Articles tagged with Memory Formation
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A study by UCLA researchers found that sedentary behavior is a significant predictor of thinning in the medial temporal lobe, a region critical for memory formation. Regular physical activity, even at high levels, is insufficient to offset the harmful effects of prolonged sitting.
Researchers at the University of Sussex have identified a specific molecule that plays a key role in forming long-term memories. By controlling this molecule, a drug could be developed to relieve the block on new memories in dementia patients and help repress painful memories in post-traumatic stress disorder sufferers.
Researchers have discovered that removing a molecular brake pad called histone deacetylase 3 (HDAC3) restores flexibility and allows the brain to form long-term memories normally. This breakthrough could potentially lead to new treatments for improving memory formation in older individuals.
Researchers investigated how the brain constructs the world by integrating sensory signals from multiple modalities. They found that the posterior parietal cortex plays a crucial role in merging signals to form meaningful representations of objects and memories.
Researchers identify protein Npas4 as key controller of synaptic strength in CA3, essential for encoding contextual memories. Without Npas4, synapses become over-strong and unable to be further strengthened.
A study by NUS researchers has identified the potential role of a neuropeptide named Substance P as a mediator of social memory in area CA2 of the hippocampus. This finding suggests that Substance P may play a key role in forming social memories, including distinguishing between familiar and novel faces or objects.
A University of Idaho-led team found a way to stimulate the formation of new neural connections in the adult brain, which could help humans fend off memory loss and brain trauma. The study used genetic manipulation in mice to induce axon and dendrite outgrowth, leading to the formation of stable, functional connections.
A recent NIH-funded study used innovative NeuroGrid technology to show that sleep boosts communication between the hippocampus and association neocortex, crucial for memory formation. The research suggests that neural dialogue between these regions helps retain information during sleep.
Researchers suggest existing models of memory formation should be revised due to existence of 'silent engrams' which store memories even when they cannot be retrieved through natural cues. Memories are stored in a specific pattern of connections that form between cells during the first few minutes after an event occurs.
Researchers discovered a new learning mechanism that spans seconds, allowing for the storage of entire sequences of events, including places traversed. This finding challenges the widely accepted Hebbian learning rule, suggesting no causal relationship between interconnected neurons is required to form long-lasting associations.
Researchers have identified a distinct 'detour' circuit in the hippocampus that is necessary for memory recall, but not for memory formation. This circuit branches off from the original memory circuit and connects to the entorhinal cortex, enabling easier editing or updating of memories.
A research team at UC Riverside has developed a method to selectively erase specific fear memories by weakening the connections between neurons involved in forming these memories. This breakthrough has therapeutic implications for treating PTSD and phobias, allowing beneficial memories to be retained while detrimental ones are suppressed.
A Harvard Medical School study found that neurons involved in learning and memory are less stable than previously thought, but more flexible. This flexibility allows the brain to easily integrate new information and adapt to changing circumstances.
Research finds that a neural stopover in the subiculum is necessary for retrieving episodic memories, but not forming them. Activating or inhibiting this pathway affects memory recall and stress hormone levels related to fear responses.
Researchers argue that synaptic plasticity and intrinsic plasticity are crucial in forming physical memory traces in the brain. Intrinsic plasticity plays an important role in adapting to new information and experiences, often without changes to connections between neurons.
Research reveals that novelty detection triggers brain states that enhance new memory formation, suggesting a shift in how we make memories. The study's findings have implications for developing novel early warning tests and management strategies for memory impairments like Alzheimer's disease.
Max Planck Florida Institute for Neuroscience researchers optimized imaging methods to visualize CaMKII activation induced by calcium level increases. They found that CaMKII activity spiked in response to each pulse, just like calcium, but with longer-lasting and step-wise patterns that influenced synapse strength and structure.
Weizmann Institute scientists have successfully erased fear memories in mice by disrupting the communication between two brain regions. The study, published in Nature Neuroscience, may one day lead to novel therapies for post-traumatic stress disorder (PTSD) and other anxiety disorders.
Researchers found evidence of long-lasting engram cells in the frontal part of the brain, which mature as new memories become permanent. These cells were activated naturally only after weeks of conditioning, suggesting a maturation process that requires input from hippocampal engram cells.
Cognitive psychologists at Johns Hopkins University have made a key discovery about human memory, linking it to the ability to track an object's movement. They found that people's memories improve significantly with rich details about how an object's appearance changes as it moves through space and time.
Researchers found that manipulating the fkbp5 gene, affected by dexamethasone, can prevent fearful memories and hyperarousal associated with PTSD. The study suggests using dexamethasone as a preventative treatment to reduce PTSD risk in traumatic events.
Ron Davis, a Scripps Florida scientist, has been awarded a $5 million Outstanding Investigator Grant to investigate the biological processes underlying memory formation. The grant aims to understand how the brain organizes memories and suppresses their formation, with potential applications in treating neurological disorders.
Honeybee memories may hold clues to understanding human long-term memory formation and combating degenerative brain diseases. DNA methylation plays a crucial role in regulating memory specificity, with implications for treating conditions like Alzheimer's and dementia.
Researchers at Bar-Ilan University discovered that the brain temporarily blocks new memory formation upon waking to prevent disruption of memory consolidation during sleep. This process involves a protein synthesis-dependent mechanism that inhibits learning just after awakening.
Researchers at the Stowers Institute discovered Orb2's role in encoding memory and forming long-term memory in fruit flies. The protein's prion-like ability transforms into clusters under certain conditions, which helps stabilize memories.
A study by the University of Edinburgh has found that attention-grabbing experiences activate a specific area of the brain, releasing memory-boosting chemicals. Researchers discovered that mice who had new experiences just before or after learning a new location remembered it better the next day.
A team of researchers has built a mathematical model that describes the molecular events associated with the beginning stage of learning and memory formation. The study focuses on dendritic spines, which are dynamic structures changing in size, shape, and number during development and aging.
Researchers found that middle-aged adults activated the medial prefrontal cortex instead of the visual cortex when recalling details, suggesting a change in what information they prioritize as they age. This shift may be beneficial for daily life tasks but could impact memory performance if not adapted to.
Researchers discovered that methylation of RNA can strengthen memory formation by reducing the brain's ability to remove methyl groups. This process may have significant implications for treating memory-related disorders such as post-traumatic stress disorder or phobia.
A team of scientists has identified a back-up mechanism for memory storage that takes over when the molecular mechanism of primary long-term memory storage fails. They found that mice engineered without an enzyme crucial to long-term memory storage still form memories because they deploy an alternative method, involving PKCλ/ι.
A new study by SUNY Downstate resolves the controversy over PKMzeta's importance in forming and retaining memories. Mice lacking PKMzeta recruit a closely related molecule, PKCiota/lambda, to compensate for its absence, highlighting the brain's memory system durability.
Research at Gladstone Institutes found that the apoE4 protein disrupts brain activity in mice, impairing memory replay and consolidation. The study suggests that disrupted slow gamma activity during ripples is a major consequence of apoE4 expression, likely leading to impaired memory loss.
Researchers found that ants form rafts with different members occupying specific positions based on experience, demonstrating collective memory and cooperation. This phenomenon has implications for our understanding of social insects and potential applications in robotics and medicine.
Scientists have identified a unique memory suppressor gene in Drosophila that could hold the key to developing new Alzheimer's treatments. The gene, known as DmSLC22A, is involved in filtering information and storing important parts when the brain prioritizes memories.
Researchers have designed molecules that promote the formation and retention of memories by increasing dendritic spine density in neurons. The compounds also prevent the loss of these spines in the presence of amyloid-beta, a protein implicated in Alzheimer's disease.
Researchers have developed an entirely new form of digital memory using antiferromagnets, which can be controlled with electrical pulses. This technology has the potential to increase storage density, reduce energy consumption and improve speed.
Researchers discovered a cellular circuit in the mouse brain that enables it to remember safe environments and differentiate them from dangerous ones. The study found that disrupting this circuitry may contribute to conditions like posttraumatic stress and anxiety disorders.
A study published in The Journal of Neuroscience found that playing 3D video games improved memory performance by 12% in non-gamer college students, while 2D gamers did not. This suggests that environmental enrichment through immersive gaming may be a viable route to stem cognitive aging.
Researchers found joiner neurons that can be pre-positioned for rapid recruitment into memories, changing how brain networks adjust to build memories. This discovery has implications for understanding memory formation and developing new strategies for brain injury recovery.
A new study has identified specific genes that are repressed after memory formation, providing insights into how long-term memories are formed. The researchers found that estrogen receptor alpha (ESR1) and Nrsn1 genes play a crucial role in modulating gene-regulatory networks after learning.
Researchers at USC and Wake Forest Baptist Medical Center have developed a brain prosthesis that mimics how memories are translated from short-term to long-term storage. The device has shown high accuracy in predicting neural signals with about 90% accuracy in hundreds of trials conducted with nine patients.
A brain circuit has been identified that processes the 'when' and 'where' components of memory, separating location and timing into two streams of information. This discovery sheds light on how the brain represents time and place in episodic memories.
Ocean cells differentiate environmental contexts, which are then sent to the hippocampus for memory formation. The entorhinal cortex plays a crucial role in context-dependent learning, and understanding Ocean cells' contribution may help diagnose Alzheimer's disease.
Researchers have developed a light-activated switch that enables precise control of NMDA receptors, which are crucial for forming and storing memories. This tool promises to provide new insights into the mechanisms underlying synaptic plasticity and memory formation.
Researchers identified individual neurons in the medial temporal lobe that changed their firing to encode new associations at the exact moment of the experience. This finding may lead to a better understanding of memory loss and new methods to fight it in Alzheimer's and other neurological diseases.
Scientists reveal that neurons change their firing properties to encode new associations, forming new memories in a matter of seconds. The study demonstrates the neural processes underlying real-life memory formation, showing that a single exposure is enough to create lasting memories.
Researchers recorded individual neuron activity in patients to understand episodic memory creation. They found that neurons signal new contextual associations between people and places with dramatic changes after a single trial.
Scientists from Scripps Research Institute have identified five microRNAs that are necessary for memory formation, while others decrease it, affecting neuronal physiology and nervous system development. The study provides valuable insights into the complex mechanisms of learning and memory.
Researchers have found that artificially reactivating positive memories can suppress the effects of stress-induced depression in mice. The study reveals how brain circuits interact with negative experiences and provides a potential target for therapeutic approaches.
Researchers at Ruhr-University Bochum recreated memory formation in the hippocampus using computer simulations, challenging the existing model. They found that the CA1 region plays a key role in completing memories, while the CA3 region is not as crucial as previously thought.
A study published in Springer's Chemosensory Perception journal found that fragrance preferences are driven by personal emotional memories. The researchers discovered that odor-evoked memories elicit potent emotional responses, influencing customers' likes and ratings.
A team of NYU researchers discovered that two growth factor families, TrkB and TGFβr-II, play distinct roles in creating long-term memories by exerting their actions in different parts of the brain. At different times, these molecules swap roles to facilitate memory formation.
Researchers found that extra sleep can restore memory formation in fruit flies with disrupted genes, similar to Alzheimer's disease. The study suggests that sleep helps reinforce connections between brain cells and cut back on useless information.
The study suggests the hippocampus is primarily associated with memory formation and not spatial skills. Patients with hippocampal lesions can perform spatial tasks as long as these tasks don't depend on long-term memory, supported by frontal lobe functions.
Researchers at MIT developed a system that cleverly distributes data around multicore chips' memory banks, improving execution times by 18 percent on average while increasing energy efficiency. In simulations involving a 64-core chip, the system increased computational speeds by 46 percent while reducing power consumption by 36 percent.
Gene expression in neurons is crucial for memory formation. After fear conditioning, researchers found altered gene expression in the auditory thalamus and cortex regions of the brain.
A new study identifies a neural mechanism for translating unpleasant experiences into fear memories by changing amygdala connections. The findings suggest that Hebbian plasticity is partially correct but requires concurrent activation of noradrenaline to form memories.
A new international study led by the Research Institute of McGill University Health Centre has identified a molecule that puts a brake on brain processing and when removed, brain function and memory recall are improved. The study found that suppressing the production of molecules required for building new memories leads to stronger con...
A study published in PLOS Computational Biology proposes a theoretical framework for understanding memory formation and modification. The researchers suggest that large prediction errors lead to memory formation, while small errors result in memory modification. Damage to the hippocampus can impair the brain's ability to carve memories.
Researchers have created a novel technology to simulate the hippocampus, a key region in memory formation. By analyzing the 3D model, they found that the hippocampus' shape and size can explain why neurons fire at specific frequencies.