Articles tagged with Tissue
Epithelial tissues behave like solids while retaining the disordered structure of liquids. The team developed an active vertex model that incorporated mechanochemical feedback to reproduce experimental signatures of glass dynamics, revealing a link between cellular mechanics, actin organisation, and collective tissue behaviour.
Researchers have discovered a key protein, Mylpf, essential for fast-twitch muscle fibers to form and contract. The study found that even partial reduction in Mylpf function can hinder muscle formation, leading to diseases like muscular dystrophy.
Researchers from UH, Baylor College of Medicine and MD Anderson Cancer Center propose a new treatment approach for Crohn's disease by targeting the stress signal that fuels inflammation. They found that repurposing two existing cancer medications can promote natural repair and regeneration of the intestinal lining.
A study by researchers at Institute of Science Tokyo has identified a key gene, DOCK10, involved in abnormal insulin secretion in insulinomas. The findings pave the way for novel diagnostic biomarkers and treatment options.
Researchers from the University of Tokyo successfully developed a high-pressure freezing method that reduces CPA concentration to 20-30% and improves cell viability and metabolic activity. The method holds promise for cryopreservation in regenerative medicine research, with potential applications in drug testing and cell transplantation.
Researchers developed GluBs to target ASCT2 in aggressive cancers, bypassing the LAT1 route. The agents showed efficacy in limiting tumor growth and demonstrating potential to treat cancers with limited LAT1 expression.
Scientists at UCSF created a new material that enables more predictable organoid growth, allowing for better study of disease and potential tissue replacement. The dynamic gel, invented by Zev Gartner, mimics the body's soft environment and enables precise 3D printing of stem cells.
This study reclassified patients according to modern WHO Classification criteria, revealing molecular subtyping limitations, pathway co-activation patterns, and strong anatomical-molecular correlations. IDH1/2 mutations and TERT promoter mutations played key roles in determining prognosis.
Researchers at Brown University discovered that the shape of spheroid aggregates influences cell behavior, with cells invading outward from sharper ends. The study used fluorescent proteins to track cell movement and measured forces exerted by cells as they move.
Electrospinning fabricates electroactive fibrous scaffolds that mimic the structure of the extracellular matrix while providing electrical activity, enabling non-invasive and self-powered tissue repair. This technology promotes diverse intelligent applications in tissue regeneration, including conductive, piezoelectric, and triboelectr...
Researchers discovered genes that regulate fibroblast growth, which builds the scaffolding between cells. Adjusting these factors reversed age-related changes and improved health outcomes in mice. The study offers new opportunities to understand and reverse aging-related diseases.
Researchers at the University of Plymouth investigate why drugs used to treat other tumours are ineffective against NF2-related schwannoma and meningioma tumours. They explore repurposing clinically tested cancer drugs to target MDR mechanisms, which may lead to effective therapies for patients with these tumours.
A study of 101 glioma cases reveals that one-third of patients develop permanent paralysis after surgery. High tumor grade, pre-operative motor deficits, and larger tumor volume are key predictors. The work underscores the importance of careful surgical planning to maximize survival while safeguarding motor function.
Researchers developed a novel bioelectronic material that transforms from a rigid film to a soft, tissue-like interface upon hydration, enabling seamless integration with living tissues. The device, called THIN, has been shown to record biological signals with high fidelity and stability in animal experiments.
Researchers at the University of Plymouth will receive a £2.8 million funding boost to accelerate new treatments for low-grade brain tumors. The center aims to deepen understanding and translate knowledge into life-changing therapies.
Engineers from the University of Rochester's Department of Biomedical Engineering are studying how cells interact mechanically with the extracellular matrix to build tissues and organs. The study aims to shed light on developmental diseases, such as cancer and failed wound healing, which involve distorted principles during development.
Researchers at Sanford Burnham Prebys Medical Discovery Institute found that aging accelerates pancreatic cancer progression, leading to faster tumor growth and metastasis. By understanding the impact of age on the tumor microenvironment, they developed a new approach to treating this disease in frail patients.
Researchers at UC Riverside discovered that two toxic chemicals can form when propylene glycol is heated, harming human lung cells. The chemicals, methylglyoxal and acetaldehyde, disrupt cell functions and cause damage even at low levels.
The study found that 1-year DMEK success rates were high regardless of donor diabetes status. No restrictions on using tissue from donors with diabetes for DMEK are recommended based on the results.
A randomized clinical trial showed that DMEK graft success is comparable between diabetes-positive and non-diabetes donor corneas after 1 year. The study's findings support the use of diabetes-positive donor corneas for endothelial keratoplasty procedures.
A team from EPFL's School of Engineering has created MEDS, a pill-sized bioprinter that can guide bio-ink into damaged tissues in the gastrointestinal tract for repair. In experiments, the device successfully repaired artificial ulcers and sealed simulated hemorrhages.
Research reveals that ovarian aging is not just about egg quality, but also the surrounding cells and tissues. The study found that eggs cluster in pockets surrounded by egg-free zones, which decline in density with age, influencing egg lifespan and maturation.
Researchers use microchips with human tissue to study brain damage caused by sepsis and neurodegenerative diseases, finding that the blood-brain barrier breaks down under stress. The technology also reveals how pericytes support the barrier and may lead to new treatments for preserving or introducing these cells.
Researchers at the University of Arizona are developing a new optical technology that can image deep into biological tissues without invasive procedures. This approach aims to overcome current challenges in skin cancer imaging, allowing for earlier detection, precise evaluation, and real-time monitoring of treatment response.
Researchers developed a new imaging method using multiphoton microscopy to rapidly identify pancreatic neuroendocrine tumors with high accuracy. Machine learning algorithms achieved 80.6% accuracy, while convolutional neural networks outperformed with accuracies ranging from 90.8% to 96.4%.
Researchers developed a novel method to precisely measure tissue deformation, providing highly accurate measurements to enhance compression-based apparel. The approach minimizes motion artifacts, offering actionable insights on material properties and garment design.
Scientists have developed a method to make a juvenile mouse's scalp transparent, allowing them to image the developing connections in a living mouse's brain. This breakthrough enables researchers to study neurodevelopmental disorders and potentially lead to new interventions.
Researchers at the University of Minnesota have developed a groundbreaking process to combine 3D printing, stem cell biology, and lab-grown tissues for spinal cord injury recovery. The method involves creating 3D-printed scaffolds with microscopic channels that promote the growth of new nerve fibers.
A new study demonstrates the potential to produce cellular spheroids from clinically relevant embryonic stem cells to generate scaffold-free chondrogenic or osteochondrogenic graft tissues. The researchers successfully cultured ES-MSC cellular spheroids, which matured into neocartilage tissues expressing cartilage-associated genes.
Researchers analyzed data from over 10,000 solid tumor samples and found that more than 90 percent contained genetic changes that could guide treatment. The study identified biomarkers associated with approved therapies and rare mutations missed by simpler tests.
A new treatment for corneal scarring is being developed by University of Houston optometry researcher Tarsis G. Ferreira. The treatment uses a natural protein called decorin to block scarring and unwanted blood vessel growth, offering hope for people with injured corneas.
Researchers discovered a novel mode of contact between somatic and germ cells in the ovaries of two arthropod species, challenging the general understanding of epithelial layer function. The basement membrane, typically a barrier, is penetrated by follicle cells to establish direct contact with oocytes.
Researchers from Yokohama National University have developed a method to fabricate complex oriented tissues with multiple directionality using 3D printing. This technique utilizes flow to orient collagen fibers and cells, allowing for the creation of fine, micro-oriented structures in both horizontal and vertical directions.
Researchers developed a hybrid bioink that maintains physiological properties of adipose tissue, promoting differentiation and regeneration. Bioprinted adipose tissues promoted wound healing in mice by inducing re-epithelialization, tissue remodeling, and blood vessel formation.
Advanced research identifies potential molecular instructions determining echinoderms' ability to adapt and regenerate tissues. The breakthrough could lead to new regenerative therapies and smart collagen-based biomaterials for treating human health conditions.
A team of researchers at Penn State developed a novel bioprinting technique that uses spheroids to create complex tissue, producing tissue 10-times faster and with high cell density. The technique enables the rapid fabrication of functional tissues and organs, opening new opportunities for regenerative medicine.
A retrospective cohort study found associations between COVID-19 and the long-term risk of various autoimmune and autoinflammatory connective tissue disorders. Long-term monitoring and care are crucial to mitigate these risks, taking into account demographic factors, disease severity, and vaccination status.
TU Graz researcher Gerhard A. Holzapfel leads a six-year project to develop AI-based methods for analyzing soft tissue mechanical properties using transcriptomics and microstructure imaging. The team aims to improve disease diagnosis and therapy in clinical practice.
Researchers discovered a calcium-based mechanism that aids in disposing of dead cells, shedding light on how bodies protect themselves from injury and disease. The study found that calcium ion levels are essential for efficient removal of dying or apoptotic cells from epithelial tissues.
A clinical trial by the ECOG-ACRIN Cancer Research Group shows striking results from chemotherapy before surgery to shrink tumors and reduce tissue removal. Patients who received chemotherapy had a 50% chance of preserving vital organs, compared to 15% for those having surgery.
A team of researchers created a microfluidic human cervix model that replicates the complex interactions between cervical epithelial cells, mucus production, and microbiome. The Cervix Chip technology offers a new testbed for bacterial vaginosis therapeutics and other treatments, addressing a key women's health gap.
Researchers have challenged the conventional view of myriapod ovarian morphology by discovering structural specialization in pill-millipede Hyleoglomeris japonica. The follicle epithelium, previously considered a homogenous structure, exhibits two distinct regions with enhanced and reduced metabolic activities.
Scientists have found an effective treatment for spitting cobra snakebites by blocking one of the major dermonecrosis-causing toxins with varespladib. The study suggests that this repurposed drug can prevent tissue damage and may become a valuable treatment against black-necked and red spitting cobra venoms.
Researchers have identified a mechanism by which embryonic cells organize themselves to send signals to surrounding cells. The study found that cells feeling stronger pressure stop growing and start sending signals to organize other cells in the formation of organs.
Researchers aim to improve glioma treatment with direct light therapy that targets cancer cells without harming healthy ones. The project will investigate the efficacy and safety of this approach, potentially leading to improved treatment outcomes.
The University of Rochester is establishing a new NIH-funded center focused on developing FDA-qualified drug development tools related to barrier functions in disease. Researchers will create microphysiological systems with ultrathin membranes of human cells, aiming to reduce animal trials and improve drug efficacy.
A Learning Health System model is being developed to increase organ donation and reduce disparities in access to transplantation. The project, led by Hennepin Healthcare Research Institute, will use data tools to track progress and improve equity in organ donation across the US.
Using plasma circulating tumor DNA testing can expedite biomarker testing and time to treatment for patients with suspected advanced lung cancer. The study suggests that this approach may improve patient outcomes.
Researchers from Korea University Medicine have discovered a potential therapeutic target for overcoming cisplatin resistance and neuropathic pain in cervical cancer. By inhibiting TRPV1, they found that resistant tumors became vulnerable to cisplatin, improving the outlook for patients.
Researchers from the University of Tokyo have identified the Wnt6 morphogen as a crucial regulator of heart development in vertebrates. The study used mathematical modeling and experiments to understand how Wnt6 morphogen distribution is regulated, with potential implications for drug design and tissue repair.
Researchers have uncovered how tissue stiffness determines cell positioning and regulates cell migration in various types of cancer, including brain tumors and breast cancer. The study provides new possibilities for stopping and directing cancer cell migration.
The study provides a single-cell transcriptome map of 45 tissues and organs from long-tailed macaque monkeys, identifying 113 major cell types. This will improve the ability to pinpoint how to develop potential treatments for human diseases with greater precision.
Lipedema is a chronic condition characterized by a build-up of fat in the legs and arms, causing pain, swelling, and easy bruising. Researchers at Virginia Tech and Temple University will study its causes and treatments using innovative techniques and computational models.
The CLASSY gene family controls tissue-specific DNA methylation patterns in Arabidopsis, which has broad implications for agriculture and medicine. The study reveals that CLSY genes modulate DNA methylation patterns in different plant tissues.
Scientists from the University of Johannesburg found that shining two lasers on adult stem cells accelerates their transformation into different types of cells. The consecutive irradiation increases proliferation and differentiation under laboratory conditions, paving the way for potential therapies to repair damaged tissues.
A team of researchers from Japan has developed a platform using nanofibers to capture and control the migration of brain tumor cells, including glioblastoma multiforme. The study found that varying fiber densities can slow or speed up cell movement, leading to the creation of 'cell traps' that can restrict tumor cell growth.