Researchers found that flies use brain circuitry for spatial navigation to remember where a plume boundary lies and steer back to it. By tracking the edge of an odor plume, flies store a directional memory that allows them to navigate towards the scent source even in turbulent conditions.
A new review proposes a roadmap for developing cognitive brain-computer interfaces to treat cognitive disorders, integrating BCI research and clinical neuromodulation. The emerging field aims to detect dysfunctional brain states and respond with adaptive neurostimulation.
A Mayo Clinic study found that bringing clinical trial activities directly to patients can increase participation among rural and underserved communities. The decentralized program expanded access to research, increasing enrollment from 16.6% to 24.9% in rural communities and 12.5% to 17.4% among underserved racial and ethnic populations.
Nigel provides clinicians with fast, evidence-based answers, helping them make faster, more confident decisions. The platform reduces cognitive burden by enabling quick access to current evidence and reducing time spent on literature searches.
The Robert A. Winn Excellence in Clinical Trials Award Program is training a new generation of physicians to solve healthcare's representation challenge through immersive education and mentorship. The program has grown rapidly, drawing hundreds of applicants annually from medical schools across the country.
The University of Colorado Anschutz, along with UCHealth and Children’s Hospital Colorado, have formed a strategic alliance with Bayer to accelerate medical discovery and expand patient access to investigational therapies. Initial focus areas include oncology, cardiovascular disease, and cell and gene therapy.
A young woman's quality of life and ability to walk were restored after a specialized procedure at Semmelweis University. The laparoscopic removal of a rare, benign tumor of neurological origin in the lesser pelvis, known as a schwannoma, was performed using intraoperative electrophysiological monitoring.
A pilot study found that an examiner-worn, neck-mounted camera can supplement the observation and review of clinical skills during OSCE assessments. The results showed moderate to strong agreement between live and video-based assessments, with the wearable camera enabling more observations to be evaluated than the fixed camera.
The Robert A. Winn Clinical Investigator Pathway Program is launching its fifth cohort, welcoming 80 medical students from across the US and Puerto Rico for a six-week immersion in clinical research, community engagement, and improving clinical trial participation. Students will gain hands-on experience at leading institutions nationwide.
Eighty medical students from across the US and Puerto Rico are selected for a six-week summer experience to introduce them to clinical research early in their careers. The program aims to develop the next generation of clinical investigators equipped to engage communities and improve participation in clinical trials.
The Columbia University Irving Medical Center has received a $75 million Clinical and Translational Science Award from the National Institutes of Health. This funding will support translational science at CUIMC, advancing biomedical research from bench to bedside.
Dr. Josep Maria Ribera receives the EHA Clinical Excellence Award for his distinguished career in Acute Lymphoblastic Leukaemia treatment and patient care improvements. He is also recognized for his academic mentorship, training numerous haematologists who now lead positions in the field.
A new study from Bradley Hospital researchers shows that cannabis use during adolescence is associated with reduced dopamine-related neurophysiology and altered reward processing. The study found that teens who repeatedly used cannabis showed signs of reduced tissue iron levels in brain regions involved in motivation and reward.
A new framework, VIBEMed, uses multi-agent collaboration to break complex clinical decisions into specialist roles and employs a three-level self-evolution mechanism to improve performance over time. This approach demonstrates superior performance in complex medical reasoning and treatment planning tasks.
Ochsner Health celebrated its 23rd Annual Research Week from May 18 through May 21, featuring scientific findings and recognized excellence in discovery and patient outcomes. The week also showcased award-winning lectures and presentations on cancer biology, precision medicine, and innovative clinical trials.
The UMass Center for Clinical and Translational Science has received a seven-year, $50 million grant from the NIH. The funding supports collaboration among researchers at multiple UMass campuses and clinical partners.
A national survey of 971 clinicians found that burnout, chronic workplace stress, administrative burden, and unrealistic patient expectations are now among the top reasons physicians leave clinical practice early. The study also highlights gender disparities in physician decisions to exit clinical practice.
The International Progressive MS Alliance has launched the MS Clinical and Imaging Data Resource (MS CIDR) to accelerate understanding of MS progression. The resource contains anonymized data from 14 pharmaceutical industry clinical trials, including MRI scans and clinical visits data from over 13,000 people with progressive MS.
A new study shows that large language models (LLMs) excel in physicians' clinical reasoning tasks, including emergency room decisions and diagnoses. LLMs surpassed earlier AI systems in complex cases, but the findings raise questions about their future implementation in clinical care.
Scientists found that the brain adapts to noise-induced damage within 24 hours by increasing excitability and inhibitory inputs in the superior paraolivary nucleus. This enables the restoration of critical timing information for sound processing, despite diminished sensitivity to quieter sounds.
Independent academic clinical trials are essential for improving patient outcomes, reducing inequalities in care, and strengthening healthcare systems. The Lancet Oncology Commission aims to deliver actionable recommendations to ensure these trials continue to benefit patients and society worldwide.
The Keck School of Medicine of USC and Tempus are creating a system-wide framework to integrate clinical care, clinical trials, and research through AI-powered precision medicine tools. The goal is to enhance patient care and accelerate research and innovation.
Terrence Sejnowski receives Scientific Breakthrough Award for his foundational development of Boltzmann machines, providing the architectural bedrock for deep learning and generative AI. His work has had a profound impact on modern artificial intelligence and tools like ChatGPT.
The study found a concerning trend towards trial consolidation at top-performing sites in the US, with more limited access to clinical trials for lower-volume locations. This may be due to factors such as increased complexity of phase I trials and regulatory burdens.
A study of 21 large language models found that they excel at accurate final diagnoses but falter at differential diagnoses, highlighting the need for human oversight in healthcare. The researchers developed a novel measure, PrIME-LLM, to evaluate AI's clinical competency across different stages of reasoning.
The Robert A. Winn Excellence in Clinical Trials Award Program has partnered with AstraZeneca to support five medical students participating in the Winn Clinical Investigator Pathway Program (Winn CIPP). The program provides immersive training, mentorship, and hands-on experience to prepare students for careers in clinical research.
The Robert A. Winn Excellence in Clinical Trials Award Program is expanding its career development award to include neuropsychiatry researcher-physicians. This expansion aims to improve clinical trial enrollment and represent diverse patient populations affected by complex disorders.
Researchers studied Norwegians with reported chronic health problems linked to tick bites, finding no objective evidence of persistent infections. The study suggests that physical activity and labour force participation may be more related to symptoms than tick exposure.
Epicurrents is an open-source web browser application that enables users to view various clinical neurophysiology recordings directly in a web browser. It supports easy, secure, and cost-effective remote teaching and can be used for both educational purposes and scientific research.
The University of Missouri has launched its first human clinical trial using Eye90 microspheres, a radiopharmaceutical breakthrough device manufactured on campus. The study aims to assess the safety and effectiveness of Eye90 in treating unresectable liver tumors, including hepatocellular carcinoma and metastatic colorectal cancer.
Halle Zhang joins Insilico Medicine to lead global clinical development strategy for the company's oncology portfolio. She brings over 20 years of experience in oncology clinical development and a track record of advancing therapies through registrational trials.
The UTA Pediatric Brain Health and Neurosciences Center will focus on developing novel treatments for drug-resistant epilepsy in children. Dr. Papadelis' team has already made significant discoveries in identifying the epileptogenic zone and predicting surgical outcomes.
Dr. Bo Yuan has been recognized with the 2026 Dr. Michael S. Watson Genetic and Genomic Medicine Innovation Award for his pioneering work in genetic disorders, artificial intelligence-driven tools, and pharmacogenomics. His research aims to improve clinical care, scientific understanding, and public health through innovative technologies.
Researchers from CAMH and RWTH Aachen deciphered the molecular signature of sleeping nociceptors, a type of pain-sensing nerve cell that drives chronic pain. The findings reveal specific molecular hallmarks, including OSMR and Nav1.9, which could lead to the development of targeted therapies.
UVA experts Bruce Greyson and Marieta Pehlivanova argue that the NEPTUNE model leaves many unanswered questions about near-death experiences. Despite its sophistication, the model selectively ignores scientific evidence and fails to address key aspects of NDEs.
The Mount Sinai Health System has launched an AI-powered clinical trial-matching platform, PRISM, to help connect patients with life-saving trials. The platform uses machine learning to match patients with trials based on their electronic health records and diagnosis.
Scientists at Lund University have created a new method to directly reprogram glial cells into parvalbumin neurons, which can help regulate brain activity and potentially treat disorders such as schizophrenia and epilepsy. The breakthrough could lead to therapies that replace lost or damaged brain cells in the future.
A systematic review of randomized controlled trials evaluating large language models in digestive diseases found only 14 eligible studies worldwide. Most focused on gastrointestinal and hepatobiliary diseases, with clinical decision-making and patient education being common applications. The authors emphasize the need for high-quality ...
Boston Children's Hospital will provide clinical research coordination for the IMPACT Network, a multisite clinical trial infrastructure enabling rapid and effective therapeutic development for autism. The grant, from ARIA, will support the development of study design protocols, recruitment strategies, and efficient workflows.
The UCLA-led Clinical Coordinating Center will standardize clinical and data processes, accelerating the development of therapies for people with autism and related conditions.
A team of researchers has captured the process of synaptic vesicle fusion with neurotransmitters, revealing a direct form of vesicle recruitment that enables neurons to send signals over longer periods. This breakthrough could lead to targeted therapies for synaptic disorders and improve our understanding of brain function.
Mass General Brigham's new AI company, AIwithCare, has developed a software platform that leverages generative AI to screen patients for clinical trial eligibility. The tool, RECTIFIER, was found to accurately identify eligible patients and enroll them in clinical trials at a lower cost than traditional methods.
The International Linked Clinical Trials Program aims to change that by supporting and facilitating clinical trials of potentially disease-modifying treatments. Over 6,800 people with Parkinson's have participated in these trials, and approximately 40% of prioritized drugs have been approved for clinical trials.
The company's AI tool, RECTIFIER, uses generative AI to screen patients for clinical trial eligibility, significantly outperforming manual screening in accuracy and efficiency. The tool has been shown to more accurately identify eligible patients and reduce the burden of manual chart review in various healthcare settings.
Andres M. Álvarez-Pinzón joins NRG Developmental Therapeutics Committee, bringing expertise in oncology clinical trials and translational medicine. Ronald Chen becomes Chair of the NRG Patient Centered Outcomes Research Committee, focusing on improving cancer outcomes through clinical trials and patient-reported outcomes.
Linda Bulone, a Queens Cancer Center Oncology nurse, received the 2025 Alliance Clinical Research Professionals Research Integrity Service Excellence (CRP RISE) Award. She has significantly increased clinical trial participation, expanded early screening efforts, and supported reductions in late-stage diagnoses.
John DeLuca, PhD, received the 2025 Reitan Clinical Excellence Award for his significant contributions to clinical practice in neuropsychology. He has shaped cognitive rehabilitation approaches and advanced understanding of brain function in populations affected by neurological injury and disease.
The Mount Sinai Tisch Cancer Center has introduced a real-time data integration tool to automate the transfer of clinical data from its electronic health record system into clinical trial platforms. This technology streamlines data flow, reducing manual transcription time by up to 70% and improving data quality and workforce efficiency.
A Griffith University study published in Nature Mental Health found that integrating nature-based therapies into clinical healthcare could address global declines in mental health. Nature experiences designed to improve mental health are not yet incorporated in regulated clinical healthcare, but embedding nature therapy into clinical h...
New tools, such as CheatBlocker and QuotaConfig, help address challenges of data integrity in decentralized clinical trials. CheatBlocker detects fraud, while QuotaConfig ensures sample representativeness. These innovations aim to increase the reliability and security of remote clinical trials.
The Mount Sinai team will investigate neural mechanisms underlying bipolar disorder and pioneer novel neuromodulation-based treatment strategies.
Developed a novel EEG transformer model, Augmenting Electroencephalogram Transformer (AETF), to enhance steady-state visually evoked potential-based brain–computer interface (BCI) systems. The AETF model improves decoding efficiency by capturing temporal, spatial, and frequency features of dynamic EEG signals.
A recent study published in CANCER found that the number and complexity of cancer clinical trials have varied greatly across low- and middle-income countries (LMICs) since 2001. While economic growth has been a contributing factor, it is not the sole determinant of cancer clinical trial growth among LMICs.
Terrence Sejnowski, a renowned neuroscientist at Salk Institute, has been awarded the 2025 NIH Director's Pioneer Award to develop advanced computational techniques for analyzing working memory. His research aims to better understand and treat memory disorders in mental health conditions.
The new centre supports multiple clinical trials in parallel, enabling comprehensive evaluations of organ health across physiological systems. It also provides hands-on training opportunities for healthcare professionals, bridging the gap between theoretical knowledge and practical application.
Mayo Clinic's new program enables biopharma companies to accelerate clinical development by providing access to de-identified data, advanced AI tools, and a global distribution network. This collaboration streamlines access to Mayo Clinic's world-class research expertise, allowing companies to move efficiently from discovery to delivery.
Researchers identified 33 plasma proteins that differ significantly in patients with ALS, suggesting the disease could be detected up to 10 years before symptoms appear. Machine learning models showed strong performance in separating ALS cases from non-ALS cases, with an accuracy of over 98.3%.
A study discovered six causal molecular biomarkers (CNPY4, ENTPD6, HLA-A) and eight clinical biomarkers for metabolic dysfunction-associated steatotic liver disease (MASLD). Serum total protein levels partially mediated the effect of HLA-A on MASLD.
The Alliance for Clinical Trials in Oncology will host a public webinar showcasing key findings from the 2025 ASCO Annual Meeting. Researchers will discuss latest information on colorectal, squamous cell, and renal cell cancers.