Articles tagged with Systems Physiology
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A global study by UniSA researchers found that 94% of people who use wearable activity trackers are open to sharing their health information with healthcare providers. This could lead to more personalized and responsive care. The demand for personalized healthcare is on the rise, and wearable activity tracker market is increasing.
The device uses AI technology to detect potential heart problems and provides real-time health insights. It has multiple points touching the skin near the heart, allowing for more accurate tracking even during movement.
Researchers have developed a bioanalytical test system using human cells on a silk matrix to test active ingredients under realistic conditions. The new method enables efficient evaluation of future cancer diagnostics and has the potential to significantly reduce animal testing, accelerating the development of radiopharmaceuticals.
The study categorizes CROP-AP models into four key types, highlighting five major applications in agricultural productivity simulation. Future research priorities focus on strengthening model validation and simulating multi-scale interactions to support sustainable global food production.
Researchers developed Janus-type supramolecules that form stable ribbon-type assemblies, guiding the arrangement of ion channels across lipid membranes. The supramolecular channels mediate efficient and selective K+ transport, disrupting cancer cell balance and inducing apoptosis.
Researchers at University of the Basque Country discover molecule that protects brain and reverses initial cognitive damage caused by dementia; increases activity of cannabinoid and cholinergic systems, improving memory. Further studies needed to identify similar molecules for clinical trials.
Researchers have developed a simple model system to break down fibrils into their constituent single units or liquid droplets. This discovery has the potential to treat neurodegenerative diseases such as Alzheimer's and Parkinson's by targeting pathological fibrils.
The JAX-Allentown partnership launches an AI-powered home-cage monitoring system to enhance preclinical research efficiency and improve translatability. The Envision platform captures digital measures of mouse behavior and physiology, promoting animal welfare and superior data quality.
Swallow populations infected with parasites exhibit altered movement patterns, including reduced home ranges and foraging activity. This can lead to decreased foraging success and increased mortality rates.
Researchers used ex vivo lentiviral gene therapy to treat MPS IVA in mice, achieving partial correction of bone pathology and complete correction of heart pathology. The study suggests potential for novel therapies to treat patients with MPS IVA.
A new AI-based system, BELA, accurately assesses IVF embryo quality by analyzing time-lapse video images and maternal age. The system generates a predictive score for euploidy or aneuploidy, offering an objective measure of embryo quality.
A study from Goethe University Frankfurt reveals that venomous crustaceans, specifically remipede crabs in Mexican cenote caves, contain a variety of toxins with pharmacological potential. The xibalbines peptides effectively inhibit potassium channels and activate signaling pathways involved in pain sensitization.
Researchers engineered miniature linear and split-belt treadmills to study insect locomotion, gaining insights into proprioception's role in natural activities like walking. The study showed that flies can modify their steps to continue walking straight despite rotational perturbations.
Parents who struggle with alcohol use disorders can pass along symptoms of early aging to their children, affecting them well into adulthood. These accelerated aging effects include high cholesterol, heart problems, arthritis, and early onset dementia.
Researchers created a new cell model to study the effects of senescence on lung fibroblasts. Senescent alveolar epithelial cells triggered fibrotic activation in lung fibroblasts, which was attenuated by senolytic therapy.
Scientists have discovered a new defense mechanism in bacteria that uses cell-to-cell communication to 'warn' unaffected bacteria about potential threats, allowing them to shield themselves and spread the warning signal. This mechanism has been found to be effective against various antibiotics and toxins.
Researchers developed a portable lab-on-a-chip device that uses blood to generate electricity and measure its conductivity, enabling quick and convenient diagnostics. The device has been shown to accurately assess various health parameters and detect medical conditions, opening doors to remote healthcare.
Researchers have developed a model to enrich sub-populations of cancer cells with high basal levels of mitophagy, promoting CSC features such as self-renewal, proliferation, and drug-resistance. This study highlights the importance of BNIP3/BNIP3L in maintaining cancer stem cell properties.
Researchers at Texas A&M University developed vessel-chip technology to create a platform for preclinical drug discovery, reducing the need for animal testing. The system mimics human circulatory systems using tissue-engineered microfluidic devices.
Researchers from GIST and MIT CSAIL develop a MultiSenseBadmpton dataset to enhance badminton performance analysis and AI-based coaching. The dataset captures joint movements, muscle signals, and gaze movements of badminton players.
A self-adaptive temperature control system can improve wound healing by mimicking the skin's thermoregulatory functions. The system, developed by Zhu Meifang at Donghua University, uses an interactive thermoregulatory biomimetic electronic system to regulate temperature and promote dynamic healing processes.
Researchers found that daily cranberry extract consumption for 28 days improved running speeds by 1.5% and reduced post-exercise blood lactate levels. The study also showed increased muscle oxygenation rates and slower deoxygenation.
Researchers developed a wearable device for non-invasive monitoring of hemodynamic indicators like heart rate, blood pressure, and oxygen saturation. The photoacoustic imaging watch offers valuable insights into disease diagnosis and treatment.
A novel transparent ultrasonic transducer (TUT) developed by POSTECH researchers offers exceptional optical transparency and maintains acoustic performance, surpassing conventional limitations. This breakthrough enables high-depth-to-resolution ratios for ultrasound imaging, with applications in various medical devices and fields.
Researchers at University of Tsukuba found that hydrogen sulfide production within the respiratory center alters neurotransmissions, disrupting breathing patterns. The study identified variations in this mechanism across different regions, revealing a modulating influence on neural circuits contributing to respiration stability.
A study by Washington State University researchers found epigenetic alterations associated with elk treponeme-associated hoof disease, suggesting a systemic impact. The findings also suggest that the disease may be heritable, raising concerns about its transmission and susceptibility.
A new biomimetic chip has been developed to simulate the human gastric mucosa, combining organoid and organ-on-a-chip technologies. The biochip replicates mechanical stimulation and cell-to-cell interactions, mimicking key features of the human stomach's defense mechanisms.
A new study from the University of Cincinnati explores the molecular mechanism of psychological loss through enrichment removal, identifying a key area of the brain that plays a role in this experience. The research highlights the importance of understanding how loss affects mental health and may lead to novel therapeutic targets.
A digital twin of the bladder has been developed to simulate normal and bladder outlet obstruction (BOO)-affected function. The model will help researchers better understand the connection between changes in BOO bladder wall structure and functionality, enabling them to develop new treatments and predict treatment success rates.
Researchers used proteomics and small RNA sequencing to analyze 103 human blood plasma samples, identifying 21 proteins and 315 small RNAs associated with aging. Combining protein and miRNA data improved age predictions (R2 = 0.70 ± 0.01), suggesting a broader range of age-related physiological changes.
Researchers from Universitat de Barcelona and Universitat Internacional de Catalunya discuss the non-receptor protein tyrosine kinase Src as a good example of an oncogene. Targeting the Src N-terminal regulatory element (SNRE) has potential as oncotargets to inhibit Src activity only in cancer cells.
Researchers found epigenetic changes in post-COVID patients, including genes associated with taste and smell, as well as cell metabolism. These findings may lead to the development of new diagnostic tools for this and similar diseases.
Researchers identified key metabolic pathways in tumor-associated macrophages that contribute to cancer development and progression. Targeting these pathways may provide a new perspective for immunotherapy-based cancer treatments.
A new bioreactor system developed by KAUST scientists delivers gases to maintain physiological environments, reducing unpredictable shifts in cell growth. The system allows for more accurate and reproducible experiments in biomedical research.
A large-scale Australian study found that highly processed and refined foods are the primary contributor to rising obesity rates. The 'Protein Leverage Hypothesis' suggests that people overeat fats and carbohydrates due to their strong appetite for protein, leading to an increased risk of chronic disease.
UCR researchers find that modern ventilators overextend certain regions of the lungs, causing stress and damage, unlike natural breathing. They propose a new thick-walled model to better understand pulmonary mechanics and improve ventilation strategies.
Researchers found that woodpeckers have regained the ability to sense sugar by repurposing their savory receptor. In contrast, wrynecks selectively lost this ability due to a single amino acid change in their receptor, highlighting a novel mechanism of sensory reversion.
Researchers have modelled a key mechanism by which DNA replicates, revealing details about how helicases wrangle DNA during replication. The simulations showed each step of translocation can travel more than 12 nucleotides along the backbone, pinpointing interactions involved in long-distance movement.
Rice University mechanical engineers repurpose deceased spiders as small-scale, naturally derived grippers. The spiders can lift more than 130% of their own body weight and perform tasks like sorting or moving objects around. Future research will focus on testing the concept with smaller spiders.
Researchers at Rice University have created a system that uses the physiology of deceased spiders to create small-scale grippers. The spiders' unique hydraulic system allows them to lift and manipulate objects, making them a promising technology for pick-and-place tasks and capturing smaller insects in nature.
The WVU program trains next generation of toxicologists to collect, analyze air samples from mining, fracking sites, using the university's Inhalation Facility. Students will work with preceptors from various fields to investigate health effects of inhaling toxicants.
Research found that food insecure teens are more likely to attempt weight loss, while college students who drink may compensate with unhealthy eating behaviors. Additionally, studies linked sugar-sweetened beverage consumption to higher triglyceride levels in youth and identified potential mechanisms behind this association.
Researchers developed a novel robotic replica of a human spine with an artificial disc implant and soft magnetic sensor array. The system can classify five different postures of the spine with 100% accuracy, providing physiologically relevant data before invasive surgeries.
Researchers discover changes in muscle torque recovery can predict maximum voluntary strength gains but not delayed-onset muscle soreness. The study's findings offer a promising approach to assessing muscle damage symptoms after exercise.
Rice University's Neuroengineering Initiative is working on developing noninvasive systems to monitor and control the brain. Jerzy Szablowski aims to achieve single-cell precision in 15-20 years through innovative receptor development and gene therapy.
Researchers at the University of Oregon used CRISPR-Cas9 gene editing to target a specific mutation causing Fuchs' corneal dystrophy, preserving endothelial cell density and function. The study lays the groundwork for future research on using this technique to treat genetic disorders in post-mitotic cells.
Kiyoshi Koyano, a renowned prosthodontist, has received the IADR Distinguished Scientist Award for his outstanding research contributions to the field of prosthodontics and implants. He is recognized as a prominent scientist in Japan, with numerous international positions and publications on clinical practice and prosthodontics.
NUTRITION 2021 LIVE ONLINE features leading scientists & the latest research on physiology & metabolism, clinical nutrition & food systems. The virtual meeting provides unparalleled access to a global community of nutrition experts.
A new isolated lymphatic vessel lumen perfusion system was developed to evaluate the interaction between nanoparticles and lymphatic vessels. The system enables detailed examinations of nanomaterial movements and biological safety, paving the way for safe clinical applications.
Researchers propose a new field of study converging AI, basic research, and medicine to extend human lifespan. The framework uses deep learning to predict age-related changes, enabling the development of a new field of medicine - longevity medicine.
Physical frailty is defined as a state of depleted reserves resulting in increased vulnerability to stressors. A complex systems approach suggests that interventions like physical activity can remedy frailty by addressing dysregulation across multiple interconnected physiological and biological systems.
DeepMAge is an epigenetic aging clock that accurately predicts human age on over 6,000 DNA methylation profiles, outperforming previous clocks. The clock reveals associations with various age-related conditions, including cancer, dementia, and obesity.
Deep Longevity will present research on deep aging clocks at the Kinexum webinar, combining leading researchers and a preeminent expert at the FDA to accelerate the use of aging biomarkers in therapeutic interventions. The company has developed multimodal biomarkers of aging using deep learning techniques.
Deep Longevity's 'longevity cloud' will track and analyze aging at multiple levels, providing a novel way to extend human productive longevity and improve performance. The combined company aims to create an end-to-end longevity ecosystem serving researchers, medical doctors, and enthusiasts worldwide.
Researchers developed an IoT-based exercise system that improves physical fitness in elderly individuals by measuring oxygen intake and monitoring exercise intensity. With a 5-month training program, participants increased their fitness level to match that of 10 years earlier, utilizing interval walking training (IWT).
A new metabolism regulation system was found in brown adipose tissue using the kallikrein-kinin hormonal system, which can help prevent damaging effects of excessive activation. This discovery could lead to strategies for moderating thermogenic activity in pathological situations like cancer.
A new study reveals insects experience similar physiological effects of gravity as humans, with air sacs expanding in response to orientation. Insects have an active response called functional compartmentalization, allowing them to control pressure and maintain blood flow.
Research published in Experimental Physiology shows that autophagy stimulation heals diabetics' blood vessels by clearing damaged cells. This study suggests targeting autophagy could be a potential treatment for vascular problems in Type 2 diabetic patients.
A study found that the endocannabinoid system is present in human testis tissue and may be involved in regulating sperm cell development. The system includes key components such as enzymes and receptors that degrade and interact with endocannabinoids, suggesting a potential role in reproductive function.
A study of 200,000 FAM app users found that digital self-tracking can provide valuable information for inferring underlying hormonal changes and ovulation timing. The analysis revealed patterns similar to those in small-scale clinical studies, with notable improvements in the duration and range of the follicular phase.