restore sensation in people with spinal cord injuries.
Researchers have discovered a prominent network of silencing interneurons in the human cortex, which could be linked to enhanced working memory and reasoning abilities. This unique network relies on abundant connections between inhibitory interneurons and is distinct from those found in mice.
Researchers mapped neural connections throughout entire brain after TBI, finding increased connections to inhibitory neurons but disrupted relationships. Transplanted interneurons showed promise in reconnecting damaged brain regions.
A new study suggests that oxidative stress overactivates a glucose metabolism enzyme in the developing hippocampus, impairing learning and memory. However, inhibiting this enzyme can reverse cognitive deficits, paving the way for treatment of neonatal brain injuries.
A new circuit model provides an explanation for how deep brain stimulation (DBS) relieves Parkinson's disease motor symptoms by interrupting a vicious cycle between the subthalamic nucleus and the striatum. The model suggests that DBS restores a balance with other rhythm frequencies, enabling better movement control.
Researchers found that NYX-783, a newly discovered drug, modulates NMDA receptor activity in neurons to suppress traumatic memories and spontaneous recovery of PTSD. The drug was effective in reducing fear responses and improving treatment outcomes, particularly in female mice.
Researchers found that myelination, even patchy on interneurons, is required for full inhibitory potential. Myelin loss can cause abnormal brain activity and lead to cognitive impairments.
Breakthrough research reveals Tuberous Sclerosis Complex arises from human-specific progenitor cells, explaining its pathology. Human-derived cerebral organoid models shed light on complex brain development and potential mechanisms for other diseases.
Researchers developed a gene therapy called Targeted Augmentation of Nuclear Gene Output (TANGO), which boosts SCN1A protein production in brain cells. The treatment restored normal cell function and reduced seizures in lab mice with Dravet syndrome, offering hope for the first direct treatment of the fundamental cause.
A transdisciplinary research team at Göttingen Campus has found a new perspective on the rhythmic processes in the brain. They discovered that adapting interneurons can switch between very slow rhythms and fast rhythms, challenging previous assumptions about their function.
Vanderbilt researchers discover how a protein may treat schizophrenia, including reversing working memory deficits. Enhancing the activity of mGlu1 selectively increases the activity of specific inhibitory interneurons, restoring their ability to inhibit neuronal circuits.
Researchers have found consistent patterns in GABAergic neuron development between humans and mice, shedding light on the causes of neurodevelopmental disorders like autism and schizophrenia. The study uses single-cell RNA sequencing to create detailed maps of gene expression during human brain development.
A team of scientists at the University of Utah has discovered a new type of interneuron in the mammalian retina called the Campana cell. The discovery marks a notable development for the field, as scientists work toward a better understanding of the central nervous system by identifying all classes of neurons and their connections.
Researchers found that somatostatin interneurons can cause seizures when they go haywire, disrupting the brain's balance. The study identified a rare epilepsy syndrome and developed mouse models to understand the neurological dysfunction, paving the way for new treatments.
Researchers found that brexanolone, a neuroactive steroid, alters brain oscillations in the basolateral amygdala, leading to long-lasting antidepressant effects. The study suggests that changing oscillations may be a new strategy for drug therapies.
Researchers at Max Planck Florida Institute have identified IgSF11 as a key molecule mediating layer-specific synaptic targeting in cortical Chandelier Cells. This discovery reveals that IgSF11 confers specificity through homophilic interaction, enabling the precise connection of inhibitory interneurons with target neurons.
A new study found that networks of nerve cells in the spinal cord called inhibitory interneurons lose connection to motor neurons, which could explain why motor neurons die in ALS. This loss happens before motor neuron death and affects fast-twitch motor neurons first.
Researchers used genetic engineering tools to create a virus that can enter specific neurons and insert new genetic code, inducing modified protein production. In mice tests, the alteration was sufficient to modify brain activity, indicating potential biomarker for psychiatric disorders like schizophrenia and autism.
A new study published in EPJ B reveals that inhibitory interneurons make up 20% of the brain's circuitry required for pain processing. The researchers used graph theory to model the brain's complex networks, uncovering a specific configuration of interneurons crucial for modulating information transmission.
A research team led by Michael Fox has identified the type of interneuron that produces collagen 19, a protein essential for healthy synapse formation and inhibitory circuit development in the brain. This discovery provides new insights into the molecular mechanisms underlying healthy brain development.
Researchers at the Salk Institute have mapped the physical organization of cells in the spinal cord that help mediate critical sensorimotor reflexes. The study found that different neurons in the same space had the same function, while more similar neurons located in different areas were responsible for different reflexes.
A team of researchers from Tokyo Institute of Technology identified key 'water neurons' in the subfornical organ that stimulate water intake when dehydrated. They also found CCK-producing excitatory neurons that activate GABAergic interneurons to suppress thirst under sodium-depleted conditions.
Researchers at George Washington University discovered that GABAergic interneurons in the hippocampus are excitatory during development, rather than suppressive. This finding could lead to more targeted therapies for infantile seizure disorders.
A ketone-supplemented diet has been shown to restore protective protein levels and decrease mortality rates in mice with Alzheimer's disease. By consuming a diet rich in ketones, the mice experienced fewer seizures and were less likely to die, suggesting that this intervention may help protect interneurons from damage.
Scientists have found that granule cells and interneurons in the brain process incoming signals differently due to their distinct structures and functional characteristics. This discovery sheds light on how malfunctions can arise in information processing, leading to memory impairments and neurological disorders.
Researchers at the University of California, Irvine developed a cell therapy that transplants inhibitory neurons to improve memory precision after traumatic brain injury. The treatment prevented seizures in mice with traumatic brain injuries, showing promising results for potential human treatment.
Researchers at Baylor College of Medicine discovered that removing inhibitory interneurons' ability to regulate excitatory neurons dramatically changed odor responses. The study highlights the need for better understanding cell type relationships in brain function.
Researchers have discovered a new type of neuron that acts as the brain's metronome, keeping time regularly and improving rodents' ability to detect faint sensations. This finding is significant as it supports the long-hypothesized role of gamma rhythms in synchronizing brain signals.
Research at Children's National Hospital created a novel preclinical model that mimics persistent interneuron loss in preterm human infants. The study identified specific interneuron subtypes as potential therapeutic targets to prevent or lessen neurodevelopmental risks.
Scientists at Max Planck Florida Institute for Neuroscience create a novel technique called iMT, capable of tracing intricate neural connections with unprecedented sensitivity. This breakthrough could improve our understanding of the brain and uncover novel approaches for diagnosing and treating brain disorders.
The dentate gyrus uses a process called pattern separation to store distinct memories of similar events. Researchers found that parvalbumin-expressing interneurons play a key role in this process, using lateral inhibition to keep similar memories apart.