Articles tagged with Pharmaceutical Industry
Researchers at KIT develop new NMR spectroscopy method to directly measure chiral molecular structure. This enables accelerated drug screening and simplifies the search for active ingredients in pharmaceuticals. The breakthrough could lead to significant improvements in drug development.
A team of chemists has developed a novel tool to streamline the drug-making process, enabling researchers to create new molecules quickly and efficiently. The discovery of stable nickel complexes can help reduce the time to market for life-saving medicines while increasing drug efficacy and reducing side effects.
Researchers at the California Institute of Technology have successfully developed a method to recycle samarium diiodide, a crucial reagent in synthesizing molecules that can lead to new pharmaceuticals. This breakthrough enables large-scale industrial production, making it possible to create essential compounds like taxol, an anticance...
Researchers developed a one-pot process to transform aromatic ketones into esters, simplifying the reaction process, reducing reaction times, and minimizing purification steps. The method enables seven different chemical transformations and has shown notable stability and reusability, making it scalable for industrial applications.
Five pioneering firms in agriculture, manufacturing, and pharma retail have demonstrated businesses can catalyze social and environmental change. They address complex issues using scientific methods, partner with NGOs, and prioritize purpose alignment.
Research from Bentley University shows that biotechnology companies can maintain current levels of new drug approvals in face of global revenue reductions. Strategic distribution of cost reductions and continued investment in early-stage development by biotech firms sustain pipeline, contradicting industry claims.
A Tulane University study found that pharmacists have the best success rates in helping patients with high blood pressure get their hypertension under control. Pharmacists achieved the greatest improvements, followed by community health workers, who also saw significant reductions in blood pressure.
Researchers at NUS have developed a novel method for creating 1,2-arylheteroaryl ethanes using fundamental feedstock chemicals. The new approach enables the modular assembly of diverse molecular scaffolds with potential applications in pharmaceuticals and petrochemical industries.
Researchers isolated three bacterial strains that produce amylase enzymes from sugar factory waste, showing great potential for production. The optimal conditions for amylase production were found to be 37°C and pH 7.0, leading to increased enzyme activity.
A new study by the University of Toronto Nursing found that over one million industry-sponsored events took place in the US in 2022, with a focus on physician and nurse practitioner interactions. These events were linked to specific pharmaceutical products, indicating their potential impact on prescribing practices.
Researchers at Tokyo University of Science have developed a new method to synthesize complex sulfur molecules, including phenothiazines and thianthrenes, with high stability and control over reaction conditions. This approach uses readily available aryne precursors and avoids foul odors associated with conventional methods.
Researchers at Colorado State University have developed a new approach to speed up the development of pharmaceuticals and pesticides. By deconstructing and reassembling common compounds known as heterocycles, scientists can rapidly change their characteristics without extensive synthesis.
LyoWave is commercializing microwave heating technologies developed at Purdue University, improving speed, cost-effectiveness, and product throughput. The company has entered a collaboration with Millrock Technology, applying its technology to boost freeze-drying systems' capacity for pharmaceuticals and diagnostic reagents.
Scientists have found an effective treatment for spitting cobra snakebites by blocking one of the major dermonecrosis-causing toxins with varespladib. The study suggests that this repurposed drug can prevent tissue damage and may become a valuable treatment against black-necked and red spitting cobra venoms.
A study published in JAMA analyzed industry payments to US physicians, finding that over half received at least one payment and 94% were associated with marketed medical products. Orthopedic surgeons received the most payments, while pediatric surgeons received the fewest.
Researchers at Xi'an Jiaotong-Liverpool University developed a new method that enables the efficient production of cysteine-rich peptides and microproteins in their naturally folded 3D structure. The approach uses organic solvents to mimic nature's oxidative folding process, resulting in speeds of over 100,000 times faster than aqueous...
Researchers developed an AI-driven lab called Fast-Cat that uses artificial intelligence to provide in-depth analyses of catalytic reactions. The tool conducts high-temperature gas-liquid reactions and analyzes results to determine how different variables affect the outcome of each experiment.
A UCF-developed technology uses a plasmonic platform to detect the chirality of molecules with high precision, enabling more accurate drug development and therapies. The platform improves upon current methods with sensitivity nearly 13 orders of magnitude greater.
Researchers at Salk Institute find a new method to interrupt sperm production using an HDAC inhibitor, which blocks fertility without affecting libido. The treatment's reversibility is attributed to its ability to modulate gene expression downstream of retinoic acid.
A new study reveals that utilization of PCSK9 inhibitors is low among high-risk patients, despite extensive evidence documenting their role in LDL-C reduction and the prevention of heart attacks. The study found that insurance coverage rejection or abandonment leads to significantly more cardiovascular events within 12 months.
Processing times for complaints against UK drug companies have tripled over nearly two decades, from less than three months to over eight and a half months. The industry's trade body has raised fees related to these complaints by more than 40% in an effort to tackle the backlog.
A new study suggests Mexico can grow its economy by building biorefineries to produce biofuels, chemicals, and pharmaceuticals from abundant organic waste materials. The research promotes the adoption of sustainable practices to achieve UN Sustainable Development Goals 8-12.
Scientists at the University of Rochester discovered that even small differences in grain shape can significantly alter grain segregation in dry and wet conditions. The study highlights the importance of interdisciplinary research to better understand and predict geohazards and alleviate segregation issues in industrial flows.
Despite a lack of clinical efficacy evidence, phenylephrine remained the most common oral decongestant in the US from 2012-2021, with hundreds of millions of units sold annually. Most phenylephrine products were co-formulated with antihistamines or antitussives, providing symptom relief for cough and cold symptoms.
A new study found that phenylephrine is the most popular nasal decongestant despite lack of evidence supporting its effectiveness. Removal from the market could disrupt supply chains and require significant investment in infrastructure for over-the-counter drug review.
Researchers at Delft University of Technology have developed pioneering advancements in the purification of isopropanol and acetone from waste gases through engineered bacteria. The novel process shows high-purity yields with recoveries over 99.2%, marking a significant step forward in sustainable industrial fermentation.
A study published by Geisinger College faculty and graduate students found that 55% of DSM-5-TR panel members received payments from industry, highlighting the need for stricter standards. The researchers argue that individuals with financial ties to industry should not have decision-making authority in guideline development.
Scientists in Germany developed a new analytical method to precisely elucidate the size of particles, structure, and RNA molecules in pharmaceutical products. This information can help evaluate product quality, enabling improved development of new products.
Researchers at the University of Bath have created a novel bacterial system to mass-produce cyclic proteins and peptides, addressing a significant bottleneck in the development of new therapeutic treatments. By harnessing the natural cyclization process from the Oldenlandia flower, they improved heat and chemical stability, as well as ...
A study published in the Canadian Medical Association Journal found that about 1 in 10 prescription drugs has a manufacturer-sponsored patient support program. These programs offer financial, nursing, and educational supports to patients, primarily for expensive and rare disease drugs.
Researchers at CABBI developed an economical method for producing succinic acid, a key chemical in food, agricultural, and pharmaceutical products, using acid-tolerant yeast. The new pipeline eliminates costly downstream processing steps, significantly reducing costs and emissions.
A University at Buffalo-led research team has created a new, sturdier membrane that can withstand harsh environments associated with industrial separation processes. The membrane, made from an inorganic material called carbon-doped metal oxide, is a potential alternative to energy-intensive processes like distillation and crystallization.
A new study calls for stronger regulation of pharmaceutical industry marketing practices to enhance patient health and safety. Healthcare professionals and organisations need to distance themselves from offending companies and demand tougher action.
Research has clarified how starch granules form in wheat seeds, unlocking diverse potential benefits for various industries. The discovery of the enzyme PHS1 crucial for B-type granule initiation offers opportunities to create variations in starch for different food and industrial applications.
A new fund to fast-track patient access to potentially valuable new medicines may incentivise the pharmaceutical industry to develop high-priced drugs for rare diseases with weak clinical evidence. The NHS England Innovative Medicines Fund risks disincentivising the generation of essential evidence if not implemented appropriately.
A Texas A&M University team is exploring 3D printing to create tailored medication dosage and tablet size for young children, addressing the need for greater flexibility in administering medications. The project aims to maintain drugs' integrity and effectiveness while advancing the field of pharmaceutical manufacturing.
Researchers from Tokyo University of Science have developed an innovative method to synthesize azide compounds with a protected azido group, facilitating the efficient synthesis of organonitrogen compounds. This novel approach enables the creation of a wide range of azides through transformations with various electrophiles.
Researchers found that translating consent documents can discourage investigators from recruiting patients with limited English proficiency, contributing to low rates of participation from underrepresented groups. By relieving investigators of these costs, studies can become more inclusive and results more accurate and generalizable.
A new method for polyurethane synthesis without isocyanates was developed by Kobe University and AGC Inc. using fluorinated compounds, enabling the creation of highly elastic, wear-resistant, and durable polyurethanes with improved environmental sustainability.
A new study by Bentley University reveals the NIH's significant investment in pharmaceutical innovation, with $8.1 billion spent on phased clinical trials between 2010-19. The funding represents only ~10% of reported industry costs for these trials, highlighting the public sector's limited contribution to drug development.
Researchers have developed a method to produce pharmaceutical precursors from biorenewable β-pinene, a waste by-product from the paper industry. They successfully created paracetamol and ibuprofen using this compound, presenting a potential alternative to crude oil-based products.
A German federal funding program will support a five-year research collaboration to develop specialty lipids and auxiliaries for mRNA vaccines. The project aims to enhance production capacities and improve the resilience of supply chains for future mRNA therapeutics.
Researchers found that biosimilar competitors quickly captured market share from the originator and drove prices down, with some versions declining by more than half. The study's findings support the potential of biosimilars to reduce biologic drug prices in the physician-administered market.
Researchers at Ohio State University developed an AI framework called G2 Retro to automatically generate chemical reactions for molecules. The framework was shown to cover a vast range of possible reactions and accurately predict the best synthesis routes, offering more efficient drug design options.
A significant increase in illicit ketamine seizures in the US has raised concerns about the risks of non-medical and recreational use, as well as the presence of fentanyl. The study found a 349% rise in seizures from 2017 to 2022, with the highest numbers reported in Tennessee, Florida, and California.
Researchers have developed new methods to analyze dry-coated drug particles using 3D Raman mapping, which can effectively slow down dissolution rates. Another study introduces a novel technique for detecting complex traditional Chinese medicines, preventing adulteration and counterfeiting.
A novel method combines biosensors and microfluidics to quickly identify mutant bacterial strains that produce industrially useful proteins. The approach enables the extraction of high-performing strains in a fraction of the time required by traditional methods.
A Pharmacy PhD student from the University of Huddersfield has won a prestigious award to present her research on how community pharmacies can contribute to preventing suicide in low and middle-income countries, particularly in Nigeria. She aims to raise awareness of suicide and train pharmacists to recognize signs and risk factors.
A new study from Cornell University found that the pharmaceutical industry can significantly reduce its environmental impact. The study analyzed the full life cycle of the HIV antiretroviral drug Tenofovir Disoproxil Fumarate (TDF) and found that energy usage is the biggest contributor to carbon emissions, accounting for up to 45% of t...
Dr. Vesna Najdanovic from Aston University won a $25,000 grant to develop greener analytical methods using ethyl lactate as a solvent for liquid chromatography. This environmentally friendly alternative reduces carbon footprint and pollution in the pharmaceutical industry.
Researchers at Nagoya University have successfully developed an ultrafast and simple synthetic method for producing indole derivatives. The new microflow synthesis method enables precise control of short reaction times, limiting unwanted dimerization/multimerization and increasing the yield of desired products.
A Bentley University study shows that the National Institutes of Health (NIH) invests similarly to the pharmaceutical industry in bringing new drugs to market. The NIH spent $187 billion on research related to FDA-approved drugs between 2010-2019, with an average investment per approved drug of $1.7 billion.
A pharmacy PhD student from Iraq has won the Best Oral Presentation award at a major international conference for pharmaceutical sciences. Haja Muhamad's prize-winning talk explored the effects of prandial dosing on dosage forms using imaging and spectroscopic analysis.
A new study found that acquisitions in the biopharmaceutical industry can disrupt trust and knowledge exchange routines between companies, leading to a higher risk of alliance termination. The odds of termination for exposed alliances are 11% greater than for unexposed ones.
Researchers from Kyushu University found that the single mechanosensitive protein VGLL3 induces fibrosis, thickening and scarring tissue. The study suggests targeting this protein could lead to new treatments against fibrosis.
A study found that having opioids at home increases the risk of overdose for those living with them, emphasizing the importance of proper disposal and education. Household prescription opioids are associated with a higher likelihood of overdose for others in the household, even if they don't have their own prescription.
A KAIST research team has developed an advanced AI-based drug interaction prediction technology that analyzed the interaction between Paxlovid ingredients and other prescription drugs. The study identified potential drug-drug interactions and alternative drugs with low adverse effects, which can aid in developing new treatments.
Researchers developed an acid-based electrochemical process to convert CO2 captured from emission sources or air into multicarbon products such as ethylene and ethanol. The new method improves energy efficiency by twofold compared to previous benchmarks.
The five finalists of the Bright SCIdea Challenge will compete for a £5,000 prize by pitching their scientific business ideas that could benefit society. The project ideas include burn treatments and environmental calculators.
Research by the University of the Basque Country found that gluten-free products often lack essential nutrients like fibre and protein. Gluten-free pasta, for example, is now made from millet instead of rice flour, improving nutrition.