Articles tagged with Pharmaceutical Industry
A decision-support framework was developed by management science researchers to help clinicians make informed decisions about opioid prescribing. The framework incorporates multiple factors, including recovery time, pain intensity, and patient history, to provide a quantitative model of the prescribing process.
Researchers have developed an eco-friendly and reusable solution for removing toxic synthetic dyes from wastewater using nanocomposite-based hydrogels. The new material, made from carboxymethyl cellulose (CMC) and graphene oxide, demonstrates high adsorption capacities and retains its effectiveness even after multiple cycles of use.
Researchers created edible tags with fluorescent silk proteins to track medications, providing a new way for consumers to verify authenticity. The codes are readable by a smartphone app and can be ingested without causing harm.
The partnership between pharma companies and patient influencers has raised concerns about the potential risks and benefits. While some see it as a way to improve disease awareness and treatment options, others worry about misinformation and advertising blurring the lines between opinion and ad content.
A new deep learning-based model called Highlights on Target Sequences (HoTS) predicts binding between drugs and target molecules, providing interpretable results. The model can predict target proteins' binding regions and interactions with drugs without a 3D complex.
A new tool, SPARCLD, speeds up the development of vaccines and pharmaceutical products by accelerating synthesis and analysis on a nano scale. This breakthrough method allows for the creation of 40,000 different molecules in an area smaller than a pinhead, reducing material, energy, and economic costs.
Researchers from North Carolina State University have released a dataset providing detailed information on COVID-19 vaccine shipments and wastage across the US. The data aims to inform modeling and decision-making to optimize vaccine supply chains.
A study found that female principal investigators led fewer trials and those funded by industry sponsors, but more trials led by women were associated with higher enrollment of female subjects. This highlights the need for increased female representation in clinical trial leadership.
Researchers have developed miniaturized reflectors that enlarge the uses of remote infrared spectroscopy, allowing for field-ready devices with minimal size, weight, and power requirements. The devices utilize Ge-BaF2 thin films for surface micromachined mid-wave and long-wave infrared reflectors.
Researchers found that polymer molecules interact with the flow around gas bubbles, causing a sudden increase in velocity. This knowledge can be used to predict oxygen input and design equipment for industries like biotechnology and pharmaceuticals.
Researchers from CCDC, Exscientia, and Oxford University have developed an automated method for informing the design of compound selectivity across protein families. The 'Hotspot API' uses ensemble hotspot maps to quantify the propensity for compounds to exploit interactions in preferred binding sites.
Researchers found that Neem bark components target a wide range of viral proteins, suggesting its potential as an antiviral agent against emerging coronavirus variants. The study showed the bark extract was effective in reducing virus replication and spread in SARS-CoV-2 human lung cells.
Researchers from Eötvös Loránd University have created a more efficient method for producing catalysts, which can speed up chemical transformations and reduce environmental impact. This breakthrough could lead to faster drug development and improved pesticide production.
Scientists have devised a method to pinpoint active ingredients from traditional Chinese medicine formulations, revealing 4 analytes with significant anti-inflammatory activity. This breakthrough could improve quality control standards and lead to better herbal remedies.
The Commission on the North American Opioid Crisis recommends banning direct marketing to prescribers and curbing industry influence on medical education. The group also suggests standardizing addiction care within health systems and improving access to medication-assisted treatment.
Researchers developed Inducible Directed Evolution (IDE), a new technique for controlling directed evolution in bacteria, allowing up to 30 gene modifications at a time. This approach enables finely tuned changes to bacteria, making it suitable for biopharmaceutical and chemical manufacturing industries.
The BRIGHTER project develops a new 3D bioprinting technology that creates complex and accurate human tissues, reducing the need for animal models. The technology uses light-sheet lithography to fabricate human skin and other tissues with high resolution and accuracy.
Prenatal exposure to industrial toxin TCDD may cause long-term damage to brain circuits and potentially lead to neurodevelopmental disorders like autism and ADHD. Researchers found that pharmacological manipulation can restore microglia function, suggesting a possible therapeutic avenue for these disorders.
A new study found that only 57% of Georgia pharmacies carry Plan B, while less than 1% carry the more effective ulipristal acetate. Rural pharmacies were less likely to have Plan B, highlighting existing disparities in reproductive health care access.
The Stanford-Lancet report highlights the devastating impact of the opioid crisis on US and Canadian citizens, with over 600,000 deaths since 1999. The commission proposes far-reaching reforms to address addiction and overdose deaths, including medical education, healthcare, and pharmaceutical industry regulation.
The opioid crisis is predicted to grow exponentially in North America, adding 1.2 million more overdose deaths by 2029. The epidemic began in the 1990s and has worsened over the past decade due to the availability of illicit opioids like heroin and fentanyl.
A qualitative study found that industry arguments against alcohol health warning labels were cited by World Trade Organization representatives, despite not being explicitly stated as industry demands. This highlights the need for greater transparency and curbing the alcohol industry's influence on global policy implementation.
University of Warwick scientists developed a new method to produce indolic amides, carboxylic acids, and auxins using enzymes that mimic plant production. The process is reusable, produces minimal waste products, and could help make pharmaceutical and agrochemical manufacturing more environmentally friendly.
The collaboration aims to create an interoperable global data ecosystem for rare diseases, accelerating the development of new therapies. This partnership benefits patients, regulators, advocacy stakeholders, researchers, and industry, while expanding C-Path's global capabilities in collaborating on methodologies and technologies.
A UCLA-led study found that aducanumab's ancillary care services, such as MRIs and neurologist visits, account for nearly 20% of total Medicare costs. The estimated annual spending on the drug could increase Medicare premiums.
A new procedure uses high-intensity pulses of light to dramatically accelerate the removal of organic micropollutants from water. The treatment can degrade pollutants at extraordinary rates, making it an ideal solution for high-throughput water treatment applications.
Researchers devised a novel approach to unify quality assessment of generic drugs developed through different processes. The 'population pharmaceutical quality assessment' method uses computational modeling to evaluate process information, providing a scientific tool for objective quality consistency evaluation.
The COVID-19 pandemic drove significant advancements in pharmaceutical technology, with mRNA-based vaccines proving highly effective. Oral antiviral pills, such as Merck's molnupiravir and Pfizer's PF-0732133, showed promise in reducing hospitalization and death rates among unvaccinated individuals.
The study found that flu vaccination rates are significantly lower among individuals without regular healthcare providers compared to those with a provider. Vaccination rates increased with age and were higher among those with more medical conditions.
Researchers at Osaka City University developed a new quantum algorithm that calculates potential energy curves of molecules without controlled time evolutions. This addresses issues with conventional quantum phase estimation algorithms, enabling parallel processing and efficient full-CI calculations.
Researchers at Tokyo University of Science have developed a novel light-based method for rapidly racemizing chiral sulfoxides, a crucial step in producing desired enantiomers. This breakthrough utilizes photocatalysts to achieve rapid racemization under moderate conditions, bypassing the need for high temperatures previously required.
Scientists at the University of Bath have developed a new method for synthesizing primary amines, used in over half of all pharmaceuticals, significantly reducing energy usage and chemical waste. This breakthrough aims to speed up drug discovery by making it easier to synthesize new chemical structures for testing.
A team of Korean researchers has successfully extracted high-quality magnesium sulphate, without calcium impurities, from seawater desalination brine using a novel ethanol-based process. The process achieved up to 67% magnesium recovery efficiency and has potential applications in the pharmaceutical and food industry.
Paxlovid demonstrates significant efficacy against SARS-CoV-2 virus, reducing hospitalization and death risks in adult patients by up to 89%. The treatment's development involved cutting-edge X-ray technology from the Advanced Photon Source.
The CryForm project aims to replace synthetic stabilizing agents with crystalline materials, enabling innovative multiphase formulations for safer, more sustainable and affordable products. The project will develop biocompatible crystals for pharmaceutical, cosmetic and food applications, contributing to the European Green Deal.
A recent survey of advanced breast cancer patients in the UK reveals that only 14% have been recruited to a trial, highlighting a need for improved access. Patients often face barriers, including clinician reluctance to discuss trials and a lack of patient-friendly databases.
A study published by The BMJ found an extensive network of financial and non-financial ties between the medical product industry and all major healthcare parties and activities. Researchers are urging enhanced oversight and transparency to protect patients from commercial influence, citing the need for better conflict of interest polic...
Researchers developed a predictive tool using %V bur (min) to categorize phosphine structures as active or inactive in many experimental datasets. This advancement will facilitate organometallic chemistry and catalysis, enabling easier computation and prediction of phosphine reactivity.
Exposure to environmental stressors like air pollution, noise exposure, and climate change significantly contributes to the high incidence of cardiovascular disease. The review discusses solutions and mitigation measures to lower the impact of environmental risk factors on cardiovascular health.
A new study funded by FDA and HHS suggests that continuous manufacturing (CM) processes could make pharmaceutical production in the US more attractive than investing in China or India. The findings show that CM processes were more economical than current batch processing, particularly under current US corporate tax rates.
Researchers developed a mathematical model to study the action of SARS-CoV-2, enabling the examination of individual virus particles and their spikes. This analysis can help fine-tune prevention and treatment by providing insights into viral load, spike distribution, and cell infection potential.
A novel combination of abiraterone acetate and prednisolone has been shown to prolong survival in patients with hormone/castration-sensitive prostate cancer. Studies PEACE-1 and STAMPEDE found that the addition of these drugs to standard therapy lengthened survival compared to standard therapy alone.
The MONALEESA-2 trial found that adding a CDK 4/6 inhibitor to first-line hormonal treatment prolongs survival by one year for postmenopausal women with HR-positive, HER2-negative advanced breast cancer. The combination of endocrine therapy and the CDK 4/6 inhibitor ribociclib also extends progression-free survival.
The KEYNOTE-716 trial shows that adjuvant pembrolizumab significantly prolongs recurrence-free survival and halves distant recurrences in stage II B/C melanoma patients. This suggests that patients with high-risk stage II melanoma should be offered adjuvant therapy.
Analysis of survey data reveals shifts in health care spending in different US population groups, with significant increases in prescription drug spending between 2001 and 2018. The study highlights the need for targeted interventions to address these trends and promote more equitable healthcare distribution.
This special collection highlights the use of biophysical methods in identifying and characterizing molecules in early drug discovery, including graphene bioelectronic sensing technology and mass spectrometry. It also showcases a fully automated acoustic ejection mass spectrometry technology for high-throughput screening.
A study found that anticholinergic medications may increase the risk of cognitive decline and falls in under-18s. In the German population, up to 6% of this age group are at risk due to these medications.
The Horizon 2020 projects RISK-HUNT3R and TOX-Free aim to develop animal-free strategies and tools for chemical risk assessment, combining in vitro and computational approaches. The projects will improve the accuracy and efficiency of safety assessments, enabling the development of sustainable alternatives.
A recent study by Portland State University researchers detected low levels of pharmaceuticals and personal care product chemicals in oysters along the Oregon and Washington coast. The concentrations were higher near wastewater sites, indicating a need to address the sources of these pollutants.
Gamma-cyclodextrin, a widely used compound in manufacturing, has been made more accessible and environmentally friendly through a new process using light-sensitive hydrazone. This process reduces energy consumption and cost, making the compound cheaper and more available for use in various consumer products.
Researchers at RUDN University developed an eco-friendly method to synthesize pyrrole and pyrazole derivatives, which exhibit fluorescent properties. The new process is safer, cheaper, and more efficient, generating a wide range of bioactive compounds with potential applications in medicine.
A research group at KAIST successfully produced seven natural rainbow colorants, including carotenoids and violacein derivatives, using engineered Escherichia coli strains. The strategies developed can be applied to the efficient production of other industrially important natural products.
A majority of Americans, including Democrats and Republicans, favor empowering the federal government to negotiate lower prescription drug prices under Medicare. The survey found that only a minority believe this would harm innovation or competition from the pharmaceutical industry, with 39% of Republicans among them.
Researchers at NUS have developed a method to increase the rate of ethylene hydrogenation by more than five times compared to typical industrial rates using oscillating electric potentials on commercial catalysts.
Researchers at the University of Manchester used time-resolved 3D imaging to study the complex dynamics of particle movement in granular materials. The findings show that particle shape and orientation play a crucial role in segregation, with larger nuts like Brazil nuts rising to the top.
Researchers have created a new catalyst that allows for more efficient and sustainable production of aromatic hydrocarbons using renewable sources like woody biomass. The catalyst reduces the need for high temperatures and pressures, minimizing energy costs and emissions.
A national registry is needed to capture all pharma/medical device industry payments and benefits made to doctors, healthcare organisations, and patient support groups in the UK. The UK government has been dragging its feet on setting up such a system despite recommendations from key reviews.
Researchers developing standardized platform for organs-on-chips with human cells, aiming to test drugs and food outside a human body. The goal is to link multiple organ chips together to simulate a whole body, eliminating harmful or ineffective drugs earlier in the process.
A Purdue University team has created a cloud-based platform that helps manufacturers track material flows and supply network demand to optimize processes and reduce waste. The platform uses mechanistic models to update network structures for industrial interactions, enabling more accurate and reliable resource flow mapping.
A new electrochemical procedure produces sulfonamides rapidly and inexpensively using cheaper starting materials, electrical current, and safe solvents. The process eliminates three reaction stages, making it scalable and cost-effective.