Articles tagged with Steroids
Research reveals that lupus patients with higher white matter free water have more severe cognitive dysfunction, related to increased cumulative dosage of medical steroids. The study suggests that reducing steroid dosage may alleviate cognitive decline in SLE patients.
Researchers discovered a molecular mechanism that alters immune response to infection in Gouin children, but not in Fulani children. The study's findings could lead to better malarial therapeutic interventions and vaccine responsiveness in populations.
Researchers have developed a new method using ion mobility-mass spectrometry to detect existing and emerging dopants in urine samples. This approach aims to characterize and identify banned substances, including steroids and glucocorticoids, and potentially predict the structure of newly created illicit steroids.
A phase III clinical trial showed that reducing steroid use in intermediate-fit older patients with newly diagnosed multiple myeloma yields similar outcomes to standard treatment. The adapted Rd treatment schedule spares steroid use after nine months, resulting in fewer adverse effects and improved event-free survival.
A study of over 14,000 U.S. young adults found that adverse childhood experiences, such as physical and sexual abuse, predict greater performance-enhancing substance use. The likelihood of using anabolic-androgenic steroids increased nine times among men and six times among women who experienced sexual abuse.
A new marker of testicular cell capacity identified as a promising biological marker, INSL3, shows suppressed levels in former steroid users compared to never-users. Long-lasting impaired gonadal capacity found in previous anabolic steroid users, increasing risk of hypogonadism later in life.
Researchers analyzed data from over 87,000 patients with inflammatory diseases and found that even low doses of glucocorticoids nearly doubled the risk of cardiovascular disease. The study suggests that long-term steroid treatment should be personalized and monitored for cardiovascular risks.
A new study suggests that female reproductive steroids play a protective role against COVID-19 symptoms, providing anti-inflammatory functions and stimulating antibody production. The research also highlights the importance of nutrition in boosting the immune system, particularly through phytoestrogen-rich foods.
Research published in Thorax finds a clear association between steroid treatment and an increased risk of osteoporosis and fragility fractures. Patients prescribed high doses or multiple courses of steroid tablets were more likely to develop these conditions, highlighting the need for bone protection guidance in asthma management.
Researchers successfully synthesized hetero-steroid-amino acid conjugates using microwave-assisted Ugi-4-CR reactions. This method improves yields and reaction rates, offering a promising approach for synthesizing novel hybrid molecules.
A Rutgers study found that children on oral steroids are at higher risk of developing diabetes, high blood pressure, and blood clots, with high-dose steroid users facing the greatest risk. The study, which examined over 933,000 US children, also found that these complications were more common among those with autoimmune diseases.
More than one quarter of asthma patients were prescribed excessive amounts of steroid tablets, posing a risk of serious side effects. Researchers recommend using preventer inhalers as the best way to avoid or minimize steroid use and its associated risks.
A new study found that young adults who used legal performance-enhancing substances were more likely to report problematic alcohol use and drinking-related risk behaviors seven years later. The study highlights the need for government oversight and regulation of these substances, which can lead to health problems and worsen mental health.
Researchers discovered that tumour T cells produce immunosuppressive steroids to evade the immune system, reducing tumour growth in mice. Preventing steroid production using a key gene or drug significantly slowed tumour formation and progression, suggesting new drug targets for cancer immunotherapy.
Researchers analyzed how ovarian function in mice responded to various levels of glyphosate exposure and found increased ovarian weight and follicle number at highest exposure levels. However, the study did not uncover evidence that glyphosate affects the healthy functioning of ovaries.
Researchers have found that steroid therapy can be life-saving for COVID-19 patients with high inflammation levels, but risks for those without significant inflammation. The study used a common blood test to identify the best candidates for treatment.
Russian scientists have discovered four new steroid substances extracted from starfish that target human breast cancer and colorectal carcinoma cells. These non-typical derivatives of polar steroids may also help nerve cells survive distress, suggesting potential applications in Alzheimer's disease prevention.
A new study found that treatment with antibodies and steroids restored heart function in most children with COVID-19-related multi-system inflammatory syndrome. The majority of patients recovered quickly with intravenous immune globulin and adjunctive steroid therapy, suggesting a promising approach to managing this condition.
A new clinical trial will assess the effectiveness of adalimumab in preventing recurrence of uveitis and improving quality of life. The study aims to identify which patients with uveitis benefit most from this medication, both in terms of vision and treatment side effects.
A new study found that cumulative doses of oral steroids are associated with increased hypertension, affecting over 24,000 adults with chronic inflammatory diseases. The researchers recommend closer monitoring of blood pressure in these patients.
Researchers at UNIGE have developed a new technique for creating chains of molecular rings that do not use standard chemical interactions but instead contact with large molecular surfaces. This discovery helps answer an old contradiction in classical chemistry and provides new prospects for molecular cyclization.
The isoperimetric soft robot is a human-scale, pneumatic robot that can move without a tether and navigate unstructured environments. It achieves this by deforming its soft fabric tubes while maintaining its perimeter constant.
Researchers identified a gene, CELSR2, associated with glucocorticoid resistance in leukemia cells. A new drug, venetoclax, may reverse resistance by inhibiting a cell death pathway. The findings suggest combining venetoclax with current therapy could improve ALL chemotherapy effectiveness.
Scientists at Fred Hutchinson Cancer Center discovered a mini-protein in scorpion venom that rapidly accumulates in joint cartilage, allowing it to deliver steroids and other drugs directly to the affected area. This approach may potentially improve the safety of arthritis treatment by reducing systemic side effects.
A new study suggests that the diabetes drug metformin can improve the clinical status of patients on glucocorticoid treatment, reducing infections, hospital admissions, and metabolic side effects. The 12-week trial found a 30% reduction in infection rates and lower hospital admissions compared to the placebo group.
Experts advise against using steroids to treat lung injury caused by coronavirus due to potential harm. Steroids can impair the immune system's ability to fight viruses, leading to prolonged illness and increased risk of complications.
A recent global trial has found that high-dose intravenous vitamin C, thiamine, and hydrocortisone therapy does not improve survival rates or treatment outcomes for patients with sepsis. The study refutes previous claims of the effectiveness of this 'Vitamin C cocktail' in treating sepsis.
A new study has developed best practice treatment guidelines to quickly identify and treat patients with e-cigarette or vaping-associated lung injury (E-VALI). The guidelines recommend shorter courses of steroids for outpatients and higher doses for critically ill patients, resulting in improved clinical outcomes.
Anabolic-androgenic steroid use is associated with decreased heart function, as revealed by a study of male weightlifters. The study found that AAS users have thicker hearts and reduced ability to contract ventricular chambers, increasing mortality risk.
A study of over 40,000 patients with polymyalgia rheumatica and/or giant cell arteritis found that oral steroid use significantly increased the risk of infection. The risk increased with higher doses, even at low daily doses.
A new study from the University of British Columbia found that steroid inhalers can lower lung cancer risk in COPD patients. The research, published in European Respiratory Journal, analyzed data from 39,676 adults with COPD and found a 25-30% reduction in lung cancer risk among those using steroids.
A recent study of nearly 300 patients with mild persistent asthma found that inhaled steroids were no more effective than placebo in nearly three-fourths of the study patients. However, for those with high levels of eosinophils, inhaled steroids were better than placebo, suggesting a potential new approach to targeting specific therapies.
A new study suggests that using performance-enhancing steroids may increase the risk of cocaine use and addiction in teens, as well as impair fertility. Researchers found that female rats exposed to anabolic steroids showed increased sensitivity to cocaine and reduced ovary weight.
Researchers found that men taking bodybuilding supplements experienced prolonged and difficult-to-treat liver injuries, often accompanied by jaundice and generalized itching. The study also revealed that many products contained illicit anabolic steroids not accurately listed on the label.
A randomized controlled trial conducted across 18 countries found that steroid use during cardiopulmonary bypass surgery did not reduce the risk of acute kidney injury in patients at high risk of death. The study included 7286 patients and found no significant difference between those receiving steroids and those on placebo.
Researchers at Osaka University found that activated adipocyte GRs restrict healthy fat expansion, causing metabolic disturbances such as insulin resistance and liver steatosis. Adipocytes are the primary sites of steroid action, contributing to the development of steroid diabetes.
A new asthma pill has shown promising results in reducing airway muscle and inflammation, potentially leading to improved symptoms and reduced attacks. The investigational drug, Fevipiprant, may also reduce the need for oral steroids, a common treatment for severe asthma.
Researchers found that older patients with chronic sinusitis have a distinct inflammatory signature characterized by innate immune function and age-dependent cytokine elevations. This may render them less responsive to traditional steroid treatments, which are often ineffective for these patients.
A new study found that anabolic steroid use is associated with a three-times higher risk of death and more hospital contacts among men. The study also revealed significant side effects such as acne, gynaecomastia, and erectile dysfunction among users.
Researchers at UCR discovered the oldest clue yet of animal life, found in molecular fossils of sponges that lived on ancient ocean floors. The discovery pushes back the known history of animal life by 100 million years.
Homemade steroids have become a widespread issue, with online tools and cryptocurrency facilitating their rapid spread. Clemson researcher Bryan Denham's study examines the impact of these substances on public health, noting that purchasing black-market steroids is similar to buying other illicit substances.
A new investigational steroid called vamorolone has been found to replicate the benefits of prednisone while reducing its side effects, offering hope for patients with chronic inflammatory diseases. The study identifies nine potential biomarkers for inflammatory diseases that could serve as a fingerprint for chronic inflammation.
Research by University of Manchester scientists found that genes regulating lungs and liver function change with the day-night cycle, impacting steroid side effects. Removing a specific molecule, Reverbα, altered gene expression and showed protective effects against fatty liver buildup.
A study of European mothers has identified a gene involved in steroid signaling as a potential factor in early birth. Mutations in the HSPA1L gene are rare but may disrupt proper functioning of cells lining the uterus, leading to preterm labor.
Researchers develop novel small molecule, PM-43I, that specifically targets STAT6 pathway, reversing preexisting allergic airway disease in mice. This breakthrough approach offers unique advantages over monoclonal antibodies, with potential benefits for patients who may not need steroid treatments.
Researchers have found a patient-centric treatment that works for people with mild asthma, using an as-needed combined-drug inhaler. The study, led by Paul O'Byrne, showed the inhaler was superior to conventional treatment strategies in reducing asthma attacks and improving symptom control.
A recent study published in The American Journal of Obstetrics & Gynecology has found that the duration, not peak exposure, is key to maturing preterm lungs. This breakthrough could lead to safer and more effective antenatal steroid treatment, benefiting millions of families worldwide.
A study by Massachusetts General Hospital found that patients with chronic sciatica have elevated levels of a neuroinflammation marker in the spinal cord and nerve roots. The study suggests that blocking neuroinflammation may be a viable treatment option for these patients, particularly those who benefit from steroid injections.
A clinical trial found that increasing inhaled steroids at the first signs of an asthma attack does not prevent attacks in children with mild to moderate asthma. Children in the high-dose group experienced slower growth rates compared to those on low-dose medication.
A new study has found that temporarily quadrupling the dose of inhaled steroids during severe episodes of asthma can reduce the risk of serious attacks by 20% and hospital admissions. The study involved nearly 2000 patient volunteers and showed promising results for patients with long-term asthma.
A large-scale study has shown that steroid treatment can reduce the duration of septic shock and time spent on life support therapy, but not necessarily lead to fewer deaths. The trial involved 3800 patients across five countries and found that steroids led to a more rapid resolution of shock and earlier discharge from intensive care.
Researchers at Dartmouth College developed a technique to produce synthetic steroids, paving the way for new drug discoveries. The process reduces time and expense to develop therapeutics from rare, mirror-image isomers of naturally occurring steroid structures.
A large study found that steroid inhalers used to treat asthma and COPD in people over 66 increase the risk of nontuberculous mycobacteria infections. The study suggests that these infections are chronic, difficult to treat, and associated with an increased risk of death.
Exclusion of solid food allows for effective control of Crohn's disease inflammation and promotes faster healing compared to steroid treatment. Liquid nutrition provides a viable option for managing the condition in pediatric patients.
A year-long trial confirms tocilizumab reduces both symptoms and steroid doses in patients with giant cell arteritis. The therapy offers a potential alternative to traditional steroid treatment, which can have serious side effects.
A new Northwestern Medicine study found that weekly glucocorticoid steroid doses, such as prednisone, promote muscle repair and recovery in muscle injuries. The study showed that daily doses cause muscle wasting, but weekly doses stimulate the production of annexins and KLF15 proteins, leading to improved muscle performance.
Researchers found that injecting an anti-inflammatory steroid directly into the tissue surrounding a leg artery reduced inflammatory biomarkers and prevented repeat blockages. The treatment showed promise for improving treatment outcomes for patients with peripheral artery disease.
Reducing glucocorticoid steroid frequency improves muscle recovery and function in mouse models of Duchenne muscular dystrophy. Intermittent dosing regimens may prevent debilitating side effects while preserving therapeutic effects on muscle function.
A study by Brigham and Women's Hospital found that Medicare spending on topical steroids increased by 226.5% and out-of-pocket costs for patients rose by 145.9% between 2011 and 2015. Researchers suggest using physician decision support to pick more affordable generic options, potentially saving $944.8 million and $66.6 million.
A new study published in JOSPT found that dry needling is as effective as cortisone injection in reducing pain and improving movement problems caused by greater trochanteric pain syndrome. Researchers treated patients with chronic hip pain, finding that both treatments resulted in decreased pain and improved function.